ISMARA results: runx1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for runx1

Z-value: 1.99

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Transcription factors associated with runx1

Gene Symbol	Gene ID	Gene Info
runx1 NCBI UniProt	ENSDARG00000087646	RUNX family transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
runx1	dr11_v1_chr1_-_1402303_1402303	0.27	9.2e-03	Click!

Activity profile of runx1 motif

Sorted Z-values of runx1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_7810348 Show fit	24.60	ENSDART00000171984	cxcl19 NCBI UniProt Show fit	chemokine (C-X-C motif) ligand 19
chr17_-_2039511 Show fit	21.89	ENSDART00000160223	spint1a NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type 1 a
chr18_+_5543677 Show fit	20.01	ENSDART00000146161 ENSDART00000136189	nnt2 NCBI UniProt Show fit	nicotinamide nucleotide transhydrogenase 2
chr7_+_22637515 Show fit	19.93	ENSDART00000158698	si:dkey-112a7.5 NCBI UniProt Show fit	si:dkey-112a7.5
chr14_+_38786298 Show fit	19.72	ENSDART00000164440	si:ch211-195b11.3 NCBI UniProt Show fit	si:ch211-195b11.3
chr20_-_14054083 Show fit	19.33	ENSDART00000009549	rhag NCBI UniProt Show fit	Rh associated glycoprotein
chr7_+_31879986 Show fit	17.28	ENSDART00000138491	mybpc3 NCBI UniProt Show fit	myosin binding protein C, cardiac
chr23_+_36653376 Show fit	16.63	ENSDART00000053189	gpr182 NCBI UniProt Show fit	G protein-coupled receptor 182
chr3_-_16784280 Show fit	16.24	ENSDART00000137108 ENSDART00000137276	si:dkey-30j10.5 NCBI UniProt Show fit	si:dkey-30j10.5
chr7_+_31879649 Show fit	15.97	ENSDART00000099789	mybpc3 NCBI UniProt Show fit	myosin binding protein C, cardiac

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of runx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	80.0	GO:0030593	neutrophil chemotaxis(GO:0030593)
0.5	71.8	GO:0042742	defense response to bacterium(GO:0042742)
0.4	35.5	GO:0009617	response to bacterium(GO:0009617)
0.4	35.4	GO:0010466	negative regulation of peptidase activity(GO:0010466)
6.7	33.3	GO:0003210	cardiac atrium formation(GO:0003210)
0.2	26.0	GO:0019221	cytokine-mediated signaling pathway(GO:0019221)
1.2	25.8	GO:0018149	peptide cross-linking(GO:0018149)
2.1	23.3	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
1.0	21.5	GO:0042541	hemoglobin biosynthetic process(GO:0042541)
5.0	20.0	GO:0006740	NADPH regeneration(GO:0006740)

Showing 1 to 10 of 308 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	162.3	GO:0005615	extracellular space(GO:0005615)
0.3	65.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	24.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	21.1	GO:0031012	extracellular matrix(GO:0031012)
0.2	19.3	GO:0005581	collagen trimer(GO:0005581)
0.3	17.4	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	15.3	GO:0005759	mitochondrial matrix(GO:0005759)
0.3	15.2	GO:0032580	Golgi cisterna membrane(GO:0032580)
1.7	13.9	GO:0043020	NADPH oxidase complex(GO:0043020)
0.9	13.7	GO:0070187	telosome(GO:0070187)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	77.3	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.5	63.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	36.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	35.9	GO:0003735	structural constituent of ribosome(GO:0003735)
3.0	33.3	GO:0032036	myosin heavy chain binding(GO:0032036)
0.4	27.8	GO:0001594	trace-amine receptor activity(GO:0001594)
1.3	25.8	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
2.2	24.6	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.2	23.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.5	21.6	GO:0048020	CCR chemokine receptor binding(GO:0048020)

Showing 1 to 10 of 221 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	39.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	30.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	26.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	17.9	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.7	17.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.6	16.2	PID RAS PATHWAY	Regulation of Ras family activation
0.5	14.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	13.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.3	13.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.7	13.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells

Showing 1 to 10 of 57 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	35.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
2.1	23.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.8	15.7	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.3	15.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.3	13.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	10.6	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	10.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.7	9.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.5	9.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.6	8.8	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins

Showing 1 to 10 of 85 entries

Results for runx1

Z-value: 1.99

Motif logo

Transcription factors associated with runx1

Activity-expression correlation:

Activity profile of runx1 motif

Sorted Z-values of runx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of runx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: