ISMARA results: rxrbb

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rxrbb

Z-value: 0.72

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Transcription factors associated with rxrbb

Gene Symbol	Gene ID	Gene Info
rxrbb NCBI UniProt	ENSDARG00000002006	retinoid x receptor, beta b
rxrbb NCBI UniProt	ENSDARG00000117079	retinoid x receptor, beta b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
rxrbb	dr11_v1_chr16_+_18535618_18535618	0.63	7.4e-12	Click!

Activity profile of rxrbb motif

Sorted Z-values of rxrbb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_25848231 Show fit	8.13	ENSDART00000027973	fabp2 NCBI UniProt Show fit	fatty acid binding protein 2, intestinal
chr13_-_9318891 Show fit	7.98	ENSDART00000137364	si:dkey-33c12.3 NCBI UniProt Show fit	si:dkey-33c12.3
chr23_-_45504991 Show fit	7.95	ENSDART00000148761	col24a1 NCBI UniProt Show fit	collagen type XXIV alpha 1
chr3_+_30257582 Show fit	6.64	ENSDART00000159497 ENSDART00000103457 ENSDART00000121883	mybpc2a NCBI UniProt Show fit	myosin binding protein C, fast type a
chr25_+_21829777 Show fit	6.57	ENSDART00000027393	ckmt1 NCBI UniProt Show fit	creatine kinase, mitochondrial 1
chr18_-_48517040 Show fit	6.42	ENSDART00000143645	kcnj1a.3 NCBI UniProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr7_-_38633867 Show fit	6.09	ENSDART00000137424	c1qtnf4 NCBI UniProt Show fit	C1q and TNF related 4
chr10_+_45128375 Show fit	5.95	ENSDART00000164805	camk2b2 NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr10_-_17745345 Show fit	5.34	ENSDART00000132690 ENSDART00000135376	si:dkey-200l5.4 NCBI UniProt Show fit	si:dkey-200l5.4
chr18_-_48492951 Show fit	5.28	ENSDART00000146346	kcnj1a.6 NCBI UniProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6

Showing 1 to 10 of 155 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of rxrbb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.4	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
1.3	7.9	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.5	6.6	GO:0046314	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2	5.9	GO:0035118	embryonic pectoral fin morphogenesis(GO:0035118)
0.2	4.6	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	4.6	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	4.1	GO:0007265	Ras protein signal transduction(GO:0007265)
0.0	3.9	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.1	3.8	GO:0003009	skeletal muscle contraction(GO:0003009)
0.1	3.7	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)

Showing 1 to 10 of 55 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	7.9	GO:0005592	collagen type XI trimer(GO:0005592)
0.1	7.1	GO:0005882	intermediate filament(GO:0005882)
0.0	5.5	GO:0005875	microtubule associated complex(GO:0005875)
0.1	4.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	4.3	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1	3.8	GO:0005861	troponin complex(GO:0005861)
0.2	3.7	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4	3.0	GO:0035517	PR-DUB complex(GO:0035517)
0.5	2.7	GO:0043034	costamere(GO:0043034)
0.1	2.4	GO:0008305	integrin complex(GO:0008305)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	19.4	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.7	10.5	GO:0005504	fatty acid binding(GO:0005504)
0.1	9.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.5	6.6	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1	5.9	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	4.9	GO:0005178	integrin binding(GO:0005178)
0.0	4.3	GO:0008017	microtubule binding(GO:0008017)
0.1	4.1	GO:0019003	GDP binding(GO:0019003)
1.2	3.7	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.3	3.7	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.9	NABA COLLAGENS	Genes encoding collagen proteins
0.1	6.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	2.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	2.0	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	2.0	PID P73PATHWAY	p73 transcription factor network
0.1	1.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	1.7	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	1.5	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	1.5	PID AP1 PATHWAY	AP-1 transcription factor network

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	2.6	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	2.6	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	2.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	2.0	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3	1.9	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.2	1.5	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	1.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.5	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA

Showing 1 to 9 of 9 entries

Results for rxrbb

Z-value: 0.72

Motif logo

Transcription factors associated with rxrbb

Activity-expression correlation:

Activity profile of rxrbb motif

Sorted Z-values of rxrbb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of rxrbb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: