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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for six4a+six4b
Z-value: 0.73
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Transcription factors associated with six4a+six4b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| six4b | dr11_v1_chr20_+_20484827_20484827 | -0.26 | 1.3e-02 | Click! |
| six4a | dr11_v1_chr13_-_31647323_31647323 | -0.13 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_10134345 Show fit | 8.61 |
ENSDART00000100725
|
alpha-2-HS-glycoprotein 2 |
|
| chr9_+_8396755 Show fit | 7.48 |
ENSDART00000043067
|
zgc:171776 |
|
| chr3_-_39152478 Show fit | 6.91 |
ENSDART00000154550
|
si:dkeyp-57f11.2 |
|
| chr2_+_24304854 Show fit | 5.60 |
ENSDART00000078972
|
fat storage-inducing transmembrane protein 1 |
|
| chr22_+_25236888 Show fit | 5.23 |
ENSDART00000037286
|
zgc:172218 |
|
| chr22_+_25242322 Show fit | 5.10 |
ENSDART00000134628
|
si:ch211-226h8.8 |
|
| chr1_+_55140970 Show fit | 5.08 |
ENSDART00000039807
|
myoglobin |
|
| chr24_+_34089977 Show fit | 5.05 |
ENSDART00000157466
|
ankyrin repeat and SOCS box containing 10 |
|
| chr22_+_25236657 Show fit | 4.64 |
ENSDART00000138012
|
zgc:172218 |
|
| chr14_-_7128980 Show fit | 4.22 |
ENSDART00000171311
|
si:ch73-43g23.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of six4a+six4b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.3 | 5.1 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 4.0 | GO:0006520 | cellular amino acid metabolic process(GO:0006520) |
| 1.3 | 3.8 | GO:1903373 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373) |
| 0.5 | 2.6 | GO:0031652 | heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072) |
| 0.4 | 2.6 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 0.1 | 2.6 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.6 | 2.5 | GO:0072149 | visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314) |
| 0.8 | 2.3 | GO:0021530 | spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.5 | 2.3 | GO:0051659 | maintenance of mitochondrion location(GO:0051659) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 1.3 | 3.8 | GO:0098826 | endoplasmic reticulum tubular network membrane(GO:0098826) |
| 0.1 | 3.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 3.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 2.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 2.1 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.2 | 2.0 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 2.0 | GO:0034703 | cation channel complex(GO:0034703) |
| 0.1 | 1.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.2 | 8.6 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.2 | 5.1 | GO:0005344 | oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825) |
| 0.4 | 4.0 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 3.8 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.1 | 2.8 | GO:0008381 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 2.7 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.4 | 2.6 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 2.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 2.6 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.8 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.8 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.6 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 1.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 1.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 0.9 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 0.8 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.8 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.6 | REACTOME FRS2 MEDIATED CASCADE | Genes involved in FRS2-mediated cascade |