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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for six6a+six6b

Z-value: 0.52

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Transcription factors associated with six6a+six6b

Gene Symbol Gene ID Gene Info
six6a
ENSDARG00000025187 SIX homeobox 6a
six6b
ENSDARG00000031316 SIX homeobox 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six6adr11_v1_chr13_+_31603988_316039880.312.1e-03Click!
six6bdr11_v1_chr20_-_20533865_205338650.287.2e-03Click!

Activity profile of six6a+six6b motif

Sorted Z-values of six6a+six6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_35745572 3.75 ENSDART00000159690
gpr75
G protein-coupled receptor 75
chr2_-_44946094 3.58 ENSDART00000036997
camk2n1a
calcium/calmodulin-dependent protein kinase II inhibitor 1a
chr24_-_26632171 3.40 ENSDART00000008374
ENSDART00000017384
tnikb
TRAF2 and NCK interacting kinase b
chr13_+_28819768 2.43 ENSDART00000191401
ENSDART00000188895
ENSDART00000101653
CU639469.1

chr19_-_32710922 2.21 ENSDART00000004034
hpca
hippocalcin
chr2_+_1881334 2.18 ENSDART00000161420
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr18_-_14677936 2.16 ENSDART00000111995
si:dkey-238o13.4
si:dkey-238o13.4
chr15_-_31514818 2.11 ENSDART00000153978
hmgb1b
high mobility group box 1b
chr2_+_47581997 2.04 ENSDART00000112579
scg2b
secretogranin II (chromogranin C), b
chr14_+_50770537 2.02 ENSDART00000158723
sncb
synuclein, beta
chr6_-_49159207 1.96 ENSDART00000041942
tspan2a
tetraspanin 2a
chr15_-_25527580 1.80 ENSDART00000167005
ENSDART00000157498
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr1_+_1789357 1.64 ENSDART00000006449
atp1a1a.2
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 2
chr7_-_31932723 1.57 ENSDART00000014843
bdnf
brain-derived neurotrophic factor
chr2_-_30249746 1.53 ENSDART00000124153
ENSDART00000142575
elocb
elongin C paralog b
chr11_-_27702778 1.49 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr2_-_30250311 1.49 ENSDART00000184144
elocb
elongin C paralog b
chr19_+_206835 1.47 ENSDART00000161137
scn1bb
sodium channel, voltage-gated, type I, beta b
chr19_+_35002479 1.46 ENSDART00000103266
wdyhv1
WDYHV motif containing 1
chr3_-_21106093 1.45 ENSDART00000156566
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr5_-_39736383 1.36 ENSDART00000127123
rasgef1ba
RasGEF domain family, member 1Ba
chr22_-_12862415 1.35 ENSDART00000145156
ENSDART00000137280
glsa
glutaminase a
chr23_+_1702624 1.32 ENSDART00000149357
rabggta
Rab geranylgeranyltransferase, alpha subunit
chr23_+_16831063 1.32 ENSDART00000104782
zgc:173570
zgc:173570
chr21_-_42055872 1.29 ENSDART00000144767
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr11_-_31039533 1.28 ENSDART00000127355
ier2b
immediate early response 2b
chr22_+_2844865 1.28 ENSDART00000139123
si:dkey-20i20.4
si:dkey-20i20.4
chr14_-_21959712 1.28 ENSDART00000021417
p2rx3a
purinergic receptor P2X, ligand-gated ion channel, 3a
chr13_-_18195942 1.26 ENSDART00000079902
slc25a16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr7_+_20535869 1.25 ENSDART00000078181
zgc:158423
zgc:158423
chr13_+_42544009 1.24 ENSDART00000145409
si:dkey-221j11.3
si:dkey-221j11.3
chr23_-_38497705 1.24 ENSDART00000109493
tshz2
teashirt zinc finger homeobox 2
chr20_-_40487208 1.18 ENSDART00000075070
ENSDART00000142029
hsf2
heat shock transcription factor 2
chr22_-_21845685 1.17 ENSDART00000105564
aes
amino-terminal enhancer of split
chr8_-_37461835 1.14 ENSDART00000013446
eif2d
eukaryotic translation initiation factor 2D
chr1_+_17527342 1.13 ENSDART00000139702
ENSDART00000140076
ENSDART00000005593
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr18_+_31410652 1.13 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr3_-_39305291 1.12 ENSDART00000102674
plcd3a
phospholipase C, delta 3a
chr20_-_49729446 1.09 ENSDART00000111089
filip1b
filamin A interacting protein 1b
chr14_+_26759332 1.09 ENSDART00000088484
ahnak
AHNAK nucleoprotein
chr19_-_17774875 1.08 ENSDART00000151133
ENSDART00000130695
top2b
DNA topoisomerase II beta
chr16_+_1802307 1.06 ENSDART00000180026
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr1_+_34701144 1.05 ENSDART00000150038
gtf2f2a
general transcription factor IIF, polypeptide 2a
chr20_-_29471577 1.05 ENSDART00000043382
grem1a
gremlin 1a, DAN family BMP antagonist
chr23_+_41679586 1.04 ENSDART00000067662
CU914487.1

chr11_+_44804685 1.04 ENSDART00000163660
strn
striatin, calmodulin binding protein
chr14_+_45883687 1.03 ENSDART00000114790
flrt1b
fibronectin leucine rich transmembrane protein 1b
chr10_-_39198942 1.03 ENSDART00000077619
b3gat1b
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) b
chr19_+_27342479 1.03 ENSDART00000184687
ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr14_-_33585809 1.03 ENSDART00000023540
sash3
SAM and SH3 domain containing 3
chr21_-_26250744 1.02 ENSDART00000044735
gria1b
glutamate receptor, ionotropic, AMPA 1b
chr8_-_33114202 1.01 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr22_+_2247645 1.00 ENSDART00000143366
ENSDART00000147852
si:dkey-4c15.8
si:dkey-4c15.8
chr17_+_24722646 1.00 ENSDART00000138356
mtfr1l
mitochondrial fission regulator 1-like
chr16_-_36979592 0.97 ENSDART00000168443
snrnp48
small nuclear ribonucleoprotein 48 (U11/U12)
chr15_+_11840311 0.96 ENSDART00000167671
prkd2
protein kinase D2
chr7_+_22767678 0.95 ENSDART00000137203
ponzr6
plac8 onzin related protein 6
chr4_+_76752707 0.92 ENSDART00000082121
ms4a17a.4
membrane-spanning 4-domains, subfamily A, member 17A.4
chr12_-_43428542 0.89 ENSDART00000192266
ptprea
protein tyrosine phosphatase, receptor type, E, a
chr19_+_7835025 0.89 ENSDART00000026276
cks1b
CDC28 protein kinase regulatory subunit 1B
chr3_-_18711288 0.88 ENSDART00000183885
grid2ipa
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a
chr18_+_43183749 0.88 ENSDART00000151166
nectin1b
nectin cell adhesion molecule 1b
chr21_-_26250443 0.88 ENSDART00000123713
gria1b
glutamate receptor, ionotropic, AMPA 1b
chr15_-_762319 0.88 ENSDART00000154306
ENSDART00000157492
si:dkey-7i4.16
znf1011
si:dkey-7i4.16
zinc finger protein 1011
chr13_-_47810394 0.87 ENSDART00000105025
zmp:0000001138
zmp:0000001138
chr10_+_41549819 0.86 ENSDART00000114210
CABZ01049847.1

chr2_-_23391266 0.85 ENSDART00000159048
ivns1abpb
influenza virus NS1A binding protein b
chr24_-_19719240 0.85 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr16_+_44906324 0.85 ENSDART00000074960
cd22
cd22 molecule
chr16_+_49005321 0.84 ENSDART00000160919
CABZ01068499.1

chr21_-_2707768 0.83 ENSDART00000165384
CABZ01101739.1

chr10_+_44903676 0.83 ENSDART00000158553
zgc:114173
zgc:114173
chr21_+_11105007 0.82 ENSDART00000128859
ENSDART00000193105
prlra
prolactin receptor a
chr16_+_30002605 0.81 ENSDART00000160555
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr22_-_3261879 0.80 ENSDART00000159643
gpr35.1
G protein-coupled receptor 35, tandem duplicate 1
chr15_-_669476 0.80 ENSDART00000153687
ENSDART00000030603
si:ch211-210b2.2
si:ch211-210b2.2
chr10_-_38243851 0.79 ENSDART00000166108
usp25
ubiquitin specific peptidase 25
chr5_-_54160809 0.77 ENSDART00000158981
arhgef15
Rho guanine nucleotide exchange factor (GEF) 15
chr17_+_25331576 0.76 ENSDART00000157309
tmem54a
transmembrane protein 54a
chr6_+_11026866 0.75 ENSDART00000189619
abcc6a
ATP-binding cassette, sub-family C (CFTR/MRP), member 6a
chr8_-_28357177 0.75 ENSDART00000182319
KLHL12 (1 of many)
kelch like family member 12
chr22_+_2198246 0.75 ENSDART00000165168
ENSDART00000157485
ENSDART00000168713
znf1157
znf1166
zinc finger protein 1157
zinc finger protein 1166
chr2_-_27775236 0.74 ENSDART00000187983
XKR4
zgc:123035
chr7_-_7766920 0.72 ENSDART00000173376
intu
inturned planar cell polarity protein
chr14_-_17576391 0.71 ENSDART00000161355
ENSDART00000168959
rnf4
ring finger protein 4
chr2_+_23039041 0.70 ENSDART00000056921
csnk1g2a
casein kinase 1, gamma 2a
chr2_-_9607879 0.68 ENSDART00000056899
txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr5_-_66749535 0.68 ENSDART00000132183
kat5b
K(lysine) acetyltransferase 5b
chr5_-_41638039 0.68 ENSDART00000144525
epg5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr10_+_45302425 0.67 ENSDART00000159954
zmiz2
zinc finger, MIZ-type containing 2
chr19_-_20777351 0.66 ENSDART00000019206
ngly1
N-glycanase 1
chr7_-_67317119 0.66 ENSDART00000183915
psmd7
proteasome 26S subunit, non-ATPase 7
chr23_+_7710447 0.65 ENSDART00000168199
kif3b
kinesin family member 3B
chr10_-_5821584 0.64 ENSDART00000166388
il6st
interleukin 6 signal transducer
chr17_+_28706946 0.64 ENSDART00000126967
strn3
striatin, calmodulin binding protein 3
chr14_+_22467672 0.63 ENSDART00000079409
ENSDART00000136597
nudt22
nudix (nucleoside diphosphate linked moiety X)-type motif 22
chr16_+_6632969 0.63 ENSDART00000109276
sall3a
spalt-like transcription factor 3a
chr5_+_64368770 0.63 ENSDART00000162246
plpp7
phospholipid phosphatase 7 (inactive)
chr5_+_25304499 0.61 ENSDART00000163425
carnmt1
carnosine N-methyltransferase 1
chr9_-_5263947 0.61 ENSDART00000088342
cytip
cytohesin 1 interacting protein
chr19_-_46018152 0.61 ENSDART00000159206
krit1
KRIT1, ankyrin repeat containing
chr5_+_36661058 0.60 ENSDART00000125653
capns1a
calpain, small subunit 1 a
chr22_-_10459880 0.60 ENSDART00000064801
ogn
osteoglycin
chr15_-_25571865 0.60 ENSDART00000077836
mmp20b
matrix metallopeptidase 20b (enamelysin)
chr1_+_52735484 0.59 ENSDART00000182076
CABZ01021532.1

chr21_-_42007213 0.59 ENSDART00000188804
ENSDART00000092821
ENSDART00000165743
gabrg2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr7_-_44970682 0.58 ENSDART00000144591
fam96b
family with sequence similarity 96, member B
chr20_+_12702923 0.58 ENSDART00000163499
zgc:153383
zgc:153383
chr12_+_19348538 0.57 ENSDART00000066388
tomm22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr4_+_76426308 0.57 ENSDART00000180424
ENSDART00000159789
FP074874.1
zgc:172128

zgc:172128
chr4_-_73266929 0.56 ENSDART00000158194
wu:fc30c06
wu:fc30c06
chr11_-_17755444 0.56 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_-_45614318 0.55 ENSDART00000149725
atf7ip
activating transcription factor 7 interacting protein
chr20_-_51656512 0.54 ENSDART00000129965
LO018154.1

chr1_-_55888970 0.54 ENSDART00000064194
asf1bb
anti-silencing function 1Bb histone chaperone
chr3_+_23726148 0.52 ENSDART00000174580
hoxb3a
homeobox B3a
chr2_+_13907452 0.52 ENSDART00000169724
ENSDART00000190691
zgc:66475
zgc:66475
chr6_-_23002373 0.50 ENSDART00000037709
ENSDART00000170369
nol11
nucleolar protein 11
chr14_-_736575 0.50 ENSDART00000168611
tlr1
toll-like receptor 1
chr4_-_75172216 0.49 ENSDART00000127522
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr1_-_31657854 0.48 ENSDART00000085309
dpcd
deleted in primary ciliary dyskinesia homolog (mouse)
chr7_+_69428831 0.47 ENSDART00000186975
elp5
elongator acetyltransferase complex subunit 5
chr18_+_16133595 0.47 ENSDART00000080423
ctsd
cathepsin D
chr15_-_30450898 0.47 ENSDART00000156584
msi2b
musashi RNA-binding protein 2b
chr21_+_35289469 0.47 ENSDART00000155140
il12bb
interleukin 12B, b
chr12_+_2446837 0.46 ENSDART00000112032
ARHGAP22
si:dkey-191m6.4
chr12_-_27212596 0.46 ENSDART00000153101
psme3
proteasome activator subunit 3
chr20_+_42918755 0.45 ENSDART00000134855
efr3bb
EFR3 homolog Bb (S. cerevisiae)
chr10_+_39199547 0.45 ENSDART00000075943
ei24
etoposide induced 2.4
chr21_-_35428039 0.44 ENSDART00000193298
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr4_-_25858620 0.43 ENSDART00000128968
nr2c1
nuclear receptor subfamily 2, group C, member 1
chr22_+_9751117 0.43 ENSDART00000121827
BX664625.1

chr3_+_13850163 0.42 ENSDART00000164872
ilf3b
interleukin enhancer binding factor 3b
chr4_-_25859305 0.42 ENSDART00000159528
nr2c1
nuclear receptor subfamily 2, group C, member 1
chr20_-_16849306 0.41 ENSDART00000131395
ENSDART00000027582
brms1lb
breast cancer metastasis-suppressor 1-like b
chr12_-_16380961 0.41 ENSDART00000086984
hectd2
HECT domain containing 2
chr13_+_49727333 0.39 ENSDART00000168799
ENSDART00000037559
ggps1
geranylgeranyl diphosphate synthase 1
chr8_+_28259347 0.39 ENSDART00000110857
fam212b
family with sequence similarity 212, member B
chr25_-_24248000 0.39 ENSDART00000073527
spty2d1
SPT2 chromatin protein domain containing 1
chr4_-_13902188 0.38 ENSDART00000032805
gxylt1b
glucoside xylosyltransferase 1b
chr18_+_36786842 0.38 ENSDART00000123264
si:ch211-160d20.3
si:ch211-160d20.3
chr23_+_37955041 0.38 ENSDART00000087148
cbln4
cerebellin 4 precursor
chr8_-_12847483 0.36 ENSDART00000146186
si:dkey-104n9.1
si:dkey-104n9.1
chr8_+_17143501 0.34 ENSDART00000061758
mier3b
mesoderm induction early response 1, family member 3 b
chr7_-_36358735 0.33 ENSDART00000188392
fto
fat mass and obesity associated
chr9_+_38883388 0.32 ENSDART00000135902
map2
microtubule-associated protein 2
chr22_+_13977772 0.31 ENSDART00000080313
arl4ca
ADP-ribosylation factor-like 4Ca
chr15_-_25094026 0.31 ENSDART00000129154
exo5
exonuclease 5
chr7_+_22313533 0.30 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr17_+_41081512 0.30 ENSDART00000056742
babam2
BRISC and BRCA1 A complex member 2
chr25_+_15287036 0.30 ENSDART00000147572
hipk3a
homeodomain interacting protein kinase 3a
chr7_-_38807819 0.30 ENSDART00000132772
ENSDART00000052324
atg13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr3_-_61387273 0.30 ENSDART00000156479
znf1143
zinc finger protein 1143
chr5_-_30079434 0.28 ENSDART00000133981
bco2a
beta-carotene oxygenase 2a
chr6_-_32315494 0.28 ENSDART00000127879
atg4c
autophagy related 4C, cysteine peptidase
chr17_-_15611744 0.28 ENSDART00000010496
fhl5
four and a half LIM domains 5
chr13_+_21826096 0.28 ENSDART00000056432
zswim8
zinc finger, SWIM-type containing 8
chr9_-_54304684 0.28 ENSDART00000109512
il13
interleukin 13
chr12_+_17439580 0.27 ENSDART00000189257
atad1b
ATPase family, AAA domain containing 1b
chr7_+_24006875 0.27 ENSDART00000033755
homezb
homeobox and leucine zipper encoding b
chr5_-_57526807 0.25 ENSDART00000022866
pisd
phosphatidylserine decarboxylase
chr4_+_76637548 0.24 ENSDART00000133799
ms4a17a.9
membrane-spanning 4-domains, subfamily A, member 17A.9
chr6_+_28124393 0.24 ENSDART00000089195
gpr17
G protein-coupled receptor 17
chr6_-_16717878 0.24 ENSDART00000153552
nomo
nodal modulator
chr3_+_37707432 0.24 ENSDART00000151236
map3k14a
mitogen-activated protein kinase kinase kinase 14a
chr15_-_1822548 0.23 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr17_+_28882977 0.22 ENSDART00000153937
prkd1
protein kinase D1
chr24_-_25788841 0.22 ENSDART00000132235
klhl24b
kelch-like family member 24b
chr1_+_54198893 0.22 ENSDART00000158948
tsc2
TSC complex subunit 2
chr8_-_50259448 0.19 ENSDART00000146056
nkx3-1
NK3 homeobox 1
chr9_-_11676491 0.19 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr7_-_2143313 0.17 ENSDART00000173871
si:cabz01007807.1
si:cabz01007807.1
chr10_-_43540196 0.17 ENSDART00000170891
si:ch73-215f7.1
si:ch73-215f7.1
chr14_-_2318590 0.16 ENSDART00000192735
pcdh2ab8
protocadherin 2 alpha b 8
chr18_+_12058403 0.15 ENSDART00000140854
ENSDART00000193632
ENSDART00000190519
ENSDART00000190685
ENSDART00000112671
bicd1a
bicaudal D homolog 1a
chr12_+_7254112 0.15 ENSDART00000092009
tfam
transcription factor A, mitochondrial
chr25_-_10630496 0.15 ENSDART00000153639
ENSDART00000181722
ENSDART00000177834
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr1_+_14466860 0.14 ENSDART00000114097
stim2a
tromal interaction molecule 2a
chr16_+_41570653 0.14 ENSDART00000102665
aste1a
asteroid homolog 1a
chr14_-_17306261 0.14 ENSDART00000191747
jakmip1
janus kinase and microtubule interacting protein 1
chr8_+_23826985 0.13 ENSDART00000187430
mapk14a
mitogen-activated protein kinase 14a
chr24_-_39772045 0.12 ENSDART00000087441
GFOD1
si:ch211-276f18.2
chr13_+_22555342 0.12 ENSDART00000193633
bmpr1aa
bone morphogenetic protein receptor, type IAa
chr10_-_25816558 0.10 ENSDART00000017240
postna
periostin, osteoblast specific factor a
chr10_-_24648228 0.10 ENSDART00000081834
ENSDART00000132830
stoml3b
stomatin (EPB72)-like 3b
chr11_+_5681762 0.09 ENSDART00000179139
arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr2_-_732864 0.09 ENSDART00000168585
CU861459.1

chr19_-_18152942 0.09 ENSDART00000190182
nfe2l3
nuclear factor, erythroid 2-like 3
chr7_+_29177191 0.09 ENSDART00000008096
aph1b
APH1B gamma secretase subunit
chr7_+_38808027 0.08 ENSDART00000052323
harbi1
harbinger transposase derived 1
chr22_+_1431743 0.08 ENSDART00000182871
BX322657.2
Danio rerio si:dkeyp-53d3.6 (si:dkeyp-53d3.6), mRNA.
chr25_+_1335530 0.08 ENSDART00000090803
fem1b
fem-1 homolog b (C. elegans)
chr6_-_9646275 0.07 ENSDART00000012903
wdr12
WD repeat domain 12
chr8_+_18615938 0.06 ENSDART00000089161
si:ch211-232d19.4
si:ch211-232d19.4
chr16_-_4769877 0.05 ENSDART00000149421
ENSDART00000054078
rpa2
replication protein A2
chr11_+_37612672 0.05 ENSDART00000157993
hp1bp3
heterochromatin protein 1, binding protein 3
chr24_+_17005647 0.05 ENSDART00000149149
zfx
zinc finger protein, X-linked
chr22_+_19640309 0.04 ENSDART00000061725
ENSDART00000140819
rgmd
RGM domain family, member D
chr4_+_11458078 0.04 ENSDART00000037600
ankrd16
ankyrin repeat domain 16
chr20_+_34596205 0.03 ENSDART00000138338
si:ch211-242b18.1
si:ch211-242b18.1

Network of associatons between targets according to the STRING database.

First level regulatory network of six6a+six6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.4 1.1 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.4 1.9 GO:0070208 protein heterotrimerization(GO:0070208)
0.3 0.9 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.3 0.8 GO:0010359 regulation of anion channel activity(GO:0010359)
0.2 1.1 GO:0007412 axon target recognition(GO:0007412)
0.2 1.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.2 1.5 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.2 0.8 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 0.6 GO:0045601 negative regulation of epithelial cell differentiation(GO:0030857) regulation of endothelial cell differentiation(GO:0045601)
0.2 1.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 1.4 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.2 0.5 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.2 0.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 3.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 0.7 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.1 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.1 0.6 GO:0097186 amelogenesis(GO:0097186)
0.1 0.3 GO:0042245 RNA repair(GO:0042245)
0.1 1.3 GO:0033198 response to ATP(GO:0033198)
0.1 0.6 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.1 1.8 GO:0014823 response to activity(GO:0014823)
0.1 0.9 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 1.6 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 2.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.6 GO:0043584 nose development(GO:0043584)
0.1 1.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.4 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.2 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 1.8 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.0 0.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.5 GO:0090309 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0060912 cardiac cell fate specification(GO:0060912)
0.0 1.0 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.3 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0 0.3 GO:0000423 macromitophagy(GO:0000423)
0.0 2.9 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.5 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.3 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.7 GO:0060173 limb development(GO:0060173)
0.0 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 1.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.0 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.7 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 1.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.7 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.9 GO:0030901 midbrain development(GO:0030901)
0.0 0.5 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.3 1.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.3 3.0 GO:0070449 elongin complex(GO:0070449)
0.2 1.1 GO:0043034 costamere(GO:0043034)
0.2 1.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.5 GO:0043514 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.1 0.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 1.5 GO:0043209 myelin sheath(GO:0043209)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.3 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.9 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.0 GO:0043679 axon terminus(GO:0043679)
0.0 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0070552 BRISC complex(GO:0070552)
0.0 0.7 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0070724 BMP receptor complex(GO:0070724)
0.0 0.7 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 2.0 GO:0030141 secretory granule(GO:0030141)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 3.2 GO:0030425 dendrite(GO:0030425)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:1903136 cuprous ion binding(GO:1903136)
0.6 3.6 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.4 1.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.3 1.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.3 1.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 1.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 0.8 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 1.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 1.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.2 1.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 1.4 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.9 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.1 GO:0036122 BMP binding(GO:0036122)
0.1 0.5 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.1 1.6 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 0.5 GO:0042164 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.1 2.1 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.3 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.1 1.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 3.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 0.3 GO:0043734 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.1 0.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.4 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 1.1 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.9 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 1.3 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.6 GO:0019955 cytokine binding(GO:0019955)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.2 PID SHP2 PATHWAY SHP2 signaling
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 1.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.2 PID IGF1 PATHWAY IGF1 pathway
0.0 1.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 1.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 1.5 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import