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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for smad3a+smad3b

Z-value: 1.45

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Transcription factors associated with smad3a+smad3b

Gene Symbol Gene ID Gene Info
smad3b
ENSDARG00000010207 SMAD family member 3b
smad3a
ENSDARG00000036096 SMAD family member 3a
smad3a
ENSDARG00000117146 SMAD family member 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smad3bdr11_v1_chr18_+_19772874_19772874-0.406.6e-05Click!
smad3adr11_v1_chr7_-_34149263_34149263-0.372.1e-04Click!

Activity profile of smad3a+smad3b motif

Sorted Z-values of smad3a+smad3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_59073203 21.54 ENSDART00000149937
ENSDART00000162201
MFAP4 (1 of many)
zgc:173915
si:zfos-2330d3.3
zgc:173915
chr7_+_66822229 16.24 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr18_+_13164325 15.98 ENSDART00000189057
tat
tyrosine aminotransferase
chr4_-_11577253 15.88 ENSDART00000144452
net1
neuroepithelial cell transforming 1
chr22_+_661711 15.82 ENSDART00000113795
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr22_+_661505 15.26 ENSDART00000149460
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr14_+_38786298 15.19 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr1_+_59073436 12.53 ENSDART00000161642
MFAP4 (1 of many)
si:zfos-2330d3.3
chr23_+_44614056 12.27 ENSDART00000188379
eno3
enolase 3, (beta, muscle)
chr2_+_32796873 11.66 ENSDART00000077511
ccr9a
chemokine (C-C motif) receptor 9a
chr16_-_17699111 11.59 ENSDART00000108581
si:dkey-17m8.1
si:dkey-17m8.1
chr6_+_49926115 11.46 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr10_+_17088261 11.01 ENSDART00000132103
si:dkey-106l3.7
si:dkey-106l3.7
chr19_-_5332784 10.55 ENSDART00000010373
krt1-19d
keratin, type 1, gene 19d
chr21_+_26071874 10.04 ENSDART00000003001
ENSDART00000146573
rpl23a
ribosomal protein L23a
chr18_+_50961953 9.99 ENSDART00000158768
ppfia1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr14_-_28052474 9.77 ENSDART00000172948
ENSDART00000135337
TSC22D3 (1 of many)
zgc:64189
si:ch211-220e11.3
zgc:64189
chr8_-_38201415 9.41 ENSDART00000155189
pdlim2
PDZ and LIM domain 2 (mystique)
chr1_-_59104145 9.24 ENSDART00000132495
ENSDART00000152457
MFAP4 (1 of many)
si:zfos-2330d3.7
si:zfos-2330d3.1
si:zfos-2330d3.7
chr3_-_48980319 9.06 ENSDART00000165319
ftr42
finTRIM family, member 42
chr24_+_39990695 9.00 ENSDART00000040281
BX323854.1

chr2_-_55337585 8.90 ENSDART00000177924
tpm4b
tropomyosin 4b
chr15_+_46344655 8.57 ENSDART00000155893
si:ch1073-340i21.2
si:ch1073-340i21.2
chr7_+_21180747 8.50 ENSDART00000185543
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr19_+_7043634 8.50 ENSDART00000133954
mhc1uka
major histocompatibility complex class I UKA
chr23_+_10352921 8.48 ENSDART00000081193
KRT18 (1 of many)
si:ch211-133j6.3
chr12_-_44016898 8.47 ENSDART00000175304
si:dkey-201i2.4
si:dkey-201i2.4
chr2_-_20599315 8.41 ENSDART00000114199
si:ch211-267e7.3
si:ch211-267e7.3
chr7_+_2228276 8.36 ENSDART00000064294
si:dkey-187j14.4
si:dkey-187j14.4
chr8_-_36287046 8.34 ENSDART00000162877
si:busm1-194e12.11
si:busm1-194e12.11
chr1_-_40189893 7.92 ENSDART00000133738
si:ch211-113e8.6
si:ch211-113e8.6
chr3_-_2091029 7.77 ENSDART00000141464
si:dkey-88j15.4
si:dkey-88j15.4
chr5_+_22459087 7.71 ENSDART00000134781
BX546499.1

chr25_-_29415369 7.48 ENSDART00000110774
ENSDART00000019183
ugt5a2
ugt5a1
UDP glucuronosyltransferase 5 family, polypeptide A2
UDP glucuronosyltransferase 5 family, polypeptide A1
chr19_+_627899 7.41 ENSDART00000148508
tert
telomerase reverse transcriptase
chr22_+_14836291 7.31 ENSDART00000122740
gtpbp1l
GTP binding protein 1, like
chr11_+_30310170 7.09 ENSDART00000127797
ugt1b3
UDP glucuronosyltransferase 1 family, polypeptide B3
chr13_+_10945337 7.08 ENSDART00000091845
abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr19_-_3754327 7.06 ENSDART00000168463
btr21
bloodthirsty-related gene family, member 21
chr10_+_8875195 7.03 ENSDART00000141045
itga2.3
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 3
chr21_-_32036597 7.02 ENSDART00000114964
zgc:165573
zgc:165573
chr8_-_18203274 7.00 ENSDART00000134078
ENSDART00000180235
ENSDART00000080006
ENSDART00000125418
ENSDART00000142114
elovl8b
ELOVL fatty acid elongase 8b
chr19_+_4062101 6.95 ENSDART00000166773
btr25
bloodthirsty-related gene family, member 25
chr2_+_25560556 6.93 ENSDART00000133623
pld1a
phospholipase D1a
chr20_-_52199296 6.86 ENSDART00000131806
ENSDART00000143668
hlx1
H2.0-like homeo box 1 (Drosophila)
chr7_-_24181159 6.75 ENSDART00000181206
zgc:153151
zgc:153151
chr2_-_59265521 6.69 ENSDART00000146341
ENSDART00000097799
ftr33
finTRIM family, member 33
chr19_+_4061699 6.69 ENSDART00000158309
ENSDART00000166512
btr25
btr26
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr6_-_8498908 6.67 ENSDART00000149222
pglyrp2
peptidoglycan recognition protein 2
chr5_-_24124118 6.63 ENSDART00000051550
capga
capping protein (actin filament), gelsolin-like a
chr19_+_4068134 6.57 ENSDART00000158285
btr26
bloodthirsty-related gene family, member 26
chr1_-_52494122 6.36 ENSDART00000131407
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr19_-_15281996 6.27 ENSDART00000103784
edn2
endothelin 2
chr7_+_24523017 6.19 ENSDART00000077047
btr09
bloodthirsty-related gene family, member 9
chr15_-_25556227 6.18 ENSDART00000156445
mmp20a
matrix metallopeptidase 20a (enamelysin)
chr17_+_14886828 6.12 ENSDART00000010507
ENSDART00000131052
ptger2a
prostaglandin E receptor 2a (subtype EP2)
chr4_-_18954001 6.05 ENSDART00000144814
si:dkey-31f5.8
si:dkey-31f5.8
chr11_+_30306606 5.96 ENSDART00000128276
ENSDART00000190222
ugt1b4
UDP glucuronosyltransferase 1 family, polypeptide B4
chr18_-_26715655 5.93 ENSDART00000181497
malt3
MALT paracaspase 3
chr14_-_32876280 5.92 ENSDART00000173168
si:rp71-46j2.7
si:rp71-46j2.7
chr3_-_4591643 5.90 ENSDART00000138144
ftr50
finTRIM family, member 50
chr1_-_59139599 5.90 ENSDART00000152233
si:ch1073-110a20.3
si:ch1073-110a20.3
chr1_-_59130383 5.68 ENSDART00000171552
FP015850.1

chr24_-_33291784 5.67 ENSDART00000124938
si:ch1073-406l10.2
si:ch1073-406l10.2
chr6_-_8498676 5.46 ENSDART00000148627
pglyrp2
peptidoglycan recognition protein 2
chr10_-_24416471 5.42 ENSDART00000135985
hephl1b
hephaestin-like 1b
chr14_+_2487672 5.39 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr5_+_38752287 5.34 ENSDART00000133571
cxcl11.8
chemokine (C-X-C motif) ligand 11, duplicate 8
chr18_+_20560442 5.25 ENSDART00000151990
wee2
WEE1 homolog 2 (S. pombe)
chr9_+_23900703 5.23 ENSDART00000127859
trim63b
tripartite motif containing 63b
chr7_-_51528661 5.19 ENSDART00000174263
nhsl2
NHS-like 2
chr3_-_58189429 5.19 ENSDART00000156092
si:ch211-256e16.11
si:ch211-256e16.11
chr15_+_47525073 5.16 ENSDART00000067583
sidt2
SID1 transmembrane family, member 2
chr15_-_25556074 5.01 ENSDART00000124677
mmp20a
matrix metallopeptidase 20a (enamelysin)
chr3_+_52753416 4.91 ENSDART00000171185
gmip
GEM interacting protein
chr10_+_5268054 4.90 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr3_+_13603272 4.89 ENSDART00000185084
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr4_+_28997595 4.88 ENSDART00000133357
si:dkey-13e3.1
si:dkey-13e3.1
chr15_-_41486793 4.83 ENSDART00000138525
si:ch211-187g4.1
si:ch211-187g4.1
chr14_-_7128980 4.80 ENSDART00000171311
si:ch73-43g23.1
si:ch73-43g23.1
chr5_+_62723233 4.65 ENSDART00000183718
nanos2
nanos homolog 2
chr22_-_10591876 4.63 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr12_-_44010532 4.61 ENSDART00000183875
si:ch211-182p11.1
si:ch211-182p11.1
chr11_-_8208464 4.57 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr13_-_10945288 4.54 ENSDART00000114315
ENSDART00000164667
ENSDART00000159482
abcg8
ATP-binding cassette, sub-family G (WHITE), member 8
chr7_+_4911404 4.49 ENSDART00000137385
si:dkey-28d5.11
si:dkey-28d5.11
chr2_+_47927026 4.49 ENSDART00000143023
ftr25
finTRIM family, member 25
chr17_-_27273296 4.48 ENSDART00000077087
id3
inhibitor of DNA binding 3
chr12_-_44122412 4.35 ENSDART00000169094
si:ch73-329n5.3
si:ch73-329n5.3
chr7_-_24390879 4.29 ENSDART00000036680
ptgr1
prostaglandin reductase 1
chr2_-_59376399 4.27 ENSDART00000137134
ftr38
finTRIM family, member 38
chr14_-_40797117 4.24 ENSDART00000122369
elf1
E74-like ETS transcription factor 1
chr7_-_69121896 4.15 ENSDART00000130227
crispld2
cysteine-rich secretory protein LCCL domain containing 2
chr11_-_23332592 4.11 ENSDART00000125024
golt1a
golgi transport 1A
chr15_-_41450823 4.09 ENSDART00000183327
nlrc9
NLR family CARD domain containing 9
chr19_+_4054036 4.04 ENSDART00000171802
btr24
bloodthirsty-related gene family, member 24
chr21_-_40173821 4.04 ENSDART00000180667
slco2b1
solute carrier organic anion transporter family, member 2B1
chr3_+_34120191 4.00 ENSDART00000020017
ENSDART00000151700
aldh3b1
aldehyde dehydrogenase 3 family, member B1
chr23_-_26880623 3.94 ENSDART00000038491
adcy6b
adenylate cyclase 6b
chr15_+_38007237 3.92 ENSDART00000182271
CR944667.2

chr9_+_29616854 3.84 ENSDART00000033902
ENSDART00000143493
phf11
PHD finger protein 11
chr4_-_25812329 3.82 ENSDART00000146658
tmcc3
transmembrane and coiled-coil domain family 3
chr25_+_16194979 3.80 ENSDART00000185592
ENSDART00000158582
ENSDART00000161109
ENSDART00000139013
mical2b
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr20_+_46897504 3.78 ENSDART00000158124
si:ch73-21k16.1
si:ch73-21k16.1
chr24_-_6038025 3.62 ENSDART00000077819
ENSDART00000139216
ftr61
finTRIM family, member 61
chr16_-_53259409 3.61 ENSDART00000157080
si:ch211-269k10.4
si:ch211-269k10.4
chr12_-_44151296 3.59 ENSDART00000168734
si:ch73-329n5.3
si:ch73-329n5.3
chr6_+_28051978 3.59 ENSDART00000143218
si:ch73-194h10.2
si:ch73-194h10.2
chr24_+_29912509 3.53 ENSDART00000168422
frrs1b
ferric-chelate reductase 1b
chr5_+_38685089 3.52 ENSDART00000139743
si:dkey-58f10.10
si:dkey-58f10.10
chr6_-_43283122 3.51 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr16_+_19013257 3.48 ENSDART00000144102
si:ch211-254p10.2
si:ch211-254p10.2
chr12_+_46386983 3.43 ENSDART00000183982
BX005305.3
Danio rerio legumain (LOC100005356), mRNA.
chr16_+_19013018 3.35 ENSDART00000191526
si:ch211-254p10.2
si:ch211-254p10.2
chr6_-_39649504 3.34 ENSDART00000179960
ENSDART00000190951
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr10_-_36214582 3.30 ENSDART00000166471
or109-11
odorant receptor, family D, subfamily 109, member 11
chr25_-_269284 3.28 ENSDART00000114972
CABZ01072254.1

chr5_+_7564644 3.28 ENSDART00000192173
CABZ01039096.1

chr20_-_2619316 3.27 ENSDART00000185777
bub1
BUB1 mitotic checkpoint serine/threonine kinase
chr2_+_19578446 3.24 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr19_-_42503143 3.23 ENSDART00000007642
zgc:110239
zgc:110239
chr21_-_17603182 3.11 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr17_-_45386546 3.07 ENSDART00000182647
tmem206
transmembrane protein 206
chr25_+_35056619 2.98 ENSDART00000154389
HIST1H4J
histone cluster 1 H4 family member j
chr7_-_3721671 2.96 ENSDART00000062732
si:ch211-282j17.8
si:ch211-282j17.8
chr9_+_30626416 2.96 ENSDART00000147813
tbc1d4
TBC1 domain family, member 4
chr25_-_35126024 2.88 ENSDART00000185109
HIST1H4I
zgc:165555
chr2_-_19520324 2.87 ENSDART00000079877
pimr52
Pim proto-oncogene, serine/threonine kinase, related 52
chr25_+_35065802 2.82 ENSDART00000182372
zgc:165555
zgc:165555
chr16_+_30961822 2.76 ENSDART00000059187
gstk2
glutathione S-transferase kappa 2
chr3_-_58644920 2.73 ENSDART00000155953
dhrs7ca
dehydrogenase/reductase (SDR family) member 7Ca
chr19_-_7043355 2.72 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr1_+_47178529 2.69 ENSDART00000158432
ENSDART00000074450
ENSDART00000137448
morc3b
MORC family CW-type zinc finger 3b
chr23_+_36052944 2.66 ENSDART00000103149
hoxc13a
homeobox C13a
chr7_+_5959203 2.62 ENSDART00000110813
zgc:165555
zgc:165555
chr4_-_75616197 2.62 ENSDART00000157778
si:dkey-71l4.3
si:dkey-71l4.3
chr15_-_41734639 2.59 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr4_-_62503772 2.59 ENSDART00000108891
si:dkey-165b20.1
si:dkey-165b20.1
chr3_-_4501026 2.59 ENSDART00000163052
zgc:162198
zgc:162198
chr22_-_17499513 2.58 ENSDART00000105460
si:ch211-197g15.6
si:ch211-197g15.6
chr10_-_24689725 2.56 ENSDART00000079566
si:ch211-287a12.9
si:ch211-287a12.9
chr6_-_39051319 2.56 ENSDART00000155093
tns2b
tensin 2b
chr8_-_3346692 2.51 ENSDART00000057874
FUT9 (1 of many)
zgc:103510
chr18_-_33093705 2.49 ENSDART00000059500
olfcd3
olfactory receptor C family, d3
chr5_+_38673168 2.46 ENSDART00000135267
si:dkey-58f10.12
si:dkey-58f10.12
chr9_-_16218097 2.44 ENSDART00000190503
myo1b
myosin IB
chr8_-_13541514 2.43 ENSDART00000063834
zgc:86586
zgc:86586
chr17_-_45386823 2.42 ENSDART00000156002
tmem206
transmembrane protein 206
chr4_+_16787488 2.40 ENSDART00000143006
golt1ba
golgi transport 1Ba
chr25_-_173165 2.35 ENSDART00000193594
CABZ01114053.1

chr25_+_36345867 2.32 ENSDART00000186527
zgc:165555
zgc:165555
chr20_+_46213553 2.31 ENSDART00000100532
stx7l
syntaxin 7-like
chr12_-_33805366 2.24 ENSDART00000030566
galk1
galactokinase 1
chr4_+_71014655 2.23 ENSDART00000170837
si:dkeyp-80d11.14
si:dkeyp-80d11.14
chr5_+_71999996 2.22 ENSDART00000179933
ENSDART00000187070
PLPP7 (1 of many)
phospholipid phosphatase 7 (inactive)
chr12_+_4573696 2.22 ENSDART00000152534
si:dkey-94f20.4
si:dkey-94f20.4
chr3_+_52275691 2.17 ENSDART00000190109
BX511132.2

chr20_-_54377933 2.17 ENSDART00000182664
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr4_-_49580812 2.16 ENSDART00000180306
si:dkey-159n16.2
si:dkey-159n16.2
chr11_+_15890984 2.11 ENSDART00000158433
pank4
pantothenate kinase 4
chr1_-_57129179 2.09 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
si:ch73-94k4.2
chr6_-_39158953 2.07 ENSDART00000050682
stat2
signal transducer and activator of transcription 2
chr4_+_8670662 2.07 ENSDART00000168768
adipor2
adiponectin receptor 2
chr3_-_62417677 2.07 ENSDART00000101888
sstr2b
somatostatin receptor 2b
chr23_+_13928346 2.06 ENSDART00000155326
si:dkey-90a13.10
si:dkey-90a13.10
chr5_+_24305877 2.02 ENSDART00000144226
ctsll
cathepsin L, like
chr23_-_19230627 2.01 ENSDART00000007122
guca1b
guanylate cyclase activator 1B
chr4_+_35576329 1.98 ENSDART00000171191
ENSDART00000161611
si:dkeyp-4c4.2
si:dkeyp-4c4.2
chr4_+_50401133 1.98 ENSDART00000150644
si:dkey-156k2.7
si:dkey-156k2.7
chr15_-_37834433 1.97 ENSDART00000189748
si:dkey-238d18.3
si:dkey-238d18.3
chr17_-_51679784 1.97 ENSDART00000103374
atp6v1c2
ATPase H+ transporting V1 subunit C2
chr15_-_37774544 1.95 ENSDART00000156119
si:dkey-42l23.9
si:dkey-42l23.9
chr15_-_5203371 1.95 ENSDART00000141582
or128-8
odorant receptor, family E, subfamily 128, member 8
chr23_-_10914275 1.93 ENSDART00000112965
pdzrn3a
PDZ domain containing RING finger 3a
chr14_-_10762629 1.91 ENSDART00000061928
fgf16
fibroblast growth factor 16
chr22_+_36914636 1.86 ENSDART00000150948
pimr205
Pim proto-oncogene, serine/threonine kinase, related 205
chr16_-_32204470 1.86 ENSDART00000143928
rwdd1
RWD domain containing 1
chr10_-_40490647 1.80 ENSDART00000143660
taar20x
trace amine associated receptor 20x
chr4_-_77636185 1.80 ENSDART00000152915
ENSDART00000131964
si:dkey-61p9.9
si:dkey-61p9.9
chr18_-_22696170 1.79 ENSDART00000147183
si:dkey-11d18.4
si:dkey-11d18.4
chr11_+_45448212 1.76 ENSDART00000173341
sos1
son of sevenless homolog 1 (Drosophila)
chr14_-_41535822 1.73 ENSDART00000149407
itga6l
integrin, alpha 6, like
chr1_-_55810730 1.68 ENSDART00000100551
zgc:136908
zgc:136908
chr2_-_7605121 1.66 ENSDART00000182099
CABZ01021599.1

chr4_-_71267461 1.66 ENSDART00000161219
ENSDART00000151838
si:dkeyp-51g9.4
si:dkeyp-51g9.4
chr3_-_10779777 1.66 ENSDART00000153911
znf1004
zinc finger protein 1004
chr13_+_17694845 1.64 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr2_-_59285407 1.64 ENSDART00000181616
ftr34
finTRIM family, member 34
chr12_-_3978306 1.61 ENSDART00000149473
ENSDART00000114857
ppp4cb
protein phosphatase 4, catalytic subunit b
chr3_-_27784457 1.60 ENSDART00000019098
dnase1
deoxyribonuclease I
chr1_+_24366110 1.59 ENSDART00000139913
pimr178
Pim proto-oncogene, serine/threonine kinase, related 178
chr12_+_16949391 1.58 ENSDART00000152635
zgc:174153
zgc:174153
chr13_-_21650404 1.57 ENSDART00000078352
tspan14
tetraspanin 14
chr10_-_33343244 1.56 ENSDART00000164191
c2cd2
C2 calcium-dependent domain containing 2
chr22_+_25774750 1.54 ENSDART00000174421
AL929192.1

chr22_-_35385810 1.53 ENSDART00000111824
HTR3C
5-hydroxytryptamine receptor 3C
chr10_+_36345176 1.51 ENSDART00000099397
or105-1
odorant receptor, family C, subfamily 105, member 1
chr24_-_6628359 1.51 ENSDART00000169731
arhgap21a
Rho GTPase activating protein 21a
chr25_-_16552135 1.47 ENSDART00000125836
si:ch211-266k8.4
si:ch211-266k8.4
chr16_-_32006737 1.41 ENSDART00000184813
ENSDART00000179827
gstk4
glutathione S-transferase kappa 4

Network of associatons between targets according to the STRING database.

First level regulatory network of smad3a+smad3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.1 GO:0098543 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
2.7 16.0 GO:0006572 tyrosine catabolic process(GO:0006572)
2.5 7.4 GO:0007571 age-dependent general metabolic decline(GO:0007571)
2.3 36.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.9 11.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.8 5.3 GO:0060631 regulation of meiosis I(GO:0060631)
1.6 6.3 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.5 12.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
1.3 5.1 GO:0032530 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
1.2 4.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.2 6.1 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
1.2 11.7 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.9 15.9 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.9 6.8 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.6 3.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.6 1.7 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.5 11.6 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.5 3.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.4 10.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.4 1.1 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.3 11.1 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 11.2 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.3 7.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 2.2 GO:0006012 galactose metabolic process(GO:0006012)
0.3 1.9 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.3 1.0 GO:0007414 axonal defasciculation(GO:0007414)
0.3 5.7 GO:0050994 regulation of lipid catabolic process(GO:0050994)
0.3 9.7 GO:0051014 actin filament severing(GO:0051014)
0.3 4.1 GO:0060325 face morphogenesis(GO:0060325)
0.3 4.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 5.4 GO:0006825 copper ion transport(GO:0006825)
0.3 4.3 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.2 16.2 GO:0001946 lymphangiogenesis(GO:0001946)
0.2 2.7 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 5.9 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 0.9 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.2 1.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039) positive regulation of reactive oxygen species metabolic process(GO:2000379)
0.2 2.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.2 23.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.2 6.5 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.2 4.9 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.2 4.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.2 0.9 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 3.9 GO:0022011 myelination in peripheral nervous system(GO:0022011)
0.2 2.1 GO:0060337 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 2.1 GO:0033866 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.1 1.3 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 5.3 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 27.5 GO:0006954 inflammatory response(GO:0006954)
0.1 6.0 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 1.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 8.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 10.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 9.1 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 1.4 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.1 0.9 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.6 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 4.7 GO:0048477 oogenesis(GO:0048477)
0.1 4.0 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 8.9 GO:0006936 muscle contraction(GO:0006936)
0.1 16.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 5.4 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 5.2 GO:0051236 nucleic acid transport(GO:0050657) RNA transport(GO:0050658) establishment of RNA localization(GO:0051236)
0.0 1.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.3 GO:0060114 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.6 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.5 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 4.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 24.8 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.3 GO:0046620 regulation of organ growth(GO:0046620)
0.0 2.7 GO:0031101 fin regeneration(GO:0031101)
0.0 1.8 GO:0051607 defense response to virus(GO:0051607)
0.0 0.6 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 3.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.3 GO:0048278 vesicle docking(GO:0048278)
0.0 2.0 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 5.6 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 6.8 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0 0.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 1.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0000333 telomerase catalytic core complex(GO:0000333)
1.5 12.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 1.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 2.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 9.4 GO:0031941 filamentous actin(GO:0031941)
0.2 10.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 3.3 GO:0000780 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 2.4 GO:0005903 brush border(GO:0005903)
0.1 8.9 GO:0005884 actin filament(GO:0005884)
0.1 10.5 GO:0048786 presynaptic active zone(GO:0048786)
0.1 11.6 GO:0005882 intermediate filament(GO:0005882)
0.1 10.8 GO:0000786 nucleosome(GO:0000786)
0.1 1.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 3.6 GO:0005902 microvillus(GO:0005902)
0.1 21.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 1.9 GO:0005844 polysome(GO:0005844)
0.0 19.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 12.0 GO:0005764 lysosome(GO:0005764)
0.0 4.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 4.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.7 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 4.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 34.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.3 GO:0031201 SNARE complex(GO:0031201)
0.0 5.8 GO:0000785 chromatin(GO:0000785)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0005925 focal adhesion(GO:0005925)
0.0 18.9 GO:0005829 cytosol(GO:0005829)
0.0 4.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 3.6 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.1 GO:0016019 peptidoglycan receptor activity(GO:0016019)
3.8 11.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
2.5 7.4 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
2.3 11.6 GO:0008432 JUN kinase binding(GO:0008432)
1.6 6.3 GO:0031708 endothelin B receptor binding(GO:0031708)
1.5 12.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.0 6.9 GO:0004630 phospholipase D activity(GO:0004630)
0.8 6.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.7 5.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.6 3.8 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.6 6.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.6 6.4 GO:0004046 aminoacylase activity(GO:0004046)
0.6 16.0 GO:0008483 transaminase activity(GO:0008483)
0.5 37.9 GO:0003823 antigen binding(GO:0003823)
0.5 4.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.5 5.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.5 9.4 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.5 16.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 4.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.4 1.1 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.4 5.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 20.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.4 2.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 4.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 7.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 5.2 GO:0022884 macromolecule transmembrane transporter activity(GO:0022884)
0.3 1.2 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.3 11.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 15.9 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.3 2.8 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.3 2.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 2.0 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 0.9 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 0.9 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 23.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 10.0 GO:0019843 rRNA binding(GO:0019843)
0.2 9.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 4.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 1.6 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 4.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 3.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 3.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 6.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.1 GO:0042923 neuropeptide binding(GO:0042923)
0.1 2.0 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 12.4 GO:0016820 P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 6.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 39.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 8.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 8.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 2.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 3.0 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 1.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 2.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 3.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 9.4 GO:0051015 actin filament binding(GO:0051015)
0.0 6.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 10.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 3.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0071949 FAD binding(GO:0071949)
0.0 1.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 15.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 16.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 2.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.3 4.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.3 9.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 4.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 3.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 6.3 PID ENDOTHELIN PATHWAY Endothelins
0.1 2.0 PID CONE PATHWAY Visual signal transduction: Cones
0.1 3.3 PID AURORA B PATHWAY Aurora B signaling
0.0 1.3 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 11.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.6 12.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 4.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.5 11.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 5.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 17.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 2.1 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 7.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.2 2.0 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.2 2.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 16.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 10.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 4.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 3.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 2.2 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates