ISMARA results: snai1a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for snai1a

Z-value: 2.40

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Transcription factors associated with snai1a

Gene Symbol	Gene ID	Gene Info
snai1a NCBI UniProt	ENSDARG00000056995	snail family zinc finger 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
snai1a	dr11_v1_chr11_-_25257045_25257045	-0.32	2.0e-03	Click!

Activity profile of snai1a motif

Sorted Z-values of snai1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_101758 Show fit	37.22	ENSDART00000173015	elmo2 NCBI UniProt Show fit	engulfment and cell motility 2
chr19_+_206835 Show fit	34.39	ENSDART00000161137	scn1bb NCBI UniProt Show fit	sodium channel, voltage-gated, type I, beta b
chr21_+_11468934 Show fit	30.70	ENSDART00000126045 ENSDART00000129744 ENSDART00000102368	grin1a NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr2_-_44282796 Show fit	29.88	ENSDART00000163040 ENSDART00000166923 ENSDART00000056372 ENSDART00000109251 ENSDART00000132682	mpz NCBI UniProt Show fit	myelin protein zero
chr6_-_14146979 Show fit	25.27	ENSDART00000089564	cacnb4b NCBI UniProt Show fit	calcium channel, voltage-dependent, beta 4b subunit
chr16_-_17207754 Show fit	21.78	ENSDART00000063804	wu:fj39g12 NCBI UniProt Show fit	wu:fj39g12
chr18_+_7345417 Show fit	20.74	ENSDART00000041429	glipr1b NCBI UniProt Show fit	GLI pathogenesis-related 1b
chr15_-_16070731 Show fit	20.73	ENSDART00000122099	dynll2a NCBI UniProt Show fit	dynein, light chain, LC8-type 2a
chr5_+_37837245 Show fit	20.60	ENSDART00000171617	epd NCBI UniProt Show fit	ependymin
chr22_+_17828267 Show fit	20.54	ENSDART00000136016	hapln4 NCBI UniProt Show fit	hyaluronan and proteoglycan link protein 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of snai1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	102.3	GO:0031175	neuron projection development(GO:0031175)
0.5	61.6	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.7	55.8	GO:0017157	regulation of exocytosis(GO:0017157)
0.6	51.7	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3	50.2	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
2.5	44.8	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
1.2	37.3	GO:0016082	synaptic vesicle priming(GO:0016082)
1.1	37.0	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.6	34.5	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.0	34.5	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)

Showing 1 to 10 of 536 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	285.3	GO:0043005	neuron projection(GO:0043005)
0.0	111.0	GO:0005634	nucleus(GO:0005634)
3.4	61.2	GO:0043209	myelin sheath(GO:0043209)
1.4	57.1	GO:0043204	perikaryon(GO:0043204)
0.6	51.9	GO:0005871	kinesin complex(GO:0005871)
0.7	51.0	GO:0043025	neuronal cell body(GO:0043025)
0.7	50.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
1.1	49.3	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
3.2	48.5	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.6	37.3	GO:0030141	secretory granule(GO:0030141)

Showing 1 to 10 of 206 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	119.0	GO:0008017	microtubule binding(GO:0008017)
0.3	100.3	GO:0005096	GTPase activator activity(GO:0005096)
0.1	97.2	GO:0005509	calcium ion binding(GO:0005509)
0.5	57.5	GO:0005516	calmodulin binding(GO:0005516)
2.6	51.6	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
1.2	49.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	47.7	GO:0003924	GTPase activity(GO:0003924)
1.6	45.9	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.7	42.2	GO:0017124	SH3 domain binding(GO:0017124)
0.1	38.6	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)

Showing 1 to 10 of 380 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	45.2	PID ILK PATHWAY	Integrin-linked kinase signaling
1.9	41.1	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.1	35.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.1	24.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	18.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	16.8	PID RAS PATHWAY	Regulation of Ras family activation
0.4	14.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
1.2	13.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	11.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
1.2	11.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events

Showing 1 to 10 of 60 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	45.1	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.1	42.2	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
2.0	30.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.9	26.0	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
1.5	23.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
1.5	20.8	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.4	19.4	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.6	17.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.0	17.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.7	12.9	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 89 entries

Results for snai1a

Z-value: 2.40

Motif logo

Transcription factors associated with snai1a

Activity-expression correlation:

Activity profile of snai1a motif

Sorted Z-values of snai1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of snai1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: