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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox12

Z-value: 0.96

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Transcription factors associated with sox12

Gene Symbol Gene ID Gene Info
sox12
ENSDARG00000025847 SRY-box transcription factor 12

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox12dr11_v1_chr11_-_24191928_241919280.862.3e-28Click!

Activity profile of sox12 motif

Sorted Z-values of sox12 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_44280061 13.70 ENSDART00000136818
mpz
myelin protein zero
chr20_-_39265453 11.72 ENSDART00000141193
clu
clusterin
chr22_-_37349967 11.21 ENSDART00000104493
sox2
SRY (sex determining region Y)-box 2
chr16_-_9897613 11.08 ENSDART00000104058
ncalda
neurocalcin delta a
chr4_+_21129752 9.29 ENSDART00000169764
syt1a
synaptotagmin Ia
chr19_-_19339285 9.24 ENSDART00000158413
ENSDART00000170479
cspg5b
chondroitin sulfate proteoglycan 5b
chr2_+_24188502 7.84 ENSDART00000181955
ENSDART00000191706
ENSDART00000125909
map4l
microtubule associated protein 4 like
chr9_-_31278048 7.62 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr6_+_36942966 7.18 ENSDART00000028895
negr1
neuronal growth regulator 1
chr4_-_2525916 7.13 ENSDART00000134123
ENSDART00000132581
ENSDART00000019508
csrp2
cysteine and glycine-rich protein 2
chr19_+_8481802 7.07 ENSDART00000050217
efna1a
ephrin-A1a
chr5_-_38384755 7.05 ENSDART00000188573
ENSDART00000051233
mink1
misshapen-like kinase 1
chr20_+_30445971 6.84 ENSDART00000153150
myt1la
myelin transcription factor 1-like, a
chr12_+_5081759 6.27 ENSDART00000164178
prrt2
proline-rich transmembrane protein 2
chr10_+_26834985 6.24 ENSDART00000147518
fam89b
family with sequence similarity 89, member B
chr22_+_21618121 6.17 ENSDART00000133939
tle2a
transducin like enhancer of split 2a
chr6_+_27667359 6.11 ENSDART00000159624
ENSDART00000049177
rab6ba
RAB6B, member RAS oncogene family a
chr8_+_26859639 6.10 ENSDART00000133440
prdm2a
PR domain containing 2, with ZNF domain a
chr7_-_38861741 6.03 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
phf21aa
PHD finger protein 21Aa
chr21_+_31150438 5.70 ENSDART00000065366
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr16_-_9897769 5.63 ENSDART00000187044
ncalda
neurocalcin delta a
chr7_+_22680560 5.58 ENSDART00000133761
ponzr4
plac8 onzin related protein 4
chr2_-_24348948 5.45 ENSDART00000136559
ano8a
anoctamin 8a
chr14_-_33297287 5.37 ENSDART00000045555
ENSDART00000138294
ENSDART00000075056
rab41
RAB41, member RAS oncogene family
chr20_-_2355357 5.16 ENSDART00000085281
EPB41L2
si:ch73-18b11.1
chr2_-_24348642 5.07 ENSDART00000181739
ano8a
anoctamin 8a
chr5_+_26221011 5.06 ENSDART00000007587
gtf2h2
general transcription factor IIH, polypeptide 2
chr8_+_42998944 4.94 ENSDART00000048819
rassf2a
Ras association (RalGDS/AF-6) domain family member 2a
chr17_+_37624704 4.82 ENSDART00000157001
tmem229b
transmembrane protein 229B
chr14_-_1955257 4.51 ENSDART00000193254
pcdh2g5
protocadherin 2 gamma 5
chr3_-_1146497 4.32 ENSDART00000149061
si:ch73-211l13.2
si:ch73-211l13.2
chr23_-_36449111 4.21 ENSDART00000110478
zgc:174906
zgc:174906
chr3_-_33437796 4.18 ENSDART00000075499
si:dkey-283b1.7
si:dkey-283b1.7
chr1_-_26023678 4.07 ENSDART00000054202
si:ch211-145b13.5
si:ch211-145b13.5
chr2_+_36862473 3.93 ENSDART00000135624
si:dkey-193b15.8
si:dkey-193b15.8
chr5_-_24231139 3.91 ENSDART00000143492
senp3a
SUMO1/sentrin/SMT3 specific peptidase 3a
chr7_+_49078890 3.77 ENSDART00000067857
b4galnt4b
beta-1,4-N-acetyl-galactosaminyl transferase 4b
chr14_-_1958994 3.76 ENSDART00000161783
pcdh2g5
protocadherin 2 gamma 5
chr25_-_12788370 3.55 ENSDART00000158551
slc7a5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr5_-_38384289 3.48 ENSDART00000135260
mink1
misshapen-like kinase 1
chr2_-_24068848 3.42 ENSDART00000145526
slc12a7a
solute carrier family 12 (potassium/chloride transporter), member 7a
chr21_+_36774542 3.38 ENSDART00000130790
prr7
proline rich 7 (synaptic)
chr10_+_21677058 3.33 ENSDART00000171499
ENSDART00000157516
pcdh1gb2
protocadherin 1 gamma b 2
chr17_+_25290136 3.33 ENSDART00000173295
kbtbd11
kelch repeat and BTB (POZ) domain containing 11
chr23_-_637347 3.23 ENSDART00000132175
l1camb
L1 cell adhesion molecule, paralog b
chr16_-_16237844 3.18 ENSDART00000168747
ENSDART00000111912
rbm12b
RNA binding motif protein 12B
chr8_+_46217861 3.16 ENSDART00000038790
angptl7
angiopoietin-like 7
chr7_-_38340674 3.16 ENSDART00000075782
slc7a10a
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10a
chr2_-_7696503 3.14 ENSDART00000169709
CABZ01055306.1

chr2_-_16217344 3.13 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr22_-_31517300 3.12 ENSDART00000164799
slc6a6b
solute carrier family 6 (neurotransmitter transporter), member 6b
chr4_-_68913650 3.11 ENSDART00000184297
si:dkey-264f17.5
si:dkey-264f17.5
chr10_-_1718395 3.07 ENSDART00000137620
si:ch73-46j18.5
si:ch73-46j18.5
chr7_+_69470442 3.03 ENSDART00000189593
gabarapb
GABA(A) receptor-associated protein b
chr1_-_44701313 2.99 ENSDART00000193926
si:dkey-28b4.8
si:dkey-28b4.8
chr10_-_42131408 2.79 ENSDART00000076693
stambpa
STAM binding protein a
chr13_-_33317323 2.77 ENSDART00000110295
ENSDART00000144848
ENSDART00000136701
tmem234
transmembrane protein 234
chr7_+_25003313 2.77 ENSDART00000131935
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr15_+_26933196 2.70 ENSDART00000023842
ppm1da
protein phosphatase, Mg2+/Mn2+ dependent, 1Da
chr11_+_37768298 2.66 ENSDART00000166886
sox13
SRY (sex determining region Y)-box 13
chr8_-_16697615 2.61 ENSDART00000187929
rpe65b
retinal pigment epithelium-specific protein 65b
chr1_+_33668236 2.57 ENSDART00000122316
ENSDART00000102184
arl13b
ADP-ribosylation factor-like 13b
chr14_-_8080416 2.55 ENSDART00000045109
zgc:92242
zgc:92242
chr4_+_15954293 2.54 ENSDART00000132695
si:dkey-117n7.4
si:dkey-117n7.4
chr4_-_13567387 2.53 ENSDART00000132971
ENSDART00000102010
mdm1
Mdm1 nuclear protein homolog (mouse)
chr1_+_37391141 2.43 ENSDART00000083593
ENSDART00000168647
sparcl1
SPARC-like 1
chr8_-_2153147 2.41 ENSDART00000124093
si:dkeyp-117b11.1
si:dkeyp-117b11.1
chr18_-_14337450 2.35 ENSDART00000061435
hsbp1b
heat shock factor binding protein 1b
chr7_-_28565230 2.35 ENSDART00000028887
tmem9b
TMEM9 domain family, member B
chr17_+_7595356 2.33 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr9_+_8929764 2.32 ENSDART00000102562
ankrd10b
ankyrin repeat domain 10b
chr9_+_24920677 2.29 ENSDART00000037025
slc39a10
solute carrier family 39 (zinc transporter), member 10
chr18_-_46063773 2.27 ENSDART00000078561
si:ch73-262h23.4
si:ch73-262h23.4
chr19_+_20708460 2.27 ENSDART00000034124
rab5aa
RAB5A, member RAS oncogene family, a
chr14_-_2004291 2.20 ENSDART00000114039
pcdh2g5
protocadherin 2 gamma 5
chr17_+_43595692 2.17 ENSDART00000156271
cfap99
cilia and flagella associated protein 99
chr14_-_2036604 2.16 ENSDART00000192446
BX005294.2

chr17_-_7436766 2.12 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr14_+_6429399 2.08 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr23_+_19814371 2.08 ENSDART00000182897
emd
emerin (Emery-Dreifuss muscular dystrophy)
chr14_-_48033073 2.08 ENSDART00000193115
ENSDART00000169300
ENSDART00000188036
ENSDART00000183432
ENSDART00000180973
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr6_-_13022166 2.02 ENSDART00000157139
tmbim1a
transmembrane BAX inhibitor motif containing 1a
chr5_-_32363372 2.00 ENSDART00000098045
gas1b
growth arrest-specific 1b
chr16_+_25343934 1.95 ENSDART00000109710
zfat
zinc finger and AT hook domain containing
chr1_+_46509176 1.95 ENSDART00000166028
mcf2la
mcf.2 cell line derived transforming sequence-like a
chr8_+_16990120 1.93 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr1_+_29798140 1.88 ENSDART00000019743
tm9sf2
transmembrane 9 superfamily member 2
chr5_-_37875636 1.81 ENSDART00000184674
arhgap35b
Rho GTPase activating protein 35b
chr16_+_32082547 1.80 ENSDART00000190122
prpf31
PRP31 pre-mRNA processing factor 31 homolog (yeast)
chr16_+_12812472 1.79 ENSDART00000008535
u2af2a
U2 small nuclear RNA auxiliary factor 2a
chr16_+_32082359 1.77 ENSDART00000140794
ENSDART00000137029
prpf31
PRP31 pre-mRNA processing factor 31 homolog (yeast)
chr14_-_2318590 1.72 ENSDART00000192735
pcdh2ab8
protocadherin 2 alpha b 8
chr6_+_28877306 1.71 ENSDART00000065137
ENSDART00000123189
ENSDART00000065135
ENSDART00000181512
ENSDART00000130799
tp63
tumor protein p63
chr6_+_18367388 1.70 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr10_-_25591194 1.58 ENSDART00000131640
tiam1a
T cell lymphoma invasion and metastasis 1a
chr7_-_30217000 1.52 ENSDART00000173646
znf710b
zinc finger protein 710b
chr19_+_22062202 1.51 ENSDART00000100181
sall3b
spalt-like transcription factor 3b
chr25_+_28825657 1.48 ENSDART00000153625
nfybb
nuclear transcription factor Y, beta b
chr11_+_7580079 1.47 ENSDART00000091550
ENSDART00000193223
ENSDART00000193386
adgrl2a
adhesion G protein-coupled receptor L2a
chr1_-_38361496 1.46 ENSDART00000015323
fbxo8
F-box protein 8
chr6_-_41135215 1.43 ENSDART00000001861
slc6a22.1
solute carrier family 6 member 22, tandem duplicate 1
chr23_-_7755373 1.34 ENSDART00000162868
PCMTD2 (1 of many)
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr3_-_16110100 1.31 ENSDART00000051807
lasp1
LIM and SH3 protein 1
chr23_+_21544227 1.30 ENSDART00000140253
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr6_-_55347616 1.28 ENSDART00000172081
pcif1
PDX1 C-terminal inhibiting factor 1
chr13_+_9559461 1.28 ENSDART00000047740
wdr32
WD repeat domain 32
chr10_-_32660716 1.27 ENSDART00000063544
ENSDART00000141013
atg101
autophagy related 101
chr8_-_16712111 1.26 ENSDART00000184147
ENSDART00000180419
ENSDART00000076600
rpe65c
retinal pigment epithelium-specific protein 65c
chr3_-_16110351 1.25 ENSDART00000064838
lasp1
LIM and SH3 protein 1
chr11_-_21267486 1.24 ENSDART00000128681
DYRK3
zgc:172180
chr19_+_20724347 1.23 ENSDART00000090757
kat2b
K(lysine) acetyltransferase 2B
chr4_-_18939338 1.21 ENSDART00000132081
ENSDART00000042250
rap1b
RAP1B, member of RAS oncogene family
chr8_-_24252933 1.20 ENSDART00000057624
zgc:110353
zgc:110353
chr1_+_26071869 1.20 ENSDART00000059264
mxd4
MAX dimerization protein 4
chr19_-_4010263 1.17 ENSDART00000159605
ENSDART00000165541
map7d1b
MAP7 domain containing 1b
chr6_-_55297274 1.16 ENSDART00000184283
ube2c
ubiquitin-conjugating enzyme E2C
chr5_-_28149767 1.15 ENSDART00000051515
zgc:110329
zgc:110329
chr25_-_35524166 1.13 ENSDART00000156782
slc5a12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr3_-_33175583 1.11 ENSDART00000126022
rarab
retinoic acid receptor, alpha b
chr20_-_29051696 1.10 ENSDART00000140350
thbs1b
thrombospondin 1b
chr22_-_16494406 1.10 ENSDART00000062727
stx6
syntaxin 6
chr22_-_784110 1.06 ENSDART00000061775
rbbp5
retinoblastoma binding protein 5
chr8_+_9149436 1.05 ENSDART00000064090
pnck
pregnancy up-regulated nonubiquitous CaM kinase
chr25_+_22017182 1.02 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr8_-_52229462 1.02 ENSDART00000185949
ENSDART00000051825
tcf7l1b
transcription factor 7 like 1b
chr1_+_41487339 1.01 ENSDART00000142508
ENSDART00000114449
si:ch211-89o9.6
si:ch211-89o9.6
chr16_+_11242443 1.00 ENSDART00000024935
gsk3ab
glycogen synthase kinase 3 alpha b
chr15_+_31911989 0.94 ENSDART00000111472
brca2
breast cancer 2, early onset
chr25_+_25124684 0.94 ENSDART00000167542
ldha
lactate dehydrogenase A4
chr24_+_20920563 0.92 ENSDART00000037224
cst14a.2
cystatin 14a, tandem duplicate 2
chr6_+_20647155 0.91 ENSDART00000193477
slc19a1
solute carrier family 19 (folate transporter), member 1
chr8_-_43456025 0.90 ENSDART00000001092
ENSDART00000140618
ncor2
nuclear receptor corepressor 2
chr3_+_61523035 0.85 ENSDART00000106530
znf1004
zinc finger protein 1004
chr10_+_43189325 0.83 ENSDART00000185584
vcanb
versican b
chr9_+_537297 0.81 ENSDART00000165149
CU984600.3

chr1_+_45839927 0.81 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr8_+_30600386 0.78 ENSDART00000164976
specc1la
sperm antigen with calponin homology and coiled-coil domains 1-like a
chr1_-_28607353 0.76 ENSDART00000191210
FO907124.1

chr10_-_35321625 0.74 ENSDART00000131268
rhbdd2
rhomboid domain containing 2
chr1_+_594736 0.73 ENSDART00000166731
jam2a
junctional adhesion molecule 2a
chr1_+_40613297 0.69 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
naa15b
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr3_+_40284598 0.69 ENSDART00000009411
bud31
BUD31 homolog (S. cerevisiae)
chr5_-_30984010 0.69 ENSDART00000182367
spns3
spinster homolog 3 (Drosophila)
chr22_+_34784075 0.67 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr17_-_21057617 0.67 ENSDART00000148095
ENSDART00000048853
ube2d1a
ubiquitin-conjugating enzyme E2D 1a
chr25_+_10485103 0.61 ENSDART00000104576
psmd13
proteasome 26S subunit, non-ATPase 13
chr20_+_4222357 0.61 ENSDART00000188331
ipcef1
interaction protein for cytohesin exchange factors 1
chr22_-_9861531 0.60 ENSDART00000193197
si:dkey-253d23.2
si:dkey-253d23.2
chr22_-_9860792 0.58 ENSDART00000155908
si:dkey-253d23.2
si:dkey-253d23.2
chr3_-_60856157 0.57 ENSDART00000053502
CABZ01087513.1

chr8_-_16697912 0.56 ENSDART00000076542
rpe65b
retinal pigment epithelium-specific protein 65b
chr15_+_37546391 0.56 ENSDART00000186625
psenen
presenilin enhancer gamma secretase subunit
chr3_+_41922114 0.53 ENSDART00000138280
lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_7534365 0.52 ENSDART00000157123
shprh
SNF2 histone linker PHD RING helicase
chr15_+_35691783 0.50 ENSDART00000183994
CT573366.1

chr13_-_12667220 0.48 ENSDART00000079594
fam241a
family with sequence similarity 241 member A
chr17_-_7218481 0.45 ENSDART00000181967
SAMD5
sterile alpha motif domain containing 5
chr23_+_9268083 0.42 ENSDART00000055054
acss2
acyl-CoA synthetase short chain family member 2
chr1_-_52790724 0.41 ENSDART00000139577
ENSDART00000100937
patl1
protein associated with topoisomerase II homolog 1 (yeast)
chr10_+_10972795 0.39 ENSDART00000127331
cdc37l1
cell division cycle 37-like 1
chr24_+_36392040 0.35 ENSDART00000136057
arf2b
ADP-ribosylation factor 2b
chr21_+_22845317 0.26 ENSDART00000065555
birc2
baculoviral IAP repeat containing 2
chr17_-_49443247 0.26 ENSDART00000059245
cga
glycoprotein hormones, alpha polypeptide
chr17_-_49443399 0.20 ENSDART00000155293
cga
glycoprotein hormones, alpha polypeptide
chr18_+_22138924 0.20 ENSDART00000183961
ripor1
RHO family interacting cell polarization regulator 1
chr10_+_3153973 0.20 ENSDART00000183223
hic2
hypermethylated in cancer 2
chr17_-_15229787 0.17 ENSDART00000039165
styx
serine/threonine/tyrosine interacting protein
chr14_+_48960078 0.16 ENSDART00000165514
mif
macrophage migration inhibitory factor
chr18_+_6479963 0.14 ENSDART00000092752
ENSDART00000136333
wash1
WAS protein family homolog 1
chr11_+_24820542 0.11 ENSDART00000135443
kdm5ba
lysine (K)-specific demethylase 5Ba
chr5_-_30984271 0.10 ENSDART00000051392
spns3
spinster homolog 3 (Drosophila)
chr7_+_24729558 0.08 ENSDART00000111542
ENSDART00000170100
shroom4
shroom family member 4
chr20_+_4221978 0.06 ENSDART00000171898
ipcef1
interaction protein for cytohesin exchange factors 1
chr12_-_22400999 0.05 ENSDART00000153194
si:dkey-38p12.3
si:dkey-38p12.3
chr12_+_2428247 0.04 ENSDART00000152529
lrrc18b
leucine rich repeat containing 18b
chr5_+_45138934 0.03 ENSDART00000041412
ENSDART00000136002
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of sox12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 11.2 GO:0021982 pineal gland development(GO:0021982)
1.1 4.4 GO:0016116 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
1.1 7.6 GO:0033278 cell proliferation in midbrain(GO:0033278)
1.1 3.2 GO:0042942 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
0.9 9.2 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.9 2.6 GO:1903441 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.8 2.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.8 2.3 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.6 3.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 3.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 9.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 11.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 0.9 GO:0015884 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.3 4.9 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.2 3.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 3.9 GO:0016926 protein desumoylation(GO:0016926)
0.2 7.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 1.2 GO:0046929 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 1.7 GO:0048730 epidermis morphogenesis(GO:0048730)
0.2 2.1 GO:0033700 phospholipid efflux(GO:0033700)
0.2 1.0 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.2 12.2 GO:1901214 regulation of neuron death(GO:1901214)
0.2 3.0 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 0.5 GO:0010893 positive regulation of steroid biosynthetic process(GO:0010893) positive regulation of steroid metabolic process(GO:0045940)
0.1 7.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 3.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.7 GO:0046660 female sex differentiation(GO:0046660)
0.1 5.1 GO:0006289 nucleotide-excision repair(GO:0006289)
0.1 3.4 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.1 7.0 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.3 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 2.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.1 GO:0003139 secondary heart field specification(GO:0003139)
0.1 0.5 GO:0055016 hypochord development(GO:0055016)
0.1 7.2 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 2.8 GO:0003094 glomerular filtration(GO:0003094)
0.1 3.1 GO:0072348 sulfur compound transport(GO:0072348)
0.1 4.2 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 0.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 2.3 GO:0014029 neural crest formation(GO:0014029)
0.1 0.4 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 2.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 1.8 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.3 GO:0060547 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544) negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 15.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.6 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.8 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 2.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.6 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.9 GO:0030225 macrophage differentiation(GO:0030225)
0.0 1.3 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.2 GO:0043393 regulation of protein binding(GO:0043393)
0.0 1.5 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.7 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.7 GO:0007520 myoblast fusion(GO:0007520)
0.0 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.3 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 2.3 GO:1990266 neutrophil migration(GO:1990266)
0.0 0.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)
0.0 2.6 GO:0006814 sodium ion transport(GO:0006814)
0.0 2.7 GO:0045165 cell fate commitment(GO:0045165)
0.0 6.4 GO:0000226 microtubule cytoskeleton organization(GO:0000226)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 21.0 GO:0042583 chromaffin granule(GO:0042583)
0.8 13.7 GO:0043209 myelin sheath(GO:0043209)
0.7 5.1 GO:0000439 core TFIIH complex(GO:0000439)
0.6 2.3 GO:0098842 postsynaptic early endosome(GO:0098842)
0.4 3.6 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.3 7.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 3.2 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.8 GO:0089701 U2AF(GO:0089701)
0.2 3.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 1.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 3.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 4.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.0 GO:0000421 autophagosome membrane(GO:0000421)
0.1 2.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.1 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.5 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 2.1 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 17.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 3.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.5 GO:0030018 Z disc(GO:0030018)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 9.2 GO:0005874 microtubule(GO:0005874)
0.0 4.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.7 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 1.1 GO:0005925 focal adhesion(GO:0005925)
0.0 11.7 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0050251 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.8 3.8 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.7 5.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.7 2.8 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.4 11.7 GO:0051787 misfolded protein binding(GO:0051787)
0.4 2.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 7.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 1.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.3 0.9 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.3 2.1 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.3 1.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.3 7.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 3.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.2 9.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 1.8 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.2 3.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 2.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 0.8 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 1.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 6.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 3.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 4.6 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.1 3.6 GO:0017069 snRNA binding(GO:0017069)
0.1 6.7 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.1 3.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.4 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.8 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 1.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 16.3 GO:0003682 chromatin binding(GO:0003682)
0.0 4.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 7.2 GO:0042802 identical protein binding(GO:0042802)
0.0 31.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 9.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 9.2 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 8.0 GO:0003924 GTPase activity(GO:0003924)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0051087 chaperone binding(GO:0051087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 18.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.1 PID ARF6 PATHWAY Arf6 signaling events
0.1 4.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 2.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 3.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 5.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 1.2 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.2 11.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 3.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 1.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 3.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.8 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway