ISMARA results: sox19a+sox2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox19a+sox2

Z-value: 3.27

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Transcription factors associated with sox19a+sox2

Gene Symbol	Gene ID	Gene Info
sox19a NCBI UniProt	ENSDARG00000010770	SRY-box transcription factor 19a
sox2 NCBI UniProt	ENSDARG00000070913	SRY-box transcription factor 2
sox19a NCBI UniProt	ENSDARG00000110497	SRY-box transcription factor 19a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sox2	dr11_v1_chr22_-_37349967_37349967	0.85	3.1e-27	Click!
sox19a	dr11_v1_chr5_-_24201437_24201437	0.67	2.3e-13	Click!

Activity profile of sox19a+sox2 motif

Sorted Z-values of sox19a+sox2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_17745345 Show fit	70.77	ENSDART00000132690 ENSDART00000135376	si:dkey-200l5.4 NCBI UniProt Show fit	si:dkey-200l5.4
chr11_+_25735478 Show fit	48.64	ENSDART00000103566	si:dkey-183j2.10 NCBI UniProt Show fit	si:dkey-183j2.10
chr6_-_43092175 Show fit	43.92	ENSDART00000084389	lrrn1 NCBI UniProt Show fit	leucine rich repeat neuronal 1
chr11_+_35364445 Show fit	41.88	ENSDART00000125766	camkvb NCBI UniProt Show fit	CaM kinase-like vesicle-associated b
chr14_-_33872092 Show fit	41.67	ENSDART00000111903	si:ch73-335m24.2 NCBI UniProt Show fit	si:ch73-335m24.2
chr2_-_21082695 Show fit	41.52	ENSDART00000032502	nebl NCBI UniProt Show fit	nebulette
chr6_+_27146671 Show fit	38.43	ENSDART00000156792	kif1aa NCBI UniProt Show fit	kinesin family member 1Aa
chr19_-_21832441 Show fit	38.29	ENSDART00000151272 ENSDART00000151442 ENSDART00000150168 ENSDART00000148797 ENSDART00000128196 ENSDART00000149259 ENSDART00000052556 ENSDART00000149658 ENSDART00000149639 ENSDART00000148424	mbpa NCBI UniProt Show fit	myelin basic protein a
chr2_+_3472832 Show fit	36.85	ENSDART00000115278	cx47.1 NCBI UniProt Show fit	connexin 47.1
chr17_+_15535501 Show fit	32.87	ENSDART00000002932	marcksb NCBI UniProt Show fit	myristoylated alanine-rich protein kinase C substrate b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sox19a+sox2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	447.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	124.6	GO:0007017	microtubule-based process(GO:0007017)
0.5	89.1	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
1.1	79.2	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
3.2	73.2	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.2	68.9	GO:0045944	positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
1.6	68.3	GO:0002028	regulation of sodium ion transport(GO:0002028)
0.3	64.1	GO:0008380	RNA splicing(GO:0008380)
1.6	61.1	GO:0014059	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3	57.1	GO:0043547	positive regulation of GTPase activity(GO:0043547)

Showing 1 to 10 of 419 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	397.3	GO:0005634	nucleus(GO:0005634)
0.3	335.1	GO:0005887	integral component of plasma membrane(GO:0005887)
0.5	206.2	GO:0043005	neuron projection(GO:0043005)
3.6	151.2	GO:0043204	perikaryon(GO:0043204)
0.6	110.3	GO:0030424	axon(GO:0030424)
0.0	85.8	GO:0005886	plasma membrane(GO:0005886)
0.2	82.8	GO:0000139	Golgi membrane(GO:0000139)
4.1	73.4	GO:0043209	myelin sheath(GO:0043209)
1.8	70.8	GO:0043679	axon terminus(GO:0043679)
0.7	68.0	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)

Showing 1 to 10 of 182 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	420.5	GO:0005509	calcium ion binding(GO:0005509)
0.1	253.0	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.6	243.8	GO:0015631	tubulin binding(GO:0015631)
0.4	134.1	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3	107.2	GO:0003924	GTPase activity(GO:0003924)
0.3	93.4	GO:0005096	GTPase activator activity(GO:0005096)
1.9	89.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.5	60.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
3.9	58.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
1.4	54.2	GO:0017075	syntaxin-1 binding(GO:0017075)

Showing 1 to 10 of 299 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	42.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.9	40.1	PID REELIN PATHWAY	Reelin signaling pathway
1.1	36.6	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.9	27.4	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.5	24.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
1.1	17.6	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.6	16.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.4	15.7	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.4	11.5	PID INSULIN PATHWAY	Insulin Pathway
1.3	11.4	PID S1P S1P4 PATHWAY	S1P4 pathway

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	32.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.4	31.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
1.2	26.5	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.9	24.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.4	22.8	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
1.2	21.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.3	20.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.9	15.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.6	14.9	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
4.9	14.6	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle

Showing 1 to 10 of 90 entries

Results for sox19a+sox2

Z-value: 3.27

Motif logo

Transcription factors associated with sox19a+sox2

Activity-expression correlation:

Activity profile of sox19a+sox2 motif

Sorted Z-values of sox19a+sox2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sox19a+sox2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: