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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox6

Z-value: 0.61

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Transcription factors associated with sox6

Gene Symbol Gene ID Gene Info
sox6
ENSDARG00000015536 SRY-box transcription factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox6dr11_v1_chr7_+_27250186_27250186-0.204.9e-02Click!

Activity profile of sox6 motif

Sorted Z-values of sox6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_2578026 9.27 ENSDART00000065821
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr5_+_35458190 8.00 ENSDART00000051313
fbp1b
fructose-1,6-bisphosphatase 1b
chr2_+_16780643 6.95 ENSDART00000125647
ENSDART00000108611
ENSDART00000181245
ENSDART00000163194
tfa
transferrin-a
chr17_-_2573021 6.60 ENSDART00000074181
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr17_-_2590222 6.42 ENSDART00000185711
CR759892.1

chr10_+_15608326 5.93 ENSDART00000188770
zfand5b
zinc finger, AN1-type domain 5b
chr19_-_27588842 5.89 ENSDART00000121643
si:dkeyp-46h3.2
si:dkeyp-46h3.2
chr12_-_22524388 5.83 ENSDART00000020942
shbg
sex hormone-binding globulin
chr13_-_20540790 5.71 ENSDART00000131467
si:ch1073-126c3.2
si:ch1073-126c3.2
chr1_-_33645967 5.33 ENSDART00000192758
cldng
claudin g
chr20_-_40754794 4.46 ENSDART00000187251
cx32.3
connexin 32.3
chr14_+_51056605 4.40 ENSDART00000159639
CABZ01078593.1

chr22_-_24967348 3.47 ENSDART00000153490
ENSDART00000084871
fam20cl
family with sequence similarity 20, member C like
chr1_-_55810730 3.33 ENSDART00000100551
zgc:136908
zgc:136908
chr7_+_39444843 3.26 ENSDART00000143999
ENSDART00000173554
ENSDART00000173698
ENSDART00000173754
ENSDART00000144075
ENSDART00000138192
ENSDART00000145457
ENSDART00000141750
ENSDART00000103056
ENSDART00000142946
ENSDART00000173748
tnnt3b
troponin T type 3b (skeletal, fast)
chr13_+_46941930 3.23 ENSDART00000056962
fbxo5
F-box protein 5
chr9_-_23891102 3.23 ENSDART00000186799
asb18
ankyrin repeat and SOCS box containing 18
chr20_+_40237441 3.23 ENSDART00000168928
si:ch211-199i15.5
si:ch211-199i15.5
chr24_-_40668208 3.22 ENSDART00000171543
smyhc1
slow myosin heavy chain 1
chr14_+_52565660 3.08 ENSDART00000188151
rpl26
ribosomal protein L26
chr12_-_33354409 2.99 ENSDART00000178515
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr16_+_25245857 2.96 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr7_-_24520866 2.81 ENSDART00000077039
faah2b
fatty acid amide hydrolase 2b
chr16_+_47308856 2.60 ENSDART00000170103
col28a1b
collagen, type XXVIII, alpha 1b
chr13_+_33368503 2.52 ENSDART00000139650
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr19_-_23249822 2.43 ENSDART00000140665
grb10a
growth factor receptor-bound protein 10a
chr3_+_29641181 2.38 ENSDART00000151517
eif3d
eukaryotic translation initiation factor 3, subunit D
chr25_+_13620555 2.37 ENSDART00000163642
si:ch211-172l8.4
si:ch211-172l8.4
chr7_-_26308098 2.35 ENSDART00000146440
ENSDART00000146935
ENSDART00000164627
zgc:77439
zgc:77439
chr2_-_24269911 2.27 ENSDART00000099532
myh7
myosin heavy chain 7
chr20_+_35445462 2.26 ENSDART00000124497
tdrd6
tudor domain containing 6
chr2_+_27386617 2.25 ENSDART00000134976
si:ch73-382f3.1
si:ch73-382f3.1
chr22_-_10541372 2.07 ENSDART00000179708
si:dkey-42i9.4
si:dkey-42i9.4
chr8_+_14158021 2.06 ENSDART00000080832
si:dkey-6n6.2
si:dkey-6n6.2
chr16_+_27349585 2.05 ENSDART00000142573
nr4a3
nuclear receptor subfamily 4, group A, member 3
chr24_-_29868151 1.99 ENSDART00000184802
aglb
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr8_+_17069577 1.95 ENSDART00000131847
si:dkey-190g11.3
si:dkey-190g11.3
chr12_+_48340133 1.89 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
ddit4
DNA-damage-inducible transcript 4
chr7_-_24995631 1.89 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr7_-_6459481 1.88 ENSDART00000173158
zgc:112234
zgc:112234
chr23_+_5499307 1.87 ENSDART00000170361
tead3a
TEA domain family member 3 a
chr14_+_48812189 1.84 ENSDART00000161454
mmp17b
matrix metallopeptidase 17b
chr5_+_55221593 1.81 ENSDART00000073638
tmc2a
transmembrane channel-like 2a
chr11_+_14280598 1.77 ENSDART00000163033
si:ch211-262i1.3
si:ch211-262i1.3
chr15_+_19458982 1.76 ENSDART00000132665
zgc:77784
zgc:77784
chr13_-_33700461 1.68 ENSDART00000160520
mad2l1bp
MAD2L1 binding protein
chr13_-_11699530 1.65 ENSDART00000192161
slc39a8
solute carrier family 39 (zinc transporter), member 8
chr14_+_11457500 1.63 ENSDART00000169202
si:ch211-153b23.5
si:ch211-153b23.5
chr22_-_37565348 1.63 ENSDART00000149482
ENSDART00000104478
fxr1
fragile X mental retardation, autosomal homolog 1
chr19_+_24575077 1.61 ENSDART00000167469
si:dkeyp-92c9.4
si:dkeyp-92c9.4
chr23_-_5685023 1.61 ENSDART00000148680
ENSDART00000149365
tnnt2a
troponin T type 2a (cardiac)
chr21_-_35853245 1.60 ENSDART00000172245
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr20_+_37295006 1.59 ENSDART00000153137
cx23
connexin 23
chr2_+_23731194 1.58 ENSDART00000155747
slc22a13a
solute carrier family 22 member 13a
chr16_-_42186093 1.53 ENSDART00000076030
fbl
fibrillarin
chr12_-_17655683 1.52 ENSDART00000066411
dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr3_+_29640996 1.50 ENSDART00000011052
eif3d
eukaryotic translation initiation factor 3, subunit D
chr9_-_22339582 1.43 ENSDART00000134805
crygm2d1
crystallin, gamma M2d1
chr2_+_49457449 1.40 ENSDART00000185470
sh3gl1a
SH3-domain GRB2-like 1a
chr18_+_47313899 1.38 ENSDART00000192389
ENSDART00000189592
ENSDART00000184281
barx2
BARX homeobox 2
chr13_-_7567707 1.38 ENSDART00000190296
ENSDART00000180348
pitx3
paired-like homeodomain 3
chr15_-_30853246 1.37 ENSDART00000112511
akap1b
A kinase (PRKA) anchor protein 1b
chr3_+_49074008 1.36 ENSDART00000168864
zgc:112146
zgc:112146
chr4_+_65607540 1.35 ENSDART00000192218
si:dkey-205i10.2
si:dkey-205i10.2
chr5_-_20195350 1.35 ENSDART00000139675
dao.1
D-amino-acid oxidase, tandem duplicate 1
chr4_+_57046954 1.34 ENSDART00000171796
si:ch211-238e22.7
si:ch211-238e22.7
chr15_+_28368823 1.33 ENSDART00000142298
slc43a2a
solute carrier family 43 (amino acid system L transporter), member 2a
chr9_+_50001746 1.29 ENSDART00000058892
slc38a11
solute carrier family 38, member 11
chr2_+_49457626 1.26 ENSDART00000129967
sh3gl1a
SH3-domain GRB2-like 1a
chr5_-_66160415 1.25 ENSDART00000073895
mboat4
membrane bound O-acyltransferase domain containing 4
chr9_-_22272181 1.25 ENSDART00000113174
crygm2d7
crystallin, gamma M2d7
chr20_-_33961697 1.25 ENSDART00000061765
selp
selectin P
chr1_-_17735861 1.24 ENSDART00000018238
pdlim3a
PDZ and LIM domain 3a
chr14_-_33978117 1.23 ENSDART00000128515
foxa
forkhead box A sequence
chr15_+_31481939 1.23 ENSDART00000134306
or102-5
odorant receptor, family C, subfamily 102, member 5
chr23_+_3538463 1.21 ENSDART00000172758
si:dkey-9l20.3
si:dkey-9l20.3
chr7_-_73852594 1.18 ENSDART00000183194
zgc:165555
zgc:165555
chr14_+_26247319 1.18 ENSDART00000192793
CCDC69
coiled-coil domain containing 69
chr21_-_41870029 1.17 ENSDART00000182035
endou2
endonuclease, polyU-specific 2
chr5_+_10046643 1.17 ENSDART00000137543
ENSDART00000186917
gstt2
glutathione S-transferase theta 2
chr9_+_3055566 1.17 ENSDART00000189906
ENSDART00000175891
ENSDART00000093021
ppp1r9ala
protein phosphatase 1 regulatory subunit 9A-like A
chr15_-_35410860 1.16 ENSDART00000191267
mecom
MDS1 and EVI1 complex locus
chr2_-_24270062 1.13 ENSDART00000192445
myh7
myosin heavy chain 7
chr4_+_18804317 1.13 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr19_-_27339844 1.12 ENSDART00000052358
ENSDART00000148238
ENSDART00000147661
ENSDART00000137346
znrd1
zinc ribbon domain containing 1
chr23_+_27068225 1.12 ENSDART00000054238
mipa
major intrinsic protein of lens fiber a
chr12_+_45677293 1.12 ENSDART00000152850
ENSDART00000153047
si:ch73-111m19.2
si:ch73-111m19.2
chr11_-_9808356 1.11 ENSDART00000167465
nlgn1
neuroligin 1
chr7_+_38255418 1.09 ENSDART00000052354
si:dkey-78a14.4
si:dkey-78a14.4
chr11_+_10541258 1.09 ENSDART00000132365
b3gnt5a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a
chr13_+_42309688 1.06 ENSDART00000158367
ide
insulin-degrading enzyme
chr19_+_47394270 1.05 ENSDART00000171281
psmb2
proteasome subunit beta 2
chr7_+_25103965 1.04 ENSDART00000192561
ENSDART00000173721
si:dkey-23i12.9
si:dkey-23i12.9
chr7_-_53117131 1.03 ENSDART00000169211
ENSDART00000168890
ENSDART00000172179
ENSDART00000167882
cdh1
cadherin 1, type 1, E-cadherin (epithelial)
chr5_+_19097194 1.02 ENSDART00000131918
unc13ba
unc-13 homolog Ba (C. elegans)
chr3_-_21402279 0.99 ENSDART00000164513
CT573446.1

chr14_-_41478265 0.98 ENSDART00000149886
ENSDART00000016002
tspan7
tetraspanin 7
chr15_-_5239536 0.98 ENSDART00000081704
or128-2
odorant receptor, family E, subfamily 128, member 2
chr22_+_3045495 0.97 ENSDART00000164061
LO017843.1

chr6_-_52675630 0.97 ENSDART00000083830
sdc4
syndecan 4
chr8_+_42941555 0.95 ENSDART00000183206
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr3_+_3545825 0.92 ENSDART00000109060
CR589947.1

chr3_+_3099492 0.90 ENSDART00000154156
si:dkey-30g5.1
si:dkey-30g5.1
chr25_+_33063762 0.87 ENSDART00000189974
tln2b
talin 2b
chr2_+_29257942 0.87 ENSDART00000184362
ENSDART00000025562
cdh18a
cadherin 18, type 2a
chr3_-_16250527 0.86 ENSDART00000146699
ENSDART00000141181
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr25_+_28567381 0.85 ENSDART00000126552
SLC15A5
si:ch211-190o6.3
chr19_-_43226124 0.83 ENSDART00000168965
gnrhr1
gonadotropin releasing hormone receptor 1
chr15_-_18067220 0.83 ENSDART00000113142
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr9_+_13986427 0.83 ENSDART00000147200
cd28
CD28 molecule
chr15_+_12429206 0.82 ENSDART00000168997
tmprss4a
transmembrane protease, serine 4a
chr24_-_21343982 0.82 ENSDART00000012653
spice1
spindle and centriole associated protein 1
chr10_+_29849497 0.81 ENSDART00000099994
ENSDART00000132212
hspa8
heat shock protein 8
chr13_+_15933168 0.80 ENSDART00000131390
fignl1
fidgetin-like 1
chr15_-_576135 0.79 ENSDART00000124170
cbln20
cerebellin 20
chr20_+_31217495 0.78 ENSDART00000020252
pdia6
protein disulfide isomerase family A, member 6
chr3_+_26244353 0.77 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr25_+_26798673 0.75 ENSDART00000157235
ca12
carbonic anhydrase XII
chr7_+_24520518 0.75 ENSDART00000173604
btr09
bloodthirsty-related gene family, member 9
chr24_-_3426620 0.74 ENSDART00000184346
nck1b
NCK adaptor protein 1b
chr21_+_36396864 0.73 ENSDART00000137309
gemin5
gem (nuclear organelle) associated protein 5
chr21_+_34119759 0.72 ENSDART00000024750
ENSDART00000128242
hmgb3b
high mobility group box 3b
chr11_-_7147540 0.71 ENSDART00000143942
bmp7a
bone morphogenetic protein 7a
chr21_-_41028665 0.70 ENSDART00000190531
plac8l1
PLAC8-like 1
chr19_+_4051695 0.68 ENSDART00000166368
btr24
bloodthirsty-related gene family, member 24
chr8_-_49499457 0.68 ENSDART00000098326
opn7d
opsin 7, group member d
chr5_+_40835601 0.63 ENSDART00000147767
si:dkey-3h3.3
si:dkey-3h3.3
chr10_+_16069987 0.62 ENSDART00000043936
megf10
multiple EGF-like-domains 10
chr5_+_7989210 0.61 ENSDART00000168071
gdnfb
glial cell derived neurotrophic factor b
chr23_-_30045661 0.59 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr10_+_2842923 0.58 ENSDART00000181895
ykt6
YKT6 v-SNARE homolog (S. cerevisiae)
chr7_-_17570923 0.57 ENSDART00000188476
ENSDART00000080624
nitr5
novel immune-type receptor 5
chr1_-_354115 0.57 ENSDART00000141590
ENSDART00000098627
pros1
protein S
chr16_-_54919260 0.56 ENSDART00000156533
kdf1a
keratinocyte differentiation factor 1a
chr2_-_10896745 0.56 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr15_+_29727799 0.54 ENSDART00000182006
zgc:153372
zgc:153372
chr7_+_48761646 0.53 ENSDART00000017467
acana
aggrecan a
chr5_-_33606729 0.53 ENSDART00000137073
si:dkey-34e4.1
si:dkey-34e4.1
chr15_-_3736149 0.53 ENSDART00000182986
lpar6a
lysophosphatidic acid receptor 6a
chr2_+_26479676 0.52 ENSDART00000056795
ENSDART00000144837
hectd3
HECT domain containing 3
chr5_-_11905920 0.52 ENSDART00000114378
fbxw8
F-box and WD repeat domain containing 8
chr9_-_14084044 0.52 ENSDART00000141571
fer1l6
fer-1-like family member 6
chr22_-_12746539 0.52 ENSDART00000175374
plcd4a
phospholipase C, delta 4a
chr14_-_34771371 0.51 ENSDART00000160598
ENSDART00000150413
ENSDART00000168910
ablim3
actin binding LIM protein family, member 3
chr5_-_46505691 0.50 ENSDART00000111589
ENSDART00000122966
ENSDART00000166907
hapln1a
hyaluronan and proteoglycan link protein 1a
chr25_-_16076257 0.50 ENSDART00000140780
ovch2
ovochymase 2
chr24_-_31194847 0.49 ENSDART00000158808
cnn3a
calponin 3, acidic a
chr23_+_30827959 0.48 ENSDART00000033429
npbwr2a
neuropeptides B/W receptor 2a
chr22_+_1028724 0.48 ENSDART00000149625
si:ch73-352p18.4
si:ch73-352p18.4
chr6_-_29537219 0.47 ENSDART00000180262
pex5la
peroxisomal biogenesis factor 5-like a
chr17_-_20228610 0.44 ENSDART00000125758
ebf3b
early B cell factor 3b
chr11_-_11890001 0.41 ENSDART00000081544
wipf2a
WAS/WASL interacting protein family, member 2a
chr25_+_13271458 0.41 ENSDART00000188307
AL772241.1

chr4_-_77432218 0.41 ENSDART00000158683
slco1d1
solute carrier organic anion transporter family, member 1D1
chr2_-_5942355 0.40 ENSDART00000110469
tmem125b
transmembrane protein 125b
chr13_+_47050726 0.39 ENSDART00000140045
anapc1
anaphase promoting complex subunit 1
chr19_-_18152407 0.38 ENSDART00000193264
ENSDART00000016135
nfe2l3
nuclear factor, erythroid 2-like 3
chr8_+_17869225 0.38 ENSDART00000080079
slc44a5b
solute carrier family 44, member 5b
chr19_+_7424347 0.38 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr22_-_10440688 0.37 ENSDART00000111962
nol8
nucleolar protein 8
chr6_-_25180438 0.37 ENSDART00000159696
lrrc8db
leucine rich repeat containing 8 VRAC subunit Db
chr5_+_35458346 0.36 ENSDART00000141239
erlin2
ER lipid raft associated 2
chr10_-_42237304 0.36 ENSDART00000140341
tcf7l1a
transcription factor 7 like 1a
chr7_-_24373662 0.33 ENSDART00000173865
PTGR1 (1 of many)
si:dkey-11k2.7
chr23_-_7826849 0.32 ENSDART00000157612
myt1b
myelin transcription factor 1b
chr15_+_17756113 0.30 ENSDART00000155197
si:ch211-213d14.2
si:ch211-213d14.2
chr23_-_25798099 0.30 ENSDART00000041833
fitm2
fat storage-inducing transmembrane protein 2
chr22_+_4443689 0.30 ENSDART00000185490
ticam1
toll-like receptor adaptor molecule 1
chr15_-_20779624 0.30 ENSDART00000181936
tpst1
tyrosylprotein sulfotransferase 1
chr22_-_15693085 0.26 ENSDART00000141861
si:ch1073-396h14.1
si:ch1073-396h14.1
chr10_+_3428194 0.25 ENSDART00000081599
ptpn11a
protein tyrosine phosphatase, non-receptor type 11, a
chr8_+_8671229 0.24 ENSDART00000131963
usp11
ubiquitin specific peptidase 11
chr12_+_38697541 0.24 ENSDART00000188648
dnai2b
dynein, axonemal, intermediate chain 2b
chr3_+_53156813 0.24 ENSDART00000114343
brd4
bromodomain containing 4
chr1_-_56213723 0.24 ENSDART00000142505
ENSDART00000137237
si:dkey-76b14.2
si:dkey-76b14.2
chr24_-_19719240 0.24 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr14_-_31060082 0.22 ENSDART00000111601
ENSDART00000161113
mbnl3
muscleblind-like splicing regulator 3
chr25_+_34862225 0.22 ENSDART00000149782
CHST6
zgc:194879
chr25_-_22889519 0.21 ENSDART00000128250
mob2a
MOB kinase activator 2a
chr7_+_24114694 0.21 ENSDART00000127177
mrpl52
mitochondrial ribosomal protein L52
chr15_-_945804 0.20 ENSDART00000063257
alox5b.1
arachidonate 5-lipoxygenase b, tandem duplicate 1
chr8_+_26205471 0.20 ENSDART00000131888
celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr10_+_44042033 0.17 ENSDART00000190006
ENSDART00000046172
cryba4
crystallin, beta A4
chr22_+_4442473 0.17 ENSDART00000170751
ticam1
toll-like receptor adaptor molecule 1
chr3_+_1942219 0.15 ENSDART00000114520
zgc:165583
zgc:165583
chr7_+_31145386 0.15 ENSDART00000075407
ENSDART00000169462
fam189a1
family with sequence similarity 189, member A1
chr23_+_42813415 0.15 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr6_+_58280936 0.14 ENSDART00000155244
ralgapb
Ral GTPase activating protein, beta subunit (non-catalytic)
chr15_-_41503392 0.12 ENSDART00000169351
si:dkey-230i18.2
si:dkey-230i18.2
chr1_+_26480890 0.11 ENSDART00000164430
uso1
USO1 vesicle transport factor
chr7_+_48761875 0.10 ENSDART00000003690
acana
aggrecan a
chr1_-_18615063 0.10 ENSDART00000014916
klf3
Kruppel-like factor 3 (basic)
chr12_+_22657925 0.09 ENSDART00000153048
si:dkey-219e21.4
si:dkey-219e21.4
chr17_-_45386546 0.09 ENSDART00000182647
tmem206
transmembrane protein 206
chr12_+_42400277 0.07 ENSDART00000166590
si:ch211-221j21.3
si:ch211-221j21.3
chr3_-_26524934 0.07 ENSDART00000087118
xylt1
xylosyltransferase I
chr6_-_11362871 0.07 ENSDART00000151125
pcnt
pericentrin
chr1_-_31534089 0.06 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr20_-_14665002 0.06 ENSDART00000152816
scrn2
secernin 2
chr10_-_28028998 0.05 ENSDART00000023545
ENSDART00000143487
ints2
integrator complex subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of sox6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0046351 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
1.3 3.9 GO:0002191 cap-dependent translational initiation(GO:0002191)
1.1 3.3 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
1.1 5.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.9 15.9 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.9 3.5 GO:0070166 enamel mineralization(GO:0070166)
0.8 3.2 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.6 6.9 GO:0019731 antibacterial humoral response(GO:0019731)
0.6 3.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.6 1.7 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.5 3.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.4 1.6 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.4 1.2 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.3 1.0 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.3 1.3 GO:0046436 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.3 0.9 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.2 1.0 GO:0036445 neuronal stem cell division(GO:0036445) somatic stem cell division(GO:0048103)
0.2 2.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 1.2 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.2 2.3 GO:0030719 P granule organization(GO:0030719)
0.2 2.3 GO:0032196 transposition(GO:0032196)
0.2 0.6 GO:0090190 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 1.8 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.2 0.6 GO:0042730 fibrinolysis(GO:0042730)
0.2 0.5 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.2 2.4 GO:1900077 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.2 1.0 GO:0090134 adherens junction maintenance(GO:0034334) mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.2 0.5 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.2 1.0 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.2 1.5 GO:0031126 snoRNA 3'-end processing(GO:0031126)
0.2 0.5 GO:0035666 regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.1 2.0 GO:0009251 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 1.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.8 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.1 1.6 GO:0007525 somatic muscle development(GO:0007525)
0.1 3.3 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.1 1.1 GO:0006833 water transport(GO:0006833)
0.1 0.6 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1 2.5 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.1 0.6 GO:0003151 outflow tract morphogenesis(GO:0003151)
0.1 1.1 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 1.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 2.0 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 1.1 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 1.5 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.4 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 1.3 GO:0032094 response to food(GO:0032094)
0.1 1.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 0.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 1.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.7 GO:0021703 locus ceruleus development(GO:0021703) negative regulation of endodermal cell fate specification(GO:0042664)
0.1 1.4 GO:0070306 adenohypophysis development(GO:0021984) lens fiber cell differentiation(GO:0070306)
0.1 1.8 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 0.8 GO:0046599 regulation of centriole replication(GO:0046599) metaphase plate congression(GO:0051310)
0.1 1.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.5 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 3.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 1.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 2.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.4 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 1.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 2.3 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 2.0 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.0 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.9 GO:0034332 adherens junction organization(GO:0034332)
0.0 0.8 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 1.2 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.0 0.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.6 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.7 GO:0030217 T cell differentiation(GO:0030217)
0.0 1.3 GO:0006865 amino acid transport(GO:0006865)
0.0 2.4 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.8 2.3 GO:0033391 chromatoid body(GO:0033391)
0.4 1.6 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.3 2.5 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.3 1.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 1.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 1.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 3.9 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.2 1.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 4.9 GO:0005861 troponin complex(GO:0005861)
0.1 9.6 GO:0005769 early endosome(GO:0005769)
0.1 1.0 GO:0030057 desmosome(GO:0030057)
0.0 19.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.4 GO:0016459 myosin complex(GO:0016459)
0.0 5.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.0 GO:0043195 terminal bouton(GO:0043195)
0.0 1.0 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.7 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.8 GO:0045180 basal cortex(GO:0045180)
0.0 1.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 4.1 GO:0005819 spindle(GO:0005819)
0.0 0.9 GO:0016342 catenin complex(GO:0016342)
0.0 1.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.3 GO:0060076 excitatory synapse(GO:0060076)
0.0 1.8 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
1.4 15.9 GO:0035804 structural constituent of egg coat(GO:0035804)
1.3 3.9 GO:0098808 mRNA cap binding(GO:0098808)
0.5 2.0 GO:0004135 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.5 1.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 4.9 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.4 1.1 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.4 2.5 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.3 1.3 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.3 2.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 3.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 0.8 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.2 2.4 GO:0005158 insulin receptor binding(GO:0005158)
0.2 1.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 2.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 1.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 0.5 GO:0030791 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.1 1.0 GO:0005549 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.1 1.1 GO:0015250 water channel activity(GO:0015250)
0.1 0.6 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.1 0.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.5 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 5.8 GO:0042562 hormone binding(GO:0042562)
0.1 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.1 3.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.2 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.8 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.9 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 2.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.3 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 1.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.8 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.0 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 1.3 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.5 GO:0051020 GTPase binding(GO:0051020)
0.0 4.8 GO:0003774 motor activity(GO:0003774)
0.0 1.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 3.2 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 3.6 GO:0042802 identical protein binding(GO:0042802)
0.0 0.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0042923 neuropeptide binding(GO:0042923)
0.0 1.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 3.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 2.1 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 3.2 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.5 PID AURORA A PATHWAY Aurora A signaling
0.1 0.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 3.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 3.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.8 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 3.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.8 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 0.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 2.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 1.2 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.4 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA