ISMARA results: sp8a+sp8b_sp4_rsl1d1+sp3a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 2.09

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Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Gene Symbol	Gene ID	Gene Info
sp8a NCBI UniProt	ENSDARG00000011870	sp8 transcription factor a
sp8b NCBI UniProt	ENSDARG00000056666	sp8 transcription factor b
sp4 NCBI UniProt	ENSDARG00000005186	sp4 transcription factor
sp3a NCBI UniProt	ENSDARG00000001549	sp3a transcription factor
rsl1d1 NCBI UniProt	ENSDARG00000005846	Sp5 transcription factor b
klf4 NCBI UniProt	ENSDARG00000079922	Kruppel-like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp8b	dr11_v1_chr16_+_19536614_19536761	-0.72	3.0e-16	Click!
FO704755.1	dr11_v1_chr6_+_3809346_3809346	-0.40	6.0e-05	Click!
sp8a	dr11_v1_chr19_-_2317558_2317558	-0.37	2.6e-04	Click!
sp3a	dr11_v1_chr9_+_2762270_2762415	0.33	9.9e-04	Click!
klf4	dr11_v1_chr21_-_435466_435466	0.18	8.1e-02	Click!
sp4	dr11_v1_chr19_+_2546775_2546775	0.17	9.4e-02	Click!

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_17197546 Show fit	64.69	ENSDART00000139939 ENSDART00000135146 ENSDART00000063800 ENSDART00000163606	gapdh NCBI UniProt Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr12_+_46634736 Show fit	39.91	ENSDART00000008009	trim16 NCBI UniProt Show fit	tripartite motif containing 16
chr10_-_41352502 Show fit	35.37	ENSDART00000052971 ENSDART00000128156	rab11fip1b NCBI UniProt Show fit	RAB11 family interacting protein 1 (class I) b
chr20_-_54564018 Show fit	32.84	ENSDART00000099832	zgc:153012 NCBI UniProt Show fit	zgc:153012
chr3_+_1211242 Show fit	31.75	ENSDART00000171287 ENSDART00000165769	poldip3 NCBI UniProt Show fit	polymerase (DNA-directed), delta interacting protein 3
chr24_-_11076400 Show fit	30.86	ENSDART00000003195	chmp4c NCBI UniProt Show fit	charged multivesicular body protein 4C
chr21_-_32436679 Show fit	29.10	ENSDART00000076974	gfpt2 NCBI UniProt Show fit	glutamine-fructose-6-phosphate transaminase 2
chr10_-_1625080 Show fit	29.06	ENSDART00000137285	nup155 NCBI UniProt Show fit	nucleoporin 155
chr16_-_17713859 Show fit	28.51	ENSDART00000149275	zgc:174935 NCBI UniProt Show fit	zgc:174935
chr22_+_11756040 Show fit	27.41	ENSDART00000105808	krt97 NCBI UniProt Show fit	keratin 97

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	58.8	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.2	55.5	GO:0006954	inflammatory response(GO:0006954)
1.4	51.5	GO:0050821	protein stabilization(GO:0050821)
0.5	46.8	GO:0045732	positive regulation of protein catabolic process(GO:0045732)
6.2	43.6	GO:0097340	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.5	33.4	GO:0007043	cell-cell junction assembly(GO:0007043)
2.5	32.8	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.2	31.2	GO:0001756	somitogenesis(GO:0001756)
1.3	30.0	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.8	29.7	GO:0007586	digestion(GO:0007586)

Showing 1 to 10 of 482 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	104.0	GO:0005829	cytosol(GO:0005829)
0.1	88.2	GO:0005615	extracellular space(GO:0005615)
0.7	70.7	GO:0005882	intermediate filament(GO:0005882)
0.6	70.3	GO:0016459	myosin complex(GO:0016459)
0.5	67.0	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
3.0	56.8	GO:0030057	desmosome(GO:0030057)
0.2	54.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	49.9	GO:0000785	chromatin(GO:0000785)
4.5	49.7	GO:0045095	keratin filament(GO:0045095)
0.1	46.4	GO:0005667	transcription factor complex(GO:0005667)

Showing 1 to 10 of 141 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	99.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2	94.6	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
15.8	63.0	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2	49.6	GO:0005198	structural molecule activity(GO:0005198)
0.4	48.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.2	45.7	GO:0051015	actin filament binding(GO:0051015)
6.2	43.6	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2	43.3	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	43.1	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
3.0	42.1	GO:0008327	methyl-CpG binding(GO:0008327)

Showing 1 to 10 of 335 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	105.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.7	75.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.6	43.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.5	42.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.6	36.5	PID MTOR 4PATHWAY	mTOR signaling pathway
1.1	27.4	PID NECTIN PATHWAY	Nectin adhesion pathway
1.7	20.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	18.3	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.5	17.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
3.5	17.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.

Showing 1 to 10 of 67 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	62.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.7	49.6	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
3.2	41.4	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	34.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.8	31.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.8	30.1	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.5	29.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.4	25.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
2.8	25.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.2	23.5	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling

Showing 1 to 10 of 109 entries

Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 2.09

Motif logo

Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Activity-expression correlation:

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: