ISMARA results: sp8a+sp8b_sp4_rsl1d1+sp3a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 2.09

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Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Gene Symbol	Gene ID	Gene Info
sp8a NCBI UniProt	ENSDARG00000011870	sp8 transcription factor a
sp8b NCBI UniProt	ENSDARG00000056666	sp8 transcription factor b
sp4 NCBI UniProt	ENSDARG00000005186	sp4 transcription factor
sp3a NCBI UniProt	ENSDARG00000001549	sp3a transcription factor
rsl1d1 NCBI UniProt	ENSDARG00000005846	Sp5 transcription factor b
klf4 NCBI UniProt	ENSDARG00000079922	Kruppel-like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp8b	dr11_v1_chr16_+_19536614_19536761	-0.72	3.0e-16	Click!
FO704755.1	dr11_v1_chr6_+_3809346_3809346	-0.40	6.0e-05	Click!
sp8a	dr11_v1_chr19_-_2317558_2317558	-0.37	2.6e-04	Click!
sp3a	dr11_v1_chr9_+_2762270_2762415	0.33	9.9e-04	Click!
klf4	dr11_v1_chr21_-_435466_435466	0.18	8.1e-02	Click!
sp4	dr11_v1_chr19_+_2546775_2546775	0.17	9.4e-02	Click!

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_17197546 Show fit	64.69	ENSDART00000139939 ENSDART00000135146 ENSDART00000063800 ENSDART00000163606	gapdh NCBI UniProt Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr12_+_46634736 Show fit	39.91	ENSDART00000008009	trim16 NCBI UniProt Show fit	tripartite motif containing 16
chr10_-_41352502 Show fit	35.37	ENSDART00000052971 ENSDART00000128156	rab11fip1b NCBI UniProt Show fit	RAB11 family interacting protein 1 (class I) b
chr20_-_54564018 Show fit	32.84	ENSDART00000099832	zgc:153012 NCBI UniProt Show fit	zgc:153012
chr3_+_1211242 Show fit	31.75	ENSDART00000171287 ENSDART00000165769	poldip3 NCBI UniProt Show fit	polymerase (DNA-directed), delta interacting protein 3
chr24_-_11076400 Show fit	30.86	ENSDART00000003195	chmp4c NCBI UniProt Show fit	charged multivesicular body protein 4C
chr21_-_32436679 Show fit	29.10	ENSDART00000076974	gfpt2 NCBI UniProt Show fit	glutamine-fructose-6-phosphate transaminase 2
chr10_-_1625080 Show fit	29.06	ENSDART00000137285	nup155 NCBI UniProt Show fit	nucleoporin 155
chr16_-_17713859 Show fit	28.51	ENSDART00000149275	zgc:174935 NCBI UniProt Show fit	zgc:174935
chr22_+_11756040 Show fit	27.41	ENSDART00000105808	krt97 NCBI UniProt Show fit	keratin 97
chr21_-_11646878 Show fit	27.13	ENSDART00000162426 ENSDART00000135937 ENSDART00000131448 ENSDART00000148097 ENSDART00000133443	cast NCBI UniProt Show fit	calpastatin
chr25_-_22187397 Show fit	26.61	ENSDART00000123211 ENSDART00000139110	pkp3a NCBI UniProt Show fit	plakophilin 3a
chr21_-_43328056 Show fit	26.56	ENSDART00000114955	sowahaa NCBI UniProt Show fit	sosondowah ankyrin repeat domain family member Aa
chr5_-_1047504 Show fit	26.44	ENSDART00000159346	mbd2 NCBI UniProt Show fit	methyl-CpG binding domain protein 2
chr22_+_661505 Show fit	25.84	ENSDART00000149460	elf3 NCBI UniProt Show fit	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr3_+_19299309 Show fit	25.49	ENSDART00000046297 ENSDART00000146955	ldlra NCBI UniProt Show fit	low density lipoprotein receptor a
chr2_+_68789 Show fit	25.17	ENSDART00000058569	cldn1 NCBI UniProt Show fit	claudin 1
chr15_+_17752928 Show fit	24.50	ENSDART00000155314	si:ch211-213d14.2 NCBI UniProt Show fit	si:ch211-213d14.2
chr24_+_42132962 Show fit	23.91	ENSDART00000187739	wwp1 NCBI UniProt Show fit	WW domain containing E3 ubiquitin protein ligase 1
chr6_-_60104628 Show fit	23.61	ENSDART00000057463 ENSDART00000169188	pmepa1 NCBI UniProt Show fit	prostate transmembrane protein, androgen induced 1
chr24_+_37449893 Show fit	23.57	ENSDART00000164405	nlrc3 NCBI UniProt Show fit	NLR family, CARD domain containing 3
chr24_+_35387517 Show fit	23.47	ENSDART00000058571	snai2 NCBI UniProt Show fit	snail family zinc finger 2
chr22_+_1006573 Show fit	23.27	ENSDART00000123458	pparda NCBI UniProt Show fit	peroxisome proliferator-activated receptor delta a
chr1_-_59232267 Show fit	23.26	ENSDART00000169658 ENSDART00000163257	akap8l NCBI UniProt Show fit	A kinase (PRKA) anchor protein 8-like
chr19_+_48111285 Show fit	23.08	ENSDART00000169420	nme2b.2 NCBI UniProt Show fit	NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2
chr21_+_25236297 Show fit	22.67	ENSDART00000112783	tmem45b NCBI UniProt Show fit	transmembrane protein 45B
chr6_-_7776612 Show fit	22.25	ENSDART00000190269	myh9a NCBI UniProt Show fit	myosin, heavy chain 9a, non-muscle
chr2_+_30379650 Show fit	22.21	ENSDART00000129542	crispld1b NCBI UniProt Show fit	cysteine-rich secretory protein LCCL domain containing 1b
chr16_+_28754403 Show fit	22.18	ENSDART00000103340	s100v1 NCBI UniProt Show fit	S100 calcium binding protein V1
chr10_-_2942900 Show fit	21.54	ENSDART00000002622	oclna NCBI UniProt Show fit	occludin a
chr15_+_28410664 Show fit	21.51	ENSDART00000132028 ENSDART00000057697 ENSDART00000057257	pitpnaa NCBI UniProt Show fit	phosphatidylinositol transfer protein, alpha a
chr22_+_835728 Show fit	21.37	ENSDART00000003325	dennd2db NCBI UniProt Show fit	DENN/MADD domain containing 2Db
chr8_+_23213320 Show fit	21.10	ENSDART00000032996 ENSDART00000137536	ppdpfa NCBI UniProt Show fit	pancreatic progenitor cell differentiation and proliferation factor a
chr21_-_39024754 Show fit	20.72	ENSDART00000056878	traf4b NCBI UniProt Show fit	tnf receptor-associated factor 4b
chr2_+_35880600 Show fit	20.56	ENSDART00000004277	lamc1 NCBI UniProt Show fit	laminin, gamma 1
chr15_+_46344655 Show fit	20.48	ENSDART00000155893	si:ch1073-340i21.2 NCBI UniProt Show fit	si:ch1073-340i21.2
chr6_+_102506 Show fit	20.47	ENSDART00000172678	ldlrb NCBI UniProt Show fit	low density lipoprotein receptor b
chr24_+_42127983 Show fit	20.09	ENSDART00000190157 ENSDART00000176032 ENSDART00000175790	wwp1 NCBI UniProt Show fit	WW domain containing E3 ubiquitin protein ligase 1
chr18_+_6558338 Show fit	19.92	ENSDART00000110892	b4galnt3b NCBI UniProt Show fit	beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr25_+_4635355 Show fit	19.83	ENSDART00000021120	pgghg NCBI UniProt Show fit	protein-glucosylgalactosylhydroxylysine glucosidase
chr22_+_661711 Show fit	19.65	ENSDART00000113795	elf3 NCBI UniProt Show fit	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_+_27456804 Show fit	18.43	ENSDART00000017756 ENSDART00000181461 ENSDART00000180178	ctsl.1 NCBI UniProt Show fit	cathepsin L.1
chr25_+_37443194 Show fit	18.40	ENSDART00000163178 ENSDART00000190262	slc10a3 NCBI UniProt Show fit	solute carrier family 10, member 3
chr22_+_883678 Show fit	18.24	ENSDART00000140588	stk38b NCBI UniProt Show fit	serine/threonine kinase 38b
chr2_-_51109476 Show fit	18.21	ENSDART00000168286	si:ch73-52e5.1 NCBI UniProt Show fit	si:ch73-52e5.1
chr19_+_9305964 Show fit	17.88	ENSDART00000136241	si:ch73-15n24.1 NCBI UniProt Show fit	si:ch73-15n24.1
chr16_+_53455638 Show fit	17.65	ENSDART00000045792 ENSDART00000154189	rbm24b NCBI UniProt Show fit	RNA binding motif protein 24b
chr22_+_24645325 Show fit	17.46	ENSDART00000159531	lpar3 NCBI UniProt Show fit	lysophosphatidic acid receptor 3
chr14_+_7048930 Show fit	17.45	ENSDART00000109138	hbegfa NCBI UniProt Show fit	heparin-binding EGF-like growth factor a
chr12_-_4331117 Show fit	17.28	ENSDART00000008893	ca15a NCBI UniProt Show fit	carbonic anhydrase XVa
chr6_+_41503854 Show fit	17.28	ENSDART00000136538 ENSDART00000140108 ENSDART00000084861	cish NCBI UniProt Show fit	cytokine inducible SH2-containing protein
chr24_-_36593876 Show fit	17.22	ENSDART00000160901	CABZ01055365.1 NCBI UniProt Show fit
chr3_-_40276057 Show fit	17.18	ENSDART00000132225 ENSDART00000074737	shmt1 NCBI UniProt Show fit	serine hydroxymethyltransferase 1 (soluble)
chr2_+_413370 Show fit	17.16	ENSDART00000122138	mylk4a NCBI UniProt Show fit	myosin light chain kinase family, member 4a
chr11_+_13524504 Show fit	16.97	ENSDART00000139889	arrdc2 NCBI UniProt Show fit	arrestin domain containing 2
chr12_-_4540564 Show fit	16.94	ENSDART00000106566	CABZ01030107.1 NCBI UniProt Show fit
chr18_-_6803424 Show fit	16.90	ENSDART00000142647	si:dkey-266m15.5 NCBI UniProt Show fit	si:dkey-266m15.5
chr7_+_1473929 Show fit	16.86	ENSDART00000050687	lpcat4 NCBI UniProt Show fit	lysophosphatidylcholine acyltransferase 4
chr23_-_10254288 Show fit	16.82	ENSDART00000081215	krt8 NCBI UniProt Show fit	keratin 8
chr21_-_308852 Show fit	16.67	ENSDART00000151613	lhfpl2a NCBI UniProt Show fit	LHFPL tetraspan subfamily member 2a
chr22_+_11775269 Show fit	16.64	ENSDART00000140272	krt96 NCBI UniProt Show fit	keratin 96
chr10_-_4980150 Show fit	16.43	ENSDART00000093228	mat2al NCBI UniProt Show fit	methionine adenosyltransferase II, alpha-like
chr16_-_12316979 Show fit	15.87	ENSDART00000182392	trpv6 NCBI UniProt Show fit	transient receptor potential cation channel, subfamily V, member 6
chr9_-_34269066 Show fit	15.60	ENSDART00000059955	ildr1b NCBI UniProt Show fit	immunoglobulin-like domain containing receptor 1b
chr12_+_23424108 Show fit	15.54	ENSDART00000077732	bambia NCBI UniProt Show fit	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a
chr1_-_53907092 Show fit	15.46	ENSDART00000007732	capn9 NCBI UniProt Show fit	calpain 9
chr22_-_607812 Show fit	15.44	ENSDART00000145983	cdkn1a NCBI UniProt Show fit	cyclin-dependent kinase inhibitor 1A
chr24_-_29777413 Show fit	15.42	ENSDART00000087724	wu:fj05g07 NCBI UniProt Show fit	wu:fj05g07
chr20_-_7293837 Show fit	15.26	ENSDART00000100060	dsc2l NCBI UniProt Show fit	desmocollin 2 like
chr5_-_23696926 Show fit	15.25	ENSDART00000021462	rnf128a NCBI UniProt Show fit	ring finger protein 128a
chr19_+_43119698 Show fit	15.20	ENSDART00000167847 ENSDART00000186962 ENSDART00000187305	eef1a1l1 NCBI UniProt Show fit	eukaryotic translation elongation factor 1 alpha 1, like 1
chr3_-_32541033 Show fit	15.16	ENSDART00000151476 ENSDART00000055324	rcn3 NCBI UniProt Show fit	reticulocalbin 3, EF-hand calcium binding domain
chr4_+_57093908 Show fit	15.14	ENSDART00000170198	si:ch211-238e22.5 NCBI UniProt Show fit	si:ch211-238e22.5
chr3_+_36972586 Show fit	15.05	ENSDART00000102784	si:ch211-18i17.2 NCBI UniProt Show fit	si:ch211-18i17.2
chr20_-_9580446 Show fit	14.92	ENSDART00000014168	zfp36l1b NCBI UniProt Show fit	zinc finger protein 36, C3H type-like 1b
chr24_+_17005647 Show fit	14.87	ENSDART00000149149	zfx NCBI UniProt Show fit	zinc finger protein, X-linked
chr3_+_32492467 Show fit	14.81	ENSDART00000151329	trpm4a NCBI UniProt Show fit	transient receptor potential cation channel, subfamily M, member 4a
chr9_+_1654284 Show fit	14.79	ENSDART00000062854	nfe2l2a NCBI UniProt Show fit	nuclear factor, erythroid 2-like 2a
chr15_+_46357080 Show fit	14.68	ENSDART00000155571 ENSDART00000156541	wu:fb18f06 NCBI UniProt Show fit	wu:fb18f06
chr4_-_4612116 Show fit	14.59	ENSDART00000130601	CABZ01020840.1 NCBI UniProt Show fit	Danio rerio apoptosis facilitator Bcl-2-like protein 14 (LOC101885512), mRNA.
chr25_+_3104959 Show fit	14.45	ENSDART00000167130	rab3il1 NCBI UniProt Show fit	RAB3A interacting protein (rabin3)-like 1
chr5_-_1047222 Show fit	14.41	ENSDART00000181112	mbd2 NCBI UniProt Show fit	methyl-CpG binding domain protein 2
chr8_+_47099033 Show fit	14.30	ENSDART00000142979	arhgef16 NCBI UniProt Show fit	Rho guanine nucleotide exchange factor (GEF) 16
chr22_+_396840 Show fit	14.16	ENSDART00000163198	capzb NCBI UniProt Show fit	capping protein (actin filament) muscle Z-line, beta
chr21_-_32060993 Show fit	14.14	ENSDART00000131651	si:ch211-160j14.2 NCBI UniProt Show fit	si:ch211-160j14.2
chr3_+_29469283 Show fit	14.14	ENSDART00000103592	fam83fa NCBI UniProt Show fit	family with sequence similarity 83, member Fa
chr12_+_48841182 Show fit	14.07	ENSDART00000109315 ENSDART00000185609 ENSDART00000187217	dlg5b.1 NCBI UniProt Show fit	discs, large homolog 5b (Drosophila), tandem duplicate 1
chr1_-_54107321 Show fit	13.81	ENSDART00000148382 ENSDART00000150357	rfx1b NCBI UniProt Show fit	regulatory factor X, 1b (influences HLA class II expression)
chr1_+_59538755 Show fit	13.71	ENSDART00000166354	sp6 NCBI UniProt Show fit	Sp6 transcription factor
chr3_+_726000 Show fit	13.56	ENSDART00000158510	dicp1.17 NCBI UniProt Show fit	diverse immunoglobulin domain-containing protein 1.17
chr24_-_32582378 Show fit	13.49	ENSDART00000066590	rdh12l NCBI UniProt Show fit	retinol dehydrogenase 12, like
chr25_+_34013093 Show fit	13.48	ENSDART00000011967	anxa2a NCBI UniProt Show fit	annexin A2a
chr4_+_78008298 Show fit	13.41	ENSDART00000174237	cct2 NCBI UniProt Show fit	chaperonin containing TCP1, subunit 2 (beta)
chr21_+_1647990 Show fit	13.39	ENSDART00000148540	fech NCBI UniProt Show fit	ferrochelatase
chr14_+_97017 Show fit	13.38	ENSDART00000159300 ENSDART00000169523	mcm7 NCBI UniProt Show fit	minichromosome maintenance complex component 7
chr8_+_6576940 Show fit	13.32	ENSDART00000138135	vsig8b NCBI UniProt Show fit	V-set and immunoglobulin domain containing 8b
chr19_-_6193448 Show fit	13.30	ENSDART00000151405	erf NCBI UniProt Show fit	Ets2 repressor factor
chr22_+_20720808 Show fit	13.25	ENSDART00000171321	si:dkey-211f22.5 NCBI UniProt Show fit	si:dkey-211f22.5
chr19_+_19989380 Show fit	13.00	ENSDART00000142841	osbpl3a NCBI UniProt Show fit	oxysterol binding protein-like 3a
chr25_+_186583 Show fit	12.83	ENSDART00000161504	pclaf NCBI UniProt Show fit	PCNA clamp associated factor
chr25_+_6122823 Show fit	12.70	ENSDART00000191824 ENSDART00000067514	rbpms2a NCBI UniProt Show fit	RNA binding protein with multiple splicing 2a
chr24_+_38671054 Show fit	12.69	ENSDART00000154214	si:ch73-70c5.1 NCBI UniProt Show fit	si:ch73-70c5.1
chr15_+_46356879 Show fit	12.50	ENSDART00000154388	wu:fb18f06 NCBI UniProt Show fit	wu:fb18f06
chr25_+_3306858 Show fit	12.44	ENSDART00000137077	slc25a3b NCBI UniProt Show fit	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b
chr20_+_26538137 Show fit	12.33	ENSDART00000045397	stx11b.1 NCBI UniProt Show fit	syntaxin 11b, tandem duplicate 1
chr11_-_25384213 Show fit	12.28	ENSDART00000103650	mafbb NCBI UniProt Show fit	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb
chr12_+_48841419 Show fit	12.25	ENSDART00000125331	dlg5b.1 NCBI UniProt Show fit	discs, large homolog 5b (Drosophila), tandem duplicate 1
chr15_-_20468302 Show fit	12.11	ENSDART00000018514	dlc NCBI UniProt Show fit	deltaC
chr1_-_59216197 Show fit	12.07	ENSDART00000062426	lpar2b NCBI UniProt Show fit	lysophosphatidic acid receptor 2b
chr8_-_53490376 Show fit	12.04	ENSDART00000158789	chdh NCBI UniProt Show fit	choline dehydrogenase
chr18_+_6558146 Show fit	12.03	ENSDART00000169401	b4galnt3b NCBI UniProt Show fit	beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr7_-_52498175 Show fit	12.00	ENSDART00000129769	cgnl1 NCBI UniProt Show fit	cingulin-like 1
chr8_+_53051701 Show fit	11.91	ENSDART00000131514	nadka NCBI UniProt Show fit	NAD kinase a
chr18_+_44649804 Show fit	11.89	ENSDART00000059063	ehd2b NCBI UniProt Show fit	EH-domain containing 2b
chr2_+_55365727 Show fit	11.89	ENSDART00000162943	FP245456.1 NCBI UniProt Show fit
chr7_+_38349667 Show fit	11.88	ENSDART00000010046	rhpn2 NCBI UniProt Show fit	rhophilin, Rho GTPase binding protein 2
chr20_+_34400715 Show fit	11.86	ENSDART00000061632	fam129aa NCBI UniProt Show fit	family with sequence similarity 129, member Aa
chr8_+_8927870 Show fit	11.80	ENSDART00000081985	pim2 NCBI UniProt Show fit	Pim-2 proto-oncogene, serine/threonine kinase
chr1_-_51734524 Show fit	11.77	ENSDART00000109640 ENSDART00000122628	junba NCBI UniProt Show fit	JunB proto-oncogene, AP-1 transcription factor subunit a
chr17_+_51746830 Show fit	11.70	ENSDART00000184230	odc1 NCBI UniProt Show fit	ornithine decarboxylase 1
chr21_+_43328685 Show fit	11.68	ENSDART00000109620 ENSDART00000139668	sept8a NCBI UniProt Show fit	septin 8a
chr23_-_10177442 Show fit	11.65	ENSDART00000144280 ENSDART00000129044	krt5 NCBI UniProt Show fit	keratin 5
chr23_-_5818992 Show fit	11.62	ENSDART00000148730	csrp1a NCBI UniProt Show fit	cysteine and glycine-rich protein 1a
chr22_-_16275236 Show fit	11.51	ENSDART00000149051	cdc14ab NCBI UniProt Show fit	cell division cycle 14Ab
chr6_-_39313027 Show fit	11.40	ENSDART00000012644	krt4 NCBI UniProt Show fit	keratin 4
chr3_+_5575313 Show fit	11.27	ENSDART00000134693 ENSDART00000101807	si:ch211-106h11.3 NCBI UniProt Show fit	si:ch211-106h11.3
chr17_+_389218 Show fit	11.22	ENSDART00000162898	si:rp71-62i8.1 NCBI UniProt Show fit	si:rp71-62i8.1
chr8_+_52637507 Show fit	11.11	ENSDART00000163830	si:dkey-90l8.3 NCBI UniProt Show fit	si:dkey-90l8.3
chr21_-_13856689 Show fit	11.09	ENSDART00000102197	fam129ba NCBI UniProt Show fit	family with sequence similarity 129, member Ba
chr8_+_19356072 Show fit	10.99	ENSDART00000063272	mpeg1.2 NCBI UniProt Show fit	macrophage expressed 1, tandem duplicate 2
chr8_+_51958968 Show fit	10.97	ENSDART00000139509 ENSDART00000186544	gna14a NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), alpha 14a
chr19_-_11031145 Show fit	10.96	ENSDART00000151375 ENSDART00000027598 ENSDART00000137865 ENSDART00000188025	tpm3 NCBI UniProt Show fit	tropomyosin 3
chr4_-_17409533 Show fit	10.94	ENSDART00000011943	pah NCBI UniProt Show fit	phenylalanine hydroxylase
chr13_-_42673978 Show fit	10.87	ENSDART00000133848 ENSDART00000099738 ENSDART00000099729 ENSDART00000169083	lrrfip2 NCBI UniProt Show fit	leucine rich repeat (in FLII) interacting protein 2
chr16_+_23431189 Show fit	10.81	ENSDART00000004679	icn NCBI UniProt Show fit	ictacalcin
chr6_+_3334710 Show fit	10.81	ENSDART00000132848	st3gal3a NCBI UniProt Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr14_+_4151379 Show fit	10.81	ENSDART00000160431	dhrs13l1 NCBI UniProt Show fit	dehydrogenase/reductase (SDR family) member 13 like 1
chr5_+_46293850 Show fit	10.62	ENSDART00000140636	si:ch211-130m23.2 NCBI UniProt Show fit	si:ch211-130m23.2
chr5_+_66132394 Show fit	10.55	ENSDART00000073892	zgc:114041 NCBI UniProt Show fit	zgc:114041
chr10_-_15048781 Show fit	10.54	ENSDART00000038401 ENSDART00000155674	si:ch211-95j8.2 NCBI UniProt Show fit	si:ch211-95j8.2
chr23_-_31436524 Show fit	10.53	ENSDART00000140519	zgc:153284 NCBI UniProt Show fit	zgc:153284
chr6_+_49926115 Show fit	10.50	ENSDART00000018523	ahcy NCBI UniProt Show fit	adenosylhomocysteinase
chr23_-_2513300 Show fit	10.49	ENSDART00000067652	snai1b NCBI UniProt Show fit	snail family zinc finger 1b
chr23_-_31645760 Show fit	10.40	ENSDART00000035031	sgk1 NCBI UniProt Show fit	serum/glucocorticoid regulated kinase 1
chr6_-_607063 Show fit	10.37	ENSDART00000189900	lgals2b NCBI UniProt Show fit	lectin, galactoside-binding, soluble, 2b
chr18_-_48547564 Show fit	10.34	ENSDART00000138607	kcnj1a.1 NCBI UniProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr3_+_32410746 Show fit	10.19	ENSDART00000025496	rras NCBI UniProt Show fit	RAS related
chr21_-_5056812 Show fit	10.15	ENSDART00000139713 ENSDART00000140859	zgc:77838 NCBI UniProt Show fit	zgc:77838
chr14_+_26439227 Show fit	10.12	ENSDART00000054183	gpr137 NCBI UniProt Show fit	G protein-coupled receptor 137
chr10_+_31809226 Show fit	10.12	ENSDART00000087898	foxo1b NCBI UniProt Show fit	forkhead box O1 b
chr10_-_44017642 Show fit	9.97	ENSDART00000135240 ENSDART00000014669	acads NCBI UniProt Show fit	acyl-CoA dehydrogenase short chain
chr5_+_72152813 Show fit	9.94	ENSDART00000149910	abl1 NCBI UniProt Show fit	c-abl oncogene 1, non-receptor tyrosine kinase
chr16_+_23282655 Show fit	9.91	ENSDART00000015956	efna1b NCBI UniProt Show fit	ephrin-A1b
chr4_-_20181964 Show fit	9.88	ENSDART00000022539	fgl2a NCBI UniProt Show fit	fibrinogen-like 2a
chr8_+_29962635 Show fit	9.87	ENSDART00000007640	ptch1 NCBI UniProt Show fit	patched 1
chr19_-_1855368 Show fit	9.84	ENSDART00000029646	rplp1 NCBI UniProt Show fit	ribosomal protein, large, P1
chr2_+_48073972 Show fit	9.81	ENSDART00000186442	klf6b NCBI UniProt Show fit	Kruppel-like factor 6b
chr25_+_3306620 Show fit	9.77	ENSDART00000182085 ENSDART00000034704	slc25a3b NCBI UniProt Show fit	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b
chr10_-_15053507 Show fit	9.64	ENSDART00000157446 ENSDART00000170441	CLDN23 NCBI UniProt Show fit	si:ch211-95j8.5
chr13_-_36582341 Show fit	9.58	ENSDART00000137335	lgals3a NCBI UniProt Show fit	lectin, galactoside binding soluble 3a
chr8_-_2616326 Show fit	9.51	ENSDART00000027214	slc25a25a NCBI UniProt Show fit	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr12_+_695619 Show fit	9.46	ENSDART00000161691	abcc3 NCBI UniProt Show fit	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr25_-_37284370 Show fit	9.44	ENSDART00000103222	nudt7 NCBI UniProt Show fit	nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr19_+_19988869 Show fit	9.37	ENSDART00000151024	osbpl3a NCBI UniProt Show fit	oxysterol binding protein-like 3a
chr2_-_48826707 Show fit	9.32	ENSDART00000134711	svilb NCBI UniProt Show fit	supervillin b
chr23_-_45398622 Show fit	9.32	ENSDART00000053571 ENSDART00000149464	zgc:100911 NCBI UniProt Show fit	zgc:100911
chr25_+_10547228 Show fit	9.31	ENSDART00000067678	zgc:110339 NCBI UniProt Show fit	zgc:110339
chr2_+_48074243 Show fit	9.27	ENSDART00000056291	klf6b NCBI UniProt Show fit	Kruppel-like factor 6b
chr25_+_34915762 Show fit	9.25	ENSDART00000191776	sntb2 NCBI UniProt Show fit	syntrophin, beta 2
chr11_+_11719575 Show fit	9.20	ENSDART00000003891	jupa NCBI UniProt Show fit	junction plakoglobin a
chr5_-_68022631 Show fit	9.18	ENSDART00000143199	wasf3a NCBI UniProt Show fit	WAS protein family, member 3a
chr17_-_20558961 Show fit	9.15	ENSDART00000155993	sh3pxd2ab NCBI UniProt Show fit	SH3 and PX domains 2Ab
chr7_+_58730201 Show fit	9.09	ENSDART00000073640	plag1 NCBI UniProt Show fit	pleiomorphic adenoma gene 1
chr6_+_50451337 Show fit	9.08	ENSDART00000155051	mych NCBI UniProt Show fit	myelocytomatosis oncogene homolog
chr24_-_4450238 Show fit	9.02	ENSDART00000066835	fzd8a NCBI UniProt Show fit	frizzled class receptor 8a
chr17_+_24615091 Show fit	9.01	ENSDART00000064739	rpl13a NCBI UniProt Show fit	ribosomal protein L13a
chr15_+_36105581 Show fit	9.00	ENSDART00000184099	col4a3 NCBI UniProt Show fit	collagen, type IV, alpha 3
chr21_-_11632403 Show fit	9.00	ENSDART00000171708 ENSDART00000138619 ENSDART00000136308 ENSDART00000144770	cast NCBI UniProt Show fit	calpastatin
chr8_-_4100365 Show fit	8.95	ENSDART00000142846	cux2b NCBI UniProt Show fit	cut-like homeobox 2b
chr8_+_7033049 Show fit	8.93	ENSDART00000064172 ENSDART00000134440	gpd1a NCBI UniProt Show fit	glycerol-3-phosphate dehydrogenase 1a
chr9_+_30421489 Show fit	8.88	ENSDART00000145025 ENSDART00000132058	zgc:113314 NCBI UniProt Show fit	zgc:113314
chr19_-_6193067 Show fit	8.87	ENSDART00000092656 ENSDART00000140347	erf NCBI UniProt Show fit	Ets2 repressor factor
chr2_-_51630555 Show fit	8.85	ENSDART00000171746	pigr NCBI UniProt Show fit	polymeric immunoglobulin receptor
chr23_-_45407631 Show fit	8.83	ENSDART00000148484 ENSDART00000150186	zgc:101853 NCBI UniProt Show fit	zgc:101853
chr22_-_27136451 Show fit	8.83	ENSDART00000153589	si:dkey-16m19.1 NCBI UniProt Show fit	si:dkey-16m19.1
chr7_-_10560964 Show fit	8.73	ENSDART00000172761 ENSDART00000170476	mthfs NCBI UniProt Show fit	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr5_-_46505691 Show fit	8.62	ENSDART00000111589 ENSDART00000122966 ENSDART00000166907	hapln1a NCBI UniProt Show fit	hyaluronan and proteoglycan link protein 1a
chr13_+_25410594 Show fit	8.61	ENSDART00000112092	calhm3 NCBI UniProt Show fit	calcium homeostasis modulator 3
chr19_+_46113828 Show fit	8.61	ENSDART00000159331 ENSDART00000161826	rbm24a NCBI UniProt Show fit	RNA binding motif protein 24a
chr21_+_15713097 Show fit	8.61	ENSDART00000015841	gstt1b NCBI UniProt Show fit	glutathione S-transferase theta 1b
chr6_-_40657653 Show fit	8.56	ENSDART00000154359	ppil1 NCBI UniProt Show fit	peptidylprolyl isomerase (cyclophilin)-like 1
chr8_-_38201415 Show fit	8.54	ENSDART00000155189	pdlim2 NCBI UniProt Show fit	PDZ and LIM domain 2 (mystique)
chr5_+_4533244 Show fit	8.54	ENSDART00000158826	CABZ01058650.1 NCBI UniProt Show fit	Danio rerio thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (LOC561325), mRNA.
chr1_+_22654875 Show fit	8.53	ENSDART00000019698 ENSDART00000161874	anxa5b NCBI UniProt Show fit	annexin A5b
chr11_+_329687 Show fit	8.51	ENSDART00000172882	cyp27b1 NCBI UniProt Show fit	cytochrome P450, family 27, subfamily B, polypeptide 1
chr25_-_35960229 Show fit	8.50	ENSDART00000073434	snx20 NCBI UniProt Show fit	sorting nexin 20
chr25_-_16724913 Show fit	8.50	ENSDART00000157075	galnt8a.2 NCBI UniProt Show fit	polypeptide N-acetylgalactosaminyltransferase 8a, tandem duplicate 2
chr13_+_22480496 Show fit	8.48	ENSDART00000136863 ENSDART00000131870 ENSDART00000078720 ENSDART00000078740 ENSDART00000139218	ldb3a NCBI UniProt Show fit	LIM domain binding 3a
chr1_-_54100988 Show fit	8.39	ENSDART00000192662	rfx1b NCBI UniProt Show fit	regulatory factor X, 1b (influences HLA class II expression)
chr10_-_320153 Show fit	8.38	ENSDART00000161493	akt2l NCBI UniProt Show fit	v-akt murine thymoma viral oncogene homolog 2, like

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.7	29.1	GO:0036228	protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
6.7	6.7	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
6.6	26.3	GO:0003228	atrial cardiac muscle tissue development(GO:0003228)
6.2	43.6	GO:0097340	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
6.1	18.3	GO:0002369	T cell cytokine production(GO:0002369)
5.8	17.5	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
5.7	17.2	GO:0006565	L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264)
4.8	23.9	GO:0002159	desmosome assembly(GO:0002159)
4.6	18.4	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
4.4	22.2	GO:0072104	renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
4.2	25.5	GO:0032367	intracellular cholesterol transport(GO:0032367)
4.0	12.0	GO:0019695	choline metabolic process(GO:0019695)
4.0	15.9	GO:0045023	G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
3.6	10.8	GO:0046689	response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
3.5	24.4	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
3.4	23.6	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
3.1	15.3	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
3.0	12.2	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
3.0	9.0	GO:0021531	spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
3.0	8.9	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
2.8	8.4	GO:0007571	age-dependent general metabolic decline(GO:0007571)
2.8	19.3	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
2.7	8.2	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
2.7	13.5	GO:0010591	regulation of lamellipodium assembly(GO:0010591)
2.7	16.2	GO:0048635	negative regulation of muscle organ development(GO:0048635)
2.7	24.0	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
2.6	7.8	GO:0061614	pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
2.6	7.8	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
2.5	12.7	GO:0051145	smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
2.5	32.8	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
2.5	10.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
2.3	16.4	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
2.3	6.8	GO:0052576	carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
2.2	2.2	GO:0006572	tyrosine catabolic process(GO:0006572)
2.2	8.9	GO:0006116	NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
2.1	8.6	GO:0032208	regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
2.1	10.5	GO:0003261	cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
2.1	8.4	GO:0006598	polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
2.1	16.7	GO:0046546	development of primary male sexual characteristics(GO:0046546)
2.1	10.3	GO:0010719	negative regulation of epithelial to mesenchymal transition(GO:0010719)
2.0	6.1	GO:1904983	transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
2.0	6.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
2.0	4.0	GO:1903428	regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
1.9	7.8	GO:0002934	desmosome organization(GO:0002934)
1.9	5.8	GO:0006600	creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
1.9	17.4	GO:2000273	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
1.9	5.6	GO:0005997	xylulose metabolic process(GO:0005997)
1.8	7.2	GO:0006526	arginine biosynthetic process(GO:0006526)
1.8	7.2	GO:2000767	positive regulation of cytoplasmic translation(GO:2000767)
1.8	21.4	GO:0050962	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
1.7	12.2	GO:0006741	NADP biosynthetic process(GO:0006741)
1.7	12.2	GO:1902623	negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
1.7	12.1	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
1.7	1.7	GO:1903537	meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
1.7	5.0	GO:0097384	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
1.7	6.7	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
1.7	3.3	GO:2000471	regulation of hematopoietic stem cell migration(GO:2000471)
1.6	4.8	GO:0071896	protein localization to adherens junction(GO:0071896)
1.6	6.4	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.6	4.7	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
1.5	10.7	GO:0046294	formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
1.5	14.8	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
1.5	7.4	GO:0060231	mesenchymal to epithelial transition(GO:0060231)
1.5	10.2	GO:0043201	response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
1.4	15.9	GO:0036388	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.4	23.1	GO:0046051	UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
1.4	51.5	GO:0050821	protein stabilization(GO:0050821)
1.4	11.1	GO:0001579	medium-chain fatty acid transport(GO:0001579)
1.3	18.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
1.3	5.2	GO:0033301	cell cycle comprising mitosis without cytokinesis(GO:0033301)
1.3	30.0	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
1.3	5.2	GO:0003241	growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
1.3	2.6	GO:1902745	positive regulation of lamellipodium organization(GO:1902745)
1.2	3.7	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
1.2	1.2	GO:0010878	cholesterol storage(GO:0010878) regulation of cholesterol storage(GO:0010885)
1.2	58.8	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
1.2	3.6	GO:0048785	hatching gland development(GO:0048785)
1.2	4.7	GO:0001782	B cell homeostasis(GO:0001782)
1.2	4.7	GO:0008356	asymmetric cell division(GO:0008356)
1.2	3.5	GO:0010312	detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
1.2	6.9	GO:0051818	killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
1.1	11.4	GO:0098719	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
1.1	11.3	GO:0071850	mitotic cell cycle arrest(GO:0071850)
1.1	4.5	GO:0042559	pteridine-containing compound biosynthetic process(GO:0042559)
1.1	7.8	GO:0040016	embryonic cleavage(GO:0040016)
1.1	8.7	GO:0072488	ammonium transmembrane transport(GO:0072488)
1.1	23.1	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
1.0	21.0	GO:0071350	interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
1.0	4.2	GO:0060437	lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
1.0	3.1	GO:0003071	renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
1.0	15.4	GO:0035904	aorta development(GO:0035904)
1.0	2.0	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
1.0	4.1	GO:0052746	inositol phosphorylation(GO:0052746)
1.0	15.2	GO:0048922	posterior lateral line neuromast deposition(GO:0048922)
1.0	3.0	GO:0000103	sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
1.0	6.0	GO:0070650	actin filament bundle distribution(GO:0070650)
1.0	2.0	GO:0001778	plasma membrane repair(GO:0001778)
1.0	5.9	GO:0034498	early endosome to Golgi transport(GO:0034498)
1.0	3.9	GO:1903723	negative regulation of centriole elongation(GO:1903723)
1.0	5.8	GO:0048260	positive regulation of receptor-mediated endocytosis(GO:0048260)
1.0	8.6	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.9	8.4	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.9	10.9	GO:1902221	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.9	13.6	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.9	5.4	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.9	3.5	GO:0010898	regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.9	5.3	GO:0038065	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.9	5.3	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.9	10.6	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.9	2.6	GO:1900182	positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.9	4.3	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.9	2.6	GO:0003173	ventriculo bulbo valve development(GO:0003173)
0.9	7.7	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.9	11.1	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.9	2.6	GO:0035676	anterior lateral line neuromast hair cell development(GO:0035676)
0.8	29.7	GO:0007586	digestion(GO:0007586)
0.8	2.5	GO:0035973	aggrephagy(GO:0035973)
0.8	17.7	GO:0043249	erythrocyte maturation(GO:0043249)
0.8	0.8	GO:0061195	tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195)
0.8	10.9	GO:0019433	triglyceride catabolic process(GO:0019433)
0.8	3.3	GO:0010610	regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.8	3.3	GO:0055107	Golgi to secretory granule transport(GO:0055107)
0.8	3.2	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.8	3.2	GO:0042754	negative regulation of circadian rhythm(GO:0042754)
0.8	6.5	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.8	4.8	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.8	12.8	GO:0019985	translesion synthesis(GO:0019985)
0.8	2.4	GO:0098773	skin epidermis development(GO:0098773)
0.8	5.5	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.8	3.1	GO:0032534	regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.7	11.2	GO:0034724	DNA replication-independent nucleosome organization(GO:0034724)
0.7	15.5	GO:1903845	negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.7	3.0	GO:0018377	N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.7	2.2	GO:0072068	distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.7	8.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.7	2.2	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.7	2.9	GO:0030224	monocyte differentiation(GO:0030224)
0.7	3.6	GO:0048730	epidermis morphogenesis(GO:0048730)
0.7	10.7	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.7	4.9	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.7	2.0	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.7	3.4	GO:0033499	galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.7	3.4	GO:0002184	cytoplasmic translational termination(GO:0002184)
0.7	16.9	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.7	8.1	GO:0006098	pentose-phosphate shunt(GO:0006098)
0.7	13.4	GO:0060351	cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.7	2.7	GO:0014743	regulation of muscle hypertrophy(GO:0014743)
0.6	5.8	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.6	2.6	GO:0048913	anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.6	3.2	GO:0019478	D-amino acid catabolic process(GO:0019478) D-serine catabolic process(GO:0036088) D-amino acid metabolic process(GO:0046416) D-serine metabolic process(GO:0070178)
0.6	7.1	GO:0061026	cardiac muscle tissue regeneration(GO:0061026)
0.6	1.9	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.6	3.8	GO:0071800	podosome assembly(GO:0071800)
0.6	4.5	GO:0045604	regulation of epidermal cell differentiation(GO:0045604)
0.6	4.5	GO:0006552	leucine catabolic process(GO:0006552)
0.6	5.1	GO:0031063	regulation of histone deacetylation(GO:0031063)
0.6	9.4	GO:0046130	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.6	2.5	GO:0070257	regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.6	9.2	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.6	3.1	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.6	6.7	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.6	8.3	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.6	4.1	GO:0045901	positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.6	1.8	GO:0034214	protein hexamerization(GO:0034214)
0.6	4.6	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.6	8.6	GO:0003181	atrioventricular valve morphogenesis(GO:0003181)
0.6	6.8	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.6	5.6	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.6	2.8	GO:0032776	DNA methylation on cytosine(GO:0032776)
0.6	2.2	GO:1990402	embryonic liver development(GO:1990402)
0.6	1.7	GO:0035751	regulation of lysosomal lumen pH(GO:0035751)
0.6	5.6	GO:0050819	negative regulation of coagulation(GO:0050819)
0.6	5.6	GO:0031639	plasminogen activation(GO:0031639)
0.6	3.9	GO:0097107	postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.5	16.7	GO:0051014	actin filament severing(GO:0051014)
0.5	4.3	GO:0030859	polarized epithelial cell differentiation(GO:0030859)
0.5	3.2	GO:1901315	negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.5	0.5	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.5	1.6	GO:0032060	bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.5	2.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.5	5.7	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.5	3.0	GO:0035989	tendon development(GO:0035989)
0.5	46.8	GO:0045732	positive regulation of protein catabolic process(GO:0045732)
0.5	3.0	GO:0031507	heterochromatin assembly(GO:0031507)
0.5	2.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.5	3.9	GO:0045338	farnesyl diphosphate metabolic process(GO:0045338)
0.5	3.9	GO:0006543	glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.5	12.6	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.5	1.0	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.5	5.3	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.5	10.1	GO:0015671	oxygen transport(GO:0015671)
0.5	2.9	GO:0039023	pronephric duct morphogenesis(GO:0039023)
0.5	33.4	GO:0007043	cell-cell junction assembly(GO:0007043)
0.5	2.3	GO:2000765	regulation of cytoplasmic translation(GO:2000765)
0.5	3.3	GO:0030104	water homeostasis(GO:0030104)
0.5	5.1	GO:0006622	protein targeting to lysosome(GO:0006622)
0.5	2.3	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.5	1.8	GO:0038093	Fc receptor signaling pathway(GO:0038093)
0.5	1.8	GO:0036149	phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.4	8.1	GO:0043687	post-translational protein modification(GO:0043687)
0.4	4.0	GO:0090398	cellular senescence(GO:0090398)
0.4	8.4	GO:0071456	cellular response to hypoxia(GO:0071456)
0.4	6.6	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4	1.3	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.4	20.0	GO:0035272	exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.4	15.5	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.4	1.3	GO:1902975	cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.4	2.5	GO:0061055	myotome development(GO:0061055)
0.4	6.3	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.4	5.5	GO:0070189	kynurenine metabolic process(GO:0070189)
0.4	2.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.4	5.9	GO:0009409	response to cold(GO:0009409)
0.4	2.9	GO:0021535	cell migration in hindbrain(GO:0021535)
0.4	2.1	GO:0003210	cardiac atrium formation(GO:0003210)
0.4	3.7	GO:0003160	endocardium morphogenesis(GO:0003160)
0.4	4.1	GO:0035588	adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.4	2.8	GO:0060017	parathyroid gland development(GO:0060017)
0.4	23.3	GO:0006414	translational elongation(GO:0006414)
0.4	2.0	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.4	12.2	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.4	2.0	GO:0010456	cell proliferation in dorsal spinal cord(GO:0010456)
0.4	7.8	GO:0097178	ruffle assembly(GO:0097178)
0.4	5.4	GO:1900077	negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.4	12.4	GO:0048268	clathrin coat assembly(GO:0048268)
0.4	10.8	GO:0043407	negative regulation of MAP kinase activity(GO:0043407)
0.4	6.1	GO:0042574	retinal metabolic process(GO:0042574)
0.4	1.9	GO:0043363	nucleate erythrocyte differentiation(GO:0043363)
0.4	1.1	GO:0042539	hypotonic response(GO:0006971) hypotonic salinity response(GO:0042539)
0.4	0.4	GO:0042023	regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.4	6.0	GO:2000117	negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.4	3.0	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
0.4	4.0	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4	2.2	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.4	19.0	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.4	1.1	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.4	9.2	GO:0006884	cell volume homeostasis(GO:0006884)
0.4	3.9	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.4	4.6	GO:0043248	proteasome assembly(GO:0043248)
0.4	23.6	GO:0015718	monocarboxylic acid transport(GO:0015718)
0.4	9.1	GO:0006801	superoxide metabolic process(GO:0006801)
0.3	3.5	GO:0045324	late endosome to vacuole transport(GO:0045324)
0.3	1.7	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.3	3.8	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.3	1.0	GO:0042373	vitamin K metabolic process(GO:0042373)
0.3	4.5	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.3	4.1	GO:0002757	immune response-activating signal transduction(GO:0002757)
0.3	3.1	GO:0030323	respiratory tube development(GO:0030323) lung development(GO:0030324)
0.3	12.5	GO:0032402	melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.3	2.7	GO:0072395	signal transduction involved in cell cycle checkpoint(GO:0072395)
0.3	3.0	GO:0043144	snoRNA processing(GO:0043144)
0.3	3.6	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.3	1.6	GO:0060855	venous endothelial cell migration involved in lymph vessel development(GO:0060855)
0.3	2.6	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516)
0.3	4.5	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3	19.1	GO:0042493	response to drug(GO:0042493)
0.3	2.8	GO:0043981	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.3	1.6	GO:0050680	negative regulation of endothelial cell proliferation(GO:0001937) negative regulation of epithelial cell proliferation(GO:0050680)
0.3	7.2	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.3	1.9	GO:0010269	response to selenium ion(GO:0010269)
0.3	3.4	GO:0009303	rRNA transcription(GO:0009303)
0.3	3.0	GO:0000186	activation of MAPKK activity(GO:0000186)
0.3	0.9	GO:0060343	trabecula formation(GO:0060343) heart trabecula formation(GO:0060347)
0.3	1.2	GO:0051149	positive regulation of muscle cell differentiation(GO:0051149)
0.3	1.8	GO:0014823	response to activity(GO:0014823)
0.3	5.3	GO:0051764	actin crosslink formation(GO:0051764)
0.3	4.4	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.3	1.7	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3	0.6	GO:0090280	positive regulation of calcium ion import(GO:0090280)
0.3	8.7	GO:0006749	glutathione metabolic process(GO:0006749)
0.3	3.2	GO:0006611	protein export from nucleus(GO:0006611)
0.3	6.3	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.3	1.7	GO:0060149	positive regulation of translational initiation(GO:0045948) negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.3	19.7	GO:0042074	cell migration involved in gastrulation(GO:0042074)
0.3	1.1	GO:0090342	regulation of cell aging(GO:0090342)
0.3	18.7	GO:0001945	lymph vessel development(GO:0001945)
0.3	0.8	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.3	2.2	GO:0051013	microtubule severing(GO:0051013)
0.3	16.1	GO:0015914	phospholipid transport(GO:0015914)
0.3	2.3	GO:0042026	protein refolding(GO:0042026)
0.3	1.8	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.3	9.1	GO:0032924	activin receptor signaling pathway(GO:0032924)
0.3	0.5	GO:0002188	translation reinitiation(GO:0002188)
0.2	6.5	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.2	1.7	GO:1900094	BMP signaling pathway involved in determination of left/right symmetry(GO:0003154) BMP signaling pathway involved in heart jogging(GO:0003303) negative regulation of endodermal cell fate specification(GO:0042664) regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry(GO:1900094) negative regulation of endodermal cell differentiation(GO:1903225)
0.2	31.2	GO:0001756	somitogenesis(GO:0001756)
0.2	55.5	GO:0006954	inflammatory response(GO:0006954)
0.2	1.2	GO:0006309	apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.2	1.4	GO:0019859	thymine catabolic process(GO:0006210) valine catabolic process(GO:0006574) thymine metabolic process(GO:0019859)
0.2	1.3	GO:0033146	regulation of intracellular steroid hormone receptor signaling pathway(GO:0033143) regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.2	0.9	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.2	1.8	GO:0051673	membrane disruption in other organism(GO:0051673)
0.2	6.8	GO:0036297	interstrand cross-link repair(GO:0036297)
0.2	4.8	GO:0006094	gluconeogenesis(GO:0006094)
0.2	0.9	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.2	11.6	GO:0009410	response to xenobiotic stimulus(GO:0009410)
0.2	3.7	GO:0007032	endosome organization(GO:0007032)
0.2	9.8	GO:1990266	granulocyte migration(GO:0097530) neutrophil migration(GO:1990266)
0.2	2.1	GO:0030878	thyroid gland development(GO:0030878)
0.2	0.6	GO:1901994	meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.2	6.7	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2	1.7	GO:0071340	skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2	3.5	GO:0030259	lipid glycosylation(GO:0030259)
0.2	1.2	GO:0001840	neural plate development(GO:0001840)
0.2	5.6	GO:0014866	skeletal myofibril assembly(GO:0014866)
0.2	0.4	GO:0010002	cardioblast differentiation(GO:0010002)
0.2	9.5	GO:0031076	embryonic camera-type eye development(GO:0031076)
0.2	1.5	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.2	1.1	GO:0071347	interleukin-1-mediated signaling pathway(GO:0070498) cellular response to interleukin-1(GO:0071347)
0.2	3.7	GO:0032438	melanosome organization(GO:0032438)
0.2	7.4	GO:0007259	JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.2	9.0	GO:0099515	vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.2	3.6	GO:0032506	cytokinetic process(GO:0032506)
0.2	5.2	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.2	1.1	GO:0032218	riboflavin transport(GO:0032218)
0.2	1.6	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.2	0.9	GO:0060036	notochord cell vacuolation(GO:0060036)
0.2	1.6	GO:0071376	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2	0.5	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin biosynthetic process(GO:0032049)
0.2	1.2	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2	2.6	GO:0033555	multicellular organismal response to stress(GO:0033555)
0.2	0.5	GO:1990519	pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2	2.4	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.2	1.0	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.2	1.7	GO:0051601	exocyst localization(GO:0051601)
0.2	1.5	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.2	1.5	GO:0021684	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2	6.2	GO:0032456	endocytic recycling(GO:0032456)
0.2	0.6	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.2	1.5	GO:0097345	mitochondrial outer membrane permeabilization(GO:0097345)
0.2	0.2	GO:0042177	negative regulation of protein catabolic process(GO:0042177)
0.2	1.8	GO:0035090	maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.2	2.7	GO:0007520	myoblast fusion(GO:0007520)
0.2	3.4	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.2	2.3	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134)
0.2	4.3	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.2	0.8	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1	3.1	GO:0006491	N-glycan processing(GO:0006491)
0.1	1.5	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1	2.4	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.1	1.8	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.1	0.7	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.9	GO:0032447	tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1	14.7	GO:0008284	positive regulation of cell proliferation(GO:0008284)
0.1	5.6	GO:0071391	response to estrogen(GO:0043627) cellular response to estrogen stimulus(GO:0071391)
0.1	0.6	GO:0097535	lymphoid progenitor cell differentiation(GO:0002320) lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1	5.3	GO:0030217	T cell differentiation(GO:0030217)
0.1	4.4	GO:0043534	blood vessel endothelial cell migration(GO:0043534)
0.1	1.7	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1	1.6	GO:0007172	signal complex assembly(GO:0007172)
0.1	2.8	GO:0032508	DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.1	0.7	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.1	5.7	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968)
0.1	0.9	GO:0046620	regulation of organ growth(GO:0046620)
0.1	8.7	GO:0006979	response to oxidative stress(GO:0006979)
0.1	0.7	GO:0000731	DNA synthesis involved in DNA repair(GO:0000731)
0.1	4.0	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.1	0.8	GO:0030216	keratinocyte differentiation(GO:0030216)
0.1	2.8	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.1	1.9	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1	3.9	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.1	2.7	GO:0038127	ERBB signaling pathway(GO:0038127)
0.1	1.4	GO:1901222	regulation of NIK/NF-kappaB signaling(GO:1901222)
0.1	0.7	GO:0019427	acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1	1.0	GO:0090660	cerebrospinal fluid circulation(GO:0090660) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1	2.1	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1	3.0	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.1	6.3	GO:0008285	negative regulation of cell proliferation(GO:0008285)
0.1	3.1	GO:0001878	response to yeast(GO:0001878) response to fungus(GO:0009620)
0.1	1.5	GO:0044154	histone H3-K14 acetylation(GO:0044154)
0.1	0.6	GO:0048048	embryonic eye morphogenesis(GO:0048048)
0.1	1.3	GO:0032094	response to food(GO:0032094)
0.1	0.9	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.1	1.3	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.1	3.4	GO:0003146	heart jogging(GO:0003146)
0.1	0.5	GO:0060561	apoptotic process involved in morphogenesis(GO:0060561)
0.1	1.0	GO:2000036	regulation of stem cell population maintenance(GO:2000036)
0.1	3.2	GO:0032543	mitochondrial translation(GO:0032543)
0.1	6.6	GO:0030178	negative regulation of Wnt signaling pathway(GO:0030178)
0.1	1.0	GO:0090329	regulation of DNA-dependent DNA replication(GO:0090329)
0.1	0.5	GO:0044034	viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism metabolic process(GO:0044033) multi-organism biosynthetic process(GO:0044034)
0.1	0.8	GO:0046580	negative regulation of Ras protein signal transduction(GO:0046580)
0.1	0.9	GO:0014003	oligodendrocyte development(GO:0014003)
0.1	0.8	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1	2.5	GO:0042098	T cell proliferation(GO:0042098) regulation of T cell proliferation(GO:0042129)
0.1	1.2	GO:0021772	olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1	1.8	GO:0048846	axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1	1.1	GO:0051122	lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1	0.4	GO:0032616	interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1	1.2	GO:0019835	cytolysis(GO:0019835)
0.1	2.0	GO:0046330	positive regulation of JNK cascade(GO:0046330)
0.1	2.1	GO:0019432	triglyceride biosynthetic process(GO:0019432) neutral lipid biosynthetic process(GO:0046460) acylglycerol biosynthetic process(GO:0046463)
0.1	1.4	GO:0007634	optokinetic behavior(GO:0007634)
0.1	6.1	GO:0021782	glial cell development(GO:0021782)
0.1	10.7	GO:0006869	lipid transport(GO:0006869)
0.1	0.3	GO:0015871	choline transport(GO:0015871)
0.1	1.0	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.1	0.5	GO:0030183	B cell differentiation(GO:0030183)
0.1	20.2	GO:0006486	protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1	2.3	GO:0046033	AMP metabolic process(GO:0046033)
0.1	6.1	GO:0006956	complement activation(GO:0006956) protein activation cascade(GO:0072376)
0.1	0.9	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.1	0.9	GO:0006298	mismatch repair(GO:0006298)
0.1	2.8	GO:0045104	intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.1	1.0	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1	6.1	GO:0030155	regulation of cell adhesion(GO:0030155)
0.1	3.0	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.1	2.1	GO:0071560	transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.1	6.8	GO:0007283	spermatogenesis(GO:0007283)
0.1	0.9	GO:0097324	melanocyte migration(GO:0097324)
0.1	2.2	GO:0001894	tissue homeostasis(GO:0001894)
0.1	2.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.1	0.3	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.1	0.3	GO:0010828	positive regulation of glucose transport(GO:0010828)
0.1	1.2	GO:0043277	apoptotic cell clearance(GO:0043277)
0.1	0.9	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1	0.6	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.1	2.9	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1	0.4	GO:0060974	cell migration involved in heart formation(GO:0060974)
0.1	0.7	GO:0001569	patterning of blood vessels(GO:0001569)
0.1	0.5	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1	1.7	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1	0.2	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1	1.5	GO:0043406	positive regulation of MAP kinase activity(GO:0043406)
0.1	2.9	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.1	1.0	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.1	2.6	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.1	0.7	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.1	0.5	GO:0072498	embryonic skeletal joint development(GO:0072498)
0.1	5.5	GO:0007160	cell-matrix adhesion(GO:0007160)
0.1	0.7	GO:0031167	rRNA methylation(GO:0031167)
0.1	0.6	GO:0001573	ganglioside metabolic process(GO:0001573) ganglioside catabolic process(GO:0006689)
0.0	1.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.3	GO:0048634	regulation of muscle organ development(GO:0048634)
0.0	11.1	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	1.4	GO:0010466	negative regulation of peptidase activity(GO:0010466)
0.0	0.6	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	2.9	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	3.0	GO:0009615	response to virus(GO:0009615)
0.0	1.1	GO:0002440	production of molecular mediator of immune response(GO:0002440)
0.0	4.8	GO:0051321	meiotic cell cycle(GO:0051321)
0.0	0.4	GO:0003159	morphogenesis of an endothelium(GO:0003159) endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.0	20.1	GO:0051603	proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0	23.2	GO:0010941	regulation of cell death(GO:0010941)
0.0	0.7	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0	2.1	GO:0006637	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0	0.5	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	0.4	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0	0.3	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.6	GO:0035118	embryonic pectoral fin morphogenesis(GO:0035118)
0.0	0.2	GO:0060092	regulation of synaptic transmission, glycinergic(GO:0060092)
0.0	0.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	3.1	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.3	GO:0002574	thrombocyte differentiation(GO:0002574)
0.0	0.5	GO:0034198	cellular response to amino acid starvation(GO:0034198)
0.0	2.2	GO:0050919	negative chemotaxis(GO:0050919)
0.0	0.9	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	1.0	GO:0061053	somite development(GO:0061053)
0.0	1.2	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.0	0.7	GO:0006081	cellular aldehyde metabolic process(GO:0006081)
0.0	2.0	GO:0048015	phosphatidylinositol-mediated signaling(GO:0048015)
0.0	1.6	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.8	GO:0030048	actin filament-based movement(GO:0030048)
0.0	1.3	GO:0006354	DNA-templated transcription, elongation(GO:0006354)
0.0	0.3	GO:0042159	protein depalmitoylation(GO:0002084) lipoprotein catabolic process(GO:0042159) macromolecule depalmitoylation(GO:0098734)
0.0	0.3	GO:0030038	contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0072028	nephron morphogenesis(GO:0072028)
0.0	0.8	GO:0050817	coagulation(GO:0050817)
0.0	0.2	GO:0002154	thyroid hormone mediated signaling pathway(GO:0002154)
0.0	0.4	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	6.9	GO:0043043	translation(GO:0006412) peptide biosynthetic process(GO:0043043)
0.0	1.0	GO:0045087	innate immune response(GO:0045087)
0.0	0.3	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.0	0.3	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	6.6	GO:0016567	protein ubiquitination(GO:0016567)
0.0	3.3	GO:0000122	negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0	0.2	GO:0030206	chondroitin sulfate metabolic process(GO:0030204) chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0043550	regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0	0.6	GO:0045010	actin nucleation(GO:0045010)
0.0	0.4	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.0	0.3	GO:0048545	response to steroid hormone(GO:0048545)
0.0	0.1	GO:0010738	regulation of protein kinase A signaling(GO:0010738)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.3	29.1	GO:0044611	nuclear pore inner ring(GO:0044611)
4.5	49.7	GO:0045095	keratin filament(GO:0045095)
3.5	14.2	GO:0008290	F-actin capping protein complex(GO:0008290)
3.5	17.7	GO:0097433	dense body(GO:0097433)
3.2	12.8	GO:0070319	Golgi to plasma membrane transport vesicle(GO:0070319)
3.0	56.8	GO:0030057	desmosome(GO:0030057)
2.8	8.4	GO:0000333	telomerase catalytic core complex(GO:0000333)
2.6	7.8	GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
2.5	34.3	GO:0000815	ESCRT III complex(GO:0000815)
2.2	41.9	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.1	31.6	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
1.9	11.5	GO:1902636	kinociliary basal body(GO:1902636)
1.9	15.3	GO:0001772	immunological synapse(GO:0001772)
1.9	5.7	GO:0098536	deuterosome(GO:0098536)
1.5	8.9	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.4	8.4	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
1.4	15.3	GO:0005832	chaperonin-containing T-complex(GO:0005832)
1.2	6.2	GO:0071540	eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
1.1	15.9	GO:0042555	MCM complex(GO:0042555)
1.0	10.9	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.9	5.3	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.9	9.7	GO:0035101	FACT complex(GO:0035101)
0.9	9.5	GO:0098833	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.8	6.5	GO:0061700	GATOR2 complex(GO:0061700)
0.8	11.9	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.7	70.7	GO:0005882	intermediate filament(GO:0005882)
0.7	2.9	GO:0098890	extrinsic component of postsynaptic membrane(GO:0098890)
0.7	13.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.7	3.4	GO:0018444	translation release factor complex(GO:0018444)
0.7	4.7	GO:0005826	actomyosin contractile ring(GO:0005826)
0.7	9.2	GO:0048179	activin receptor complex(GO:0048179)
0.6	28.9	GO:0031941	filamentous actin(GO:0031941)
0.6	7.2	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.6	8.5	GO:0070187	telosome(GO:0070187)
0.6	13.0	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.6	70.3	GO:0016459	myosin complex(GO:0016459)
0.6	7.7	GO:0002102	podosome(GO:0002102)
0.5	11.5	GO:0030127	COPII vesicle coat(GO:0030127)
0.5	67.0	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.5	46.2	GO:0005604	basement membrane(GO:0005604)
0.5	12.3	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.5	29.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.5	5.3	GO:0030904	retromer complex(GO:0030904)
0.5	9.1	GO:0044666	MLL3/4 complex(GO:0044666)
0.5	28.3	GO:0031901	early endosome membrane(GO:0031901)
0.5	2.7	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.5	7.3	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.5	1.4	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.4	1.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.4	4.6	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.4	26.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.4	2.3	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4	21.7	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.3	22.4	GO:0005884	actin filament(GO:0005884)
0.3	4.1	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.3	0.9	GO:0031166	integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3	3.3	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.3	12.6	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.3	1.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.3	10.9	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.3	22.8	GO:0030018	Z disc(GO:0030018)
0.3	23.4	GO:0005769	early endosome(GO:0005769)
0.3	2.3	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.3	1.3	GO:0000811	GINS complex(GO:0000811)
0.2	1.0	GO:0044609	DBIRD complex(GO:0044609)
0.2	4.7	GO:0045277	respiratory chain complex IV(GO:0045277)
0.2	2.2	GO:0019908	cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.2	6.7	GO:0005839	proteasome core complex(GO:0005839)
0.2	3.8	GO:0005579	membrane attack complex(GO:0005579)
0.2	4.6	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.2	12.7	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.2	54.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	0.9	GO:1904423	dehydrodolichyl diphosphate synthase complex(GO:1904423)
0.2	1.3	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.2	4.0	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.2	13.8	GO:0030027	lamellipodium(GO:0030027)
0.2	1.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.2	2.4	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.2	43.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	49.9	GO:0000785	chromatin(GO:0000785)
0.2	17.1	GO:0016324	apical plasma membrane(GO:0016324)
0.2	38.4	GO:0005764	lysosome(GO:0005764)
0.2	7.3	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.2	1.1	GO:0042788	polysomal ribosome(GO:0042788)
0.1	7.2	GO:0016342	catenin complex(GO:0016342)
0.1	1.5	GO:0036449	microtubule minus-end(GO:0036449)
0.1	2.7	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.1	10.3	GO:0005581	collagen trimer(GO:0005581)
0.1	46.4	GO:0005667	transcription factor complex(GO:0005667)
0.1	5.6	GO:0016605	PML body(GO:0016605)
0.1	10.6	GO:0005814	centriole(GO:0005814)
0.1	6.2	GO:0005811	lipid particle(GO:0005811)
0.1	5.2	GO:0005770	late endosome(GO:0005770)
0.1	0.7	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.1	5.6	GO:0016592	mediator complex(GO:0016592)
0.1	0.9	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.1	2.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	5.9	GO:0022626	cytosolic ribosome(GO:0022626)
0.1	0.3	GO:0032997	Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.1	1.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.1	2.2	GO:0030496	midbody(GO:0030496)
0.1	0.8	GO:0034991	nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.1	14.0	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.1	0.8	GO:0032783	ELL-EAF complex(GO:0032783)
0.1	0.5	GO:0030914	STAGA complex(GO:0030914)
0.1	0.4	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.1	8.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	1.5	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	4.4	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	5.2	GO:0005643	nuclear pore(GO:0005643)
0.1	2.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	10.7	GO:0031012	extracellular matrix(GO:0031012)
0.1	104.0	GO:0005829	cytosol(GO:0005829)
0.1	1.7	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.1	0.9	GO:0032300	mismatch repair complex(GO:0032300)
0.1	88.2	GO:0005615	extracellular space(GO:0005615)
0.1	6.9	GO:0005925	focal adhesion(GO:0005925)
0.1	3.8	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1	3.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	0.6	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	1.0	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.1	6.7	GO:0016607	nuclear speck(GO:0016607)
0.1	0.9	GO:0005922	connexon complex(GO:0005922)
0.1	22.0	GO:0000139	Golgi membrane(GO:0000139)
0.1	3.0	GO:0036064	ciliary basal body(GO:0036064)
0.1	0.6	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	13.9	GO:0005730	nucleolus(GO:0005730)
0.0	1.3	GO:0008305	integrin complex(GO:0008305)
0.0	0.5	GO:0000421	autophagosome membrane(GO:0000421)
0.0	1.8	GO:0005861	troponin complex(GO:0005861)
0.0	4.1	GO:0009986	cell surface(GO:0009986)
0.0	0.4	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	0.9	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	1.9	GO:0005840	ribosome(GO:0005840)
0.0	0.9	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	3.4	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	0.5	GO:0043596	nuclear replication fork(GO:0043596)
0.0	0.6	GO:0000145	exocyst(GO:0000145)
0.0	0.3	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	1.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.2	GO:0030139	endocytic vesicle(GO:0030139)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.8	63.0	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
7.4	36.9	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
6.4	31.9	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
6.4	25.5	GO:0030228	lipoprotein particle receptor activity(GO:0030228)
6.2	43.6	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
5.7	17.2	GO:0070905	glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905)
4.7	23.6	GO:0070412	R-SMAD binding(GO:0070412)
4.4	13.1	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
4.2	12.5	GO:0008119	thiopurine S-methyltransferase activity(GO:0008119)
4.1	16.4	GO:0004478	methionine adenosyltransferase activity(GO:0004478)
4.1	16.2	GO:0097108	hedgehog family protein binding(GO:0097108)
4.0	12.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
3.5	17.7	GO:0098973	structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
3.5	27.8	GO:0001217	bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
3.1	18.4	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
3.1	15.3	GO:0019863	IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
3.0	42.1	GO:0008327	methyl-CpG binding(GO:0008327)
2.8	8.4	GO:0003721	telomerase RNA reverse transcriptase activity(GO:0003721)
2.8	19.5	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
2.7	13.4	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
2.6	18.3	GO:0008118	N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
2.2	8.9	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
2.2	17.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
2.1	29.5	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
2.1	6.3	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
2.1	6.3	GO:0005093	Rab GDP-dissociation inhibitor activity(GO:0005093)
2.0	8.1	GO:0004576	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
2.0	6.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
2.0	8.0	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
2.0	30.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
1.8	7.4	GO:1904121	phosphatidylethanolamine transporter activity(GO:1904121)
1.8	16.5	GO:0045294	alpha-catenin binding(GO:0045294)
1.8	14.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.7	8.5	GO:0070644	vitamin D response element binding(GO:0070644)
1.7	11.9	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.6	6.4	GO:0031708	endothelin B receptor binding(GO:0031708)
1.6	4.7	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
1.5	41.4	GO:0042805	actinin binding(GO:0042805)
1.5	4.6	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.5	7.5	GO:0098634	C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
1.5	5.8	GO:0033906	hyaluronoglucuronidase activity(GO:0033906)
1.5	10.2	GO:0070728	leucine binding(GO:0070728)
1.4	8.6	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
1.4	12.7	GO:0016936	galactoside binding(GO:0016936)
1.4	39.2	GO:0048306	calcium-dependent protein binding(GO:0048306)
1.4	4.1	GO:0004904	interferon receptor activity(GO:0004904)
1.3	17.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
1.3	3.9	GO:0004311	farnesyltranstransferase activity(GO:0004311)
1.3	6.5	GO:0004645	phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
1.2	12.2	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
1.2	10.9	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
1.2	8.4	GO:0019809	spermidine binding(GO:0019809)
1.2	15.0	GO:0004859	phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
1.1	5.7	GO:0051903	alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
1.1	3.4	GO:0003978	UDP-glucose 4-epimerase activity(GO:0003978)
1.1	6.8	GO:0016361	activin receptor activity, type I(GO:0016361)
1.0	29.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
1.0	9.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.0	25.3	GO:0005112	Notch binding(GO:0005112)
1.0	9.1	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
1.0	3.0	GO:0004020	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
1.0	12.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
1.0	2.9	GO:0004485	methylcrotonoyl-CoA carboxylase activity(GO:0004485)
1.0	25.1	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
1.0	8.6	GO:0004586	ornithine decarboxylase activity(GO:0004586)
1.0	11.4	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
1.0	21.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.9	9.3	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.9	3.7	GO:0003796	lysozyme activity(GO:0003796)
0.9	12.9	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.9	8.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.9	20.5	GO:0015926	glucosidase activity(GO:0015926)
0.9	14.1	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.9	29.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.8	3.2	GO:0016841	ammonia-lyase activity(GO:0016841)
0.8	23.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.8	12.5	GO:0005080	protein kinase C binding(GO:0005080)
0.8	7.0	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.8	4.6	GO:0061133	endopeptidase activator activity(GO:0061133)
0.7	3.0	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.7	3.0	GO:0019215	intermediate filament binding(GO:0019215)
0.7	10.3	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.7	3.0	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.7	8.1	GO:0047676	arachidonate-CoA ligase activity(GO:0047676)
0.7	22.6	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.7	9.5	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.7	11.0	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.7	4.0	GO:0033781	cholesterol 24-hydroxylase activity(GO:0033781)
0.7	8.0	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.7	10.0	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.7	2.6	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.6	2.6	GO:0016842	amidine-lyase activity(GO:0016842)
0.6	15.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.6	18.9	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.6	6.8	GO:0032036	myosin heavy chain binding(GO:0032036)
0.6	17.0	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.6	16.3	GO:0015248	sterol transporter activity(GO:0015248)
0.6	7.2	GO:0031720	haptoglobin binding(GO:0031720)
0.6	4.8	GO:0036122	BMP binding(GO:0036122)
0.6	5.3	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.6	8.3	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.6	5.3	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.6	5.6	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.6	3.9	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.6	2.8	GO:0001223	transcription coactivator binding(GO:0001223)
0.6	3.9	GO:0004630	phospholipase D activity(GO:0004630)
0.5	14.1	GO:0004806	triglyceride lipase activity(GO:0004806)
0.5	1.6	GO:0003999	adenine phosphoribosyltransferase activity(GO:0003999)
0.5	1.6	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.5	7.8	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.5	2.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.5	6.8	GO:0005163	nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.5	2.6	GO:0038132	neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.5	21.1	GO:0005109	frizzled binding(GO:0005109)
0.5	4.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.5	4.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.5	15.1	GO:0016881	acid-amino acid ligase activity(GO:0016881)
0.5	13.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.5	12.8	GO:0016289	CoA hydrolase activity(GO:0016289)
0.5	3.8	GO:0008026	ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.5	15.1	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.5	2.7	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.5	2.7	GO:0072349	modified amino acid transmembrane transporter activity(GO:0072349)
0.5	1.4	GO:0004736	pyruvate carboxylase activity(GO:0004736)
0.5	6.3	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.4	4.0	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4	1.8	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.4	3.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.4	1.8	GO:0015369	calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.4	1.7	GO:0005463	UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.4	3.9	GO:0004359	glutaminase activity(GO:0004359)
0.4	5.5	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.4	8.8	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4	9.2	GO:0015379	cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.4	2.9	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.4	3.3	GO:0033878	hormone-sensitive lipase activity(GO:0033878)
0.4	3.2	GO:0008200	ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.4	8.8	GO:0005003	ephrin receptor activity(GO:0005003)
0.4	9.0	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.4	17.6	GO:0003746	translation elongation factor activity(GO:0003746)
0.4	8.5	GO:0004364	glutathione transferase activity(GO:0004364)
0.4	2.3	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.4	1.5	GO:0004419	hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.4	4.5	GO:0005158	insulin receptor binding(GO:0005158)
0.4	48.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.4	7.3	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.4	12.2	GO:0015459	potassium channel regulator activity(GO:0015459)
0.4	1.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.4	6.7	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4	9.2	GO:0016769	transferase activity, transferring nitrogenous groups(GO:0016769)
0.3	4.5	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3	3.3	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.3	6.6	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3	2.9	GO:0019825	oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.3	4.5	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.3	8.9	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.3	5.7	GO:0017147	Wnt-protein binding(GO:0017147)
0.3	3.1	GO:0015924	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3	4.2	GO:0048185	activin binding(GO:0048185)
0.3	0.9	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3	2.3	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.3	0.9	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.3	5.1	GO:0035497	cAMP response element binding(GO:0035497)
0.3	3.9	GO:0030165	PDZ domain binding(GO:0030165)
0.3	24.9	GO:0045296	cadherin binding(GO:0045296)
0.3	1.1	GO:0017020	myosin phosphatase regulator activity(GO:0017020)
0.3	1.3	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.3	14.2	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.3	2.4	GO:0043515	kinetochore binding(GO:0043515)
0.3	2.9	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3	5.8	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3	20.2	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3	2.3	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.3	9.9	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2	10.0	GO:0019956	chemokine binding(GO:0019956)
0.2	1.7	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2	2.2	GO:0030332	cyclin binding(GO:0030332)
0.2	8.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.2	12.2	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2	1.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2	3.6	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.2	8.7	GO:0016879	ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.2	0.7	GO:0016713	cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.2	1.4	GO:0015616	DNA translocase activity(GO:0015616)
0.2	94.6	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.2	3.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2	1.3	GO:0030331	estrogen receptor binding(GO:0030331)
0.2	1.3	GO:0008142	oxysterol binding(GO:0008142)
0.2	1.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2	43.3	GO:0046982	protein heterodimerization activity(GO:0046982)
0.2	25.3	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.2	5.3	GO:0016790	thiolester hydrolase activity(GO:0016790)
0.2	1.8	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2	1.4	GO:0004974	leukotriene receptor activity(GO:0004974)
0.2	12.8	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.2	1.5	GO:0005052	peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2	20.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	0.8	GO:0030586	[methionine synthase] reductase activity(GO:0030586)
0.2	1.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.2	3.4	GO:0004622	lysophospholipase activity(GO:0004622)
0.2	1.9	GO:0005459	UDP-galactose transmembrane transporter activity(GO:0005459)
0.2	10.3	GO:0008028	monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2	37.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	41.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	1.7	GO:0008494	translation activator activity(GO:0008494)
0.2	1.7	GO:0015929	hexosaminidase activity(GO:0015929)
0.2	1.7	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.2	2.9	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2	0.9	GO:0043236	laminin binding(GO:0043236)
0.2	1.1	GO:0032217	riboflavin transporter activity(GO:0032217)
0.2	3.0	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2	1.6	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.2	1.6	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.2	5.8	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.2	1.9	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2	0.5	GO:0015218	pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2	0.9	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.2	4.7	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2	1.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.2	2.8	GO:0043138	3'-5' DNA helicase activity(GO:0043138)
0.2	0.7	GO:0070182	DNA polymerase binding(GO:0070182)
0.2	3.7	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.2	49.6	GO:0005198	structural molecule activity(GO:0005198)
0.2	1.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.2	1.0	GO:0004692	cGMP-dependent protein kinase activity(GO:0004692)
0.2	45.7	GO:0051015	actin filament binding(GO:0051015)
0.2	3.3	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.2	4.0	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.2	1.9	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.2	10.4	GO:0005484	SNAP receptor activity(GO:0005484)
0.2	6.0	GO:0019213	deacetylase activity(GO:0019213)
0.1	1.9	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	1.8	GO:0005223	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1	2.4	GO:0008301	DNA binding, bending(GO:0008301)
0.1	2.5	GO:0048038	quinone binding(GO:0048038)
0.1	0.8	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.1	1.8	GO:0042910	xenobiotic transporter activity(GO:0042910)
0.1	2.6	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1	0.9	GO:0070888	E-box binding(GO:0070888)
0.1	0.5	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1	0.4	GO:0004017	adenylate kinase activity(GO:0004017)
0.1	8.8	GO:0042803	protein homodimerization activity(GO:0042803)
0.1	7.2	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.1	7.0	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1	0.5	GO:0070513	death domain binding(GO:0070513)
0.1	2.7	GO:1990782	protein tyrosine kinase binding(GO:1990782)
0.1	1.4	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.1	0.9	GO:0030983	mismatched DNA binding(GO:0030983)
0.1	0.7	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	1.2	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.1	21.8	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.1	1.9	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.6	GO:0060182	apelin receptor activity(GO:0060182)
0.1	15.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	1.5	GO:0030507	spectrin binding(GO:0030507)
0.1	0.3	GO:0019763	immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
0.1	7.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	10.4	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.1	1.5	GO:0051787	misfolded protein binding(GO:0051787)
0.1	1.3	GO:1990404	protein ADP-ribosylase activity(GO:1990404)
0.1	10.7	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.1	1.9	GO:0010181	FMN binding(GO:0010181)
0.1	3.7	GO:0030170	pyridoxal phosphate binding(GO:0030170)
0.1	1.5	GO:0010484	H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1	1.5	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.1	5.2	GO:0031491	nucleosome binding(GO:0031491)
0.1	2.6	GO:0008171	O-methyltransferase activity(GO:0008171)
0.1	0.7	GO:0050262	ribosylnicotinamide kinase activity(GO:0050262)
0.1	0.4	GO:0004104	cholinesterase activity(GO:0004104)
0.1	4.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.1	0.7	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1	4.3	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	0.6	GO:0017095	heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1	0.7	GO:0016433	rRNA (adenine) methyltransferase activity(GO:0016433)
0.1	2.1	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1	0.9	GO:0050700	CARD domain binding(GO:0050700)
0.1	3.8	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.1	0.8	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1	0.6	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	1.2	GO:0043022	ribosome binding(GO:0043022)
0.1	9.3	GO:0015293	symporter activity(GO:0015293)
0.1	0.9	GO:0016783	sulfurtransferase activity(GO:0016783)
0.1	1.6	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.1	3.3	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.1	0.4	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1	6.2	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1	5.1	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1	3.0	GO:0003727	single-stranded RNA binding(GO:0003727)
0.1	0.4	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1	0.9	GO:0045503	dynein light chain binding(GO:0045503)
0.1	3.0	GO:0008094	DNA-dependent ATPase activity(GO:0008094)
0.1	43.1	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1	1.2	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1	2.0	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	0.4	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	2.2	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1	0.6	GO:0005042	netrin receptor activity(GO:0005042)
0.1	4.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	99.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	1.9	GO:0015485	cholesterol binding(GO:0015485)
0.1	2.1	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.1	0.4	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1	7.8	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1	0.6	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1	1.3	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.9	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.5	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.9	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	1.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	1.7	GO:0019003	GDP binding(GO:0019003)
0.0	1.8	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0031151	histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	4.8	GO:0005125	cytokine activity(GO:0005125)
0.0	0.3	GO:0005549	olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.0	2.7	GO:0003724	RNA helicase activity(GO:0003724)
0.0	1.8	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
0.0	9.9	GO:0016757	transferase activity, transferring glycosyl groups(GO:0016757)
0.0	1.2	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0	0.2	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.3	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	2.4	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	0.3	GO:0008199	ferric iron binding(GO:0008199)
0.0	1.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	7.7	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	0.4	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0004968	gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0	0.2	GO:0004096	catalase activity(GO:0004096)
0.0	0.5	GO:0019838	growth factor binding(GO:0019838)
0.0	0.8	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	7.7	GO:0008270	zinc ion binding(GO:0008270)
0.0	0.5	GO:0003678	DNA helicase activity(GO:0003678)
0.0	0.8	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.5	17.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
1.7	75.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
1.7	20.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
1.7	105.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.1	27.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.9	7.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.8	13.5	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.8	6.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.7	9.7	PID IL3 PATHWAY	IL3-mediated signaling events
0.7	8.9	PID EPHB FWD PATHWAY	EPHB forward signaling
0.6	36.5	PID MTOR 4PATHWAY	mTOR signaling pathway
0.6	43.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.6	5.6	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.5	17.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.5	42.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.5	18.3	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.5	1.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.5	5.2	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.4	2.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.4	12.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	16.7	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.4	9.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.4	14.3	PID ATR PATHWAY	ATR signaling pathway
0.4	3.0	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.3	3.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	15.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.3	5.9	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.3	1.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.3	2.6	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	10.4	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.3	4.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.3	1.6	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.3	5.7	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	3.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.2	1.7	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	3.0	ST GA12 PATHWAY	G alpha 12 Pathway
0.2	1.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	4.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.2	1.7	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.2	3.3	PID BCR 5PATHWAY	BCR signaling pathway
0.2	6.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	2.3	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.2	3.8	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	2.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.2	1.3	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	5.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	1.7	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	0.5	PID FOXO PATHWAY	FoxO family signaling
0.1	1.2	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	1.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	1.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	1.7	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	2.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	1.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	14.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	1.1	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	0.7	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	5.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.1	PID AURORA B PATHWAY	Aurora B signaling
0.1	1.1	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.6	PID BARD1 PATHWAY	BARD1 signaling events
0.0	0.6	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.6	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	0.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.2	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.7	18.4	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
3.2	41.4	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
3.0	62.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
2.8	25.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.8	31.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
1.6	9.5	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
1.4	20.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
1.3	5.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
1.2	23.5	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
1.2	3.7	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
1.2	3.7	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.1	15.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
1.1	10.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
1.1	8.4	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
1.0	15.4	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
1.0	1.0	REACTOME PI3K AKT ACTIVATION	Genes involved in PI3K/AKT activation
1.0	17.3	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.9	22.9	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.8	30.1	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.7	5.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.7	6.7	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.7	7.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.7	15.3	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.7	49.6	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.7	10.0	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6	12.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6	8.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.6	7.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.6	6.9	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.6	11.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	4.4	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.5	13.0	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.5	29.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.5	15.8	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.5	10.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	3.3	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.5	10.1	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.5	5.0	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.4	18.6	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.4	3.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.4	15.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.4	3.6	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.4	9.9	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.4	25.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	3.0	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.3	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	1.6	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3	34.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	8.2	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.3	4.3	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.2	4.5	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.2	6.6	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.2	5.6	REACTOME CELL CELL JUNCTION ORGANIZATION	Genes involved in Cell-cell junction organization
0.2	4.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.2	3.3	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.2	4.4	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression
0.2	4.7	REACTOME KINESINS	Genes involved in Kinesins
0.2	7.4	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.2	7.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	1.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	5.4	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2	2.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	0.5	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.2	4.3	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.2	4.1	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.2	4.0	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.2	4.8	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2	0.7	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.2	21.7	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2	15.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	1.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	2.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	2.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	1.0	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.1	9.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	0.8	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	2.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	2.1	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1	6.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.7	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1	0.5	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.1	1.4	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.1	1.4	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.1	9.4	REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1	8.0	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.1	2.9	REACTOME TRANSLATION	Genes involved in Translation
0.1	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.5	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	2.0	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	1.0	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	1.3	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.1	1.7	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	1.7	REACTOME TRANSCRIPTION COUPLED NER TC NER	Genes involved in Transcription-coupled NER (TC-NER)
0.1	1.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	0.6	REACTOME SHC MEDIATED CASCADE	Genes involved in SHC-mediated cascade
0.1	0.5	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	0.6	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.1	1.5	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	1.8	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	2.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	3.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.9	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.7	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.7	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	2.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.6	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	1.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 2.09

Motif logo

Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Activity-expression correlation:

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: