ISMARA results: spi1a+spi1b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for spi1a+spi1b

Z-value: 4.34

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Transcription factors associated with spi1a+spi1b

Gene Symbol	Gene ID	Gene Info
spi1b NCBI UniProt	ENSDARG00000000767	Spi-1 proto-oncogene b
spi1a NCBI UniProt	ENSDARG00000067797	Spi-1 proto-oncogene a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
spi1a	dr11_v1_chr25_+_35553542_35553542	0.78	7.8e-21	Click!
spi1b	dr11_v1_chr7_-_32659048_32659048	0.75	5.8e-18	Click!

Activity profile of spi1a+spi1b motif

Sorted Z-values of spi1a+spi1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_43872889 Show fit	40.25	ENSDART00000170553	mslna NCBI UniProt Show fit	mesothelin a
chr6_-_8489810 Show fit	38.27	ENSDART00000124643	rasal3 NCBI UniProt Show fit	RAS protein activator like 3
chr15_+_20239141 Show fit	37.98	ENSDART00000101152 ENSDART00000152473	spint2 NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type, 2
chr21_+_25765734 Show fit	36.97	ENSDART00000021664	cldnb NCBI UniProt Show fit	claudin b
chr7_-_34265481 Show fit	34.45	ENSDART00000173596	si:ch211-98n17.5 NCBI UniProt Show fit	si:ch211-98n17.5
chr15_+_12435975 Show fit	34.27	ENSDART00000168011	tmprss4a NCBI UniProt Show fit	transmembrane protease, serine 4a
chr3_-_32859335 Show fit	33.00	ENSDART00000158916	si:dkey-16l2.20 NCBI UniProt Show fit	si:dkey-16l2.20
chr6_-_49063085 Show fit	31.84	ENSDART00000156124	si:ch211-105j21.9 NCBI UniProt Show fit	si:ch211-105j21.9
chr7_+_49664174 Show fit	31.49	ENSDART00000137059 ENSDART00000131210	rassf7b NCBI UniProt Show fit	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr23_-_10177442 Show fit	30.33	ENSDART00000144280 ENSDART00000129044	krt5 NCBI UniProt Show fit	keratin 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of spi1a+spi1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	98.7	GO:0007160	cell-matrix adhesion(GO:0007160)
0.3	98.7	GO:0006955	immune response(GO:0006955)
1.4	79.8	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
1.0	74.2	GO:0030048	actin filament-based movement(GO:0030048)
0.3	72.1	GO:0043087	regulation of GTPase activity(GO:0043087)
2.9	60.6	GO:0002574	thrombocyte differentiation(GO:0002574)
0.3	60.3	GO:0009617	response to bacterium(GO:0009617)
0.7	54.7	GO:0060348	bone development(GO:0060348)
1.2	52.1	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
2.2	49.8	GO:0000028	ribosomal small subunit assembly(GO:0000028)

Showing 1 to 10 of 436 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	257.3	GO:0005764	lysosome(GO:0005764)
0.1	143.7	GO:0005576	extracellular region(GO:0005576)
0.4	103.9	GO:0009897	external side of plasma membrane(GO:0009897)
1.9	89.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	78.1	GO:0016021	integral component of membrane(GO:0016021)
0.6	73.8	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
1.4	73.6	GO:0005902	microvillus(GO:0005902)
1.1	68.0	GO:0022626	cytosolic ribosome(GO:0022626)
0.6	65.8	GO:0005884	actin filament(GO:0005884)
3.4	60.9	GO:0005885	Arp2/3 protein complex(GO:0005885)

Showing 1 to 10 of 189 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	158.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.4	144.7	GO:0030695	GTPase regulator activity(GO:0030695)
0.4	131.1	GO:0051015	actin filament binding(GO:0051015)
0.2	122.0	GO:0005525	GTP binding(GO:0005525)
0.6	84.8	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.4	83.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.1	74.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.8	64.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	60.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
1.1	59.6	GO:0000146	microfilament motor activity(GO:0000146)

Showing 1 to 10 of 325 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	86.9	PID RAC1 PATHWAY	RAC1 signaling pathway
1.7	64.3	PID EPO PATHWAY	EPO signaling pathway
0.8	35.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	35.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.6	35.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
1.5	29.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
1.6	29.1	PID TRAIL PATHWAY	TRAIL signaling pathway
1.2	26.7	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
1.2	25.8	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.7	25.3	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 83 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	94.0	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8	85.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.0	72.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
4.2	50.7	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
3.1	34.5	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
2.8	30.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.0	29.8	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.4	28.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.8	28.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
1.9	28.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Showing 1 to 10 of 123 entries

Results for spi1a+spi1b

Z-value: 4.34

Motif logo

Transcription factors associated with spi1a+spi1b

Activity-expression correlation:

Activity profile of spi1a+spi1b motif

Sorted Z-values of spi1a+spi1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of spi1a+spi1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: