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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for spi2+spic
Z-value: 3.69
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Transcription factors associated with spi2+spic
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| spic | dr11_v1_chr4_-_17812131_17812131 | 0.63 | 1.6e-11 | Click! |
| spi2 | dr11_v1_chr4_-_17805128_17805128 | 0.32 | 1.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_20934353 Show fit | 38.72 |
ENSDART00000052660
|
src kinase associated phosphoprotein 2 |
|
| chr3_+_36424055 Show fit | 34.81 |
ENSDART00000170318
|
si:ch1073-443f11.2 |
|
| chr22_+_5478353 Show fit | 30.07 |
ENSDART00000160596
|
tubulin polymerization promoting protein |
|
| chr25_+_13191391 Show fit | 29.99 |
ENSDART00000109937
|
si:ch211-147m6.2 |
|
| chr25_+_13191615 Show fit | 29.18 |
ENSDART00000168849
|
si:ch211-147m6.2 |
|
| chr21_+_27448856 Show fit | 28.92 |
ENSDART00000100784
|
complement factor b-like |
|
| chr17_-_6451801 Show fit | 25.59 |
ENSDART00000064700
|
alpha-L-fucosidase 2 |
|
| chr20_+_26880668 Show fit | 25.43 |
ENSDART00000077769
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
|
| chr10_+_41159241 Show fit | 24.72 |
ENSDART00000141657
|
annexin A4 |
|
| chr2_+_24762567 Show fit | 23.92 |
ENSDART00000078866
|
interferon, gamma-inducible protein 30 |
Network of associatons between targets according to the STRING database.
First level regulatory network of spi2+spic
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 125.6 | GO:0006955 | immune response(GO:0006955) |
| 0.6 | 55.9 | GO:0006956 | complement activation(GO:0006956) |
| 1.2 | 51.9 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.2 | 50.8 | GO:0032970 | regulation of actin filament-based process(GO:0032970) |
| 3.8 | 41.3 | GO:0006032 | chitin catabolic process(GO:0006032) |
| 1.1 | 39.7 | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.1 | 39.6 | GO:0006412 | translation(GO:0006412) |
| 6.1 | 36.5 | GO:2001279 | neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 1.7 | 34.0 | GO:0035723 | interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350) |
| 5.6 | 33.7 | GO:0006004 | fucose metabolic process(GO:0006004) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 197.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 131.9 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 113.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.4 | 107.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 75.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.4 | 56.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.5 | 49.5 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 46.4 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.7 | 44.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 40.9 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 90.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 78.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 66.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 54.6 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 1.2 | 51.9 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 48.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.0 | 44.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.6 | 44.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 41.7 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 3.8 | 41.3 | GO:0004568 | chitinase activity(GO:0004568) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 43.3 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.8 | 37.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.1 | 28.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 25.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 25.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.3 | 23.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 23.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.8 | 22.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.5 | 17.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.9 | 15.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 79.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 6.2 | 49.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 2.8 | 25.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 1.3 | 19.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 1.8 | 19.5 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 1.0 | 18.8 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.9 | 16.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.9 | 16.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.8 | 15.2 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.6 | 15.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |