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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for spi2+spic

Z-value: 3.69

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Transcription factors associated with spi2+spic

Gene Symbol Gene ID Gene Info
spic
ENSDARG00000012435 Spi-C transcription factor (Spi-1/PU.1 related)
spi2
ENSDARG00000087438 Spi-2 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
spicdr11_v1_chr4_-_17812131_178121310.631.6e-11Click!
spi2dr11_v1_chr4_-_17805128_178051280.321.8e-03Click!

Activity profile of spi2+spic motif

Sorted Z-values of spi2+spic motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_20934353 38.72 ENSDART00000052660
skap2
src kinase associated phosphoprotein 2
chr3_+_36424055 34.81 ENSDART00000170318
si:ch1073-443f11.2
si:ch1073-443f11.2
chr22_+_5478353 30.07 ENSDART00000160596
tppp
tubulin polymerization promoting protein
chr25_+_13191391 29.99 ENSDART00000109937
si:ch211-147m6.2
si:ch211-147m6.2
chr25_+_13191615 29.18 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr21_+_27448856 28.92 ENSDART00000100784
cfbl
complement factor b-like
chr17_-_6451801 25.59 ENSDART00000064700
fuca2
alpha-L-fucosidase 2
chr20_+_26880668 25.43 ENSDART00000077769
serpinb1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr10_+_41159241 24.72 ENSDART00000141657
anxa4
annexin A4
chr2_+_24762567 23.92 ENSDART00000078866
ifi30
interferon, gamma-inducible protein 30
chr5_+_37087583 23.90 ENSDART00000049900
tagln2
transgelin 2
chr18_+_31073265 23.06 ENSDART00000023539
cyba
cytochrome b-245, alpha polypeptide
chr12_-_30558694 22.38 ENSDART00000153417
si:ch211-28p3.3
si:ch211-28p3.3
chr21_-_26114886 21.90 ENSDART00000139320
nipal4
NIPA-like domain containing 4
chr22_-_31020690 21.32 ENSDART00000130604
ssuh2.4
ssu-2 homolog, tandem duplicate 4
chr19_+_7045033 21.29 ENSDART00000146579
mhc1uka
major histocompatibility complex class I UKA
chr20_+_36812368 21.14 ENSDART00000062931
abracl
ABRA C-terminal like
chr20_-_14054083 20.96 ENSDART00000009549
rhag
Rh associated glycoprotein
chr23_+_17980875 20.92 ENSDART00000163452
chia.6
chitinase, acidic.6
chr23_+_17981127 20.37 ENSDART00000012571
ENSDART00000145200
chia.6
chitinase, acidic.6
chr21_-_25756119 20.21 ENSDART00000002341
cldnc
claudin c
chr7_-_52417777 20.10 ENSDART00000110265
myzap
myocardial zonula adherens protein
chr5_+_54938634 20.10 ENSDART00000163050
ENSDART00000145765
cd180
CD180 molecule
chr3_+_29510818 19.92 ENSDART00000055407
ENSDART00000193743
ENSDART00000123619
rac2
Rac family small GTPase 2
chr15_+_36445350 19.88 ENSDART00000154552
si:dkey-262k9.2
si:dkey-262k9.2
chr7_+_49664174 19.83 ENSDART00000137059
ENSDART00000131210
rassf7b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr20_+_16881883 19.72 ENSDART00000130107
nfkbiaa
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr3_-_32965848 19.62 ENSDART00000050930
casp6
caspase 6, apoptosis-related cysteine peptidase
chr21_-_22720381 19.52 ENSDART00000130789
c1qc
complement component 1, q subcomponent, C chain
chr20_-_34127415 19.39 ENSDART00000010028
ptgs2b
prostaglandin-endoperoxide synthase 2b
chr24_-_27436319 18.71 ENSDART00000171489
si:dkey-25o1.7
si:dkey-25o1.7
chr5_-_25583125 18.66 ENSDART00000031665
ENSDART00000145353
anxa1a
annexin A1a
chr1_-_45347393 18.63 ENSDART00000173024
si:ch211-243a20.4
si:ch211-243a20.4
chr4_-_22310956 18.06 ENSDART00000162585
hcls1
hematopoietic cell-specific Lyn substrate 1
chr2_-_40199780 17.93 ENSDART00000113901
ccl34a.4
chemokine (C-C motif) ligand 34a, duplicate 4
chr15_+_46356879 17.88 ENSDART00000154388
wu:fb18f06
wu:fb18f06
chr5_-_25582721 17.86 ENSDART00000123986
anxa1a
annexin A1a
chr9_+_24088062 17.56 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr19_-_5669122 17.40 ENSDART00000112211
si:ch211-264f5.2
si:ch211-264f5.2
chr7_+_32901658 17.27 ENSDART00000115420
ano9b
anoctamin 9b
chr1_-_55942055 16.91 ENSDART00000142371
si:ch73-343l4.2
si:ch73-343l4.2
chr10_+_42358426 16.88 ENSDART00000025691
dbnla
drebrin-like a
chr7_-_50764714 16.88 ENSDART00000110283
iqgap1
IQ motif containing GTPase activating protein 1
chr2_-_6482240 16.69 ENSDART00000132623
rgs13
regulator of G protein signaling 13
chr17_-_43022468 16.57 ENSDART00000002945
NPC2 (1 of many)
zgc:193725
chr14_+_36886950 16.41 ENSDART00000183719
si:ch211-132p1.3
si:ch211-132p1.3
chr7_+_26545911 16.39 ENSDART00000135313
tnk1
tyrosine kinase, non-receptor, 1
chr1_-_29658721 16.25 ENSDART00000132063
si:dkey-1h24.6
si:dkey-1h24.6
chr9_+_21165017 16.13 ENSDART00000145933
ENSDART00000142985
si:rp71-68n21.9
si:rp71-68n21.9
chr14_-_40797117 16.05 ENSDART00000122369
elf1
E74-like ETS transcription factor 1
chr1_-_25177086 16.03 ENSDART00000144711
ENSDART00000177225
tmem154
transmembrane protein 154
chr21_+_30937690 15.84 ENSDART00000022562
rhogb
ras homolog family member Gb
chr10_-_7785930 15.81 ENSDART00000043961
ENSDART00000111058
mpx
myeloid-specific peroxidase
chr1_-_9228007 15.70 ENSDART00000147277
ENSDART00000135219
gng13a
guanine nucleotide binding protein (G protein), gamma 13a
chr8_-_2153147 15.40 ENSDART00000124093
si:dkeyp-117b11.1
si:dkeyp-117b11.1
chr10_+_35422802 15.21 ENSDART00000147303
hhla2a.1
HERV-H LTR-associating 2a, tandem duplicate 1
chr17_+_27456804 15.16 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
ctsl.1
cathepsin L.1
chr5_-_51166025 15.03 ENSDART00000097471
card9
caspase recruitment domain family, member 9
chr21_-_17956739 14.98 ENSDART00000148154
stx2a
syntaxin 2a
chr11_+_29975830 14.88 ENSDART00000148929
si:ch73-226l13.2
si:ch73-226l13.2
chr20_+_10498986 14.81 ENSDART00000064114
zgc:100997
zgc:100997
chr11_+_29965822 14.62 ENSDART00000127049
il1fma
interleukin-1 family member A
chr1_+_12394205 14.59 ENSDART00000138622
ENSDART00000136421
ENSDART00000139440
ENSDART00000184296
ENSDART00000008127
zgc:77739
zgc:77739
chr15_-_2652640 14.57 ENSDART00000146094
cldnf
claudin f
chr16_+_29514473 14.48 ENSDART00000034102
ctss2.2
cathepsin S, ortholog 2, tandem duplicate 2
chr24_+_264839 14.38 ENSDART00000066872
ccr12b.2
chemokine (C-C motif) receptor 12b, tandem duplicate 2
chr7_-_26049282 14.31 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr21_+_19347655 14.22 ENSDART00000093155
hpse
heparanase
chr8_-_29713595 14.18 ENSDART00000131988
ENSDART00000077637
mpeg1.1
macrophage expressed 1, tandem duplicate 1
chr4_-_5240128 13.98 ENSDART00000144048
ada2b
adenosine deaminase 2b
chr3_-_32603191 13.90 ENSDART00000150997
si:ch73-248e21.7
si:ch73-248e21.7
chr7_+_26545502 13.78 ENSDART00000140528
tnk1
tyrosine kinase, non-receptor, 1
chr2_-_13268556 13.76 ENSDART00000127693
ENSDART00000079757
vps4b
vacuolar protein sorting 4b homolog B (S. cerevisiae)
chr5_+_27421639 13.73 ENSDART00000146285
cyb561a3a
cytochrome b561 family, member A3a
chr1_-_16665044 13.70 ENSDART00000040434
asah1b
N-acylsphingosine amidohydrolase (acid ceramidase) 1b
chr5_-_61445697 13.70 ENSDART00000050898
ncf1
neutrophil cytosolic factor 1
chr18_+_13182528 13.68 ENSDART00000166298
zgc:56622
zgc:56622
chr16_-_41488023 13.63 ENSDART00000169312
cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr23_+_39089574 13.46 ENSDART00000164711
nfatc2a
nuclear factor of activated T cells 2a
chr22_-_15577060 13.37 ENSDART00000176291
hsh2d
hematopoietic SH2 domain containing
chr6_+_112579 13.32 ENSDART00000034505
ap1m2
adaptor-related protein complex 1, mu 2 subunit
chr16_+_38277339 13.27 ENSDART00000085143
bnipl
BCL2 interacting protein like
chr6_-_14010554 13.26 ENSDART00000004656
zgc:92027
zgc:92027
chr15_+_5086338 13.25 ENSDART00000155402
mxf
myxovirus (influenza virus) resistance F
chr17_+_33415319 13.17 ENSDART00000140805
ENSDART00000025501
ENSDART00000146447
snap23.1
synaptosomal-associated protein 23.1
chr8_-_50482781 13.12 ENSDART00000056361
ido1
indoleamine 2,3-dioxygenase 1
chr6_+_49095646 13.11 ENSDART00000103385
slc25a55a
solute carrier family 25, member 55a
chr22_+_5687615 13.07 ENSDART00000133241
ENSDART00000019854
ENSDART00000138102
dnase1l4.2
deoxyribonuclease 1 like 4, tandem duplicate 2
chr21_-_38853737 13.01 ENSDART00000184100
tlr22
toll-like receptor 22
chr9_-_28687484 12.95 ENSDART00000136537
si:ch73-7i4.3
si:ch73-7i4.3
chr4_-_18954001 12.90 ENSDART00000144814
si:dkey-31f5.8
si:dkey-31f5.8
chr5_+_22510639 12.87 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr10_-_15128771 12.86 ENSDART00000101261
spp1
secreted phosphoprotein 1
chr19_-_18626515 12.83 ENSDART00000160624
rps18
ribosomal protein S18
chr17_+_30843881 12.74 ENSDART00000149600
ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr16_+_31542645 12.69 ENSDART00000163724
SLA (1 of many)
Src like adaptor
chr10_+_13209580 12.66 ENSDART00000000887
ENSDART00000136932
rassf6
Ras association (RalGDS/AF-6) domain family 6
chr3_-_40528333 12.51 ENSDART00000193047
actb2
actin, beta 2
chr22_+_36719821 12.48 ENSDART00000149093
TRIM35 (1 of many)
si:ch1073-324l1.1
chr21_-_35534401 12.47 ENSDART00000112308
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr23_-_40766518 12.44 ENSDART00000127420
si:dkeyp-27c8.2
si:dkeyp-27c8.2
chr4_-_22311610 12.44 ENSDART00000137814
hcls1
hematopoietic cell-specific Lyn substrate 1
chr4_-_5239904 12.42 ENSDART00000190664
ada2b
adenosine deaminase 2b
chr19_+_348729 12.37 ENSDART00000114284
mcl1a
MCL1, BCL2 family apoptosis regulator a
chr19_-_3821678 12.35 ENSDART00000169639
si:dkey-206d17.12
si:dkey-206d17.12
chr3_+_32099507 12.28 ENSDART00000044238
zgc:92066
zgc:92066
chr13_-_36050303 12.20 ENSDART00000134955
ENSDART00000139087
lgmn
legumain
chr24_-_26479841 12.11 ENSDART00000079984
rpl22l1
ribosomal protein L22-like 1
chr19_-_40175800 12.11 ENSDART00000102904
illr4
immune-related, lectin-like receptor 4
chr20_-_35470891 12.08 ENSDART00000152993
ENSDART00000016090
pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_-_18209672 12.03 ENSDART00000141508
ENSDART00000136280
btr16
bloodthirsty-related gene family, member 16
chr19_+_4038589 12.03 ENSDART00000169271
btr23
bloodthirsty-related gene family, member 23
chr2_+_30281444 12.01 ENSDART00000172756
si:dkey-82k12.13
si:dkey-82k12.13
chr21_+_33454147 11.94 ENSDART00000053208
rps14
ribosomal protein S14
chr13_+_23623346 11.88 ENSDART00000057619
il22ra2
interleukin 22 receptor, alpha 2
chr21_+_28747069 11.87 ENSDART00000014058
zgc:100829
zgc:100829
chr1_-_8980665 11.73 ENSDART00000148182
si:ch73-191k20.3
si:ch73-191k20.3
chr17_+_33415542 11.55 ENSDART00000183169
snap23.1
synaptosomal-associated protein 23.1
chr18_+_36631923 11.49 ENSDART00000098980
znf296
zinc finger protein 296
chr17_-_27382826 11.31 ENSDART00000186657
ENSDART00000155986
ENSDART00000191060
ENSDART00000077608
si:ch1073-358c10.1
si:ch1073-358c10.1
chr14_+_10505464 11.29 ENSDART00000091224
p2ry10
P2Y receptor family member 10
chr12_+_10134366 11.27 ENSDART00000127343
smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr14_-_16810401 11.26 ENSDART00000158396
ENSDART00000170758
tcirg1b
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr5_+_24086227 11.19 ENSDART00000051549
ENSDART00000177458
ENSDART00000135934
tp53
tumor protein p53
chr3_-_16719244 11.17 ENSDART00000055859
pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr19_+_18758014 11.17 ENSDART00000158935
clic1
chloride intracellular channel 1
chr2_-_30182353 11.09 ENSDART00000019149
rpl7
ribosomal protein L7
chr10_+_24690534 11.08 ENSDART00000079549
tpte
transmembrane phosphatase with tensin homology
chr6_+_39290777 11.03 ENSDART00000155700
si:dkey-195m11.11
si:dkey-195m11.11
chr8_-_30242706 11.02 ENSDART00000139864
ENSDART00000143809
zgc:162939
zgc:162939
chr10_-_33557299 10.93 ENSDART00000099732
il2rga
interleukin 2 receptor, gamma a
chr20_+_18994059 10.85 ENSDART00000152380
tdh
L-threonine dehydrogenase
chr3_-_34561624 10.81 ENSDART00000129313
sept9a
septin 9a
chr14_-_706345 10.79 ENSDART00000166632
si:zfos-741a10.3
si:zfos-741a10.3
chr16_-_31756859 10.75 ENSDART00000149170
ENSDART00000126617
ENSDART00000182722
ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr5_+_66312359 10.64 ENSDART00000137534
malt1
MALT paracaspase 1
chr17_-_29213710 10.62 ENSDART00000076481
ehd4
EH-domain containing 4
chr16_-_46605160 10.56 ENSDART00000189070
ENSDART00000181194
tmem176l.3a
transmembrane protein 176l.3a
chr16_-_22303130 10.47 ENSDART00000142181
si:dkey-92i15.4
si:dkey-92i15.4
chr8_-_3312384 10.43 ENSDART00000035965
fut9b
fucosyltransferase 9b
chr5_-_23909934 10.43 ENSDART00000142516
si:ch211-135f11.1
si:ch211-135f11.1
chr16_+_21867161 10.33 ENSDART00000060424
zmp:0000000608
zmp:0000000608
chr13_-_12581388 10.29 ENSDART00000079655
enpep
glutamyl aminopeptidase
chr6_+_13506841 10.24 ENSDART00000032331
gmppab
GDP-mannose pyrophosphorylase Ab
chr15_-_14064302 10.21 ENSDART00000156384
BX927244.1

chr1_+_57787642 10.21 ENSDART00000127091
si:dkey-1c7.2
si:dkey-1c7.2
chr5_-_24029228 10.15 ENSDART00000051546
rps6ka3a
ribosomal protein S6 kinase a, polypeptide 3a
chr14_+_3038473 10.13 ENSDART00000026021
ENSDART00000150000
cd74a
CD74 molecule, major histocompatibility complex, class II invariant chain a
chr22_+_9806867 10.09 ENSDART00000137182
ENSDART00000106103
si:ch211-236g6.1
si:ch211-236g6.1
chr3_+_18579806 10.08 ENSDART00000180967
ENSDART00000089765
arhgap17b
Rho GTPase activating protein 17b
chr19_-_11431278 10.06 ENSDART00000109889
hsbp1l1
heat shock factor binding protein 1 like 1
chr2_-_51500957 9.99 ENSDART00000172481
pigrl3.5
polymeric immunoglobulin receptor-like 3.5
chr4_+_76745015 9.94 ENSDART00000155883
ms4a17a.10
membrane-spanning 4-domains, subfamily A, member 17A.10
chr4_+_76637548 9.93 ENSDART00000133799
ms4a17a.9
membrane-spanning 4-domains, subfamily A, member 17A.9
chr1_+_52735484 9.92 ENSDART00000182076
CABZ01021532.1

chr9_-_704667 9.92 ENSDART00000147092
cflarb
CASP8 and FADD-like apoptosis regulator b
chr19_-_18626952 9.90 ENSDART00000168004
ENSDART00000162034
ENSDART00000165486
ENSDART00000167971
rps18
ribosomal protein S18
chr5_+_50953240 9.86 ENSDART00000148501
ENSDART00000149892
ENSDART00000190312
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr14_-_16807206 9.83 ENSDART00000157957
tcirg1b
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr23_+_24989387 9.81 ENSDART00000172299
ENSDART00000145307
arhgap4a
Rho GTPase activating protein 4a
chr25_+_5068442 9.79 ENSDART00000097522
parvg
parvin, gamma
chr25_-_34280080 9.77 ENSDART00000085251
gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr21_-_7035599 9.71 ENSDART00000139777
si:ch211-93g21.1
si:ch211-93g21.1
chr1_+_57774454 9.63 ENSDART00000152507
si:dkey-1c7.2
si:dkey-1c7.2
chr18_+_14684115 9.63 ENSDART00000108469
spata2l
spermatogenesis associated 2-like
chr22_-_4769140 9.59 ENSDART00000165235
calr3a
calreticulin 3a
chr14_-_11529311 9.57 ENSDART00000127208
si:ch211-153b23.7
si:ch211-153b23.7
chr3_-_30941362 9.56 ENSDART00000076830
coro1a
coronin, actin binding protein, 1A
chr11_-_27953135 9.55 ENSDART00000168338
ece1
endothelin converting enzyme 1
chr18_+_18863167 9.45 ENSDART00000091094
pllp
plasmolipin
chr21_+_19844195 9.41 ENSDART00000065674
ENSDART00000157188
fybb
FYN binding protein b
chr16_-_41487589 9.37 ENSDART00000188115
cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr16_-_17586883 9.36 ENSDART00000017142
m6pr
mannose-6-phosphate receptor (cation dependent)
chr7_-_38659477 9.34 ENSDART00000138071
npsn
nephrosin
chr13_+_31716820 9.29 ENSDART00000034745
prkcha
protein kinase C, eta, a
chr23_-_29394505 9.25 ENSDART00000017728
pgd
phosphogluconate dehydrogenase
chr20_+_18994465 9.24 ENSDART00000152778
tdh
L-threonine dehydrogenase
chr4_-_25812329 9.23 ENSDART00000146658
tmcc3
transmembrane and coiled-coil domain family 3
chr25_+_13205878 9.18 ENSDART00000162319
ENSDART00000162283
si:ch211-147m6.2
si:ch211-147m6.2
chr2_+_36646451 9.11 ENSDART00000039174
klhl6
kelch-like family member 6
chr12_+_48815988 9.01 ENSDART00000149089
anxa11b
annexin A11b
chr20_+_2039518 8.98 ENSDART00000043157
CABZ01088134.1

chr16_-_46619967 8.91 ENSDART00000158341
tmem176l.3a
transmembrane protein 176l.3a
chr15_-_36533322 8.81 ENSDART00000156466
ENSDART00000121755
si:dkey-262k9.4
si:dkey-262k9.4
chr2_-_51507540 8.77 ENSDART00000166605
ENSDART00000161093
pigrl2.3
polymeric immunoglobulin receptor-like 2.3
chr16_-_17699111 8.76 ENSDART00000108581
si:dkey-17m8.1
si:dkey-17m8.1
chr23_+_20803270 8.74 ENSDART00000097381
zgc:154075
zgc:154075
chr6_+_52212927 8.69 ENSDART00000143458
ywhaba
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr19_+_40350468 8.68 ENSDART00000087444
hepacam2
HEPACAM family member 2
chr16_-_21888047 8.60 ENSDART00000162282
ENSDART00000124099
dicp3.3
diverse immunoglobulin domain-containing protein 3.3
chr5_-_68876211 8.56 ENSDART00000097254
sftpbb
surfactant protein Bb
chr7_+_19502744 8.54 ENSDART00000171258
ENSDART00000173691
si:ch211-212k18.9
si:ch211-212k18.9
chr19_-_31765615 8.51 ENSDART00000103636
si:dkeyp-120h9.1
si:dkeyp-120h9.1
chr3_+_43826018 8.51 ENSDART00000166197
ENSDART00000165145
litaf
lipopolysaccharide-induced TNF factor
chr9_+_21165484 8.50 ENSDART00000177286
si:rp71-68n21.9
si:rp71-68n21.9
chr5_-_26879302 8.47 ENSDART00000098571
ENSDART00000139086
zgc:64051
zgc:64051
chr8_+_45361775 8.45 ENSDART00000015193
chmp4bb
charged multivesicular body protein 4Bb
chr17_-_24587686 8.45 ENSDART00000143084
aftphb
aftiphilin b
chr11_+_34921492 8.42 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr21_+_28747236 8.40 ENSDART00000137874
zgc:100829
zgc:100829

Network of associatons between targets according to the STRING database.

First level regulatory network of spi2+spic

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.7 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
6.1 36.5 GO:2001279 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
5.6 33.7 GO:0006004 fucose metabolic process(GO:0006004)
5.3 26.4 GO:0046103 adenosine catabolic process(GO:0006154) inosine metabolic process(GO:0046102) inosine biosynthetic process(GO:0046103)
5.2 21.0 GO:0015840 urea transport(GO:0015840)
5.1 10.1 GO:0002828 regulation of type 2 immune response(GO:0002828)
4.8 19.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
4.6 13.9 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
4.6 13.7 GO:0097264 self proteolysis(GO:0097264)
4.0 19.9 GO:2000391 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
3.8 41.3 GO:0006032 chitin catabolic process(GO:0006032)
3.7 11.2 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
3.7 7.4 GO:2000108 positive regulation of leukocyte apoptotic process(GO:2000108)
3.4 13.7 GO:0045730 respiratory burst(GO:0045730)
3.4 16.9 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
3.3 23.1 GO:0042554 superoxide anion generation(GO:0042554)
3.1 12.4 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
3.0 12.2 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
2.9 11.5 GO:2000171 negative regulation of dendrite development(GO:2000171)
2.8 8.4 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
2.8 11.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
2.7 8.2 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
2.5 20.1 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
2.4 24.2 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
2.4 11.8 GO:2000561 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
2.3 7.0 GO:0019323 pentose catabolic process(GO:0019323)
2.1 10.6 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
2.0 10.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
2.0 12.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
2.0 11.7 GO:0006013 mannose metabolic process(GO:0006013)
1.9 7.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
1.9 5.7 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
1.8 20.1 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
1.8 5.3 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
1.7 5.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.7 8.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521) regulation of cellular amine metabolic process(GO:0033238)
1.7 34.0 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
1.6 13.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
1.6 4.9 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
1.5 21.1 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
1.5 5.8 GO:0010039 response to iron ion(GO:0010039)
1.4 15.7 GO:0050909 sensory perception of taste(GO:0050909)
1.3 5.3 GO:0048940 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
1.3 13.1 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
1.3 9.1 GO:0050853 B cell receptor signaling pathway(GO:0050853)
1.3 21.9 GO:0015693 magnesium ion transport(GO:0015693)
1.3 11.3 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
1.2 7.5 GO:0032367 intracellular cholesterol transport(GO:0032367)
1.2 51.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
1.2 8.6 GO:0060855 venous endothelial cell migration involved in lymph vessel development(GO:0060855)
1.2 15.8 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
1.2 4.7 GO:0052746 inositol phosphorylation(GO:0052746)
1.2 17.5 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
1.1 4.6 GO:0032534 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
1.1 10.1 GO:0034605 cellular response to heat(GO:0034605)
1.1 39.7 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
1.1 4.2 GO:0060043 regulation of cardiac muscle tissue growth(GO:0055021) regulation of cardiac muscle cell proliferation(GO:0060043)
1.1 29.4 GO:0016601 Rac protein signal transduction(GO:0016601)
1.0 6.9 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
1.0 18.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.9 3.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.9 9.2 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.9 4.5 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.9 2.7 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.9 31.8 GO:0042113 B cell activation(GO:0042113)
0.9 2.6 GO:0001779 natural killer cell differentiation(GO:0001779)
0.9 4.3 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.9 5.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.9 9.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.8 5.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.8 8.4 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.8 4.2 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.8 12.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.8 3.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.8 4.8 GO:0032218 riboflavin transport(GO:0032218)
0.8 7.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.8 4.7 GO:1990108 protein linear deubiquitination(GO:1990108)
0.8 13.1 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.8 19.6 GO:0032944 regulation of mononuclear cell proliferation(GO:0032944) regulation of T cell proliferation(GO:0042129) regulation of lymphocyte proliferation(GO:0050670) regulation of leukocyte proliferation(GO:0070663)
0.7 7.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.7 5.7 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.7 6.4 GO:0006167 AMP biosynthetic process(GO:0006167)
0.7 7.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.7 2.8 GO:0045475 locomotor rhythm(GO:0045475)
0.7 6.7 GO:0031125 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) rRNA 3'-end processing(GO:0031125)
0.7 6.6 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.7 10.5 GO:0050930 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.6 9.5 GO:0016486 peptide hormone processing(GO:0016486)
0.6 6.9 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.6 4.4 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.6 3.1 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.6 5.6 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.6 3.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.6 3.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.6 1.8 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.6 3.0 GO:0030329 prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.6 7.5 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.6 17.2 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.6 11.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.6 14.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.6 4.5 GO:0072422 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.6 55.9 GO:0006956 complement activation(GO:0006956)
0.6 5.1 GO:0042987 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.5 4.9 GO:0002688 regulation of leukocyte chemotaxis(GO:0002688)
0.5 2.2 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.5 3.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.5 29.2 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.5 2.7 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.5 2.1 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.5 6.3 GO:0070527 platelet aggregation(GO:0070527)
0.5 7.7 GO:0030041 actin filament polymerization(GO:0030041)
0.5 23.5 GO:0042742 defense response to bacterium(GO:0042742)
0.5 2.5 GO:0070189 kynurenine metabolic process(GO:0070189)
0.5 22.5 GO:0032456 endocytic recycling(GO:0032456)
0.5 6.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.5 2.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 2.0 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.5 3.9 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.5 7.3 GO:0035108 limb morphogenesis(GO:0035108)
0.5 2.9 GO:0060347 trabecula formation(GO:0060343) heart trabecula formation(GO:0060347)
0.5 13.8 GO:0042476 odontogenesis(GO:0042476)
0.5 8.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.5 21.4 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.5 2.3 GO:0044273 sulfur compound catabolic process(GO:0044273)
0.5 1.4 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.4 7.8 GO:0043114 regulation of vascular permeability(GO:0043114)
0.4 5.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 2.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.4 8.8 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.4 7.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.4 4.9 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.4 15.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.4 1.6 GO:0051660 establishment of centrosome localization(GO:0051660)
0.4 12.9 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.4 6.6 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.4 1.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.4 10.1 GO:0043588 skin development(GO:0043588)
0.4 1.5 GO:0046755 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.4 14.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.4 9.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 1.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.4 8.0 GO:0015701 bicarbonate transport(GO:0015701)
0.4 4.3 GO:0071222 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.4 25.4 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.4 30.7 GO:0060326 cell chemotaxis(GO:0060326)
0.4 10.3 GO:0043171 peptide catabolic process(GO:0043171)
0.4 5.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.3 9.0 GO:0032506 cytokinetic process(GO:0032506)
0.3 2.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.3 3.7 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.3 1.3 GO:0001818 negative regulation of cytokine production(GO:0001818)
0.3 1.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 5.2 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.3 125.6 GO:0006955 immune response(GO:0006955)
0.3 4.8 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.3 14.6 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.3 1.2 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.3 4.5 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.3 5.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.3 9.6 GO:0030098 lymphocyte differentiation(GO:0030098)
0.3 5.2 GO:0019935 cyclic-nucleotide-mediated signaling(GO:0019935)
0.3 0.9 GO:1903358 regulation of Golgi organization(GO:1903358)
0.3 0.8 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.3 4.0 GO:0032094 response to food(GO:0032094)
0.3 8.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.3 9.4 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.3 7.5 GO:0051923 sulfation(GO:0051923)
0.3 6.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 2.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.3 1.8 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.3 2.8 GO:0042572 retinol metabolic process(GO:0042572)
0.2 6.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 0.9 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.2 12.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 13.8 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.2 3.7 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.2 4.1 GO:0007032 endosome organization(GO:0007032)
0.2 0.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219) negative regulation of phospholipid metabolic process(GO:1903726)
0.2 50.8 GO:0032970 regulation of actin filament-based process(GO:0032970)
0.2 9.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.2 15.7 GO:0048565 digestive tract development(GO:0048565)
0.2 4.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.2 0.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.2 3.2 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 10.7 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.2 12.9 GO:0060348 bone development(GO:0060348)
0.2 1.7 GO:0006999 nuclear pore organization(GO:0006999)
0.2 2.8 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.2 10.5 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.2 5.7 GO:0030282 bone mineralization(GO:0030282)
0.2 1.0 GO:1902269 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.2 0.7 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.1 8.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 1.0 GO:0035909 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.1 0.8 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 2.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 1.1 GO:0010737 protein kinase A signaling(GO:0010737)
0.1 5.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 2.2 GO:0009749 response to glucose(GO:0009749)
0.1 2.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 24.3 GO:0042127 regulation of cell proliferation(GO:0042127)
0.1 0.1 GO:0090342 regulation of cell aging(GO:0090342)
0.1 7.6 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 4.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 24.3 GO:0060047 heart contraction(GO:0060047)
0.1 0.9 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 3.0 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 2.7 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 2.0 GO:0008272 sulfate transport(GO:0008272)
0.1 6.8 GO:0071560 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.1 0.9 GO:0071356 response to tumor necrosis factor(GO:0034612) cellular response to tumor necrosis factor(GO:0071356)
0.1 4.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 10.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 11.9 GO:0007626 locomotory behavior(GO:0007626)
0.1 0.4 GO:0061056 sclerotome development(GO:0061056)
0.1 4.3 GO:0010842 retina layer formation(GO:0010842)
0.1 39.6 GO:0006412 translation(GO:0006412)
0.1 1.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 11.8 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.1 0.3 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.1 0.9 GO:0042026 protein refolding(GO:0042026)
0.1 1.6 GO:1901215 negative regulation of neuron death(GO:1901215)
0.1 0.3 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.1 1.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 2.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.3 GO:1904589 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.1 2.3 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.1 2.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 2.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 2.7 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 6.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 7.6 GO:0042391 regulation of membrane potential(GO:0042391)
0.1 1.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 4.8 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 4.8 GO:0006821 chloride transport(GO:0006821)
0.0 2.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.4 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 1.1 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.0 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 1.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 9.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.6 GO:0009306 protein secretion(GO:0009306)
0.0 1.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 1.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.4 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.5 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.0 1.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 1.2 GO:1903706 regulation of hemopoiesis(GO:1903706)
0.0 2.0 GO:0006457 protein folding(GO:0006457)
0.0 1.5 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 1.1 GO:0003341 cilium movement(GO:0003341)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 23.1 GO:0043020 NADPH oxidase complex(GO:0043020)
2.5 12.5 GO:0097433 dense body(GO:0097433)
2.4 36.5 GO:0016328 lateral plasma membrane(GO:0016328)
2.2 11.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.2 15.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
2.1 8.5 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
2.1 21.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
1.5 4.6 GO:0016528 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
1.5 4.4 GO:0043614 multi-eIF complex(GO:0043614)
1.3 5.3 GO:0098842 postsynaptic early endosome(GO:0098842)
1.3 10.1 GO:0042613 MHC class II protein complex(GO:0042613)
1.2 16.9 GO:0002102 podosome(GO:0002102)
1.0 18.2 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
1.0 17.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.9 7.8 GO:0031526 brush border membrane(GO:0031526)
0.8 3.8 GO:1990923 PET complex(GO:1990923)
0.7 5.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.7 44.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 30.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.7 5.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 2.5 GO:0033186 CAF-1 complex(GO:0033186)
0.6 5.0 GO:0070552 BRISC complex(GO:0070552)
0.6 8.4 GO:0000815 ESCRT III complex(GO:0000815)
0.6 6.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.5 11.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.5 4.7 GO:0071797 LUBAC complex(GO:0071797)
0.5 38.8 GO:0015935 small ribosomal subunit(GO:0015935)
0.5 2.6 GO:0043198 dendritic shaft(GO:0043198)
0.5 49.5 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.5 3.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 5.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.5 131.9 GO:0005764 lysosome(GO:0005764)
0.5 6.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 5.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 40.9 GO:0031201 SNARE complex(GO:0031201)
0.4 2.5 GO:0070876 SOSS complex(GO:0070876)
0.4 107.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 56.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 1.5 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.3 2.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 7.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 10.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 2.9 GO:0000974 Prp19 complex(GO:0000974)
0.3 24.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789) nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.3 5.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 3.0 GO:0005903 brush border(GO:0005903)
0.3 11.4 GO:0031012 extracellular matrix(GO:0031012)
0.3 6.6 GO:0005685 U1 snRNP(GO:0005685)
0.3 0.9 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.3 2.0 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 5.3 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.2 0.9 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 1.2 GO:0070390 transcription export complex 2(GO:0070390)
0.2 12.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 0.6 GO:0097361 CIA complex(GO:0097361)
0.2 16.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 5.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 7.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 9.3 GO:0005811 lipid particle(GO:0005811)
0.2 2.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 1.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.2 10.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 0.7 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.2 18.5 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.2 6.5 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.2 2.1 GO:0017119 Golgi transport complex(GO:0017119)
0.2 197.9 GO:0005615 extracellular space(GO:0005615)
0.1 1.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 6.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 17.1 GO:0043296 apical junction complex(GO:0043296)
0.1 10.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.8 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 46.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 75.3 GO:0005576 extracellular region(GO:0005576)
0.1 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 5.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.5 GO:0031902 late endosome membrane(GO:0031902)
0.1 4.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 6.2 GO:0010008 endosome membrane(GO:0010008)
0.1 5.6 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.5 GO:0055037 recycling endosome(GO:0055037)
0.1 0.6 GO:0070652 HAUS complex(GO:0070652)
0.1 0.8 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.1 0.3 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 19.6 GO:0005730 nucleolus(GO:0005730)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 17.8 GO:0000785 chromatin(GO:0000785)
0.1 11.2 GO:0005938 cell cortex(GO:0005938)
0.1 4.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.9 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.9 GO:0005871 kinesin complex(GO:0005871)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:0000502 proteasome complex(GO:0000502)
0.0 6.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 25.7 GO:0005829 cytosol(GO:0005829)
0.0 1.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 113.4 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 25.6 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
6.1 36.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
6.0 23.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
4.8 19.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
4.4 13.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
4.0 20.1 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
3.8 41.3 GO:0004568 chitinase activity(GO:0004568)
3.4 13.7 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
2.9 8.6 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
2.7 13.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
2.7 8.1 GO:0042806 fucose binding(GO:0042806)
2.6 7.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
2.6 10.2 GO:0004475 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
2.5 12.5 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
2.1 10.6 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
2.1 10.5 GO:0042609 CD4 receptor binding(GO:0042609)
2.0 20.1 GO:0050700 CARD domain binding(GO:0050700)
2.0 44.1 GO:0042289 MHC class II protein binding(GO:0042289)
1.9 5.8 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
1.8 11.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
1.8 8.8 GO:0008432 JUN kinase binding(GO:0008432)
1.7 11.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.7 6.6 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
1.6 4.9 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
1.6 6.5 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
1.6 12.4 GO:0003993 acid phosphatase activity(GO:0003993)
1.5 13.7 GO:0016176 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.3 26.4 GO:0004000 adenosine deaminase activity(GO:0004000)
1.3 13.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
1.3 18.8 GO:0051117 ATPase binding(GO:0051117)
1.3 13.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
1.2 11.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
1.2 4.9 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.2 14.5 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
1.2 11.8 GO:0016936 galactoside binding(GO:0016936)
1.2 6.9 GO:0015616 DNA translocase activity(GO:0015616)
1.2 51.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.1 21.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
1.1 13.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
1.1 5.3 GO:0038132 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
1.0 11.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.9 7.6 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.9 3.6 GO:0044548 S100 protein binding(GO:0044548)
0.9 2.7 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.9 7.1 GO:0030619 U1 snRNA binding(GO:0030619)
0.9 9.4 GO:0005537 mannose binding(GO:0005537)
0.8 2.5 GO:0047804 cysteine-S-conjugate beta-lyase activity(GO:0047804)
0.8 2.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.8 5.7 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.8 4.0 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.8 7.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.8 4.8 GO:0032217 riboflavin transporter activity(GO:0032217)
0.8 3.9 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.8 10.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.8 33.0 GO:0019843 rRNA binding(GO:0019843)
0.8 9.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.7 11.7 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.7 2.2 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.7 2.9 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.7 4.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 12.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.7 4.6 GO:0004630 phospholipase D activity(GO:0004630)
0.6 7.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.6 6.9 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.6 9.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.6 44.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.6 5.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.6 3.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.6 3.1 GO:0046592 polyamine oxidase activity(GO:0046592)
0.6 15.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.6 8.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 1.8 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.6 3.0 GO:0001735 prenylcysteine oxidase activity(GO:0001735)
0.6 23.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.6 5.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.5 12.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 17.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.5 1.6 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.5 2.7 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.5 1.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.5 3.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.5 6.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.5 39.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5 3.8 GO:0034584 piRNA binding(GO:0034584)
0.5 4.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.5 11.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.5 9.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.5 4.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 5.0 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.4 24.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.4 66.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 5.2 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.4 5.1 GO:0008026 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.4 2.2 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.4 2.9 GO:0015154 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.4 10.0 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.4 28.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.4 7.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.3 21.3 GO:0031072 heat shock protein binding(GO:0031072)
0.3 2.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 9.3 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.3 32.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 7.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 4.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3 8.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.3 14.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 0.8 GO:0005502 11-cis retinal binding(GO:0005502)
0.3 18.2 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.3 3.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 2.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.3 1.3 GO:1902388 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.3 16.2 GO:0030276 clathrin binding(GO:0030276)
0.3 11.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 6.5 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.2 40.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 90.5 GO:0051015 actin filament binding(GO:0051015)
0.2 36.1 GO:0005125 cytokine activity(GO:0005125)
0.2 6.7 GO:0016208 AMP binding(GO:0016208)
0.2 6.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 2.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 25.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 5.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 48.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 18.1 GO:0005254 chloride channel activity(GO:0005254)
0.2 2.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 78.7 GO:0003924 GTPase activity(GO:0003924)
0.2 4.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.2 9.2 GO:0050661 NADP binding(GO:0050661)
0.2 1.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 38.1 GO:0005525 GTP binding(GO:0005525)
0.2 5.5 GO:0016209 antioxidant activity(GO:0016209)
0.2 1.0 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.2 8.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 7.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 1.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.2 0.7 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.2 4.0 GO:0034979 NAD-dependent protein deacetylase activity(GO:0034979)
0.2 6.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 2.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 2.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.2 4.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.2 1.2 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 2.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 11.1 GO:0003724 RNA helicase activity(GO:0003724)
0.1 2.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 7.1 GO:0005126 cytokine receptor binding(GO:0005126)
0.1 11.5 GO:0045296 cadherin binding(GO:0045296)
0.1 20.1 GO:0020037 heme binding(GO:0020037)
0.1 0.4 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 4.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 9.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 16.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 41.7 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 1.2 GO:0005158 insulin receptor binding(GO:0005158)
0.1 8.7 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 30.7 GO:0003779 actin binding(GO:0003779)
0.1 9.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 6.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 2.2 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.9 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 1.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 4.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.4 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 6.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 54.6 GO:0004888 transmembrane signaling receptor activity(GO:0004888)
0.0 9.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 1.6 GO:0004175 endopeptidase activity(GO:0004175)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 5.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 2.9 GO:0008083 growth factor activity(GO:0008083)
0.0 1.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 3.6 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 5.8 GO:0008134 transcription factor binding(GO:0008134)
0.0 2.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
1.1 28.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.9 15.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.9 12.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.9 7.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.8 25.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.8 22.6 PID IL3 PATHWAY IL3-mediated signaling events
0.8 37.3 PID RAC1 PATHWAY RAC1 signaling pathway
0.8 23.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.8 14.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.7 13.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.7 43.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.6 4.5 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.6 8.1 PID ALK2 PATHWAY ALK2 signaling events
0.5 17.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.5 4.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 8.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 14.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.4 7.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 9.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 2.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 3.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 23.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 7.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 4.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 6.9 PID PLK1 PATHWAY PLK1 signaling events
0.2 5.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 25.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 1.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 1.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 2.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 10.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.6 PID BCR 5PATHWAY BCR signaling pathway
0.1 3.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.8 PID E2F PATHWAY E2F transcription factor network
0.1 2.5 PID P73PATHWAY p73 transcription factor network
0.1 3.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 7.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling
0.0 4.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 49.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
2.8 25.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.8 19.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.3 19.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
1.2 8.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
1.2 13.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.1 11.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
1.0 18.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.0 12.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.0 13.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.9 11.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.9 11.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.9 16.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.9 16.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.8 3.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.8 15.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.7 2.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.7 4.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.7 10.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.7 79.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.6 7.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 15.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.6 14.5 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.6 5.8 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.5 13.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.5 11.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.5 10.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.5 9.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 8.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 3.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.4 5.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 2.6 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 5.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 12.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 2.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 4.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 1.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 7.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 8.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 4.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 6.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 12.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 6.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 2.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 0.8 REACTOME OPSINS Genes involved in Opsins
0.1 1.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.7 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 8.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 7.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 10.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 2.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 3.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.8 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 7.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 2.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 0.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 1.1 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 3.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 5.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions