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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for srebf2

Z-value: 0.63

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Transcription factors associated with srebf2

Gene Symbol Gene ID Gene Info
srebf2
ENSDARG00000063438 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srebf2dr11_v1_chr3_+_1107102_1107102-0.132.3e-01Click!

Activity profile of srebf2 motif

Sorted Z-values of srebf2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_21271373 7.57 ENSDART00000060001
pnp6
purine nucleoside phosphorylase 6
chr14_-_21618005 6.84 ENSDART00000043162
reep2
receptor accessory protein 2
chr17_-_48915427 5.31 ENSDART00000054781
lgals8b
galectin 8b
chr2_+_24203229 4.98 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr7_-_30082931 4.16 ENSDART00000075600
tspan3b
tetraspanin 3b
chr22_-_11614973 3.74 ENSDART00000063135
pcyt2
phosphate cytidylyltransferase 2, ethanolamine
chr10_-_31782616 3.52 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr24_-_3477103 3.42 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr3_-_61099004 3.41 ENSDART00000112043
cacng4b
calcium channel, voltage-dependent, gamma subunit 4b
chr4_-_20511595 3.23 ENSDART00000185806
rassf8b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr21_-_43550120 3.21 ENSDART00000151627
si:ch73-362m14.2
si:ch73-362m14.2
chr9_+_54417141 3.20 ENSDART00000056810
drd1b
dopamine receptor D1b
chr4_+_19535946 3.00 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
lrrc4.1
leucine rich repeat containing 4.1
chr22_-_13466246 2.86 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr16_+_41873708 2.75 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
scn1ba
sodium channel, voltage-gated, type I, beta a
chr8_+_52491436 2.59 ENSDART00000164298
si:ch1073-392o20.1
si:ch1073-392o20.1
chr1_+_9557212 2.53 ENSDART00000111131
elfn1b
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr6_-_34958274 2.52 ENSDART00000113097
hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr5_+_45976130 2.49 ENSDART00000175670
sv2c
synaptic vesicle glycoprotein 2C
chr14_-_33894915 2.35 ENSDART00000143290
urp1
urotensin-related peptide 1
chr23_-_18057270 2.32 ENSDART00000173385
zgc:92287
zgc:92287
chr5_-_12524996 2.26 ENSDART00000142258
si:ch73-263f13.1
si:ch73-263f13.1
chr20_-_27311675 2.25 ENSDART00000026088
ENSDART00000148361
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr17_-_7436766 2.21 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr19_-_25113660 2.19 ENSDART00000035538
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr3_+_26288981 2.04 ENSDART00000163500
rhot1a
ras homolog family member T1a
chr9_-_43082945 2.01 ENSDART00000142257
ccdc141
coiled-coil domain containing 141
chr16_-_29164379 1.96 ENSDART00000132589
mef2d
myocyte enhancer factor 2d
chr23_-_29878643 1.95 ENSDART00000058407
slc25a33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr7_+_22616212 1.81 ENSDART00000052844
cldn7a
claudin 7a
chr8_-_26961779 1.77 ENSDART00000099214
slc16a1b
solute carrier family 16 (monocarboxylate transporter), member 1b
chr12_-_23009312 1.72 ENSDART00000111801
mkxa
mohawk homeobox a
chr11_+_21587950 1.63 ENSDART00000162251
FAM72B
zgc:101564
chr17_-_33552363 1.54 ENSDART00000154400
tmem121aa
transmembrane protein 121Aa
chr1_+_41690402 1.52 ENSDART00000177298
fbxo41
F-box protein 41
chr13_+_4409294 1.49 ENSDART00000146437
si:ch211-130h14.4
si:ch211-130h14.4
chr3_-_48612078 1.38 ENSDART00000169923
ndel1b
nudE neurodevelopment protein 1-like 1b
chr7_-_41013575 1.37 ENSDART00000150139
insig1
insulin induced gene 1
chr12_+_33395748 1.33 ENSDART00000129458
fasn
fatty acid synthase
chr6_-_15639087 1.33 ENSDART00000128940
ENSDART00000183092
mlpha
melanophilin a
chr9_-_30363770 1.31 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr7_-_5640822 1.30 ENSDART00000143767
BX000524.1

chr4_+_41311345 1.26 ENSDART00000151905
si:dkey-16p19.8
si:dkey-16p19.8
chr13_+_30572172 1.25 ENSDART00000010052
ENSDART00000144417
ppifa
peptidylprolyl isomerase Fa
chr11_-_3334248 1.22 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr24_+_40860320 1.12 ENSDART00000161351
gorasp1b
golgi reassembly stacking protein 1b
chr5_-_37871526 1.12 ENSDART00000136450
arhgap35b
Rho GTPase activating protein 35b
chr5_+_37032038 1.07 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr10_-_35220285 1.02 ENSDART00000180439
ypel2a
yippee-like 2a
chr13_-_992458 1.02 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr17_+_15041647 0.96 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr14_-_29826659 0.93 ENSDART00000138413
sorbs2b
sorbin and SH3 domain containing 2b
chr18_+_39649825 0.92 ENSDART00000087960
gldn
gliomedin
chr14_-_30390145 0.89 ENSDART00000045423
slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr22_-_6959769 0.87 ENSDART00000105866
si:ch73-213k20.5
si:ch73-213k20.5
chr24_+_9590188 0.80 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr18_-_39188664 0.78 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr1_+_12178215 0.75 ENSDART00000090380
stra6l
STRA6-like
chr8_+_4745340 0.72 ENSDART00000182894
ufd1l
ubiquitin recognition factor in ER associated degradation 1
chr8_+_22916536 0.71 ENSDART00000136403
cacna1fb
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr5_-_15321451 0.67 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr4_-_54100377 0.66 ENSDART00000188064
si:dkey-199m13.7
si:dkey-199m13.7
chr12_+_2660733 0.65 ENSDART00000152235
irbpl
interphotoreceptor retinoid-binding protein like
chr7_+_25920792 0.64 ENSDART00000026295
arrb2b
arrestin, beta 2b
chr20_+_39223235 0.56 ENSDART00000132132
reps1
RALBP1 associated Eps domain containing 1
chr6_-_19351495 0.56 ENSDART00000164287
grb2a
growth factor receptor-bound protein 2a
chr2_-_48539673 0.55 ENSDART00000168202
CR391991.4

chr16_+_41874001 0.51 ENSDART00000161278
scn1ba
sodium channel, voltage-gated, type I, beta a
chr22_+_17286841 0.51 ENSDART00000133176
FAM163A
si:dkey-171o17.8
chr12_+_21684239 0.50 ENSDART00000043546
mrpl27
mitochondrial ribosomal protein L27
chr6_+_10094061 0.49 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr3_-_34296361 0.47 ENSDART00000181485
ENSDART00000113726
tnrc6c1
trinucleotide repeat containing 6C1
chr19_+_20785724 0.46 ENSDART00000038942
adnp2b
ADNP homeobox 2b
chr15_+_22333778 0.44 ENSDART00000114937
pde9al
phosphodiesterase 9A like
chr23_-_20258490 0.43 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr21_-_19006631 0.41 ENSDART00000080269
ENSDART00000191682
pgam2
phosphoglycerate mutase 2 (muscle)
chr10_-_5053589 0.40 ENSDART00000193579
tmem150c
transmembrane protein 150C
chr5_+_36513605 0.37 ENSDART00000013590
wnt11
wingless-type MMTV integration site family, member 11
chr4_+_48769555 0.37 ENSDART00000150725
znf1020
zinc finger protein 1020
chr18_+_14342326 0.36 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
si:dkey-246g23.2
chr1_-_55905967 0.35 ENSDART00000138446
si:ch73-343l4.6
si:ch73-343l4.6
chr14_-_46117345 0.32 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr13_-_33398735 0.25 ENSDART00000182601
ENSDART00000103628
btbd6a
BTB (POZ) domain containing 6a
chr24_-_28229618 0.24 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a
chr21_-_1742159 0.24 ENSDART00000151049
onecut2
one cut homeobox 2
chr23_-_27694960 0.22 ENSDART00000135129
IKZF4
si:dkey-166n8.9
chr9_-_19610436 0.21 ENSDART00000108697
fgf9
fibroblast growth factor 9
chr9_+_907459 0.21 ENSDART00000034850
ENSDART00000144114
dbi
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr10_-_31563049 0.19 ENSDART00000023575
robo3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr25_-_17367578 0.18 ENSDART00000064591
ENSDART00000110692
cyp2x6
cytochrome P450, family 2, subfamily X, polypeptide 6
chr20_-_7176809 0.16 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr2_+_34138376 0.13 ENSDART00000137170
dars2
aspartyl-tRNA synthetase 2, mitochondrial
chr19_-_10196370 0.13 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr2_+_10127762 0.10 ENSDART00000100726
insl5b
insulin-like 5b
chr25_-_34632050 0.07 ENSDART00000170671
megf8
multiple EGF-like-domains 8
chr25_+_3008263 0.06 ENSDART00000160484
neo1b
neogenin 1b
chr18_-_27628784 0.05 ENSDART00000180885
BX005470.1

chr3_-_51109286 0.03 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr1_-_20826023 0.02 ENSDART00000054472
tll1
tolloid-like 1
chr22_-_8931093 0.01 ENSDART00000181813
FO393424.3

Network of associatons between targets according to the STRING database.

First level regulatory network of srebf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.7 2.0 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.6 6.8 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.5 3.3 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.5 1.4 GO:2000638 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.5 3.2 GO:0042311 vasodilation(GO:0042311)
0.4 3.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.3 1.3 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 1.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 2.0 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.2 3.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 0.6 GO:1900120 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.2 2.0 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.2 0.8 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 0.9 GO:0097638 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.1 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.7 GO:0043029 T cell homeostasis(GO:0043029)
0.1 2.5 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 1.7 GO:0045445 myoblast differentiation(GO:0045445)
0.1 0.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 2.0 GO:0019226 transmission of nerve impulse(GO:0019226)
0.1 2.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.7 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.8 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 2.4 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 1.2 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 3.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0016203 muscle attachment(GO:0016203)
0.0 7.4 GO:0009116 nucleoside metabolic process(GO:0009116)
0.0 1.8 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.5 1.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 2.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 3.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 5.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.4 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 6.4 GO:0005874 microtubule(GO:0005874)
0.0 3.7 GO:0030424 axon(GO:0030424)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.8 7.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.7 2.0 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.5 3.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 3.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.3 2.2 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.2 1.4 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.6 GO:0031701 angiotensin receptor binding(GO:0031701)
0.1 1.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.9 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.4 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 1.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 4.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.0 GO:0030371 translation repressor activity(GO:0030371)
0.0 13.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.3 GO:0017022 myosin binding(GO:0017022)
0.0 0.6 GO:0019840 retinoid binding(GO:0005501) isoprenoid binding(GO:0019840)
0.0 5.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 2.5 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 6.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis