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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for srfa+srfb
Z-value: 2.99
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Transcription factors associated with srfa+srfb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| srfb | dr11_v1_chr13_-_51922290_51922290 | 0.64 | 6.3e-12 | Click! |
| srfa | dr11_v1_chr22_+_35089031_35089031 | -0.30 | 3.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_9980318 Show fit | 81.33 |
ENSDART00000080664
|
zgc:86709 |
|
| chr12_-_26064480 Show fit | 79.44 |
ENSDART00000158215
ENSDART00000171206 ENSDART00000171212 ENSDART00000182956 ENSDART00000186779 |
LIM domain binding 3b |
|
| chr12_-_26064105 Show fit | 71.08 |
ENSDART00000168825
|
LIM domain binding 3b |
|
| chr13_+_24279021 Show fit | 64.83 |
ENSDART00000058629
|
actin, alpha 1b, skeletal muscle |
|
| chr1_+_53945934 Show fit | 61.72 |
ENSDART00000052838
|
actin, alpha 1a, skeletal muscle |
|
| chr15_-_551177 Show fit | 54.42 |
ENSDART00000066774
ENSDART00000154617 |
transgelin |
|
| chr2_+_30916188 Show fit | 45.09 |
ENSDART00000137012
|
myomesin 1a (skelemin) |
|
| chr22_-_15602760 Show fit | 44.63 |
ENSDART00000009054
|
tropomyosin 4a |
|
| chr23_+_42813415 Show fit | 40.06 |
ENSDART00000055577
|
myosin, light chain 9a, regulatory |
|
| chr23_+_44611864 Show fit | 37.42 |
ENSDART00000145905
ENSDART00000132361 |
enolase 3, (beta, muscle) |
Network of associatons between targets according to the STRING database.
First level regulatory network of srfa+srfb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 175.4 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.4 | 137.5 | GO:0061061 | muscle structure development(GO:0061061) |
| 0.9 | 95.5 | GO:0048747 | muscle fiber development(GO:0048747) |
| 26.7 | 80.1 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 3.3 | 75.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 1.3 | 44.1 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
| 7.3 | 43.8 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 4.7 | 37.4 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
| 2.5 | 34.8 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 34.1 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 158.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 2.4 | 158.0 | GO:0005884 | actin filament(GO:0005884) |
| 9.1 | 144.9 | GO:0005869 | dynactin complex(GO:0005869) |
| 1.0 | 122.0 | GO:0016459 | myosin complex(GO:0016459) |
| 4.8 | 99.8 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 82.8 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.8 | 58.3 | GO:0030018 | Z disc(GO:0030018) |
| 6.3 | 44.1 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 4.7 | 37.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 6.8 | 34.2 | GO:0097433 | dense body(GO:0097433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 484.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 7.5 | 150.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.1 | 70.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 8.8 | 44.1 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763) |
| 0.1 | 38.3 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 4.7 | 37.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 2.5 | 34.8 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 34.3 | GO:0003779 | actin binding(GO:0003779) |
| 6.8 | 34.2 | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.3 | 34.1 | GO:0004896 | cytokine receptor activity(GO:0004896) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 71.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.4 | 31.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 24.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.8 | 17.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.7 | 16.6 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.4 | 10.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 7.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.7 | 7.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 7.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 5.5 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 63.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.9 | 43.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.8 | 37.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.8 | 34.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 2.0 | 10.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 1.0 | 7.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 7.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.2 | 6.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.9 | 5.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 1.1 | 5.5 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |