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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for srfa+srfb

Z-value: 2.99

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Transcription factors associated with srfa+srfb

Gene Symbol Gene ID Gene Info
srfa
ENSDARG00000053918 serum response factor a
srfb
ENSDARG00000102867 serum response factor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srfbdr11_v1_chr13_-_51922290_519222900.646.3e-12Click!
srfadr11_v1_chr22_+_35089031_35089031-0.303.1e-03Click!

Activity profile of srfa+srfb motif

Sorted Z-values of srfa+srfb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_9980318 81.33 ENSDART00000080664
ACTC1
zgc:86709
chr12_-_26064480 79.44 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
ldb3b
LIM domain binding 3b
chr12_-_26064105 71.08 ENSDART00000168825
ldb3b
LIM domain binding 3b
chr13_+_24279021 64.83 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr1_+_53945934 61.72 ENSDART00000052838
acta1a
actin, alpha 1a, skeletal muscle
chr15_-_551177 54.42 ENSDART00000066774
ENSDART00000154617
tagln
transgelin
chr2_+_30916188 45.09 ENSDART00000137012
myom1a
myomesin 1a (skelemin)
chr22_-_15602760 44.63 ENSDART00000009054
tpm4a
tropomyosin 4a
chr23_+_42813415 40.06 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr23_+_44611864 37.42 ENSDART00000145905
ENSDART00000132361
eno3
enolase 3, (beta, muscle)
chr7_-_71758613 35.57 ENSDART00000166724
myom1b
myomesin 1b
chr10_+_6318227 34.87 ENSDART00000170872
ENSDART00000162428
ENSDART00000158994
tpm2
tropomyosin 2 (beta)
chr8_-_11229523 33.81 ENSDART00000002164
unc45b
unc-45 myosin chaperone B
chr17_-_25326296 32.46 ENSDART00000168822
pabpc4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr13_+_33606739 32.14 ENSDART00000026464
cfl1l
cofilin 1 (non-muscle), like
chr14_+_49251331 31.88 ENSDART00000148882
anxa6
annexin A6
chr12_-_20373058 31.25 ENSDART00000066382
aqp8a.1
aquaporin 8a, tandem duplicate 1
chr8_+_40628926 31.19 ENSDART00000163598
dusp2
dual specificity phosphatase 2
chr22_-_15602593 30.88 ENSDART00000036075
tpm4a
tropomyosin 4a
chr20_+_40150612 30.82 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
trdn
triadin
chr20_+_53577502 30.09 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr21_+_25765734 29.95 ENSDART00000021664
cldnb
claudin b
chr2_+_15100742 28.80 ENSDART00000027171
f3b
coagulation factor IIIb
chr5_+_37087583 28.15 ENSDART00000049900
tagln2
transgelin 2
chr7_+_29952169 27.49 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr2_-_24269911 27.29 ENSDART00000099532
myh7
myosin heavy chain 7
chr19_+_46158078 26.67 ENSDART00000183933
ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr20_-_29420713 26.50 ENSDART00000147464
ryr3
ryanodine receptor 3
chr22_+_336256 24.68 ENSDART00000019155
btg2
B-cell translocation gene 2
chr6_+_1787160 24.29 ENSDART00000113505
myl9b
myosin, light chain 9b, regulatory
chr5_-_32292965 24.03 ENSDART00000183522
ENSDART00000131983
myhz1.2
myosin, heavy polypeptide 1.2, skeletal muscle
chr17_-_15611744 23.83 ENSDART00000010496
fhl5
four and a half LIM domains 5
chr5_-_32309129 23.48 ENSDART00000123003
myhz1.1
myosin, heavy polypeptide 1.1, skeletal muscle
chr19_+_348729 23.17 ENSDART00000114284
mcl1a
MCL1, BCL2 family apoptosis regulator a
chr1_+_9994811 23.02 ENSDART00000143719
ENSDART00000110749
si:dkeyp-75b4.10
si:dkeyp-75b4.10
chr14_+_34514336 22.01 ENSDART00000024440
foxi3b
forkhead box I3b
chr1_-_14332283 20.57 ENSDART00000090025
wfs1a
Wolfram syndrome 1a (wolframin)
chr13_+_29238850 19.46 ENSDART00000026000
myofl
myoferlin like
chr13_+_8840772 19.40 ENSDART00000059321
epcam
epithelial cell adhesion molecule
chr7_-_71758307 19.11 ENSDART00000161067
ENSDART00000165253
myom1b
myomesin 1b
chr12_+_17100021 18.39 ENSDART00000177923
acta2
actin, alpha 2, smooth muscle, aorta
chr9_+_6587056 17.80 ENSDART00000193421
fhl2a
four and a half LIM domains 2a
chr5_+_37785152 17.75 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr17_-_20118145 17.62 ENSDART00000149737
ENSDART00000165606
ryr2b
ryanodine receptor 2b (cardiac)
chr21_-_17603182 17.40 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr10_-_373575 17.19 ENSDART00000114487
DMPK
DM1 protein kinase
chr25_+_33192796 17.09 ENSDART00000125892
ENSDART00000121680
ENSDART00000014851
TPM1 (1 of many)
zgc:171719
chr1_+_1805294 17.07 ENSDART00000103850
atp1a1a.3
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr25_+_33192404 16.87 ENSDART00000193592
TPM1 (1 of many)
zgc:171719
chr9_+_6587364 16.67 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr2_-_24270062 16.47 ENSDART00000192445
myh7
myosin heavy chain 7
chr14_-_32824380 15.62 ENSDART00000172791
ENSDART00000105745
inppl1b
inositol polyphosphate phosphatase-like 1b
chr10_+_15603082 15.31 ENSDART00000024450
zfand5b
zinc finger, AN1-type domain 5b
chr18_+_36770166 14.64 ENSDART00000078151
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr1_-_8651718 14.47 ENSDART00000133319
actb1
actin, beta 1
chr1_-_8652648 14.07 ENSDART00000138324
ENSDART00000141407
ENSDART00000054987
actb1
actin, beta 1
chr3_-_22228602 13.85 ENSDART00000017750
myl4
myosin, light chain 4, alkali; atrial, embryonic
chr7_+_29951997 13.26 ENSDART00000173453
tpma
alpha-tropomyosin
chr3_+_58167288 13.23 ENSDART00000155874
ENSDART00000010395
uqcrc2a
ubiquinol-cytochrome c reductase core protein 2a
chr14_+_164556 12.72 ENSDART00000185606
WDR1
WD repeat domain 1
chr17_-_43666166 12.69 ENSDART00000077990
egr2a
early growth response 2a
chr18_-_41650648 12.60 ENSDART00000024087
fzd9b
frizzled class receptor 9b
chr6_-_45905746 12.15 ENSDART00000025428
epha2a
eph receptor A2 a
chr23_-_35064785 12.02 ENSDART00000172240
BX294434.1

chr22_-_17458070 11.60 ENSDART00000139658
si:ch211-197g15.10
si:ch211-197g15.10
chr20_-_14875308 11.32 ENSDART00000141290
dnm3a
dynamin 3a
chr20_-_46554440 11.07 ENSDART00000043298
ENSDART00000060680
fosab
v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
chr1_-_69444 10.58 ENSDART00000166954
si:zfos-1011f11.1
si:zfos-1011f11.1
chr18_+_36769758 10.38 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr6_+_41191482 10.08 ENSDART00000000877
opn1mw3
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr17_+_25849332 10.02 ENSDART00000191994
acss1
acyl-CoA synthetase short chain family member 1
chr13_+_23132666 9.90 ENSDART00000164639
sorbs1
sorbin and SH3 domain containing 1
chr14_-_30747686 9.04 ENSDART00000008373
fosl1a
FOS-like antigen 1a
chr2_-_24554416 8.96 ENSDART00000052061
cnn2
calponin 2
chr18_-_46258612 8.71 ENSDART00000153930
si:dkey-244a7.1
si:dkey-244a7.1
chr7_-_18168493 8.62 ENSDART00000127428
peli3
pellino E3 ubiquitin protein ligase family member 3
chr5_-_41845116 8.39 ENSDART00000112382
si:dkey-65b12.6
si:dkey-65b12.6
chr1_-_37383741 7.92 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
scpp1
secretory calcium-binding phosphoprotein 1
chr16_-_17347727 7.85 ENSDART00000144392
zyx
zyxin
chr10_-_7892192 7.77 ENSDART00000145480
smtna
smoothelin a
chr3_+_1211242 7.77 ENSDART00000171287
ENSDART00000165769
poldip3
polymerase (DNA-directed), delta interacting protein 3
chr3_+_32410746 7.69 ENSDART00000025496
rras
RAS related
chr20_-_31018569 7.60 ENSDART00000136039
fndc1
fibronectin type III domain containing 1
chr3_-_18410968 7.43 ENSDART00000041842
ndufb10
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10
chr19_+_43715911 7.37 ENSDART00000006344
cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr20_+_1996202 7.36 ENSDART00000184143
CABZ01092781.1

chr13_-_3155243 6.66 ENSDART00000139183
ENSDART00000050934
pkdcca
protein kinase domain containing, cytoplasmic a
chr7_-_53117131 6.52 ENSDART00000169211
ENSDART00000168890
ENSDART00000172179
ENSDART00000167882
cdh1
cadherin 1, type 1, E-cadherin (epithelial)
chr6_+_41200500 6.43 ENSDART00000000678
opn1mw4
opsin 1 (cone pigments), medium-wave-sensitive, 4
chr11_+_30647545 6.32 ENSDART00000114792
gb:eh507706
expressed sequence EH507706
chr20_+_46572550 6.16 ENSDART00000139051
ENSDART00000161320
batf
basic leucine zipper transcription factor, ATF-like
chr11_+_6115621 6.01 ENSDART00000165031
ENSDART00000027666
ENSDART00000161458
nr2f6b
nuclear receptor subfamily 2, group F, member 6b
chr13_-_9598320 5.94 ENSDART00000184613
cpxm1a
carboxypeptidase X (M14 family), member 1a
chr3_-_40529782 5.64 ENSDART00000055194
ENSDART00000141737
actb2
actin, beta 2
chr21_+_30043054 5.63 ENSDART00000065448
fabp6
fatty acid binding protein 6, ileal (gastrotropin)
chr18_+_35407921 5.59 ENSDART00000057733
zgc:153119
zgc:153119
chr13_-_40398556 5.55 ENSDART00000191921
nkx3.3
NK3 homeobox 3
chr4_-_16644708 5.51 ENSDART00000042307
sinhcaf
SIN3-HDAC complex associated factor
chr16_-_31754102 5.48 ENSDART00000185043
ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr21_-_31286428 5.45 ENSDART00000185334
ca4c
carbonic anhydrase IV c
chr7_-_66868543 5.42 ENSDART00000149680
ampd3a
adenosine monophosphate deaminase 3a
chr16_+_28383758 5.36 ENSDART00000059038
ENSDART00000141061
itga8
integrin, alpha 8
chr9_-_44948488 5.33 ENSDART00000059228
vil1
villin 1
chr24_+_31277360 5.32 ENSDART00000165993
f3a
coagulation factor IIIa
chr19_-_20403845 5.23 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
dazl
deleted in azoospermia-like
chr23_+_19655301 5.14 ENSDART00000104441
ENSDART00000135269
abhd6b
abhydrolase domain containing 6b
chr21_+_8533533 5.11 ENSDART00000077924
FO834888.1

chr8_+_26059677 5.10 ENSDART00000009178
impdh2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr14_+_17137023 4.93 ENSDART00000080712
slc43a3b
solute carrier family 43, member 3b
chr12_-_20120702 4.85 ENSDART00000153387
ENSDART00000158412
ENSDART00000112768
ubald1a
UBA-like domain containing 1a
chr21_+_21811867 4.80 ENSDART00000185752
neu3.4
sialidase 3 (membrane sialidase), tandem duplicate 4
chr10_+_8101729 4.79 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr13_-_25303303 4.76 ENSDART00000133153
plaua
plasminogen activator, urokinase a
chr25_+_19680962 4.63 ENSDART00000167260
si:dkeyp-110c12.3
si:dkeyp-110c12.3
chr16_-_30421275 4.56 ENSDART00000003752
cct3
chaperonin containing TCP1, subunit 3 (gamma)
chr10_-_15910974 4.42 ENSDART00000148169
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr7_+_24522308 4.32 ENSDART00000173542
btr09
bloodthirsty-related gene family, member 9
chr7_+_5494565 4.29 ENSDART00000135271
MYADM
si:dkeyp-67a8.2
chr3_+_1724941 4.03 ENSDART00000193402
BX321875.2

chr23_+_24272421 3.92 ENSDART00000029974
clcnk
chloride channel K
chr5_+_9428876 3.80 ENSDART00000081791
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr4_-_49133107 3.78 ENSDART00000150806
znf1146
zinc finger protein 1146
chr2_+_24376373 3.70 ENSDART00000135323
nr2f6a
nuclear receptor subfamily 2, group F, member 6a
chr22_-_29922872 3.66 ENSDART00000020249
dusp5
dual specificity phosphatase 5
chr12_-_35054354 3.59 ENSDART00000075351
zgc:112285
zgc:112285
chr10_+_42169982 3.47 ENSDART00000190905
CU467905.1

chr13_-_28688104 3.46 ENSDART00000133827
pcgf6
polycomb group ring finger 6
chr21_+_42717424 3.39 ENSDART00000166936
ENSDART00000172135
sh3pxd2b
SH3 and PX domains 2B
chr1_+_45754868 3.37 ENSDART00000084512
pkn1a
protein kinase N1a
chr22_-_3275888 3.36 ENSDART00000164743
si:zfos-943e10.1
si:zfos-943e10.1
chr11_+_25459697 3.28 ENSDART00000161481
opn1sw2
opsin 1 (cone pigments), short-wave-sensitive 2
chr6_+_58915889 3.26 ENSDART00000083628
ddit3
DNA-damage-inducible transcript 3
chr2_-_37477654 3.20 ENSDART00000193921
dapk3
death-associated protein kinase 3
chr19_-_42424599 3.13 ENSDART00000077042
zgc:153441
zgc:153441
chr4_+_28997595 3.07 ENSDART00000133357
si:dkey-13e3.1
si:dkey-13e3.1
chr22_+_9206514 3.05 ENSDART00000141625
si:ch211-156p11.1
si:ch211-156p11.1
chr14_+_743346 3.04 ENSDART00000110511
klb
klotho beta
chr20_+_35279968 2.97 ENSDART00000168216
ENSDART00000153332
fam49a
family with sequence similarity 49, member A
chr5_-_71765780 2.70 ENSDART00000011955
gpsm1b
G protein signaling modulator 1b
chr20_+_6590220 2.60 ENSDART00000136567
tns3.2
tensin 3, tandem duplicate 2
chr15_+_2534740 2.52 ENSDART00000138469
cux1b
cut-like homeobox 1b
chr3_+_28594713 2.52 ENSDART00000179799
sept12
septin 12
chr4_+_28998230 2.50 ENSDART00000183828
si:dkey-13e3.1
si:dkey-13e3.1
chr3_+_32553714 2.42 ENSDART00000165638
pax10
paired box 10
chr23_+_28378543 2.41 ENSDART00000145327
zgc:153867
zgc:153867
chr22_-_382955 2.38 ENSDART00000082406
ora3
olfactory receptor class A related 3
chr14_-_10492072 2.37 ENSDART00000182525
lpar4
lysophosphatidic acid receptor 4
chr10_-_690072 2.35 ENSDART00000164871
ENSDART00000142833
glis3
GLIS family zinc finger 3
chr13_+_9496748 2.28 ENSDART00000147050
ENSDART00000102120
CR848040.4

chr1_+_50976975 2.18 ENSDART00000022290
ENSDART00000140982
mdh1aa
malate dehydrogenase 1Aa, NAD (soluble)
chr2_+_31804582 2.11 ENSDART00000086646
rnf182
ring finger protein 182
chr2_+_47718605 2.10 ENSDART00000189180
ENSDART00000148824
mbnl1
muscleblind-like splicing regulator 1
chr4_-_22310956 2.09 ENSDART00000162585
hcls1
hematopoietic cell-specific Lyn substrate 1
chr24_-_20192996 2.07 ENSDART00000011143
myd88
myeloid differentiation primary response 88
chr11_+_6281647 2.03 ENSDART00000002459
ctns
cystinosin, lysosomal cystine transporter
chr21_+_4313039 1.91 ENSDART00000141146
HTRA2 (1 of many)
si:dkey-84o3.4
chr18_+_45504362 1.88 ENSDART00000140089
cngb1a
cyclic nucleotide gated channel beta 1a
chr4_+_33461796 1.85 ENSDART00000150445
si:dkey-247i3.1
si:dkey-247i3.1
chr13_-_50341004 1.74 ENSDART00000038120
cacul1
CDK2 associated cullin domain 1
chr21_+_6114709 1.73 ENSDART00000065858
fpgs
folylpolyglutamate synthase
chr16_-_12496632 1.71 ENSDART00000019941
slc2a3b
solute carrier family 2 (facilitated glucose transporter), member 3b
chr8_+_26268726 1.69 ENSDART00000180883
slc26a6
solute carrier family 26, member 6
chr3_-_33395233 1.66 ENSDART00000167349
si:dkey-283b1.6
si:dkey-283b1.6
chr7_-_28549361 1.59 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr21_+_30721733 1.51 ENSDART00000040443
zgc:110224
zgc:110224
chr13_-_9091354 1.45 ENSDART00000140319
ENSDART00000142697
HTRA2 (1 of many)
si:dkey-112g5.13
chr16_-_24832038 1.44 ENSDART00000153731
si:dkey-79d12.5
si:dkey-79d12.5
chr24_-_7728409 1.44 ENSDART00000131392
ptprh
protein tyrosine phosphatase, receptor type, h
chr13_-_9070754 1.38 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
si:dkey-112g5.12
chr4_+_12612723 1.32 ENSDART00000133767
lmo3
LIM domain only 3
chr13_-_377256 1.31 ENSDART00000137398
ch1073-291c23.1
ch1073-291c23.1
chr13_-_9045879 1.31 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
si:dkey-112g5.11
chr8_+_25902170 1.31 ENSDART00000193130
rhoab
ras homolog gene family, member Ab
chr21_+_4388489 1.25 ENSDART00000144555
HTRA2 (1 of many)
si:dkey-84o3.3
chr14_-_25309058 1.24 ENSDART00000159569
htr4
5-hydroxytryptamine receptor 4
chr15_-_39945036 1.23 ENSDART00000192481
msh5
mutS homolog 5
chr1_+_44173245 1.23 ENSDART00000159450
ENSDART00000106048
ENSDART00000157763
ctnnd1
catenin (cadherin-associated protein), delta 1
chr4_-_49582758 1.19 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
si:dkey-159n16.2
chr20_+_20186706 1.17 ENSDART00000002507
rhoj
ras homolog family member J
chr13_+_9468535 1.15 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr3_+_54761569 1.14 ENSDART00000135913
ENSDART00000180983
si:ch211-74m13.1
si:ch211-74m13.1
chr3_+_3046909 1.09 ENSDART00000122435
BX004816.2

chr1_+_44173506 1.00 ENSDART00000170512
ctnnd1
catenin (cadherin-associated protein), delta 1
chr1_+_53714734 1.00 ENSDART00000114689
pus10
pseudouridylate synthase 10
chr21_-_25555355 0.99 ENSDART00000144228
si:dkey-17e16.9
si:dkey-17e16.9
chr8_+_8937723 0.94 ENSDART00000145970
si:dkey-83k24.5
si:dkey-83k24.5
chr13_-_9111927 0.93 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-19p15.4
si:dkey-112g5.12
chr13_-_9284407 0.92 ENSDART00000164798
ENSDART00000131956
ENSDART00000140150
HTRA2 (1 of many)
si:dkey-33c12.14
chr17_+_18031304 0.90 ENSDART00000127259
setd3
SET domain containing 3
chr25_-_893464 0.82 ENSDART00000159321
znf609a
zinc finger protein 609a
chr10_-_32920690 0.67 ENSDART00000136245
cux1a
cut-like homeobox 1a
chr18_+_50669456 0.67 ENSDART00000163005
si:dkey-151j17.4
si:dkey-151j17.4
chr13_+_9521629 0.67 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
si:dkey-19p15.4
chr3_-_40945710 0.66 ENSDART00000138719
ENSDART00000102416
cyp3c4
cytochrome P450, family 3, subfamily C, polypeptide 4
chr1_+_8492379 0.61 ENSDART00000184518
myo15ab
myosin XVAb
chr25_+_17860798 0.47 ENSDART00000146845
pth1a
parathyroid hormone 1a
chr7_+_71764883 0.43 ENSDART00000166865
myl12.1
myosin, light chain 12, genome duplicate 1
chr19_-_20403507 0.40 ENSDART00000052603
ENSDART00000137590
dazl
deleted in azoospermia-like
chr20_-_2949028 0.34 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cdk19
cyclin-dependent kinase 19
chr1_+_57331813 0.33 ENSDART00000152440
ENSDART00000062841
epn3b
epsin 3b

Network of associatons between targets according to the STRING database.

First level regulatory network of srfa+srfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
26.7 80.1 GO:0090131 mesenchyme migration(GO:0090131)
10.7 32.1 GO:0030043 actin filament fragmentation(GO:0030043)
8.0 31.9 GO:0003413 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
7.3 43.8 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
6.0 30.1 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
5.5 22.0 GO:0009957 epidermal cell fate specification(GO:0009957)
4.7 37.4 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
3.3 75.5 GO:0055003 cardiac myofibril assembly(GO:0055003)
2.5 34.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
2.1 6.2 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
1.7 8.6 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
1.7 10.0 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
1.5 23.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
1.3 5.3 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
1.3 34.0 GO:0019933 cAMP-mediated signaling(GO:0019933)
1.3 44.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
1.1 6.5 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
1.0 2.1 GO:0008063 Toll signaling pathway(GO:0008063)
1.0 175.4 GO:0006936 muscle contraction(GO:0006936)
0.9 5.6 GO:0060149 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.9 17.1 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.9 19.5 GO:0007520 myoblast fusion(GO:0007520)
0.9 95.5 GO:0048747 muscle fiber development(GO:0048747)
0.9 11.1 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.8 3.3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.7 17.4 GO:0051014 actin filament severing(GO:0051014)
0.7 7.7 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.7 18.9 GO:0001757 somite specification(GO:0001757)
0.6 11.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.6 29.9 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.6 3.4 GO:0071800 podosome assembly(GO:0071800)
0.5 5.1 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.5 5.4 GO:0032264 IMP salvage(GO:0032264)
0.5 4.8 GO:0031639 plasminogen activation(GO:0031639)
0.5 20.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.4 2.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.4 1.7 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.4 137.5 GO:0061061 muscle structure development(GO:0061061)
0.4 19.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.4 4.8 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.4 14.0 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.4 18.4 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.3 9.0 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.3 1.5 GO:0000012 single strand break repair(GO:0000012)
0.3 1.7 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.2 12.6 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.2 3.5 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 3.0 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.2 2.0 GO:0070293 renal absorption(GO:0070293)
0.2 26.1 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.2 1.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 1.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 1.0 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.2 34.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.2 13.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 5.5 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 3.9 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 4.6 GO:2000027 regulation of organ morphogenesis(GO:2000027)
0.1 1.2 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 1.2 GO:0032098 regulation of appetite(GO:0032098)
0.1 5.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 3.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.3 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 1.0 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 2.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.9 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 2.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 11.1 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 2.5 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.1 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.0 21.4 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.0 2.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 5.5 GO:0045087 innate immune response(GO:0045087)
0.0 3.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.9 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 144.9 GO:0005869 dynactin complex(GO:0005869)
6.8 34.2 GO:0097433 dense body(GO:0097433)
6.3 44.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
4.8 99.8 GO:0031430 M band(GO:0031430)
4.7 37.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
4.4 17.8 GO:0060171 stereocilium membrane(GO:0060171)
3.4 33.8 GO:0031672 A band(GO:0031672)
3.4 158.3 GO:0031941 filamentous actin(GO:0031941)
2.4 158.0 GO:0005884 actin filament(GO:0005884)
1.9 30.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
1.1 5.3 GO:0032433 filopodium tip(GO:0032433)
1.0 122.0 GO:0016459 myosin complex(GO:0016459)
1.0 32.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.8 31.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.8 58.3 GO:0030018 Z disc(GO:0030018)
0.6 11.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.5 5.5 GO:0016580 Sin3 complex(GO:0016580)
0.4 19.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.4 4.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 6.5 GO:0005902 microvillus(GO:0005902)
0.4 15.6 GO:0030175 filopodium(GO:0030175)
0.3 82.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.2 29.9 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2 23.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 19.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 7.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 20.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.5 GO:0035102 PRC1 complex(GO:0035102)
0.1 5.4 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 17.7 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 2.5 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 1.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 14.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 12.2 GO:0043235 receptor complex(GO:0043235)
0.0 8.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 34.0 GO:0008179 adenylate cyclase binding(GO:0008179)
8.8 44.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
7.5 150.5 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
6.8 34.2 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
4.7 37.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
3.5 31.2 GO:0015250 water channel activity(GO:0015250)
2.5 34.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
2.3 32.5 GO:0008266 poly(U) RNA binding(GO:0008266)
2.3 33.8 GO:0051879 Hsp90 protein binding(GO:0051879)
1.7 17.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.7 10.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
1.3 484.3 GO:0051015 actin filament binding(GO:0051015)
0.9 5.6 GO:0032052 bile acid binding(GO:0032052)
0.8 5.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 12.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 12.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.7 2.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 5.6 GO:0008494 translation activator activity(GO:0008494)
0.5 6.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.5 5.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 4.8 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.4 2.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 19.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.4 3.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 34.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 15.6 GO:0017124 SH3 domain binding(GO:0017124)
0.3 3.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 5.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 3.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 7.7 GO:0019003 GDP binding(GO:0019003)
0.2 5.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 2.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.9 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 18.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 3.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 34.3 GO:0003779 actin binding(GO:0003779)
0.1 1.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 38.3 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.1 6.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 70.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 3.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 2.1 GO:0045296 cadherin binding(GO:0045296)
0.1 4.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 29.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.9 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 6.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 11.3 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 1.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 5.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 2.5 GO:0060090 binding, bridging(GO:0060090)
0.0 2.4 GO:0008134 transcription factor binding(GO:0008134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 17.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.7 71.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.7 7.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.7 16.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.6 5.5 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.4 31.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 10.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 5.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 24.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 7.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 2.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.0 PID FGF PATHWAY FGF signaling pathway
0.1 4.5 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 7.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 63.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
2.2 6.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
2.0 10.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.9 43.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.8 37.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.1 5.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
1.0 7.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.9 5.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.8 34.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 5.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 3.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3 2.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.3 4.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.3 3.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 4.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 2.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 3.0 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 7.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases