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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for stat1a+stat2-1_stat1b
Z-value: 1.55
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Transcription factors associated with stat1a+stat2-1_stat1b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000006266 | signal transducer and activator of transcription 1a | |
| ENSDARG00000031647 | signal transducer and activator of transcription 2 | |
| ENSDARG00000076182 | signal transducer and activator of transcription 1b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| stat1b | dr11_v1_chr9_+_41224100_41224100 | 0.59 | 3.0e-10 | Click! |
| stat2 | dr11_v1_chr6_-_39158953_39158953 | 0.31 | 2.4e-03 | Click! |
| stat1a | dr11_v1_chr22_+_12798569_12798569 | 0.06 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of stat1a+stat2-1_stat1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.4 | GO:0072376 | protein activation cascade(GO:0072376) |
| 4.0 | 27.8 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 9.2 | 27.5 | GO:0009595 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
| 1.9 | 22.5 | GO:0050688 | regulation of defense response to virus(GO:0050688) |
| 0.4 | 21.3 | GO:0017144 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.1 | 21.0 | GO:0009116 | nucleoside metabolic process(GO:0009116) |
| 0.0 | 19.9 | GO:0042981 | regulation of apoptotic process(GO:0042981) |
| 6.0 | 18.1 | GO:0002468 | dendritic cell antigen processing and presentation(GO:0002468) |
| 6.0 | 17.9 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.3 | 17.6 | GO:1990266 | neutrophil migration(GO:1990266) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 44.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.4 | 24.1 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.2 | 23.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 16.6 | GO:0000785 | chromatin(GO:0000785) |
| 2.0 | 15.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.8 | 15.5 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
| 0.2 | 15.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.8 | 11.6 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 11.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 73.9 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.5 | 54.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.3 | 44.4 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.2 | 27.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 9.2 | 27.5 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 2.6 | 23.6 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.3 | 21.3 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.1 | 18.1 | GO:0020037 | heme binding(GO:0020037) |
| 0.2 | 17.8 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.4 | 17.2 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.0 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 3.2 | 16.0 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.4 | 14.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.8 | 11.4 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.7 | 11.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 9.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 7.7 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.3 | 7.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.3 | 7.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.6 | 7.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 33.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.2 | 19.7 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 1.4 | 17.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 15.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.0 | 11.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.5 | 11.4 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.5 | 11.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 11.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 10.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 7.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |