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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for stat3

Z-value: 1.05

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Transcription factors associated with stat3

Gene Symbol Gene ID Gene Info
stat3
ENSDARG00000022712 signal transducer and activator of transcription 3 (acute-phase response factor)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
stat3dr11_v1_chr3_+_17030665_170307040.406.1e-05Click!

Activity profile of stat3 motif

Sorted Z-values of stat3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_10175898 10.61 ENSDART00000146185
krt5
keratin 5
chr24_-_33291784 9.90 ENSDART00000124938
si:ch1073-406l10.2
si:ch1073-406l10.2
chr6_+_41503854 9.55 ENSDART00000136538
ENSDART00000140108
ENSDART00000084861
cish
cytokine inducible SH2-containing protein
chr5_+_26213874 9.08 ENSDART00000193816
ENSDART00000098514
oclnb
occludin b
chr21_-_27338639 9.00 ENSDART00000130632
hif1al2
hypoxia-inducible factor 1, alpha subunit, like 2
chr19_+_10937932 8.87 ENSDART00000168968
si:ch73-347e22.8
si:ch73-347e22.8
chr9_-_9282519 8.43 ENSDART00000146821
si:ch211-214p13.3
si:ch211-214p13.3
chr12_+_17042754 8.16 ENSDART00000066439
ch25h
cholesterol 25-hydroxylase
chr1_-_51734524 8.10 ENSDART00000109640
ENSDART00000122628
junba
JunB proto-oncogene, AP-1 transcription factor subunit a
chr3_-_57425961 7.61 ENSDART00000033716
socs3a
suppressor of cytokine signaling 3a
chr14_-_30747686 7.39 ENSDART00000008373
fosl1a
FOS-like antigen 1a
chr11_-_6265574 7.33 ENSDART00000181974
ENSDART00000104405
ccl25b
chemokine (C-C motif) ligand 25b
chr21_+_45626136 7.26 ENSDART00000158742
irf1b
interferon regulatory factor 1b
chr21_+_43328685 7.12 ENSDART00000109620
ENSDART00000139668
sept8a
septin 8a
chr17_-_10838434 7.00 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr21_-_35419486 6.94 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr3_-_44059902 6.90 ENSDART00000158485
ENSDART00000159088
ENSDART00000165628
il4r.1
interleukin 4 receptor, tandem duplicate 1
chr25_-_21822426 6.56 ENSDART00000151993
zgc:158222
zgc:158222
chr22_+_22004082 6.52 ENSDART00000148375
gna15.2
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2
chr14_+_11457500 6.27 ENSDART00000169202
si:ch211-153b23.5
si:ch211-153b23.5
chr6_+_41099787 6.15 ENSDART00000186884
fkbp5
FK506 binding protein 5
chr3_-_39488482 6.10 ENSDART00000135192
zgc:100868
zgc:100868
chr3_-_4253214 5.93 ENSDART00000155807
si:dkey-175d9.2
si:dkey-175d9.2
chr3_+_26813058 5.86 ENSDART00000055537
socs1a
suppressor of cytokine signaling 1a
chr5_+_28271412 5.56 ENSDART00000031727
vamp8
vesicle-associated membrane protein 8 (endobrevin)
chr7_+_26167420 5.39 ENSDART00000173941
si:ch211-196f2.6
si:ch211-196f2.6
chr11_-_17964525 5.25 ENSDART00000018948
cishb
cytokine inducible SH2-containing protein b
chr16_-_38001040 5.17 ENSDART00000133861
ENSDART00000138711
ENSDART00000143846
ENSDART00000146564
si:ch211-198c19.3
si:ch211-198c19.3
chr14_+_11395383 5.04 ENSDART00000106657
glod5
glyoxalase domain containing 5
chr19_+_43359075 4.96 ENSDART00000148287
ENSDART00000149856
ENSDART00000188236
ENSDART00000136695
ENSDART00000193859
yrk
Yes-related kinase
chr5_-_12587053 4.93 ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr20_-_19858936 4.85 ENSDART00000161579
ptk2bb
protein tyrosine kinase 2 beta, b
chr6_-_34220641 4.75 ENSDART00000102391
dmrt2b
doublesex and mab-3 related transcription factor 2b
chr4_+_73215536 4.70 ENSDART00000174290
LO018260.2
Danio rerio protein NLRC3-like (LOC101883187), mRNA.
chr23_-_5101847 4.70 ENSDART00000122240
etv7
ets variant 7
chr16_-_22930925 4.60 ENSDART00000133819
si:dkey-246i14.3
si:dkey-246i14.3
chr17_+_16046314 4.52 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr10_+_13209580 4.48 ENSDART00000000887
ENSDART00000136932
rassf6
Ras association (RalGDS/AF-6) domain family 6
chr4_+_7391400 4.42 ENSDART00000169111
ENSDART00000186395
tnni4a
troponin I4a
chr4_+_10616626 4.42 ENSDART00000067251
ENSDART00000143690
cped1
cadherin-like and PC-esterase domain containing 1
chr24_-_27452488 4.40 ENSDART00000136433
ccl34b.8
chemokine (C-C motif) ligand 34b, duplicate 8
chr4_+_76735113 4.39 ENSDART00000075602
ms4a17a.6
membrane-spanning 4-domains, subfamily A, member 17A.6
chr22_-_15578402 4.28 ENSDART00000062986
hsh2d
hematopoietic SH2 domain containing
chr3_-_44012748 4.27 ENSDART00000167248
ENSDART00000157463
ENSDART00000159111
il4r.1
interleukin 4 receptor, tandem duplicate 1
chr23_-_5783421 4.26 ENSDART00000131521
ENSDART00000019455
csrp1a
cysteine and glycine-rich protein 1a
chr9_-_31135901 4.22 ENSDART00000113027
ENSDART00000193210
ENSDART00000128896
si:ch211-184m13.4
si:ch211-184m13.4
chr9_-_23922011 4.15 ENSDART00000145734
col6a3
collagen, type VI, alpha 3
chr7_-_22790630 4.06 ENSDART00000173496
si:ch211-15b10.6
si:ch211-15b10.6
chr8_-_23240156 4.02 ENSDART00000131632
ptk6a
PTK6 protein tyrosine kinase 6a
chr13_+_39532050 3.96 ENSDART00000019379
marveld1
MARVEL domain containing 1
chr21_-_43328056 3.94 ENSDART00000114955
sowahaa
sosondowah ankyrin repeat domain family member Aa
chr12_-_7234915 3.91 ENSDART00000048866
ipmkb
inositol polyphosphate multikinase b
chr5_-_23619911 3.91 ENSDART00000020004
mtmr2
myotubularin related protein 2
chr16_+_38394371 3.90 ENSDART00000137954
cd83
CD83 molecule
chr9_-_23922778 3.83 ENSDART00000135769
col6a3
collagen, type VI, alpha 3
chr16_+_42772678 3.71 ENSDART00000155575
si:ch211-135n15.2
si:ch211-135n15.2
chr21_+_13387965 3.68 ENSDART00000134347
zgc:113162
zgc:113162
chr4_+_68922112 3.59 ENSDART00000159074
si:dkey-264f17.2
si:dkey-264f17.2
chr20_+_18993452 3.58 ENSDART00000025509
tdh
L-threonine dehydrogenase
chr22_-_5323482 3.58 ENSDART00000145785
s1pr4
sphingosine-1-phosphate receptor 4
chr8_+_23152244 3.53 ENSDART00000036801
ENSDART00000184298
slc17a9a
solute carrier family 17 (vesicular nucleotide transporter), member 9a
chr17_+_16046132 3.48 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr20_+_18994059 3.40 ENSDART00000152380
tdh
L-threonine dehydrogenase
chr3_-_8130926 3.35 ENSDART00000189495
si:ch211-51i16.1
si:ch211-51i16.1
chr13_-_37642890 3.27 ENSDART00000146483
ENSDART00000136071
ENSDART00000111786
si:dkey-188i13.9
si:dkey-188i13.9
chr19_+_10587307 3.26 ENSDART00000131225
si:dkey-211g8.4
si:dkey-211g8.4
chr3_-_32275975 3.07 ENSDART00000178448
cpt1cb
carnitine palmitoyltransferase 1Cb
chr5_+_25317061 3.06 ENSDART00000170097
trpm6
transient receptor potential cation channel, subfamily M, member 6
chr12_-_19346678 3.05 ENSDART00000044860
maff
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr7_-_22941472 3.05 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr9_-_14084743 3.03 ENSDART00000056105
fer1l6
fer-1-like family member 6
chr4_-_4592287 3.02 ENSDART00000155287
rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr3_+_472158 2.97 ENSDART00000134971
zgc:194659
zgc:194659
chr21_-_43457554 2.97 ENSDART00000085039
stk26
serine/threonine protein kinase 26
chr4_+_72668095 2.94 ENSDART00000182282
ENSDART00000162637
CABZ01054391.1

chr18_-_14860435 2.89 ENSDART00000018502
mapk12a
mitogen-activated protein kinase 12a
chr4_-_12323228 2.88 ENSDART00000081089
il17ra1a
interleukin 17 receptor A1a
chr20_-_37813863 2.86 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr6_+_36821621 2.85 ENSDART00000104157
tmem45a
transmembrane protein 45a
chr14_-_6987649 2.84 ENSDART00000060990
eif4ebp3l
eukaryotic translation initiation factor 4E binding protein 3, like
chr3_+_16922226 2.84 ENSDART00000017646
atp6v0a1a
ATPase H+ transporting V0 subunit a1a
chr21_-_21781158 2.79 ENSDART00000113734
chrdl2
chordin-like 2
chr20_-_35841570 2.78 ENSDART00000037855
tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr16_-_27749172 2.78 ENSDART00000145198
steap4
STEAP family member 4
chr6_+_11989537 2.76 ENSDART00000190817
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr22_-_13165186 2.74 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr20_+_35433192 2.61 ENSDART00000017485
sf3b6
splicing factor 3b, subunit 6
chr17_+_25397070 2.57 ENSDART00000164254
zgc:154055
zgc:154055
chr15_-_3282220 2.57 ENSDART00000092942
slc25a15a
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15a
chr2_+_20967673 2.50 ENSDART00000057174
arpc5a
actin related protein 2/3 complex, subunit 5A
chr18_-_16801033 2.49 ENSDART00000100100
admb
adrenomedullin b
chr20_+_25552057 2.47 ENSDART00000102913
cyp2v1
cytochrome P450, family 2, subfamily V, polypeptide 1
chr8_+_52515188 2.41 ENSDART00000163668
si:ch1073-392o20.2
si:ch1073-392o20.2
chr2_+_4402765 2.36 ENSDART00000159525
bambib
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b
chr11_+_16040517 2.36 ENSDART00000111284
agtrap
angiotensin II receptor-associated protein
chr2_+_26288301 2.35 ENSDART00000017668
ptbp1a
polypyrimidine tract binding protein 1a
chr3_+_59899452 2.34 ENSDART00000064311
arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr7_-_28696556 2.33 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr7_+_28901786 2.31 ENSDART00000113998
dok4
docking protein 4
chr6_-_55958705 2.30 ENSDART00000155963
eya2
EYA transcriptional coactivator and phosphatase 2
chr1_-_9114936 2.20 ENSDART00000163624
ENSDART00000132910
si:ch211-14k19.8
vap
si:ch211-14k19.8
vascular associated protein
chr15_+_23550890 2.18 ENSDART00000009796
ENSDART00000152720
MARK4
si:dkey-31m14.7
chr9_+_1313418 2.18 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr20_-_39273987 2.17 ENSDART00000127173
clu
clusterin
chr11_+_12720171 2.14 ENSDART00000135761
ENSDART00000122812
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_19548985 2.13 ENSDART00000123104
notch2
notch 2
chr19_+_23298037 2.13 ENSDART00000183948
irgf1
immunity-related GTPase family, f1
chr16_+_54513267 2.11 ENSDART00000161923
CABZ01088508.1

chr21_+_35215810 2.10 ENSDART00000135256
ubtd2
ubiquitin domain containing 2
chr14_+_15257658 2.09 ENSDART00000161625
ENSDART00000193577
si:dkey-77g12.4
si:dkey-203a12.5
si:dkey-77g12.4
si:dkey-203a12.5
chr16_+_25809235 2.09 ENSDART00000181196
irgq1
immunity-related GTPase family, q1
chr20_-_25412181 2.05 ENSDART00000062780
itsn2a
intersectin 2a
chr11_+_4026229 2.01 ENSDART00000041417
camk1b
calcium/calmodulin-dependent protein kinase Ib
chr21_-_5879897 2.01 ENSDART00000184034
rpl35
ribosomal protein L35
chr7_-_24373662 1.95 ENSDART00000173865
PTGR1 (1 of many)
si:dkey-11k2.7
chr25_+_15933411 1.93 ENSDART00000191581
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr5_-_26466169 1.92 ENSDART00000144035
arvcfb
ARVCF, delta catenin family member b
chr24_+_31361407 1.92 ENSDART00000162668
cremb
cAMP responsive element modulator b
chr15_+_16521785 1.91 ENSDART00000062191
galnt17
polypeptide N-acetylgalactosaminyltransferase 17
chr4_+_76637548 1.90 ENSDART00000133799
ms4a17a.9
membrane-spanning 4-domains, subfamily A, member 17A.9
chr1_-_56596701 1.90 ENSDART00000133693
LO018605.1

chr20_+_46620374 1.86 ENSDART00000005548
batf
basic leucine zipper transcription factor, ATF-like
chr1_-_10669436 1.85 ENSDART00000152421
si:dkey-31e10.5
si:dkey-31e10.5
chr7_+_12950507 1.84 ENSDART00000067629
ENSDART00000158004
saa
serum amyloid A
chr19_+_8973042 1.80 ENSDART00000039597
crabp2b
cellular retinoic acid binding protein 2, b
chr1_-_9195629 1.73 ENSDART00000143587
ENSDART00000192174
ern2
endoplasmic reticulum to nucleus signaling 2
chr2_+_41526904 1.73 ENSDART00000127520
acvr1l
activin A receptor, type 1 like
chr23_-_33558161 1.73 ENSDART00000018301
itga5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr9_-_43644261 1.72 ENSDART00000023684
cwc22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr8_+_8671229 1.72 ENSDART00000131963
usp11
ubiquitin specific peptidase 11
chr19_+_7916790 1.70 ENSDART00000081584
si:dkey-266f7.1
si:dkey-266f7.1
chr6_+_37655078 1.70 ENSDART00000122199
ENSDART00000065127
cyfip1
cytoplasmic FMR1 interacting protein 1
chr5_+_20103085 1.67 ENSDART00000079424
si:rp71-1c23.3
si:rp71-1c23.3
chr24_-_26383978 1.66 ENSDART00000031426
skilb
SKI-like proto-oncogene b
chr12_+_22657925 1.65 ENSDART00000153048
si:dkey-219e21.4
si:dkey-219e21.4
chr14_-_32744464 1.65 ENSDART00000075617
sox3
SRY (sex determining region Y)-box 3
chr3_+_44062576 1.59 ENSDART00000161277
ENSDART00000168784
nsmce1
NSE1 homolog, SMC5-SMC6 complex component
chr24_+_37406535 1.59 ENSDART00000138264
si:ch211-183d21.1
si:ch211-183d21.1
chr12_+_38983989 1.59 ENSDART00000156673
si:ch73-181m17.1
si:ch73-181m17.1
chr9_-_12659140 1.58 ENSDART00000058565
pttg1ipb
PTTG1 interacting protein b
chr21_-_34844316 1.58 ENSDART00000029708
zgc:56585
zgc:56585
chr18_+_14684115 1.57 ENSDART00000108469
spata2l
spermatogenesis associated 2-like
chr6_+_13232934 1.55 ENSDART00000089725
ino80db
INO80 complex subunit Db
chr21_-_22676323 1.53 ENSDART00000167392
gig2h
grass carp reovirus (GCRV)-induced gene 2h
chr9_+_26103814 1.51 ENSDART00000026011
efnb2a
ephrin-B2a
chr9_+_40825065 1.50 ENSDART00000137673
si:dkey-95p16.2
si:dkey-95p16.2
chr7_+_41313568 1.50 ENSDART00000016660
zgc:165532
zgc:165532
chr24_-_27461295 1.49 ENSDART00000110748
ccl34b.9
chemokine (C-C motif) ligand 34b, duplicate 9
chr5_-_42878178 1.48 ENSDART00000162981
CXCL11 (1 of many)
C-X-C motif chemokine ligand 11
chr8_-_49766205 1.48 ENSDART00000137941
ENSDART00000097919
ENSDART00000147309
hnrnpk
heterogeneous nuclear ribonucleoprotein K
chr4_+_3455665 1.47 ENSDART00000058277
znf800b
zinc finger protein 800b
chr10_-_4375190 1.46 ENSDART00000016102
CABZ01073795.1

chr8_+_26329482 1.46 ENSDART00000048676
prkar2aa
protein kinase, cAMP-dependent, regulatory, type II, alpha A
chr11_+_16040680 1.45 ENSDART00000157703
agtrap
angiotensin II receptor-associated protein
chr4_+_49322310 1.42 ENSDART00000184154
ENSDART00000167162
BX942819.1

chr9_+_13985567 1.41 ENSDART00000102296
cd28
CD28 molecule
chr4_+_57580303 1.41 ENSDART00000166492
ENSDART00000103025
ENSDART00000170786
il17ra1b
il17ra2
interleukin 17 receptor A1b
interleukin 17 receptor A2
chr23_-_19715799 1.40 ENSDART00000142072
ENSDART00000032744
ENSDART00000131860
rpl10
ribosomal protein L10
chr23_+_5524247 1.36 ENSDART00000189679
ENSDART00000083622
tead3a
TEA domain family member 3 a
chr19_-_35052451 1.33 ENSDART00000152030
macf1a
microtubule-actin crosslinking factor 1a
chr21_-_34844059 1.33 ENSDART00000136402
zgc:56585
zgc:56585
chr3_+_58984463 1.32 ENSDART00000162097
CABZ01044156.1

chr3_-_7912661 1.31 ENSDART00000161400
trim35-21
tripartite motif containing 35-21
chr22_-_12890921 1.30 ENSDART00000146484
nab1a
NGFI-A binding protein 1a (EGR1 binding protein 1)
chr16_+_31921812 1.30 ENSDART00000176928
ENSDART00000193733
rps9
ribosomal protein S9
chr18_-_26811959 1.28 ENSDART00000086250
znf592
zinc finger protein 592
chr24_-_39858710 1.28 ENSDART00000134251
slc12a7b
solute carrier family 12 (potassium/chloride transporter), member 7b
chr9_-_54304684 1.27 ENSDART00000109512
il13
interleukin 13
chr1_+_55600504 1.27 ENSDART00000123946
umod
uromodulin
chr3_-_32170850 1.26 ENSDART00000055307
ENSDART00000157366
tnnt1
troponin T type 1 (skeletal, slow)
chr22_+_5851122 1.26 ENSDART00000082044
zmp:0000001161
zmp:0000001161
chr2_-_37837056 1.25 ENSDART00000158179
ENSDART00000160317
ENSDART00000171409
mettl17
methyltransferase like 17
chr5_-_30620625 1.25 ENSDART00000098273
tcnl
transcobalamin like
chr24_-_37877743 1.24 ENSDART00000105658
tmem204
transmembrane protein 204
chr8_-_31701157 1.24 ENSDART00000141799
fbxo4
F-box protein 4
chr16_-_20870143 1.23 ENSDART00000169541
ENSDART00000040727
tax1bp1b
Tax1 (human T-cell leukemia virus type I) binding protein 1b
chr16_+_31922065 1.22 ENSDART00000131661
ENSDART00000144194
ENSDART00000145510
rps9
ribosomal protein S9
chr17_+_33415319 1.21 ENSDART00000140805
ENSDART00000025501
ENSDART00000146447
snap23.1
synaptosomal-associated protein 23.1
chr11_+_5681762 1.19 ENSDART00000179139
arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr3_+_1219344 1.16 ENSDART00000161945
rrp7a
ribosomal RNA processing 7 homolog A
chr7_+_25053331 1.16 ENSDART00000173998
si:dkey-23i12.7
si:dkey-23i12.7
chr8_-_25707421 1.15 ENSDART00000184404
sema3ga
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga
chr20_+_53521648 1.13 ENSDART00000139794
pak6b
p21 protein (Cdc42/Rac)-activated kinase 6b
chr20_-_5400395 1.13 ENSDART00000168103
snw1
SNW domain containing 1
chr7_+_32369026 1.12 ENSDART00000169588
lgr4
leucine-rich repeat containing G protein-coupled receptor 4
chr19_-_30420602 1.12 ENSDART00000144121
ppp1r10
protein phosphatase 1, regulatory subunit 10
chr10_-_5568379 1.11 ENSDART00000164558
ENSDART00000005292
syk
spleen tyrosine kinase
chr11_-_22303678 1.11 ENSDART00000159527
ENSDART00000159681
tfeb
transcription factor EB
chr7_+_17953589 1.09 ENSDART00000174778
ENSDART00000113120
taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr9_-_8670158 1.09 ENSDART00000077296
col4a1
collagen, type IV, alpha 1
chr16_-_45398408 1.08 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr6_-_2454691 1.06 ENSDART00000192820
MED8
mediator complex subunit 8
chr16_+_10841163 1.05 ENSDART00000065467
dedd1
death effector domain-containing 1
chr15_-_1485086 1.04 ENSDART00000191651
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr7_+_48319916 1.03 ENSDART00000052122
crabp1b
cellular retinoic acid binding protein 1b
chr20_-_20932760 1.02 ENSDART00000152415
ENSDART00000039907
btbd6b
BTB (POZ) domain containing 6b
chr9_-_46072805 1.02 ENSDART00000169682
hdac4
histone deacetylase 4
chr25_-_21085661 1.01 ENSDART00000099355
prr5a
proline rich 5a (renal)
chr4_+_57194439 1.00 ENSDART00000075265
si:dkey-16p6.4
si:dkey-16p6.4
chr3_-_40933415 0.98 ENSDART00000055201
foxk1
forkhead box K1

Network of associatons between targets according to the STRING database.

First level regulatory network of stat3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.2 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
2.4 7.3 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
1.9 13.4 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
1.8 5.4 GO:0002418 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.4 7.0 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
1.3 3.9 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
1.0 7.6 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.9 2.8 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.9 5.6 GO:0070254 mucus secretion(GO:0070254)
0.9 7.0 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.9 2.6 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.7 2.8 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.7 2.8 GO:0015677 copper ion import(GO:0015677)
0.6 2.5 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.6 7.3 GO:0050688 regulation of defense response to virus(GO:0050688)
0.6 2.4 GO:0060467 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
0.6 1.1 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.6 9.9 GO:0050994 regulation of lipid catabolic process(GO:0050994)
0.5 1.4 GO:1990403 embryonic brain development(GO:1990403)
0.5 1.8 GO:0001909 leukocyte mediated cytotoxicity(GO:0001909)
0.4 3.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.4 1.7 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.4 1.7 GO:0099563 modification of synaptic structure(GO:0099563)
0.4 2.3 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.4 9.0 GO:0071456 cellular response to hypoxia(GO:0071456)
0.4 4.9 GO:0007172 signal complex assembly(GO:0007172)
0.3 1.7 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.3 14.0 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.3 3.0 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.3 3.3 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.3 1.5 GO:0007412 axon target recognition(GO:0007412)
0.3 1.7 GO:0090245 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309) axis elongation involved in somitogenesis(GO:0090245)
0.3 0.8 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.3 2.3 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.3 1.0 GO:0090299 regulation of neural crest formation(GO:0090299)
0.3 1.5 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.2 2.7 GO:0001541 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.2 8.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 2.8 GO:0001845 phagolysosome assembly(GO:0001845)
0.2 5.0 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 0.9 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 1.3 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.2 1.0 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.2 6.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 3.9 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.2 1.2 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.2 1.3 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 4.8 GO:0007548 sex differentiation(GO:0007548)
0.2 0.5 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 0.5 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.2 4.0 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 0.4 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 2.1 GO:0060325 face morphogenesis(GO:0060325)
0.1 1.8 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.1 6.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 3.6 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.1 0.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.0 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.1 4.3 GO:0031102 neuron projection regeneration(GO:0031102)
0.1 10.6 GO:0031101 fin regeneration(GO:0031101)
0.1 8.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 4.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 6.9 GO:0001945 lymph vessel development(GO:0001945)
0.1 1.0 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.3 GO:0035521 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 3.3 GO:0030261 chromosome condensation(GO:0030261)
0.1 4.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.6 GO:0006301 postreplication repair(GO:0006301)
0.1 0.7 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 0.2 GO:0010039 response to iron ion(GO:0010039)
0.1 0.5 GO:0032366 intracellular sterol transport(GO:0032366)
0.1 4.0 GO:0048821 erythrocyte development(GO:0048821)
0.1 6.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.6 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.7 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1 1.1 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 4.0 GO:0042552 myelination(GO:0042552)
0.1 3.1 GO:0051262 protein tetramerization(GO:0051262)
0.1 0.2 GO:1904353 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.3 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 1.6 GO:0043049 otic placode formation(GO:0043049)
0.1 2.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.0 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 0.8 GO:0016486 peptide hormone processing(GO:0016486)
0.1 1.1 GO:0014029 neural crest formation(GO:0014029)
0.0 3.8 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 1.4 GO:0035329 hippo signaling(GO:0035329)
0.0 1.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.5 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 4.1 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 1.6 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 2.3 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 1.4 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 1.2 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 2.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.5 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.7 GO:0034453 microtubule anchoring(GO:0034453)
0.0 3.1 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 1.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.8 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.7 GO:1904018 positive regulation of angiogenesis(GO:0045766) positive regulation of vasculature development(GO:1904018)
0.0 0.6 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 1.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.4 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 1.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.5 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 1.1 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of chemotaxis(GO:0050922) negative regulation of axon guidance(GO:1902668)
0.0 6.2 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 1.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.9 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 1.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.4 GO:0048738 cardiac muscle tissue development(GO:0048738)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 10.6 GO:0045095 keratin filament(GO:0045095)
0.9 7.0 GO:0001772 immunological synapse(GO:0001772)
0.6 1.7 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.4 25.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.4 1.2 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.3 1.7 GO:0070724 BMP receptor complex(GO:0070724)
0.3 1.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.3 2.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.3 1.1 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.2 1.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 2.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 7.1 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.2 1.3 GO:0032019 mitochondrial cloud(GO:0032019)
0.2 1.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 1.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.4 GO:0033268 node of Ranvier(GO:0033268)
0.1 2.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 5.7 GO:0005861 troponin complex(GO:0005861)
0.1 1.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 2.6 GO:0005689 U2 snRNP(GO:0005686) U12-type spliceosomal complex(GO:0005689)
0.1 14.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.7 GO:0031209 SCAR complex(GO:0031209)
0.1 9.1 GO:0005581 collagen trimer(GO:0005581)
0.1 0.9 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.6 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 2.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.7 GO:0036449 microtubule minus-end(GO:0036449)
0.1 6.8 GO:0031201 SNARE complex(GO:0031201)
0.1 3.9 GO:0019814 immunoglobulin complex(GO:0019814)
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 3.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.6 GO:0031901 early endosome membrane(GO:0031901)
0.1 2.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 4.3 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 2.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 1.7 GO:0008305 integrin complex(GO:0008305)
0.0 11.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0070449 elongin complex(GO:0070449)
0.0 7.8 GO:0005912 adherens junction(GO:0005912)
0.0 3.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 2.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 3.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.7 GO:0010008 endosome membrane(GO:0010008)
0.0 0.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.4 7.0 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
1.4 7.0 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
1.3 3.9 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.2 8.2 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.8 25.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.7 2.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.6 2.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 3.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.4 2.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 4.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 3.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 5.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.3 3.3 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 2.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.3 4.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 7.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 1.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 2.8 GO:0051117 ATPase binding(GO:0051117)
0.2 14.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 0.7 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.2 4.3 GO:0042805 actinin binding(GO:0042805)
0.2 2.8 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.0 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 11.2 GO:0019838 growth factor binding(GO:0019838)
0.1 1.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 6.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 3.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.1 GO:0005112 Notch binding(GO:0005112)
0.1 1.0 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 1.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 1.7 GO:0004407 histone deacetylase activity(GO:0004407) NAD-dependent histone deacetylase activity(GO:0017136)
0.1 2.2 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.2 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.1 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.4 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 1.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.1 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.7 GO:0030507 spectrin binding(GO:0030507)
0.1 1.1 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.1 9.2 GO:0060090 binding, bridging(GO:0060090)
0.1 1.3 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 2.5 GO:0019843 rRNA binding(GO:0019843)
0.0 2.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 8.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 2.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.1 GO:0102345 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 5.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 4.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 7.2 GO:0005525 GTP binding(GO:0005525)
0.0 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 4.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 23.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.3 3.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 2.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 18.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 9.1 NABA COLLAGENS Genes encoding collagen proteins
0.2 1.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 2.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.4 7.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.3 3.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 2.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 7.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 9.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.7 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 3.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 6.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 3.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.9 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.6 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI