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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for tal1
Z-value: 2.06
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Transcription factors associated with tal1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tal1 | dr11_v1_chr22_+_16535575_16535575 | -0.74 | 2.6e-17 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_61181018 Show fit | 35.05 |
ENSDART00000187970
|
parvalbumin 4 |
|
| chr12_+_13256415 Show fit | 31.84 |
ENSDART00000144542
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like |
|
| chr8_-_1051438 Show fit | 26.67 |
ENSDART00000067093
ENSDART00000170737 |
SET and MYND domain containing 1b |
|
| chr7_+_39389273 Show fit | 25.74 |
ENSDART00000191298
|
troponin I type 2b (skeletal, fast), tandem duplicate 2 |
|
| chr22_+_20720808 Show fit | 25.03 |
ENSDART00000171321
|
si:dkey-211f22.5 |
|
| chr3_-_61203203 Show fit | 23.80 |
ENSDART00000171787
|
parvalbumin 1 |
|
| chr18_+_5547185 Show fit | 23.53 |
ENSDART00000193977
|
nicotinamide nucleotide transhydrogenase 2 |
|
| chr9_+_307863 Show fit | 23.10 |
ENSDART00000163474
|
SH3 and cysteine rich domain 3 |
|
| chr3_-_3209432 Show fit | 21.95 |
ENSDART00000140635
|
si:ch211-229i14.2 |
|
| chr3_-_1190132 Show fit | 21.76 |
ENSDART00000149709
|
single-pass membrane protein with aspartate-rich tail 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of tal1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 31.9 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 1.8 | 31.7 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.5 | 28.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 27.2 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 2.4 | 26.7 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.6 | 25.7 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 25.3 | GO:0006874 | cellular calcium ion homeostasis(GO:0006874) |
| 5.9 | 23.5 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 4.6 | 23.1 | GO:1901387 | positive regulation of voltage-gated calcium channel activity(GO:1901387) |
| 0.2 | 20.5 | GO:0006400 | tRNA modification(GO:0006400) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.0 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 34.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 1.3 | 31.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 28.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.5 | 28.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.3 | 26.7 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 26.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.6 | 25.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 25.5 | GO:0005615 | extracellular space(GO:0005615) |
| 1.4 | 23.1 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.9 | 31.9 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 1.9 | 31.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 28.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.5 | 28.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 27.6 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 1.1 | 25.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 5.9 | 23.5 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.0 | 20.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.3 | 19.4 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 12.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.4 | 11.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 11.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 10.3 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.3 | 9.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 9.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 8.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 4.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 21.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.8 | 16.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 11.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.9 | 9.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.5 | 7.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 6.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.0 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.3 | 4.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 4.5 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |