ISMARA results: tbp

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbp

Z-value: 2.76

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Transcription factors associated with tbp

Gene Symbol	Gene ID	Gene Info
tbp NCBI UniProt	ENSDARG00000014994	TATA box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tbp	dr11_v1_chr13_-_24396199_24396199	-0.80	1.0e-21	Click!

Activity profile of tbp motif

Sorted Z-values of tbp motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_32818607 Show fit	46.64	ENSDART00000075465	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr21_+_20383837 Show fit	42.96	ENSDART00000026430	hspb11 NCBI UniProt Show fit	heat shock protein, alpha-crystallin-related, b11
chr5_-_36837846 Show fit	42.10	ENSDART00000032481	ckma NCBI UniProt Show fit	creatine kinase, muscle a
chr1_+_55137943 Show fit	40.40	ENSDART00000138070 ENSDART00000150510 ENSDART00000133472 ENSDART00000136378	mb NCBI UniProt Show fit	myoglobin
chr23_+_45456490 Show fit	37.20	ENSDART00000036631	cyr61 NCBI UniProt Show fit	cysteine-rich, angiogenic inducer, 61
chr5_-_32274383 Show fit	34.72	ENSDART00000122889	myhz1.3 NCBI UniProt Show fit	myosin, heavy polypeptide 1.3, skeletal muscle
chr25_+_35020529 Show fit	34.29	ENSDART00000158016	flnca NCBI UniProt Show fit	filamin C, gamma a (actin binding protein 280)
chr12_-_17712393 Show fit	33.94	ENSDART00000143534 ENSDART00000010144	pvalb2 NCBI UniProt Show fit	parvalbumin 2
chr9_+_23900703 Show fit	29.65	ENSDART00000127859	trim63b NCBI UniProt Show fit	tripartite motif containing 63b
chr22_-_263117 Show fit	29.15	ENSDART00000158134	zgc:66156 NCBI UniProt Show fit	zgc:66156

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	86.6	GO:0002088	lens development in camera-type eye(GO:0002088)
4.2	54.9	GO:0042396	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
2.4	54.8	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.8	45.4	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
14.6	43.7	GO:1905072	cardiac jelly development(GO:1905072)
2.0	40.4	GO:0014823	response to activity(GO:0014823)
1.9	40.2	GO:0031033	myosin filament organization(GO:0031033)
3.8	34.3	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
3.0	33.4	GO:0019731	antibacterial humoral response(GO:0019731)
3.4	30.9	GO:0000185	activation of MAPKKK activity(GO:0000185)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	152.5	GO:0005615	extracellular space(GO:0005615)
0.1	80.8	GO:0005829	cytosol(GO:0005829)
0.6	71.7	GO:0016459	myosin complex(GO:0016459)
12.4	37.3	GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)
0.4	35.5	GO:0030018	Z disc(GO:0030018)
0.7	35.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.6	34.6	GO:0022626	cytosolic ribosome(GO:0022626)
0.2	27.4	GO:0005769	early endosome(GO:0005769)
0.2	24.3	GO:0000786	nucleosome(GO:0000786)
0.2	23.8	GO:0031012	extracellular matrix(GO:0031012)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	110.0	GO:0003735	structural constituent of ribosome(GO:0003735)
1.2	86.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.2	59.5	GO:0003774	motor activity(GO:0003774)
4.2	54.9	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.7	51.6	GO:0001594	trace-amine receptor activity(GO:0001594)
0.5	43.9	GO:0051427	hormone receptor binding(GO:0051427)
1.9	40.4	GO:0019825	oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.2	35.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	33.5	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	32.5	GO:0061630	ubiquitin protein ligase activity(GO:0061630)

Showing 1 to 10 of 118 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	37.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	22.1	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	12.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	10.5	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	9.4	PID P53 REGULATION PATHWAY	p53 pathway
0.2	8.5	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	7.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	5.5	ST STAT3 PATHWAY	STAT3 Pathway
0.1	4.8	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	3.7	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	75.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7	53.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.3	26.9	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.4	25.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	23.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
2.4	21.5	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
1.3	15.5	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.9	14.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	12.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
1.7	10.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts

Showing 1 to 10 of 32 entries

Results for tbp

Z-value: 2.76

Motif logo

Transcription factors associated with tbp

Activity-expression correlation:

Activity profile of tbp motif

Sorted Z-values of tbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: