ISMARA results: tbr1b_tbx16+tbx16l+tbx2a+tbx2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbr1b_tbx16+tbx16l+tbx2a+tbx2b

Z-value: 1.14

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Transcription factors associated with tbr1b_tbx16+tbx16l+tbx2a+tbx2b

Gene Symbol	Gene ID	Gene Info
tbr1b NCBI UniProt	ENSDARG00000004712	T-box brain transcription factor 1b
tbx2b NCBI UniProt	ENSDARG00000006120	T-box transcription factor 2b
tbx16l NCBI UniProt	ENSDARG00000006939	T-box transcription factor 16, like
tbx16 NCBI UniProt	ENSDARG00000007329	T-box transcription factor 16
tbx2a NCBI UniProt	ENSDARG00000018025	T-box transcription factor 2a
tbx2a NCBI UniProt	ENSDARG00000109541	T-box transcription factor 2a
tbx2b NCBI UniProt	ENSDARG00000116135	T-box transcription factor 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tbx16	dr11_v1_chr8_-_51753604_51753604	-0.77	1.6e-19	Click!
tbr1b	dr11_v1_chr9_-_51436377_51436377	-0.69	2.0e-14	Click!
tbx6l	dr11_v1_chr5_+_42280372_42280372	-0.25	1.4e-02	Click!
tbx2a	dr11_v1_chr5_-_56513825_56513825	0.15	1.5e-01	Click!
tbx2b	dr11_v1_chr15_+_27364394_27364394	0.08	4.2e-01	Click!

Activity profile of tbr1b_tbx16+tbx16l+tbx2a+tbx2b motif

Sorted Z-values of tbr1b_tbx16+tbx16l+tbx2a+tbx2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_51846224 Show fit	28.15	ENSDART00000184663	LT631684.2 NCBI UniProt Show fit
chr7_+_7048245 Show fit	15.40	ENSDART00000001649	actn3b NCBI UniProt Show fit	actinin alpha 3b
chr7_+_6969909 Show fit	12.59	ENSDART00000189886	actn3b NCBI UniProt Show fit	actinin alpha 3b
chr17_+_26965351 Show fit	11.42	ENSDART00000114215 ENSDART00000147192	grhl3 NCBI UniProt Show fit	grainyhead-like transcription factor 3
chr7_+_69841017 Show fit	11.22	ENSDART00000169107	FO818704.1 NCBI UniProt Show fit
chr9_-_42873700 Show fit	10.73	ENSDART00000125953	ttn.1 NCBI UniProt Show fit	titin, tandem duplicate 1
chr3_+_32526263 Show fit	10.62	ENSDART00000150897	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2
chr19_+_791538 Show fit	9.72	ENSDART00000146554 ENSDART00000138406	tmem79a NCBI UniProt Show fit	transmembrane protein 79a
chr23_+_23232136 Show fit	9.11	ENSDART00000126479 ENSDART00000187764	plekhn1 NCBI UniProt Show fit	pleckstrin homology domain containing, family N member 1
chr13_-_15702672 Show fit	8.63	ENSDART00000144445 ENSDART00000168950	ckba NCBI UniProt Show fit	creatine kinase, brain a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tbr1b_tbx16+tbx16l+tbx2a+tbx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.4	GO:0030239	myofibril assembly(GO:0030239)
0.9	19.6	GO:0008078	mesodermal cell migration(GO:0008078)
0.8	15.1	GO:0016203	muscle attachment(GO:0016203)
0.1	13.6	GO:0009617	response to bacterium(GO:0009617)
1.0	13.5	GO:0006603	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2	11.5	GO:0099515	vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.7	11.1	GO:0060325	face morphogenesis(GO:0060325)
0.1	11.0	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.7	10.7	GO:0048769	sarcomerogenesis(GO:0048769)
0.2	10.2	GO:0048247	lymphocyte chemotaxis(GO:0048247)

Showing 1 to 10 of 355 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	91.3	GO:0005615	extracellular space(GO:0005615)
0.1	42.8	GO:0031012	extracellular matrix(GO:0031012)
0.3	18.3	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1	15.1	GO:0005882	intermediate filament(GO:0005882)
0.1	12.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	11.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.6	10.6	GO:0030057	desmosome(GO:0030057)
0.3	10.5	GO:0031672	A band(GO:0031672)
0.2	10.5	GO:0022626	cytosolic ribosome(GO:0022626)
0.5	9.8	GO:0032588	trans-Golgi network membrane(GO:0032588)

Showing 1 to 10 of 123 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.6	GO:0030246	carbohydrate binding(GO:0030246)
0.0	29.4	GO:0003779	actin binding(GO:0003779)
0.1	25.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	18.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	17.4	GO:0005198	structural molecule activity(GO:0005198)
4.0	15.9	GO:0051059	NF-kappaB binding(GO:0051059)
1.0	13.5	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
1.0	13.4	GO:0070697	activin receptor binding(GO:0070697)
0.4	13.4	GO:0017147	Wnt-protein binding(GO:0017147)
0.2	12.8	GO:0000146	microfilament motor activity(GO:0000146)

Showing 1 to 10 of 248 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	18.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	15.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	14.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	10.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.5	9.7	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	7.8	NABA COLLAGENS	Genes encoding collagen proteins
0.6	7.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	7.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.8	7.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	6.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	11.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.2	9.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9	9.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	7.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	7.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	7.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.2	6.4	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.2	6.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.7	5.8	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis

Showing 1 to 10 of 77 entries

Results for tbr1b_tbx16+tbx16l+tbx2a+tbx2b

Z-value: 1.14

Motif logo

Transcription factors associated with tbr1b_tbx16+tbx16l+tbx2a+tbx2b

Activity-expression correlation:

Activity profile of tbr1b_tbx16+tbx16l+tbx2a+tbx2b motif

Sorted Z-values of tbr1b_tbx16+tbx16l+tbx2a+tbx2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tbr1b_tbx16+tbx16l+tbx2a+tbx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: