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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbx15_tbx1_mgaa_tbx4

Z-value: 1.47

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Transcription factors associated with tbx15_tbx1_mgaa_tbx4

Gene Symbol Gene ID Gene Info
tbx15
ENSDARG00000002582 T-box transcription factor 15
tbx1
ENSDARG00000031891 T-box transcription factor 1
mgaa
ENSDARG00000078784 MAX dimerization protein MGA a
tbx4
ENSDARG00000030058 T-box transcription factor 4
tbx4
ENSDARG00000113067 T-box transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx15dr11_v1_chr9_-_21067673_210676730.534.9e-08Click!
mgaadr11_v1_chr17_+_10578823_105788230.321.6e-03Click!
tbx4dr11_v1_chr15_+_27384798_273847980.204.8e-02Click!
tbx1dr11_v1_chr5_+_15202495_152024950.047.2e-01Click!

Activity profile of tbx15_tbx1_mgaa_tbx4 motif

Sorted Z-values of tbx15_tbx1_mgaa_tbx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_37837245 37.93 ENSDART00000171617
epd
ependymin
chr3_-_61205711 26.75 ENSDART00000055062
pvalb1
parvalbumin 1
chr7_+_6969909 24.40 ENSDART00000189886
actn3b
actinin alpha 3b
chr7_+_7048245 23.72 ENSDART00000001649
actn3b
actinin alpha 3b
chr5_-_33215261 21.24 ENSDART00000097935
ENSDART00000134777
si:dkey-226m8.10
si:dkey-226m8.10
chr24_-_6158933 19.82 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr10_-_31782616 18.92 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr7_-_38612230 16.58 ENSDART00000173678
c1qtnf4
C1q and TNF related 4
chr23_-_4855122 16.50 ENSDART00000133701
slc6a1a
solute carrier family 6 (neurotransmitter transporter), member 1a
chr25_+_37397031 16.25 ENSDART00000193643
ENSDART00000169132
slc1a2b
solute carrier family 1 (glial high affinity glutamate transporter), member 2b
chr25_+_7784582 16.11 ENSDART00000155016
dgkzb
diacylglycerol kinase, zeta b
chr14_-_26177156 15.25 ENSDART00000014149
fat2
FAT atypical cadherin 2
chr16_-_29437373 14.43 ENSDART00000148405
si:ch211-113g11.6
si:ch211-113g11.6
chr17_+_27176243 14.15 ENSDART00000162527
si:ch211-160f23.7
si:ch211-160f23.7
chr19_+_47311869 13.53 ENSDART00000136647
ext1c
exostoses (multiple) 1c
chr21_-_43550120 12.68 ENSDART00000151627
si:ch73-362m14.2
si:ch73-362m14.2
chr19_+_14921000 12.20 ENSDART00000144052
oprd1a
opioid receptor, delta 1a
chr18_-_20822045 12.09 ENSDART00000100743
cttnbp2
cortactin binding protein 2
chr16_-_12173554 11.85 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr22_-_20575679 11.12 ENSDART00000089033
lingo3a
leucine rich repeat and Ig domain containing 3a
chr16_-_17207754 10.99 ENSDART00000063804
wu:fj39g12
wu:fj39g12
chr23_+_28582865 10.65 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr16_-_13109749 10.27 ENSDART00000142610
prkcg
protein kinase C, gamma
chr9_+_32978302 9.83 ENSDART00000007630
nhlh2
nescient helix loop helix 2
chr5_-_46896541 9.65 ENSDART00000133240
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr15_-_16098531 9.24 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr2_+_33368414 9.22 ENSDART00000077462
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr22_-_12160283 8.94 ENSDART00000146785
ENSDART00000128176
tmem163b
transmembrane protein 163b
chr5_+_32228538 8.91 ENSDART00000077471
myhc4
myosin heavy chain 4
chr23_-_39849155 8.66 ENSDART00000115330
ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr16_+_53203370 8.54 ENSDART00000154669
si:ch211-269k10.2
si:ch211-269k10.2
chr7_-_51476276 8.37 ENSDART00000082464
nhsl2
NHS-like 2
chr21_-_43949208 8.32 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr16_+_50741154 8.13 ENSDART00000101627
IGLON5
zgc:110372
chr10_+_37500234 8.12 ENSDART00000132096
ENSDART00000099473
msi2a
musashi RNA-binding protein 2a
chr1_+_8662530 8.04 ENSDART00000054989
fscn1b
fascin actin-bundling protein 1b
chr7_+_30867008 7.97 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr13_+_22480496 7.77 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
ldb3a
LIM domain binding 3a
chr3_-_25814097 7.76 ENSDART00000169706
ntn1b
netrin 1b
chr23_-_30431333 7.63 ENSDART00000146633
camta1a
calmodulin binding transcription activator 1a
chr22_+_11857356 7.58 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr13_-_27653679 7.50 ENSDART00000142568
rims1a
regulating synaptic membrane exocytosis 1a
chr6_+_13606410 7.50 ENSDART00000104716
asic4b
acid-sensing (proton-gated) ion channel family member 4b
chr7_-_55675617 7.40 ENSDART00000021009
ENSDART00000188631
cbfa2t3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr12_-_35386910 7.15 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr16_-_12173399 7.01 ENSDART00000142574
clstn3
calsyntenin 3
chr6_+_40587551 6.98 ENSDART00000155554
frs3
fibroblast growth factor receptor substrate 3
chr10_-_31562695 6.77 ENSDART00000186456
robo3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr11_+_23933016 6.67 ENSDART00000000486
cntn2
contactin 2
chr4_+_11384891 6.49 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr18_+_6536293 6.41 ENSDART00000024576
fkbp4
FK506 binding protein 4
chr14_-_34771864 6.40 ENSDART00000141157
ablim3
actin binding LIM protein family, member 3
chr13_-_30027730 6.03 ENSDART00000044009
scdb
stearoyl-CoA desaturase b
chr1_-_8101495 6.02 ENSDART00000161938
si:dkeyp-9d4.3
si:dkeyp-9d4.3
chr5_+_60919378 6.00 ENSDART00000184915
doc2b
double C2-like domains, beta
chr21_-_39628771 5.98 ENSDART00000183995
aldocb
aldolase C, fructose-bisphosphate, b
chr4_-_4795205 5.78 ENSDART00000039313
zgc:162331
zgc:162331
chr3_-_33901483 5.76 ENSDART00000144774
ENSDART00000138765
cacna1aa
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a
chr13_+_4205724 5.74 ENSDART00000134105
dlk2
delta-like 2 homolog (Drosophila)
chr9_-_42873700 5.71 ENSDART00000125953
ttn.1
titin, tandem duplicate 1
chr11_-_11910225 5.67 ENSDART00000159922
si:ch211-69b7.6
si:ch211-69b7.6
chr20_+_41549200 5.67 ENSDART00000135715
fam184a
family with sequence similarity 184, member A
chr13_-_24880525 5.60 ENSDART00000136624
kat6b
K(lysine) acetyltransferase 6B
chr18_+_19419120 5.49 ENSDART00000025107
map2k1
mitogen-activated protein kinase kinase 1
chr21_-_35853245 5.31 ENSDART00000172245
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr20_-_43723860 5.30 ENSDART00000122051
mixl1
Mix paired-like homeobox
chr13_+_11439486 5.26 ENSDART00000138312
zbtb18
zinc finger and BTB domain containing 18
chr20_-_7128612 5.21 ENSDART00000146755
ENSDART00000036871
si:ch211-121a2.4
si:ch211-121a2.4
chr20_-_28800999 5.20 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr18_+_6536598 5.19 ENSDART00000149350
fkbp4
FK506 binding protein 4
chr3_+_33367954 5.17 ENSDART00000103161
mpp2a
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr17_-_20394566 5.10 ENSDART00000154667
sorcs3b
sortilin related VPS10 domain containing receptor 3b
chr7_+_39389273 5.04 ENSDART00000191298
tnni2b.2
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr23_+_40604951 4.99 ENSDART00000114959
cdh24a
cadherin 24, type 2a
chr16_-_35532937 4.93 ENSDART00000193209
ctps1b
CTP synthase 1b
chr21_+_44300689 4.91 ENSDART00000186298
ENSDART00000142810
gabra3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr8_+_47571211 4.90 ENSDART00000131460
plch2a
phospholipase C, eta 2a
chr22_+_1300587 4.89 ENSDART00000124161
si:ch73-138e16.5
si:ch73-138e16.5
chr14_+_50937757 4.87 ENSDART00000163865
rnf44
ring finger protein 44
chr11_-_26832685 4.81 ENSDART00000153519
iqsec1b
IQ motif and Sec7 domain 1b
chr12_-_26383242 4.79 ENSDART00000152941
usp54b
ubiquitin specific peptidase 54b
chr14_+_50770537 4.69 ENSDART00000158723
sncb
synuclein, beta
chr4_+_11375894 4.65 ENSDART00000190471
ENSDART00000143963
pcloa
piccolo presynaptic cytomatrix protein a
chr24_+_22022109 4.57 ENSDART00000133686
ropn1l
rhophilin associated tail protein 1-like
chr2_+_23823622 4.54 ENSDART00000099581
si:dkey-24c2.9
si:dkey-24c2.9
chr7_+_46368520 4.54 ENSDART00000192821
znf536
zinc finger protein 536
chr4_-_19016396 4.52 ENSDART00000166160
si:dkey-31f5.11
si:dkey-31f5.11
chr2_-_16224083 4.46 ENSDART00000165953
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr23_+_24611747 4.42 ENSDART00000134978
nckap5l
NCK-associated protein 5-like
chr15_+_28482862 4.42 ENSDART00000015286
ENSDART00000154320
ankrd13b
ankyrin repeat domain 13B
chr24_+_39158283 4.40 ENSDART00000053139
atp6v0cb
ATPase H+ transporting V0 subunit cb
chr10_+_20108557 4.36 ENSDART00000142708
dmtn
dematin actin binding protein
chr11_+_25583950 4.32 ENSDART00000111961
ccdc120
coiled-coil domain containing 120
chr13_+_22480857 4.30 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
ldb3a
LIM domain binding 3a
chr10_+_18952271 4.25 ENSDART00000146517
dpysl2b
dihydropyrimidinase-like 2b
chr1_-_23110740 4.17 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adgrl3.1
adhesion G protein-coupled receptor L3.1
chr20_+_21268795 4.16 ENSDART00000090016
nudt14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr22_-_15385442 4.10 ENSDART00000090975
tmem264
transmembrane protein 264
chr19_-_28360033 4.09 ENSDART00000186994
si:dkey-261i16.5
si:dkey-261i16.5
chr13_-_36264861 4.09 ENSDART00000100204
slc8a3
solute carrier family 8 (sodium/calcium exchanger), member 3
chr7_+_11197022 4.08 ENSDART00000185236
cemip
cell migration inducing protein, hyaluronan binding
chr7_-_34339845 4.07 ENSDART00000173816
madd
MAP-kinase activating death domain
chr5_-_37875636 4.07 ENSDART00000184674
arhgap35b
Rho GTPase activating protein 35b
chr11_-_12998400 4.06 ENSDART00000018614
chrna4b
cholinergic receptor, nicotinic, alpha 4b
chr9_+_34334156 4.06 ENSDART00000144272
pou2f1b
POU class 2 homeobox 1b
chr6_+_68220 3.99 ENSDART00000082955
sowahcb
sosondowah ankyrin repeat domain family Cb
chr24_+_14713776 3.97 ENSDART00000134475
gdap1
ganglioside induced differentiation associated protein 1
chr17_+_28340138 3.97 ENSDART00000033943
mdga2a
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr14_-_32744464 3.96 ENSDART00000075617
sox3
SRY (sex determining region Y)-box 3
chr15_-_18432673 3.94 ENSDART00000146853
ncam1b
neural cell adhesion molecule 1b
chr22_-_14475927 3.87 ENSDART00000135768
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr14_-_33872092 3.78 ENSDART00000111903
si:ch73-335m24.2
si:ch73-335m24.2
chr9_+_42095220 3.75 ENSDART00000148317
ENSDART00000134431
pcbp3
poly(rC) binding protein 3
chr5_+_42467867 3.66 ENSDART00000172028
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr14_+_45925810 3.61 ENSDART00000189543
flrt1b
fibronectin leucine rich transmembrane protein 1b
chr14_+_45406299 3.61 ENSDART00000173142
ENSDART00000112377
map1lc3cl
microtubule-associated protein 1 light chain 3 gamma, like
chr11_+_41540862 3.59 ENSDART00000173210
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr1_-_53750522 3.59 ENSDART00000190755
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr7_-_32599669 3.54 ENSDART00000173752
kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr23_-_20100436 3.54 ENSDART00000143445
si:dkey-32e6.6
si:dkey-32e6.6
chr1_-_51606552 3.52 ENSDART00000130828
cnrip1a
cannabinoid receptor interacting protein 1a
chr1_+_37195465 3.51 ENSDART00000043855
ENSDART00000192580
ENSDART00000181666
dclk2a
doublecortin-like kinase 2a
chr13_-_21739142 3.50 ENSDART00000078460
si:dkey-191g9.5
si:dkey-191g9.5
chr5_+_28398449 3.49 ENSDART00000165292
nsmfb
NMDA receptor synaptonuclear signaling and neuronal migration factor b
chr2_-_32501501 3.43 ENSDART00000181309
faim2a
Fas apoptotic inhibitory molecule 2a
chr17_-_3986236 3.38 ENSDART00000188794
ENSDART00000160830
PLCB1
si:ch1073-140o9.2
chr21_-_10488379 3.36 ENSDART00000163878
hcn1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr8_+_13364950 3.32 ENSDART00000159760
slc5a5
solute carrier family 5 (sodium/iodide cotransporter), member 5
chr10_-_39154778 3.31 ENSDART00000186811
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr22_-_16443199 3.27 ENSDART00000006290
ENSDART00000193335
plekhb2
pleckstrin homology domain containing, family B (evectins) member 2
chr14_-_33872616 3.25 ENSDART00000162840
si:ch73-335m24.2
si:ch73-335m24.2
chr11_+_29770966 3.24 ENSDART00000088624
ENSDART00000124471
rpgrb
retinitis pigmentosa GTPase regulator b
chr11_-_21303946 3.23 ENSDART00000185786
RASSF5
si:dkey-85p17.3
chr16_+_30301539 3.22 ENSDART00000186018
LO017848.1

chr2_+_24203229 3.22 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr3_+_16449490 3.21 ENSDART00000141467
kcnj12b
potassium inwardly-rectifying channel, subfamily J, member 12b
chr3_-_39171968 3.21 ENSDART00000154494
si:dkeyp-57f11.2
si:dkeyp-57f11.2
chr17_-_14726824 3.19 ENSDART00000162947
si:ch73-305o9.3
si:ch73-305o9.3
chr25_-_21716326 3.17 ENSDART00000152011
DOCK4 (1 of many)
si:dkey-81e3.1
chr19_+_32947910 3.16 ENSDART00000052091
atp6v1c1b
ATPase H+ transporting V1 subunit C1b
chr7_-_18656069 3.16 ENSDART00000021559
coro1b
coronin, actin binding protein, 1B
chr23_-_5032587 3.16 ENSDART00000163903
kcna2b
potassium voltage-gated channel, shaker-related subfamily, member 2b
chr4_-_20118468 3.14 ENSDART00000078587
si:dkey-159a18.1
si:dkey-159a18.1
chr15_-_16121496 3.05 ENSDART00000128624
sgk494a
uncharacterized serine/threonine-protein kinase SgK494a
chr9_+_54644626 3.04 ENSDART00000190609
egfl6
EGF-like-domain, multiple 6
chr8_-_22508055 3.03 ENSDART00000101616
si:ch211-261n11.5
si:ch211-261n11.5
chr7_+_11197940 3.01 ENSDART00000081346
cemip
cell migration inducing protein, hyaluronan binding
chr11_+_1796426 2.98 ENSDART00000173330
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr2_+_24199276 2.98 ENSDART00000140575
map4l
microtubule associated protein 4 like
chr14_+_6605675 2.96 ENSDART00000143179
adam19b
ADAM metallopeptidase domain 19b
chr9_-_21970067 2.92 ENSDART00000009920
lmo7a
LIM domain 7a
chr24_-_15131831 2.91 ENSDART00000028410
cd226
CD226 molecule
chr16_-_25285469 2.91 ENSDART00000183943
ENSDART00000191103
ENSDART00000154543
prelid3a
PRELI domain containing 3A
chr7_-_52842007 2.91 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr10_-_26430168 2.89 ENSDART00000128894
dchs1b
dachsous cadherin-related 1b
chr21_+_26726936 2.87 ENSDART00000065392
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr25_-_12788370 2.87 ENSDART00000158551
slc7a5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr9_-_18877597 2.85 ENSDART00000099446
kctd4
potassium channel tetramerization domain containing 4
chr23_+_45584223 2.84 ENSDART00000149367
si:ch73-290k24.5
si:ch73-290k24.5
chr25_-_22639133 2.83 ENSDART00000073583
islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr8_+_24861264 2.82 ENSDART00000099607
slc6a17
solute carrier family 6 (neutral amino acid transporter), member 17
chr14_+_35691889 2.80 ENSDART00000074685
glrbb
glycine receptor, beta b
chr16_+_5196226 2.73 ENSDART00000189704
soga3a
SOGA family member 3a
chr8_-_11229523 2.73 ENSDART00000002164
unc45b
unc-45 myosin chaperone B
chr16_-_22006996 2.71 ENSDART00000116114
si:dkey-71b5.7
si:dkey-71b5.7
chr17_+_9009098 2.70 ENSDART00000180856
akap6
A kinase (PRKA) anchor protein 6
chr19_-_22621811 2.69 ENSDART00000090669
pleca
plectin a
chr17_-_15498275 2.69 ENSDART00000156905
ENSDART00000080661
si:ch211-266g18.10
si:ch211-266g18.10
chr12_+_15290800 2.67 ENSDART00000145656
med1
mediator complex subunit 1
chr17_-_3291369 2.67 ENSDART00000181840
CABZ01007222.1

chr18_-_13360106 2.67 ENSDART00000091512
cmip
c-Maf inducing protein
chr9_+_17438765 2.66 ENSDART00000138953
rgcc
regulator of cell cycle
chr13_+_30054996 2.66 ENSDART00000110061
ENSDART00000186045
spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr21_+_33503835 2.66 ENSDART00000125658
clint1b
clathrin interactor 1b
chr15_+_40665310 2.66 ENSDART00000154187
ENSDART00000042082
fat3a
FAT atypical cadherin 3a
chr4_+_912563 2.64 ENSDART00000103631
ripply2
ripply transcriptional repressor 2
chr2_-_37893910 2.62 ENSDART00000143027
hbl2
hexose-binding lectin 2
chr7_+_38716048 2.61 ENSDART00000024590
syt13
synaptotagmin XIII
chr19_+_22727940 2.59 ENSDART00000052509
trhrb
thyrotropin-releasing hormone receptor b
chr8_-_18225968 2.58 ENSDART00000135504
si:ch211-241d21.5
si:ch211-241d21.5
chr23_-_29667716 2.58 ENSDART00000158302
ENSDART00000133902
clstn1
calsyntenin 1
chr19_+_13375838 2.57 ENSDART00000163093
lrp12
low density lipoprotein receptor-related protein 12
chr21_-_2217685 2.53 ENSDART00000159315
si:dkey-50i6.5
si:dkey-50i6.5
chr11_+_25257022 2.50 ENSDART00000156052
tp53inp2
tumor protein p53 inducible nuclear protein 2
chr17_+_37645633 2.49 ENSDART00000085500
tmem229b
transmembrane protein 229B
chr12_+_41510492 2.49 ENSDART00000170976
ENSDART00000176164
kif5bb
kinesin family member 5B, b
chr17_+_58211 2.48 ENSDART00000157642
si:ch1073-209e23.1
si:ch1073-209e23.1
chr7_+_57836841 2.46 ENSDART00000136175
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr14_-_2979878 2.46 ENSDART00000031211
bicc2
bicaudal C homolog 2
chr8_-_21268303 2.45 ENSDART00000067211
gpr37l1b
G protein-coupled receptor 37 like 1b
chr23_+_27912079 2.45 ENSDART00000171859
BX539336.1

chr19_-_9712530 2.43 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr7_-_9803154 2.43 ENSDART00000055593
aldh1a3
aldehyde dehydrogenase 1 family, member A3
chr24_+_26039464 2.42 ENSDART00000131017
tnk2a
tyrosine kinase, non-receptor, 2a
chr7_+_69841017 2.41 ENSDART00000169107
FO818704.1

chr16_+_7985886 2.41 ENSDART00000126041
ano10a
anoctamin 10a
chr12_-_23009312 2.41 ENSDART00000111801
mkxa
mohawk homeobox a
chr12_+_25600685 2.40 ENSDART00000077157
six3b
SIX homeobox 3b
chr15_+_22722684 2.39 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr22_+_15959844 2.39 ENSDART00000182201
stil
scl/tal1 interrupting locus

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx15_tbx1_mgaa_tbx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.9 11.6 GO:0060765 androgen receptor signaling pathway(GO:0030521) regulation of androgen receptor signaling pathway(GO:0060765)
3.1 12.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
3.0 11.9 GO:0060074 synapse maturation(GO:0060074)
2.9 8.8 GO:0021960 anterior commissure morphogenesis(GO:0021960)
2.6 23.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.3 9.2 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
2.2 6.7 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
1.5 6.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.3 4.0 GO:0021611 facial nerve formation(GO:0021611)
1.2 4.9 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
1.1 11.1 GO:1904071 presynaptic active zone assembly(GO:1904071)
1.0 5.2 GO:0006972 hyperosmotic response(GO:0006972)
1.0 2.9 GO:0002855 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.0 2.9 GO:1902410 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.9 2.8 GO:0015824 proline transport(GO:0015824)
0.9 2.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.8 17.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.8 20.7 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.7 16.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.6 13.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.6 2.3 GO:0055091 phospholipid homeostasis(GO:0055091)
0.6 8.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.6 4.6 GO:0048240 sperm capacitation(GO:0048240)
0.6 5.0 GO:0071539 protein localization to centrosome(GO:0071539)
0.5 5.3 GO:0007525 somatic muscle development(GO:0007525)
0.5 2.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.5 4.1 GO:0033292 T-tubule organization(GO:0033292)
0.5 4.1 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 11.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 2.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.5 1.4 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.5 1.9 GO:0006740 NADPH regeneration(GO:0006740)
0.5 2.3 GO:0032616 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.4 11.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.4 0.9 GO:0048389 intermediate mesoderm development(GO:0048389)
0.4 4.5 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.4 3.5 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.4 13.5 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.4 1.8 GO:1903146 regulation of mitophagy(GO:1903146)
0.4 5.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 6.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 5.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 4.1 GO:0035094 response to nicotine(GO:0035094)
0.3 20.9 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.3 1.7 GO:1901207 regulation of heart looping(GO:1901207)
0.3 6.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 3.3 GO:0098900 regulation of action potential(GO:0098900)
0.3 1.0 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.3 1.2 GO:0070983 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.3 2.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.3 1.8 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.3 3.2 GO:0046548 retinal rod cell development(GO:0046548)
0.3 6.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 1.1 GO:0034163 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.3 4.8 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 2.2 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.3 34.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.3 1.6 GO:0016572 histone phosphorylation(GO:0016572)
0.3 1.1 GO:0043114 regulation of vascular permeability(GO:0043114)
0.3 1.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.3 2.8 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 2.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 3.7 GO:0048769 sarcomerogenesis(GO:0048769)
0.2 7.4 GO:0006829 zinc II ion transport(GO:0006829)
0.2 4.9 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.2 4.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.2 13.9 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.2 2.2 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.2 7.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 0.7 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 1.7 GO:0040038 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.2 2.0 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.2 1.2 GO:0048730 epidermis morphogenesis(GO:0048730)
0.2 9.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 1.2 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.2 0.8 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 3.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 0.8 GO:0002164 larval development(GO:0002164) larval heart development(GO:0007508)
0.2 1.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 0.5 GO:0009258 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.2 7.1 GO:0072114 pronephros morphogenesis(GO:0072114)
0.2 1.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 0.9 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.2 1.0 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.2 0.8 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.2 0.5 GO:0086003 cardiac muscle cell contraction(GO:0086003)
0.2 1.2 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 2.1 GO:0050936 xanthophore differentiation(GO:0050936)
0.2 1.3 GO:0090311 regulation of protein deacetylation(GO:0090311)
0.2 1.8 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 5.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 18.1 GO:0007626 locomotory behavior(GO:0007626)
0.2 2.2 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.2 9.6 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.2 22.6 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.2 2.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 1.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 2.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.7 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 1.0 GO:0090179 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 1.4 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.1 2.4 GO:0045445 myoblast differentiation(GO:0045445)
0.1 0.7 GO:0042102 positive regulation of T cell proliferation(GO:0042102)
0.1 1.7 GO:0001964 startle response(GO:0001964)
0.1 1.0 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 1.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 10.9 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 9.5 GO:0051017 actin filament bundle assembly(GO:0051017)
0.1 0.8 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 1.4 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 0.8 GO:0021871 forebrain regionalization(GO:0021871)
0.1 0.5 GO:2000252 negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
0.1 0.4 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 1.2 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.5 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 1.7 GO:0090303 positive regulation of wound healing(GO:0090303)
0.1 2.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 5.0 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.7 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 5.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.6 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 5.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 2.6 GO:0006491 N-glycan processing(GO:0006491)
0.1 2.5 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 2.6 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 1.0 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 1.9 GO:0030316 osteoclast differentiation(GO:0030316)
0.1 1.8 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 1.7 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.3 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.1 0.9 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.3 GO:0034770 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.1 2.4 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 1.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 19.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 1.1 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.5 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.1 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.4 GO:0015871 choline transport(GO:0015871)
0.1 1.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 2.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.6 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.1 12.8 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.6 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 0.6 GO:0016203 muscle attachment(GO:0016203)
0.1 0.9 GO:0050919 negative chemotaxis(GO:0050919)
0.1 0.4 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 1.1 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 2.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 1.4 GO:0045664 regulation of neuron differentiation(GO:0045664)
0.1 6.9 GO:0016573 histone acetylation(GO:0016573)
0.1 0.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 5.2 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 0.9 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.5 GO:0043200 response to amino acid(GO:0043200) cellular response to amino acid stimulus(GO:0071230)
0.1 0.7 GO:0033700 phospholipid efflux(GO:0033700)
0.1 2.7 GO:0060349 bone morphogenesis(GO:0060349)
0.1 1.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 1.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.9 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.1 0.7 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.7 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 1.4 GO:0039020 pronephric nephron tubule development(GO:0039020)
0.1 1.4 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.9 GO:0009409 response to cold(GO:0009409)
0.1 2.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 1.6 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.1 1.7 GO:0051180 vitamin transport(GO:0051180)
0.1 2.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.6 GO:0007608 sensory perception of smell(GO:0007608)
0.1 0.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 7.6 GO:0016579 protein deubiquitination(GO:0016579)
0.1 3.3 GO:0098661 inorganic anion transmembrane transport(GO:0098661)
0.1 1.6 GO:0043049 otic placode formation(GO:0043049)
0.1 1.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 0.5 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 2.0 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.2 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.1 1.1 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.1 0.2 GO:0060031 mediolateral intercalation(GO:0060031)
0.0 3.3 GO:0010506 regulation of autophagy(GO:0010506)
0.0 3.6 GO:0031101 fin regeneration(GO:0031101)
0.0 8.7 GO:0035050 embryonic heart tube development(GO:0035050)
0.0 0.3 GO:0042311 vasodilation(GO:0042311)
0.0 0.7 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.0 3.5 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 2.6 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 1.6 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.0 0.1 GO:0045777 positive regulation of blood pressure(GO:0045777)
0.0 6.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 3.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.9 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 2.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 4.0 GO:1901342 regulation of vasculature development(GO:1901342)
0.0 9.1 GO:0098916 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.0 0.1 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.4 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.7 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.5 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.6 GO:0060037 pharyngeal system development(GO:0060037)
0.0 1.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.6 GO:0043113 receptor clustering(GO:0043113)
0.0 1.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.3 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.4 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.4 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.6 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.4 GO:0046660 female sex differentiation(GO:0046660)
0.0 0.3 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 1.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.6 GO:0030261 chromosome condensation(GO:0030261)
0.0 2.4 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.3 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 2.4 GO:0044782 cilium organization(GO:0044782)
0.0 0.7 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.3 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 2.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.9 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.3 GO:0022900 electron transport chain(GO:0022900)
0.0 7.4 GO:0031175 neuron projection development(GO:0031175)
0.0 0.1 GO:0030826 nitric oxide mediated signal transduction(GO:0007263) regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284) negative regulation of blood pressure(GO:0045776)
0.0 0.1 GO:0061036 positive regulation of chondrocyte differentiation(GO:0032332) positive regulation of cartilage development(GO:0061036)
0.0 0.3 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.8 GO:0045010 actin nucleation(GO:0045010)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.6 GO:0003407 neural retina development(GO:0003407)
0.0 0.5 GO:0009154 purine ribonucleotide catabolic process(GO:0009154)
0.0 0.3 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 6.1 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892)
0.0 0.9 GO:0007030 Golgi organization(GO:0007030)
0.0 0.2 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.0 GO:0030902 hindbrain development(GO:0030902)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:0006821 chloride transport(GO:0006821)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 21.2 GO:0016586 RSC complex(GO:0016586)
1.2 4.9 GO:0097268 cytoophidium(GO:0097268)
1.1 5.7 GO:0043034 costamere(GO:0043034)
1.1 11.1 GO:0098982 GABA-ergic synapse(GO:0098982)
1.0 2.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.9 10.7 GO:0044295 axonal growth cone(GO:0044295)
0.8 5.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.6 2.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.5 8.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 2.1 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.5 6.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.5 1.4 GO:0005592 collagen type XI trimer(GO:0005592)
0.5 2.3 GO:0033503 HULC complex(GO:0033503)
0.5 3.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.4 6.3 GO:0030056 hemidesmosome(GO:0030056)
0.4 4.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.4 6.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.4 7.5 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.3 5.5 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.3 4.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 8.1 GO:0005844 polysome(GO:0005844)
0.3 20.1 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.3 1.8 GO:0043194 axon initial segment(GO:0043194)
0.2 8.0 GO:0030426 growth cone(GO:0030426)
0.2 3.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 61.7 GO:0030424 axon(GO:0030424)
0.2 3.5 GO:0016363 nuclear matrix(GO:0016363)
0.2 2.3 GO:0045095 keratin filament(GO:0045095)
0.2 4.9 GO:0032590 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.2 4.1 GO:0035371 microtubule plus-end(GO:0035371)
0.2 3.9 GO:0005771 multivesicular body(GO:0005771)
0.2 1.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 1.8 GO:0005688 U6 snRNP(GO:0005688)
0.2 1.4 GO:0071914 prominosome(GO:0071914)
0.2 1.0 GO:0070062 extracellular exosome(GO:0070062)
0.2 27.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 1.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 11.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 8.7 GO:0005776 autophagosome(GO:0005776)
0.1 2.3 GO:0005869 dynactin complex(GO:0005869)
0.1 52.3 GO:0043005 neuron projection(GO:0043005)
0.1 7.9 GO:0016342 catenin complex(GO:0016342)
0.1 1.1 GO:0032021 NELF complex(GO:0032021)
0.1 16.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 2.9 GO:0031672 A band(GO:0031672)
0.1 2.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 4.5 GO:0005861 troponin complex(GO:0005861)
0.1 4.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.0 GO:0098978 glutamatergic synapse(GO:0098978)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.5 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 7.9 GO:0005604 basement membrane(GO:0005604)
0.1 4.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.5 GO:0032019 mitochondrial cloud(GO:0032019)
0.1 9.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 19.5 GO:0005764 lysosome(GO:0005764)
0.1 0.5 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.7 GO:0030904 retromer complex(GO:0030904)
0.1 4.1 GO:0005770 late endosome(GO:0005770)
0.1 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 2.9 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 5.0 GO:0031514 motile cilium(GO:0031514)
0.1 2.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 4.1 GO:0005814 centriole(GO:0005814)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.7 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 3.6 GO:0005581 collagen trimer(GO:0005581)
0.1 0.5 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.8 GO:0035869 ciliary transition zone(GO:0035869)
0.1 2.1 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 4.8 GO:0000786 nucleosome(GO:0000786)
0.0 2.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0089701 U2AF(GO:0089701)
0.0 0.9 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 2.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.5 GO:0048179 activin receptor complex(GO:0048179)
0.0 7.4 GO:0045202 synapse(GO:0045202)
0.0 0.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 7.0 GO:0000785 chromatin(GO:0000785)
0.0 5.8 GO:0005912 adherens junction(GO:0005912)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 3.2 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.1 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 0.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 5.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.1 GO:0000941 condensed nuclear chromosome inner kinetochore(GO:0000941)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.4 GO:0030496 midbody(GO:0030496)
0.0 1.3 GO:0043235 receptor complex(GO:0043235)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 14.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 1.0 GO:0005884 actin filament(GO:0005884)
0.0 2.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.6 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
4.1 12.2 GO:0038046 enkephalin receptor activity(GO:0038046)
3.4 13.5 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
2.9 11.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
2.1 10.7 GO:0008046 axon guidance receptor activity(GO:0008046)
1.9 15.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.6 4.7 GO:1903136 cuprous ion binding(GO:1903136)
1.5 6.0 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
1.3 16.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.2 4.9 GO:0003883 CTP synthase activity(GO:0003883)
1.2 9.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
1.0 8.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.0 5.7 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.9 3.5 GO:0070052 collagen V binding(GO:0070052)
0.7 2.1 GO:0005252 open rectifier potassium channel activity(GO:0005252)
0.7 16.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.6 7.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.6 11.1 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.6 2.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.5 5.8 GO:0031420 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.5 2.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.5 1.9 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.4 6.3 GO:0030506 ankyrin binding(GO:0030506)
0.4 2.6 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.4 2.9 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 11.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 10.7 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.4 18.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 4.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.4 4.9 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.3 2.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.3 8.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 2.8 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 1.2 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.3 1.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 0.9 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.3 9.5 GO:0019003 GDP binding(GO:0019003)
0.3 2.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 5.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 1.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 0.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 2.2 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 13.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 12.4 GO:0005178 integrin binding(GO:0005178)
0.2 3.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 0.8 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 3.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 2.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.2 0.4 GO:0043121 neurotrophin binding(GO:0043121)
0.2 6.2 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.2 3.4 GO:0030552 cAMP binding(GO:0030552)
0.2 192.6 GO:0005509 calcium ion binding(GO:0005509)
0.2 0.9 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.2 3.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 2.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 0.5 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 4.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 2.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 11.7 GO:0051427 hormone receptor binding(GO:0051427)
0.2 3.4 GO:0019894 kinesin binding(GO:0019894)
0.2 1.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 3.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 7.5 GO:0044325 ion channel binding(GO:0044325)
0.1 2.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.0 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 1.7 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.1 6.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.8 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 0.9 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.1 0.7 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.9 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 8.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 21.0 GO:0015293 symporter activity(GO:0015293)
0.1 0.6 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 1.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 1.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 2.9 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 1.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 7.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 5.1 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 2.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.9 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 28.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.8 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.6 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 9.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 7.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.5 GO:0048185 activin binding(GO:0048185)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 11.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 4.0 GO:0030276 clathrin binding(GO:0030276)
0.1 2.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 0.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.9 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 1.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 22.5 GO:0003682 chromatin binding(GO:0003682)
0.1 1.2 GO:0070122 isopeptidase activity(GO:0070122)
0.1 0.8 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 20.6 GO:0008017 microtubule binding(GO:0008017)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.9 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 6.3 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 2.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 4.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.8 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 5.7 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 15.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 2.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 2.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 4.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0032034 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.0 1.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.1 GO:0045296 cadherin binding(GO:0045296)
0.0 2.0 GO:0019902 phosphatase binding(GO:0019902)
0.0 6.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 2.2 GO:0060090 binding, bridging(GO:0060090)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 7.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)
0.0 1.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.8 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 1.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.6 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 12.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.6 GO:0019956 chemokine binding(GO:0019956) C-C chemokine binding(GO:0019957)
0.0 0.3 GO:0008569 microtubule motor activity(GO:0003777) ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 3.3 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.6 5.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 8.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 1.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 10.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 2.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 16.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 12.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 8.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 2.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 2.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 7.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.7 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 4.7 NABA COLLAGENS Genes encoding collagen proteins
0.1 3.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 0.9 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 1.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 0.6 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID FGF PATHWAY FGF signaling pathway
0.0 0.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.8 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.4 19.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.9 5.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.8 10.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.8 7.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.6 9.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.6 3.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 4.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.3 8.5 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.3 3.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 8.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 8.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 4.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 2.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 2.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 1.7 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 1.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 3.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 3.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 4.1 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 1.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 0.4 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 3.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere