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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbx3a+tbx3b

Z-value: 0.94

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Transcription factors associated with tbx3a+tbx3b

Gene Symbol Gene ID Gene Info
tbx3a
ENSDARG00000002216 T-box transcription factor 3a
tbx3b
ENSDARG00000061509 T-box transcription factor 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx3adr11_v1_chr5_-_72324371_72324371-0.511.5e-07Click!
tbx3bdr11_v1_chr5_+_26913120_26913120-0.223.7e-02Click!

Activity profile of tbx3a+tbx3b motif

Sorted Z-values of tbx3a+tbx3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_5547185 17.85 ENSDART00000193977
nnt2
nicotinamide nucleotide transhydrogenase 2
chr25_-_13188678 13.43 ENSDART00000125754
si:ch211-147m6.1
si:ch211-147m6.1
chr7_-_73752955 12.45 ENSDART00000171254
ENSDART00000009888
casq1b
calsequestrin 1b
chr13_-_37180815 12.21 ENSDART00000139907
si:dkeyp-77c8.1
si:dkeyp-77c8.1
chr23_-_5683147 11.71 ENSDART00000102766
ENSDART00000067351
tnnt2a
troponin T type 2a (cardiac)
chr13_-_51903150 7.14 ENSDART00000090644
mrpl2
mitochondrial ribosomal protein L2
chr12_-_26415499 6.82 ENSDART00000185779
synpo2lb
synaptopodin 2-like b
chr18_+_29145681 6.69 ENSDART00000089031
ENSDART00000193336
ppfibp2a
PTPRF interacting protein, binding protein 2a (liprin beta 2)
chr12_-_26406323 5.97 ENSDART00000131896
myoz1b
myozenin 1b
chr25_-_27819838 5.74 ENSDART00000067106
lmod2a
leiomodin 2 (cardiac) a
chr20_+_53577502 5.56 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr24_+_35947077 5.26 ENSDART00000173406
obscnb
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
chr24_+_854877 5.10 ENSDART00000188408
piezo2a.2
piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2
chr8_+_26818446 5.02 ENSDART00000134987
ENSDART00000138835
si:ch211-156j16.1
si:ch211-156j16.1
chr3_-_33967767 4.87 ENSDART00000151493
ENSDART00000151160
ighv1-4
immunoglobulin heavy variable 1-4
chr13_+_25486608 4.81 ENSDART00000057689
bag3
BCL2 associated athanogene 3
chr1_-_38813679 4.78 ENSDART00000148917
asb5b
ankyrin repeat and SOCS box containing 5b
chr9_-_105135 4.78 ENSDART00000180126
FQ377903.3

chr2_-_37103622 4.34 ENSDART00000137849
zgc:101744
zgc:101744
chr21_-_33478164 4.20 ENSDART00000191542
si:ch73-42p12.2
si:ch73-42p12.2
chr23_+_2421689 4.18 ENSDART00000180200
tcp1
t-complex 1
chr17_+_8175998 4.09 ENSDART00000131200
myct1b
myc target 1b
chr6_-_1514767 3.95 ENSDART00000067586
chchd6b
coiled-coil-helix-coiled-coil-helix domain containing 6b
chr8_-_25336589 3.32 ENSDART00000009682
atp5pb
ATP synthase peripheral stalk-membrane subunit b
chr3_+_5297493 3.30 ENSDART00000138596
si:ch211-150d5.3
si:ch211-150d5.3
chr21_+_21655755 3.28 ENSDART00000079524
or125-8
odorant receptor, family E, subfamily 125, member 8
chr5_-_38197080 3.19 ENSDART00000140708
si:ch211-284e13.9
si:ch211-284e13.9
chr18_+_37272568 3.13 ENSDART00000132749
tmem123
transmembrane protein 123
chr3_-_1187727 2.96 ENSDART00000180343
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr17_-_50071748 2.95 ENSDART00000075188
zgc:113886
zgc:113886
chr17_-_47090440 2.90 ENSDART00000163542
CABZ01056321.1

chr1_+_218524 2.87 ENSDART00000109529
tmco3
transmembrane and coiled-coil domains 3
chr24_-_31306724 2.83 ENSDART00000165399
acp5b
acid phosphatase 5b, tartrate resistant
chr22_+_344763 2.67 ENSDART00000181934
CU914780.1

chr1_+_56502706 2.57 ENSDART00000188665
CABZ01059403.1

chr12_+_27141140 2.57 ENSDART00000136415
hoxb1b
homeobox B1b
chr3_-_6191950 2.56 ENSDART00000161931
si:ch73-144l3.1
si:ch73-144l3.1
chr7_-_3836635 2.55 ENSDART00000104350
si:dkey-88n24.8
si:dkey-88n24.8
chr7_+_65121743 2.50 ENSDART00000108471
ipo7
importin 7
chr5_+_29803702 2.49 ENSDART00000147569
usf1l
upstream transcription factor 1, like
chr19_+_9212031 2.43 ENSDART00000052930
ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chr19_-_18127808 2.43 ENSDART00000108627
snx10a
sorting nexin 10a
chr19_-_18127629 2.42 ENSDART00000187722
snx10a
sorting nexin 10a
chr9_+_50001746 2.42 ENSDART00000058892
slc38a11
solute carrier family 38, member 11
chr8_-_32894203 2.37 ENSDART00000147822
si:dkey-56i24.1
si:dkey-56i24.1
chr20_+_51464670 2.35 ENSDART00000150110
thbd
thrombomodulin
chr23_-_20345473 2.34 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr1_-_45177373 2.33 ENSDART00000143142
ENSDART00000034549
zgc:111983
zgc:111983
chr7_+_22702437 2.33 ENSDART00000182054
si:dkey-165a24.9
si:dkey-165a24.9
chr22_+_9294336 2.28 ENSDART00000193694
si:ch211-250k18.7
si:ch211-250k18.7
chr24_-_26479841 2.27 ENSDART00000079984
rpl22l1
ribosomal protein L22-like 1
chr5_-_67783593 2.26 ENSDART00000010934
casr
calcium-sensing receptor
chr14_-_28052474 2.23 ENSDART00000172948
ENSDART00000135337
TSC22D3 (1 of many)
zgc:64189
si:ch211-220e11.3
zgc:64189
chr18_-_21748966 2.22 ENSDART00000181910
pskh1
protein serine kinase H1
chr12_+_20506197 2.22 ENSDART00000153010
si:zfos-754c12.2
si:zfos-754c12.2
chr19_-_23674904 2.19 ENSDART00000187300
BX927234.2

chr15_-_21678634 2.19 ENSDART00000061139
bco2b
beta-carotene oxygenase 2b
chr10_-_15048781 2.09 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr22_-_9157364 2.08 ENSDART00000182762
si:ch211-213a13.5
si:ch211-213a13.5
chr13_-_11984867 2.05 ENSDART00000157538
npm3
nucleophosmin/nucleoplasmin, 3
chr5_+_29803380 2.05 ENSDART00000005263
ENSDART00000137558
ENSDART00000146963
ENSDART00000134900
usf1l
upstream transcription factor 1, like
chr16_-_14587332 2.04 ENSDART00000012479
dscc1
DNA replication and sister chromatid cohesion 1
chr7_+_2236317 2.03 ENSDART00000075859
zgc:172065
zgc:172065
chr3_-_2072630 1.97 ENSDART00000189404
BX005442.3

chr8_+_20918207 1.96 ENSDART00000144039
si:ch73-196i15.5
si:ch73-196i15.5
chr22_-_9649627 1.94 ENSDART00000164721
si:dkey-286j17.4
si:dkey-286j17.4
chr7_-_3826794 1.92 ENSDART00000064229
ENSDART00000142138
si:dkey-88n24.10
si:dkey-88n24.10
chr1_-_2453174 1.90 ENSDART00000055779
ENSDART00000152555
ggact.2
ggact.3
gamma-glutamylamine cyclotransferase, tandem duplicate 2
gamma-glutamylamine cyclotransferase, tandem duplicate 3
chr16_-_41990421 1.81 ENSDART00000055921
pycard
PYD and CARD domain containing
chr14_-_8903435 1.77 ENSDART00000160584
zgc:153681
zgc:153681
chr24_+_12074340 1.76 ENSDART00000170997
ENSDART00000166227
ccr9b
chemokine (C-C motif) receptor 9b
chr6_+_15250672 1.76 ENSDART00000155951
si:ch73-23l24.1
si:ch73-23l24.1
chr8_-_46897734 1.75 ENSDART00000138125
hes2.2
hes family bHLH transcription factor 2, tandem duplicate 2
chr19_+_22930177 1.73 ENSDART00000151737
si:ch211-244a23.1
si:ch211-244a23.1
chr14_+_46287296 1.72 ENSDART00000183620
cabp2b
calcium binding protein 2b
chr4_+_14981854 1.70 ENSDART00000067046
cax1
cation/H+ exchanger protein 1
chr12_+_18663154 1.69 ENSDART00000057918
si:ch211-147h1.4
si:ch211-147h1.4
chr14_+_20911310 1.68 ENSDART00000160318
lygl2
lysozyme g-like 2
chr7_+_22702225 1.68 ENSDART00000173672
si:dkey-165a24.9
si:dkey-165a24.9
chr7_-_3836896 1.67 ENSDART00000136227
si:dkey-88n24.8
si:dkey-88n24.8
chr5_-_5035683 1.62 ENSDART00000170025
lmx1ba
LIM homeobox transcription factor 1, beta a
chr24_-_25184553 1.61 ENSDART00000166917
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr15_-_1765098 1.60 ENSDART00000149980
ENSDART00000093074
bud23
BUD23, rRNA methyltransferase and ribosome maturation factor
chr4_-_75812937 1.57 ENSDART00000125096
si:ch211-203c5.3
si:ch211-203c5.3
chr21_-_20725853 1.55 ENSDART00000114502
si:ch211-22d5.2
si:ch211-22d5.2
chr4_-_36792144 1.53 ENSDART00000159147
si:dkeyp-87d1.1
si:dkeyp-87d1.1
chr25_-_15512819 1.51 ENSDART00000142684
si:dkeyp-67e1.2
si:dkeyp-67e1.2
chr25_-_15504559 1.50 ENSDART00000139294
BX323543.5

chr18_-_40913294 1.46 ENSDART00000059196
ENSDART00000098878
polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr16_-_50918908 1.43 ENSDART00000108744
CU855821.1

chr2_-_21438492 1.41 ENSDART00000046098
plcd1b
phospholipase C, delta 1b
chr2_-_38992304 1.40 ENSDART00000114085
ENSDART00000146812
si:ch211-119o8.6
si:ch211-119o8.6
chr3_+_37790351 1.39 ENSDART00000151506
si:dkey-260c8.8
si:dkey-260c8.8
chr22_+_15323930 1.38 ENSDART00000142416
si:dkey-236e20.3
si:dkey-236e20.3
chr23_+_20687340 1.35 ENSDART00000143503
usp21
ubiquitin specific peptidase 21
chr13_+_33462232 1.35 ENSDART00000177841
zgc:136302
zgc:136302
chr8_+_23521974 1.32 ENSDART00000188130
ENSDART00000129378
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr6_-_55399214 1.31 ENSDART00000168367
ctsa
cathepsin A
chr12_+_31537604 1.28 ENSDART00000153340
si:ch73-205h11.1
si:ch73-205h11.1
chr4_+_62598975 1.26 ENSDART00000163548
si:ch211-79g12.2
si:ch211-79g12.2
chr2_+_20472150 1.26 ENSDART00000168537
agla
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a
chr20_-_34164278 1.24 ENSDART00000153128
hmcn1
hemicentin 1
chr3_-_36690348 1.21 ENSDART00000192513
myh11b
myosin, heavy chain 11b, smooth muscle
chr24_-_23942722 1.18 ENSDART00000080810
arxa
aristaless related homeobox a
chr5_+_69856153 1.17 ENSDART00000124128
ENSDART00000073663
ugt2a6
UDP glucuronosyltransferase 2 family, polypeptide A6
chr4_+_53246788 1.17 ENSDART00000184708
ENSDART00000169256
si:dkey-250k10.1
si:dkey-250k10.1
chr14_+_45645024 1.16 ENSDART00000168278
si:ch211-276i12.4
si:ch211-276i12.4
chr4_+_77681389 1.13 ENSDART00000099727
gbp4
guanylate binding protein 4
chr2_+_27403300 1.12 ENSDART00000099180
elovl8a
ELOVL fatty acid elongase 8a
chr25_-_35599887 1.11 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr4_-_49987980 1.09 ENSDART00000150428
si:dkey-156k2.4
si:dkey-156k2.4
chr16_+_32029090 1.08 ENSDART00000041054
tmc4
transmembrane channel-like 4
chr5_-_10236599 1.07 ENSDART00000099834
si:ch73-42k18.1
si:ch73-42k18.1
chr25_-_3647277 0.99 ENSDART00000166363
si:ch211-272n13.3
si:ch211-272n13.3
chr17_-_53329704 0.99 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1
chr21_+_7332963 0.97 ENSDART00000169834
AP3B1
adaptor related protein complex 3 beta 1 subunit
chr20_-_26532167 0.95 ENSDART00000061914
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr3_+_17314997 0.92 ENSDART00000139763
stat5a
signal transducer and activator of transcription 5a
chr15_-_41677689 0.92 ENSDART00000187063
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr7_+_13756374 0.90 ENSDART00000180808
rasl12
RAS-like, family 12
chr15_-_35031523 0.89 ENSDART00000154848
si:ch211-272b8.6
si:ch211-272b8.6
chr21_+_21611867 0.87 ENSDART00000189148
b9d2
B9 domain containing 2
chr9_-_25094181 0.86 ENSDART00000132160
rubcnl
RUN and cysteine rich domain containing beclin 1 interacting protein like
chr21_-_27195256 0.85 ENSDART00000133152
ENSDART00000065401
zgc:110782
zgc:110782
chr25_-_15496485 0.81 ENSDART00000140245
si:dkeyp-67e1.6
si:dkeyp-67e1.6
chr8_+_15251448 0.78 ENSDART00000063717
zgc:171480
zgc:171480
chr13_-_32635859 0.78 ENSDART00000146249
ENSDART00000145395
ENSDART00000148040
ENSDART00000100650
matn3b
matrilin 3b
chr11_-_23219367 0.75 ENSDART00000003646
optc
opticin
chr9_-_374693 0.74 ENSDART00000166571
si:dkey-11f4.7
si:dkey-11f4.7
chr13_-_32577386 0.66 ENSDART00000016535
kcns3a
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3a
chr2_+_42005475 0.63 ENSDART00000056461
gbp2
guanylate binding protein 2
chr16_+_23331633 0.59 ENSDART00000187455
krtcap2
keratinocyte associated protein 2
chr2_-_43745146 0.58 ENSDART00000056164
ENSDART00000098052
ftr96
finTRIM family, member 96
chr22_-_5441893 0.56 ENSDART00000161421
zgc:194627
zgc:194627
chr21_+_21612214 0.51 ENSDART00000008099
b9d2
B9 domain containing 2
chr12_+_20583552 0.49 ENSDART00000170035
arsg
arylsulfatase G
chr19_-_25464291 0.48 ENSDART00000112915
umad1
UBAP1-MVB12-associated (UMA) domain containing 1
chr9_-_23156908 0.44 ENSDART00000135461
lypd6b
LY6/PLAUR domain containing 6B
chr12_-_26491464 0.39 ENSDART00000153361
si:dkey-287g12.6
si:dkey-287g12.6
chr2_+_43895103 0.35 ENSDART00000007074
gbp3
guanylate binding protein 3
chr8_-_50979047 0.33 ENSDART00000184788
ENSDART00000180906
zgc:91909
zgc:91909
chr15_-_38154616 0.30 ENSDART00000099392
irgq2
immunity-related GTPase family, q2
chr4_+_77908076 0.26 ENSDART00000168811
si:zfos-2131b9.2
si:zfos-2131b9.2
chr13_+_3954715 0.21 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
lrrc73
leucine rich repeat containing 73
chr4_+_43700319 0.18 ENSDART00000141967
si:ch211-226o13.1
si:ch211-226o13.1
chr7_+_17106160 0.12 ENSDART00000190048
ENSDART00000180004
ENSDART00000013409
prmt3
protein arginine methyltransferase 3
chr7_-_33960170 0.08 ENSDART00000180766
skor1a
SKI family transcriptional corepressor 1a
chr13_+_30163515 0.06 ENSDART00000040926
eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
chr23_-_19831739 0.04 ENSDART00000125066
haus7
HAUS augmin-like complex, subunit 7
chr23_-_15090782 0.03 ENSDART00000133624
si:ch211-218g4.2
si:ch211-218g4.2

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx3a+tbx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 17.9 GO:0006740 NADPH regeneration(GO:0006740)
4.2 12.5 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
2.9 11.7 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
1.6 4.8 GO:0010660 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
1.0 4.8 GO:0070986 left/right axis specification(GO:0070986)
0.9 5.6 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
0.9 2.6 GO:0021570 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.7 2.0 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.6 5.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.6 5.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.6 1.7 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.4 1.6 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.4 2.3 GO:0005513 detection of calcium ion(GO:0005513)
0.3 3.2 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.3 1.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.3 2.2 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.3 2.8 GO:0045453 bone resorption(GO:0045453)
0.2 6.8 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 1.3 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.2 1.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.2 7.1 GO:0032543 mitochondrial translation(GO:0032543)
0.2 0.6 GO:0042543 protein N-linked glycosylation via arginine(GO:0042543)
0.2 1.1 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.2 3.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 2.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 0.9 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1 1.6 GO:0021592 fourth ventricle development(GO:0021592)
0.1 3.9 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.1 3.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.3 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 4.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 6.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 1.2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.9 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 1.4 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 1.8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 1.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 1.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.0 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 4.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 4.2 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 1.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 5.3 GO:0030239 myofibril assembly(GO:0030239)
0.0 1.2 GO:0071711 basement membrane organization(GO:0071711)
0.0 2.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.4 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 6.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.0 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 4.2 GO:0060271 cilium morphogenesis(GO:0060271)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.7 2.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.5 1.8 GO:0061702 inflammasome complex(GO:0061702)
0.4 4.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 3.9 GO:0061617 MICOS complex(GO:0061617)
0.3 17.5 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.3 5.3 GO:0031430 M band(GO:0031430)
0.2 3.0 GO:1990246 uniplex complex(GO:1990246)
0.2 3.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.0 GO:1990923 PET complex(GO:1990923)
0.2 17.6 GO:0030018 Z disc(GO:0030018)
0.2 7.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 4.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.4 GO:0036038 MKS complex(GO:0036038)
0.1 2.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 6.8 GO:0016459 myosin complex(GO:0016459)
0.0 3.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 2.3 GO:0005840 ribosome(GO:0005840)
0.0 1.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 17.9 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
1.1 11.7 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.6 6.0 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.5 5.7 GO:0005523 tropomyosin binding(GO:0005523)
0.5 4.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 1.7 GO:0015369 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.4 1.7 GO:0003796 lysozyme activity(GO:0003796)
0.4 2.8 GO:0003993 acid phosphatase activity(GO:0003993)
0.3 1.3 GO:0004135 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.3 1.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 2.2 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.2 6.9 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 2.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 2.9 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 0.9 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 1.8 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 2.4 GO:0010181 NADH dehydrogenase (ubiquinone) activity(GO:0008137) FMN binding(GO:0010181) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.6 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 4.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 0.4 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 5.3 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 1.1 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 10.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.4 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 3.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 6.8 GO:0003774 motor activity(GO:0003774)
0.0 5.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 1.0 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 1.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 5.9 GO:0046983 protein dimerization activity(GO:0046983)
0.0 6.5 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 2.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 5.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 2.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase