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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for tbx3a+tbx3b
Z-value: 0.94
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Transcription factors associated with tbx3a+tbx3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tbx3a | dr11_v1_chr5_-_72324371_72324371 | -0.51 | 1.5e-07 | Click! |
| tbx3b | dr11_v1_chr5_+_26913120_26913120 | -0.22 | 3.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_5547185 Show fit | 17.85 |
ENSDART00000193977
|
nicotinamide nucleotide transhydrogenase 2 |
|
| chr25_-_13188678 Show fit | 13.43 |
ENSDART00000125754
|
si:ch211-147m6.1 |
|
| chr7_-_73752955 Show fit | 12.45 |
ENSDART00000171254
ENSDART00000009888 |
calsequestrin 1b |
|
| chr13_-_37180815 Show fit | 12.21 |
ENSDART00000139907
|
si:dkeyp-77c8.1 |
|
| chr23_-_5683147 Show fit | 11.71 |
ENSDART00000102766
ENSDART00000067351 |
troponin T type 2a (cardiac) |
|
| chr13_-_51903150 Show fit | 7.14 |
ENSDART00000090644
|
mitochondrial ribosomal protein L2 |
|
| chr12_-_26415499 Show fit | 6.82 |
ENSDART00000185779
|
synaptopodin 2-like b |
|
| chr18_+_29145681 Show fit | 6.69 |
ENSDART00000089031
ENSDART00000193336 |
PTPRF interacting protein, binding protein 2a (liprin beta 2) |
|
| chr12_-_26406323 Show fit | 5.97 |
ENSDART00000131896
|
myozenin 1b |
|
| chr25_-_27819838 Show fit | 5.74 |
ENSDART00000067106
|
leiomodin 2 (cardiac) a |
Network of associatons between targets according to the STRING database.
First level regulatory network of tbx3a+tbx3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 17.9 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 4.2 | 12.5 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 2.9 | 11.7 | GO:0003228 | atrial cardiac muscle tissue development(GO:0003228) |
| 0.2 | 7.1 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.2 | 6.8 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.1 | 6.7 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 6.2 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.6 | 5.8 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.6 | 5.7 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.9 | 5.6 | GO:0055014 | atrial cardiac muscle cell development(GO:0055014) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.3 | 17.5 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 1.8 | 12.5 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 7.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 6.8 | GO:0016459 | myosin complex(GO:0016459) |
| 0.3 | 5.3 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 4.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.4 | 4.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.4 | 3.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.2 | 3.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 17.9 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 1.1 | 11.7 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.1 | 10.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 6.9 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 6.8 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 6.5 | GO:0005525 | GTP binding(GO:0005525) |
| 0.6 | 6.0 | GO:0031433 | telethonin binding(GO:0031433) FATZ binding(GO:0051373) |
| 0.0 | 5.9 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.5 | 5.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 5.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 0.9 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.2 | 2.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 2.3 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.4 | 1.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.5 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |