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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for tbx5a+tbx5b
Z-value: 0.91
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Transcription factors associated with tbx5a+tbx5b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tbx5b | dr11_v1_chr5_+_23152282_23152282 | -0.18 | 8.5e-02 | Click! |
| tbx5a | dr11_v1_chr5_-_72289648_72289648 | -0.15 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_32526263 Show fit | 14.14 |
ENSDART00000150897
|
si:ch73-367p23.2 |
|
| chr21_+_30351256 Show fit | 11.44 |
ENSDART00000078341
|
forkhead box I3a |
|
| chr3_+_32526799 Show fit | 10.28 |
ENSDART00000185755
|
si:ch73-367p23.2 |
|
| chr2_+_2470687 Show fit | 10.24 |
ENSDART00000184024
ENSDART00000061955 |
myosin, light chain 13 |
|
| chr13_-_7031033 Show fit | 10.02 |
ENSDART00000193211
|
|
|
| chr6_-_46941245 Show fit | 9.68 |
ENSDART00000037875
|
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 1 |
|
| chr7_+_22680560 Show fit | 7.26 |
ENSDART00000133761
|
plac8 onzin related protein 4 |
|
| chr18_+_5547185 Show fit | 6.86 |
ENSDART00000193977
|
nicotinamide nucleotide transhydrogenase 2 |
|
| chr21_+_20383837 Show fit | 6.80 |
ENSDART00000026430
|
heat shock protein, alpha-crystallin-related, b11 |
|
| chr17_-_15611744 Show fit | 6.40 |
ENSDART00000010496
|
four and a half LIM domains 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tbx5a+tbx5b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 2.9 | 11.4 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.7 | 10.7 | GO:0016203 | muscle attachment(GO:0016203) |
| 0.0 | 7.4 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 1.7 | 6.9 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.3 | 6.8 | GO:0031033 | myosin filament organization(GO:0031033) |
| 0.1 | 6.4 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 1.0 | 6.2 | GO:0097101 | blood vessel endothelial cell fate specification(GO:0097101) |
| 1.0 | 5.9 | GO:0033292 | T-tubule organization(GO:0033292) |
| 0.5 | 5.6 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 20.8 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.0 | 20.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 11.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.0 | 10.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 8.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.2 | 7.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 7.5 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.2 | 7.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 7.0 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.3 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 14.8 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.1 | 10.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 8.8 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 0.0 | 8.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 8.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.7 | 6.9 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.4 | 6.0 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.2 | 5.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 5.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 6.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 6.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 3.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 3.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.3 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 3.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 8.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 3.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 3.0 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.2 | 2.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 2.7 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 2.6 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 2.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |