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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbxta+tbxtb

Z-value: 0.76

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Transcription factors associated with tbxta+tbxtb

Gene Symbol Gene ID Gene Info
tbxtb
ENSDARG00000039806 T-box transcription factor Tb
tbxta
ENSDARG00000101576 T-box transcription factor Ta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbxtbdr11_v1_chr13_+_4439074_44390740.132.0e-01Click!
tbxtadr11_v1_chr19_-_14191592_141915920.075.0e-01Click!

Activity profile of tbxta+tbxtb motif

Sorted Z-values of tbxta+tbxtb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_7591381 9.33 ENSDART00000136313
si:dkeyp-1h4.6
si:dkeyp-1h4.6
chr19_-_5372572 8.06 ENSDART00000151326
krt17
keratin 17
chr7_+_66565930 7.26 ENSDART00000154597
tmem176l.3b
transmembrane protein 176l.3b
chr23_-_20100436 7.11 ENSDART00000143445
si:dkey-32e6.6
si:dkey-32e6.6
chr25_+_31227747 6.39 ENSDART00000033872
tnni2a.1
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr12_-_43711918 5.94 ENSDART00000193110
CU914622.2

chr17_+_26965351 5.45 ENSDART00000114215
ENSDART00000147192
grhl3
grainyhead-like transcription factor 3
chr7_-_48667056 5.33 ENSDART00000006378
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr14_+_29769336 5.08 ENSDART00000105898
si:dkey-34l15.1
si:dkey-34l15.1
chr18_+_45796096 5.07 ENSDART00000087070
abcc5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr7_-_26579465 4.62 ENSDART00000173820
si:dkey-62k3.6
si:dkey-62k3.6
chr8_+_36142734 4.44 ENSDART00000159361
ENSDART00000161194
mhc2b
major histocompatibility complex class II integral membrane beta chain gene
chr11_+_6650966 4.36 ENSDART00000131236
si:dkey-246j7.1
si:dkey-246j7.1
chr5_+_56026031 4.32 ENSDART00000050970
fzd9a
frizzled class receptor 9a
chr20_-_8110672 4.22 ENSDART00000113993
si:ch211-232i5.1
si:ch211-232i5.1
chr23_-_29812667 3.74 ENSDART00000006120
pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr5_-_33215261 3.70 ENSDART00000097935
ENSDART00000134777
si:dkey-226m8.10
si:dkey-226m8.10
chr9_-_1951144 3.67 ENSDART00000082355
hoxd4a
homeobox D4a
chr7_+_57725708 3.56 ENSDART00000056466
ENSDART00000142259
ENSDART00000166198
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr4_+_76722754 3.55 ENSDART00000153867
ms4a17a.3
membrane-spanning 4-domains, subfamily A, member 17A.3
chr3_+_29510818 3.28 ENSDART00000055407
ENSDART00000193743
ENSDART00000123619
rac2
Rac family small GTPase 2
chr3_-_32958505 3.24 ENSDART00000147374
ENSDART00000136919
casp6l1
caspase 6, apoptosis-related cysteine peptidase, like 1
chr15_-_1941042 3.18 ENSDART00000112946
ENSDART00000155504
dock10
dedicator of cytokinesis 10
chr21_+_26726936 3.16 ENSDART00000065392
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr20_+_9223514 3.07 ENSDART00000023293
kcnk5b
potassium channel, subfamily K, member 5b
chr9_+_33423170 3.07 ENSDART00000141542
si:dkey-216e24.9
si:dkey-216e24.9
chr10_-_31782616 2.92 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr23_+_23232136 2.90 ENSDART00000126479
ENSDART00000187764
plekhn1
pleckstrin homology domain containing, family N member 1
chr2_+_15069011 2.89 ENSDART00000145893
cnn3b
calponin 3, acidic b
chr25_-_29363934 2.82 ENSDART00000166889
nptna
neuroplastin a
chr7_+_2797795 2.81 ENSDART00000161208
si:ch211-217i17.1
si:ch211-217i17.1
chr5_+_62374092 2.79 ENSDART00000082965
CU928117.1

chr7_+_57836841 2.79 ENSDART00000136175
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr3_-_15451097 2.79 ENSDART00000163836
BX784026.1
Danio rerio linker for activation of T cells (lat), mRNA.
chr9_-_327901 2.76 ENSDART00000159956
ndufa4l2a
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2a
chr2_+_5620742 2.76 ENSDART00000028390
fgf12a
fibroblast growth factor 12a
chr12_+_10062953 2.73 ENSDART00000148689
slc4a1b
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr6_-_18121075 2.68 ENSDART00000171072
SEC14L1
si:dkey-237i9.1
chr10_-_17103651 2.68 ENSDART00000108959
RNF208
ring finger protein 208
chr5_-_66397688 2.55 ENSDART00000161483
hip1rb
huntingtin interacting protein 1 related b
chr4_-_880415 2.55 ENSDART00000149162
aim1b
crystallin beta-gamma domain containing 1b
chr2_+_36121373 2.52 ENSDART00000187002
CT867973.2

chr2_-_28102264 2.49 ENSDART00000013638
cdh6
cadherin 6
chr2_+_5521671 2.49 ENSDART00000099647
ENSDART00000138443
crfb16
cytokine receptor family member B16
chr8_+_22277198 2.38 ENSDART00000005989
dffb
DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
chr2_+_35595454 2.33 ENSDART00000098734
cacybp
calcyclin binding protein
chr19_+_12915498 2.25 ENSDART00000132892
cthrc1a
collagen triple helix repeat containing 1a
chr22_+_9806867 2.19 ENSDART00000137182
ENSDART00000106103
si:ch211-236g6.1
si:ch211-236g6.1
chr5_-_22615087 2.12 ENSDART00000146035
zgc:113208
zgc:113208
chr19_+_42061699 2.08 ENSDART00000125579
si:ch211-13c6.2
si:ch211-13c6.2
chr7_-_8014186 2.06 ENSDART00000190012
si:cabz01030277.1
si:cabz01030277.1
chr16_+_40301056 2.05 ENSDART00000058578
rspo3
R-spondin 3
chr11_+_1657221 2.00 ENSDART00000164394
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr2_-_44283554 1.99 ENSDART00000184684
mpz
myelin protein zero
chr24_-_31123365 1.94 ENSDART00000182947
tmem56a
transmembrane protein 56a
chr1_-_16507812 1.92 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr3_-_36364903 1.89 ENSDART00000028883
gna13b
guanine nucleotide binding protein (G protein), alpha 13b
chr2_+_9821757 1.88 ENSDART00000018408
ENSDART00000141227
ENSDART00000144681
ENSDART00000148227
anxa13l
annexin A13, like
chr18_+_16053455 1.86 ENSDART00000189163
ENSDART00000188269
FO834850.1

chr7_+_65673885 1.86 ENSDART00000169182
parvab
parvin, alpha b
chr18_+_27732285 1.84 ENSDART00000141835
tspan18b
tetraspanin 18b
chr18_+_27571448 1.80 ENSDART00000147886
cd82b
CD82 molecule b
chr12_+_27061720 1.78 ENSDART00000153426
srcap
Snf2-related CREBBP activator protein
chr16_-_26140768 1.78 ENSDART00000143960
cd79a
CD79a molecule, immunoglobulin-associated alpha
chr9_+_30633184 1.76 ENSDART00000191310
tbc1d4
TBC1 domain family, member 4
chr8_+_47571211 1.70 ENSDART00000131460
plch2a
phospholipase C, eta 2a
chr10_+_22527715 1.70 ENSDART00000134864
gigyf1b
GRB10 interacting GYF protein 1b
chr9_-_30385059 1.69 ENSDART00000060134
piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr5_+_61998641 1.68 ENSDART00000137110
selenow1
selenoprotein W, 1
chr6_+_56141852 1.67 ENSDART00000149665
tfap2c
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr14_+_28486213 1.66 ENSDART00000161852
stag2b
stromal antigen 2b
chr14_+_28518349 1.65 ENSDART00000159961
stag2b
stromal antigen 2b
chr8_+_12930216 1.65 ENSDART00000115405
KIF2A
zgc:103670
chr6_-_18618106 1.64 ENSDART00000161562
znf207b
zinc finger protein 207, b
chr16_+_50741154 1.63 ENSDART00000101627
IGLON5
zgc:110372
chr19_-_11014641 1.63 ENSDART00000183745
tpm3
tropomyosin 3
chr4_-_13973213 1.62 ENSDART00000067177
ENSDART00000144127
prickle1b
prickle homolog 1b
chr22_+_38767780 1.57 ENSDART00000149499
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr3_+_28939759 1.54 ENSDART00000141904
lgals1l1
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr6_+_24661736 1.54 ENSDART00000169283
znf644b
zinc finger protein 644b
chr1_-_31515746 1.50 ENSDART00000190886
cenpk
centromere protein K
chr1_-_23110740 1.46 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adgrl3.1
adhesion G protein-coupled receptor L3.1
chr5_+_50913034 1.46 ENSDART00000149787
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr3_+_32842825 1.46 ENSDART00000122228
prr14
proline rich 14
chr17_-_21368775 1.46 ENSDART00000058027
shtn1
shootin 1
chr12_+_19281189 1.45 ENSDART00000153428
tnrc6b
trinucleotide repeat containing 6b
chr18_-_44526940 1.45 ENSDART00000077125
aplp2
amyloid beta (A4) precursor-like protein 2
chr22_+_9523479 1.44 ENSDART00000189473
ENSDART00000143953
strip1
striatin interacting protein 1
chr18_+_19419120 1.43 ENSDART00000025107
map2k1
mitogen-activated protein kinase kinase 1
chr9_-_13871935 1.41 ENSDART00000146597
raph1a
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr3_-_26341959 1.40 ENSDART00000169344
ENSDART00000142878
ENSDART00000087196
zgc:153240
zgc:153240
chr12_-_10567188 1.39 ENSDART00000144283
myof
myoferlin
chr10_+_26944418 1.38 ENSDART00000135493
frmd8
FERM domain containing 8
chr13_+_4205724 1.35 ENSDART00000134105
dlk2
delta-like 2 homolog (Drosophila)
chr17_+_38255105 1.34 ENSDART00000005296
nkx2.9
NK2 transcription factor related, locus 9 (Drosophila)
chr5_+_26075230 1.29 ENSDART00000098473
klf9
Kruppel-like factor 9
chr24_-_15131831 1.28 ENSDART00000028410
cd226
CD226 molecule
chr3_+_6325895 1.27 ENSDART00000167386
ENSDART00000165000
zgc:136767
zgc:136767
chr18_+_22285992 1.26 ENSDART00000079139
ENSDART00000151922
ctcf
CCCTC-binding factor (zinc finger protein)
chr21_+_6961635 1.25 ENSDART00000137281
si:ch211-93g21.2
si:ch211-93g21.2
chr14_-_14659023 1.23 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr22_+_19365220 1.20 ENSDART00000132781
ENSDART00000135672
ENSDART00000153630
si:dkey-21e2.12
si:dkey-21e2.12
chr3_+_13569806 1.11 ENSDART00000170105
si:ch73-106n3.2
si:ch73-106n3.2
chr4_-_12790886 1.10 ENSDART00000182535
ENSDART00000067131
ENSDART00000186426
irak3
interleukin-1 receptor-associated kinase 3
chr7_+_51795667 1.10 ENSDART00000174201
ENSDART00000073839
slc38a7
solute carrier family 38, member 7
chr2_+_36007449 1.02 ENSDART00000161837
lamc2
laminin, gamma 2
chr2_-_59285085 1.01 ENSDART00000131880
ftr34
finTRIM family, member 34
chr22_+_19311411 1.01 ENSDART00000133234
ENSDART00000138284
si:dkey-21e2.16
si:dkey-21e2.16
chr17_+_20237727 0.99 ENSDART00000180115
smndc1
survival motor neuron domain containing 1
chr2_-_59247811 0.97 ENSDART00000141384
ftr32
finTRIM family, member 32
chr5_+_50913357 0.97 ENSDART00000092938
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr17_-_28749640 0.96 ENSDART00000000948
coch
coagulation factor C homolog, cochlin (Limulus polyphemus)
chr9_-_4754746 0.95 ENSDART00000133090
fmnl2a
formin-like 2a
chr7_+_11197022 0.94 ENSDART00000185236
cemip
cell migration inducing protein, hyaluronan binding
chr3_+_23488652 0.92 ENSDART00000126282
nr1d1
nuclear receptor subfamily 1, group d, member 1
chr13_+_31297016 0.91 ENSDART00000141786
ENSDART00000086143
antxr1d
anthrax toxin receptor 1d
chr4_-_12794045 0.91 ENSDART00000189678
ENSDART00000192018
b2m
beta-2-microglobulin
chr2_-_47870649 0.91 ENSDART00000142854
ftr05
finTRIM family, member 5
chr9_+_17438765 0.87 ENSDART00000138953
rgcc
regulator of cell cycle
chr22_+_20169352 0.87 ENSDART00000169055
ENSDART00000061617
hmg20b
high mobility group 20B
chr5_-_68456987 0.87 ENSDART00000157810
ENSDART00000170819
ephb4a
eph receptor B4a
chr25_-_34281411 0.86 ENSDART00000189932
gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr9_-_30385278 0.85 ENSDART00000183416
piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr15_+_863931 0.82 ENSDART00000154083
si:dkey-7i4.12
si:dkey-7i4.12
chr16_-_30878521 0.81 ENSDART00000141403
dennd3b
DENN/MADD domain containing 3b
chr21_-_28920245 0.80 ENSDART00000132884
cxxc5a
CXXC finger protein 5a
chr5_+_4436405 0.79 ENSDART00000167969
CABZ01079241.1

chr9_+_12907574 0.78 ENSDART00000102348
si:dkey-230p4.1
si:dkey-230p4.1
chr10_-_8032885 0.74 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr17_-_50220228 0.72 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr11_-_25853212 0.71 ENSDART00000145655
tmem51b
transmembrane protein 51b
chr24_+_26337623 0.71 ENSDART00000145637
mynn
myoneurin
chr15_-_4568154 0.69 ENSDART00000155254
rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr7_+_24496894 0.69 ENSDART00000149994
nelfa
negative elongation factor complex member A
chr21_-_26715270 0.68 ENSDART00000053794
banf1
barrier to autointegration factor 1
chr13_+_1799003 0.68 ENSDART00000029343
col21a1
collagen, type XXI, alpha 1
chr8_-_24113575 0.68 ENSDART00000099692
ENSDART00000186211
dclre1b
DNA cross-link repair 1B
chr3_-_49514874 0.67 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr7_-_27798509 0.67 ENSDART00000173932
PDE3B
si:ch211-79e4.4
chr15_-_6976851 0.66 ENSDART00000158474
ENSDART00000168943
ENSDART00000169944
si:ch73-311h14.2
si:ch73-311h14.2
chr1_-_50291266 0.65 ENSDART00000175142
ENSDART00000043309
tbck
TBC1 domain containing kinase
chr9_+_4252839 0.65 ENSDART00000169740
kalrna
kalirin RhoGEF kinase a
chr20_-_54075136 0.63 ENSDART00000074255
mgat2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr5_-_31856681 0.61 ENSDART00000187817
pkn3
protein kinase N3
chr11_+_18612166 0.60 ENSDART00000162694
ncoa3
nuclear receptor coactivator 3
chr20_-_31018569 0.60 ENSDART00000136039
fndc1
fibronectin type III domain containing 1
chr13_-_36535128 0.59 ENSDART00000043312
srsf5a
serine/arginine-rich splicing factor 5a
chr8_-_34427364 0.59 ENSDART00000112854
ENSDART00000161282
ENSDART00000113230
gapvd1
GTPase activating protein and VPS9 domains 1
chr6_-_16394528 0.58 ENSDART00000089445
agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr7_-_28658143 0.57 ENSDART00000173556
adgrg1
adhesion G protein-coupled receptor G1
chr22_+_26600834 0.55 ENSDART00000157411
adcy9
adenylate cyclase 9
chr7_+_17782436 0.54 ENSDART00000173793
ENSDART00000165110
si:dkey-28a3.2
si:dkey-28a3.2
chr2_-_32501501 0.53 ENSDART00000181309
faim2a
Fas apoptotic inhibitory molecule 2a
chr4_+_43700319 0.53 ENSDART00000141967
si:ch211-226o13.1
si:ch211-226o13.1
chr7_+_11459235 0.52 ENSDART00000159611
il16
interleukin 16
chr2_+_24867534 0.52 ENSDART00000158050
rab3aa
RAB3A, member RAS oncogene family, a
chr21_-_2217685 0.52 ENSDART00000159315
si:dkey-50i6.5
si:dkey-50i6.5
chr11_-_24532988 0.51 ENSDART00000067078
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr8_-_14609284 0.51 ENSDART00000146175
cep350
centrosomal protein 350
chr10_-_9115383 0.51 ENSDART00000139324
si:dkeyp-41f9.3
si:dkeyp-41f9.3
chr13_-_18088229 0.51 ENSDART00000143223
washc2c
WASH complex subunit 2C
chr21_+_41468856 0.49 ENSDART00000161175
bod1
biorientation of chromosomes in cell division 1
chr22_-_9618867 0.46 ENSDART00000131246
si:ch73-286h23.4
si:ch73-286h23.4
chr14_-_5916580 0.45 ENSDART00000054866
ENSDART00000154992
loxl3a
lysyl oxidase-like 3a
chr5_+_25311309 0.43 ENSDART00000169638
wu:fa19b12
wu:fa19b12
chr23_+_7518294 0.43 ENSDART00000081536
hck
HCK proto-oncogene, Src family tyrosine kinase
chr21_+_41468210 0.42 ENSDART00000192287
bod1
biorientation of chromosomes in cell division 1
chr9_-_41323746 0.40 ENSDART00000140564
glsb
glutaminase b
chr3_-_7464250 0.40 ENSDART00000159873
znf1001
zinc finger protein 1001
chr22_-_12160283 0.37 ENSDART00000146785
ENSDART00000128176
tmem163b
transmembrane protein 163b
chr3_+_2754885 0.36 ENSDART00000188692
CR388047.2

chr16_-_35952789 0.36 ENSDART00000180118
eva1ba
eva-1 homolog Ba (C. elegans)
chr7_+_35193832 0.36 ENSDART00000189002
zdhhc1
zinc finger, DHHC-type containing 1
chr3_-_1520657 0.36 ENSDART00000053201
polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr19_-_20148469 0.34 ENSDART00000134476
si:ch211-155k24.1
si:ch211-155k24.1
chr21_+_33503835 0.34 ENSDART00000125658
clint1b
clathrin interactor 1b
chr5_+_64277604 0.33 ENSDART00000111282
qsox2
quiescin Q6 sulfhydryl oxidase 2
chr22_-_3595439 0.32 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr5_+_69868911 0.30 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
ugt2a5
UDP glucuronosyltransferase 2 family, polypeptide A5
chr2_-_59303338 0.30 ENSDART00000100987
ENSDART00000140840
ftr35
finTRIM family, member 35
chr15_-_41333064 0.30 ENSDART00000144678
si:dkey-121n8.7
si:dkey-121n8.7
chr22_-_34609528 0.28 ENSDART00000190781
ENSDART00000171712
terf2ip
telomeric repeat binding factor 2, interacting protein
chr13_+_27951688 0.27 ENSDART00000050303
b3gat2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr20_-_38787047 0.27 ENSDART00000152913
ENSDART00000153430
dnajc5ga
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr21_+_11923701 0.26 ENSDART00000109292
ubap2a
ubiquitin associated protein 2a
chr10_+_1052591 0.26 ENSDART00000123405
unc5c
unc-5 netrin receptor C
chr20_-_15922210 0.26 ENSDART00000152412
ENSDART00000152354
ENSDART00000152828
ENSDART00000013453
ENSDART00000152357
fam20b
family with sequence similarity 20, member B (H. sapiens)
chr22_+_10678141 0.24 ENSDART00000193341
hyal2b
hyaluronoglucosaminidase 2b
chr13_+_12396316 0.24 ENSDART00000143557
atp10d
ATPase phospholipid transporting 10D
chr22_+_9772754 0.22 ENSDART00000130194
BX664625.2

chr4_+_73941991 0.22 ENSDART00000130643
CABZ01069020.1

chr2_-_59285407 0.22 ENSDART00000181616
ftr34
finTRIM family, member 34
chr22_-_20575679 0.21 ENSDART00000089033
lingo3a
leucine rich repeat and Ig domain containing 3a
chr22_+_5135193 0.21 ENSDART00000106156
mydgf
myeloid-derived growth factor
chr9_+_41914378 0.21 ENSDART00000130434
ENSDART00000007058
col18a1a
collagen type XVIII alpha 1 chain a
chr20_+_1278184 0.20 ENSDART00000039616
lrp11
low density lipoprotein receptor-related protein 11
chr13_+_47821524 0.20 ENSDART00000109978
zc3h6
zinc finger CCCH-type containing 6
chr18_-_26876559 0.19 ENSDART00000134351
si:dkey-24l11.2
si:dkey-24l11.2
chr22_+_2459591 0.17 ENSDART00000182602
si:ch73-92e7.4
si:ch73-92e7.4
chr3_-_53508580 0.17 ENSDART00000073978
zgc:171711
zgc:171711

Network of associatons between targets according to the STRING database.

First level regulatory network of tbxta+tbxtb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.3 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.7 2.9 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.7 3.3 GO:2000391 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.5 2.1 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.5 5.1 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.5 1.9 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.4 1.3 GO:0002418 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.4 1.1 GO:0071706 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.4 1.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.4 5.4 GO:0060325 face morphogenesis(GO:0060325)
0.3 2.4 GO:0006309 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.3 7.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 0.9 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.3 1.7 GO:0010269 response to selenium ion(GO:0010269)
0.2 3.7 GO:0048696 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.2 2.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 0.5 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 2.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 0.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 5.4 GO:0019882 antigen processing and presentation(GO:0019882)
0.2 2.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 1.6 GO:0021535 cell migration in hindbrain(GO:0021535)
0.1 0.9 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.1 0.3 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 4.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.7 GO:0031627 telomeric loop formation(GO:0031627)
0.1 1.7 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.1 3.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.7 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 1.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 2.8 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 0.9 GO:1901998 toxin transport(GO:1901998)
0.1 1.5 GO:0051383 kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.1 0.7 GO:1900118 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.6 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 5.5 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.1 1.5 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.5 GO:2000320 regulation of T-helper 17 type immune response(GO:2000316) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) regulation of T-helper 17 cell lineage commitment(GO:2000328) negative regulation of T-helper 17 cell lineage commitment(GO:2000329) positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.1 0.6 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.7 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 4.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 2.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.8 GO:0030183 B cell differentiation(GO:0030183)
0.1 4.3 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.1 8.1 GO:0031101 fin regeneration(GO:0031101)
0.1 2.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.4 GO:0007520 myoblast fusion(GO:0007520)
0.1 2.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.7 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 1.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 0.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.7 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.4 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 3.7 GO:0001570 vasculogenesis(GO:0001570)
0.0 1.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.3 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.0 1.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 2.0 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 2.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 3.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.3 GO:0001878 response to yeast(GO:0001878)
0.0 0.5 GO:0050930 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.0 1.9 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 1.4 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.2 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 1.7 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 3.5 GO:0007059 chromosome segregation(GO:0007059)
0.0 2.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 1.4 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 1.5 GO:1901342 regulation of vasculature development(GO:1901342)
0.0 2.5 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 4.4 GO:0007264 small GTPase mediated signal transduction(GO:0007264)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 1.5 GO:0000941 condensed nuclear chromosome inner kinetochore(GO:0000941)
0.5 3.7 GO:0016586 RSC complex(GO:0016586)
0.4 1.8 GO:0019815 B cell receptor complex(GO:0019815)
0.4 2.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 1.9 GO:0031526 brush border membrane(GO:0031526)
0.2 2.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.8 GO:0000812 Swr1 complex(GO:0000812)
0.2 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 3.3 GO:0008278 cohesin complex(GO:0008278)
0.1 1.5 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.0 GO:0043209 myelin sheath(GO:0043209)
0.1 4.5 GO:0005861 troponin complex(GO:0005861)
0.1 0.7 GO:0032021 NELF complex(GO:0032021)
0.1 8.1 GO:0005882 intermediate filament(GO:0005882)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 3.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 2.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.9 GO:0016342 catenin complex(GO:0016342)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 8.2 GO:0030424 axon(GO:0030424)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.9 GO:0005925 focal adhesion(GO:0005925)
0.0 5.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 3.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 1.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.8 GO:0000776 kinetochore(GO:0000776)
0.0 1.2 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0070052 collagen V binding(GO:0070052)
1.0 2.9 GO:1901612 cardiolipin binding(GO:1901612)
0.7 5.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.6 1.9 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.6 2.3 GO:0044548 S100 protein binding(GO:0044548)
0.4 4.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 1.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 2.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 3.7 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.3 4.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 2.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 3.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 1.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 2.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.2 1.5 GO:0016936 galactoside binding(GO:0016936)
0.1 1.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 6.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.5 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 2.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 0.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 2.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.2 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 1.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.7 GO:0051117 ATPase binding(GO:0051117)
0.0 1.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.9 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.1 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 2.4 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 5.1 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 11.8 GO:0003682 chromatin binding(GO:0003682)
0.0 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.6 GO:0009931 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698) calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 2.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.9 GO:0045296 cadherin binding(GO:0045296)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 2.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 7.1 GO:0005198 structural molecule activity(GO:0005198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 3.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 2.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 7.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 1.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.7 PID TNF PATHWAY TNF receptor signaling pathway
0.0 3.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 5.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 1.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 3.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 0.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.7 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.8 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 1.7 REACTOME KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis