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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tcf7

Z-value: 0.64

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Transcription factors associated with tcf7

Gene Symbol Gene ID Gene Info
tcf7
ENSDARG00000038672 transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tcf7dr11_v1_chr21_+_45268112_452681120.214.0e-02Click!

Activity profile of tcf7 motif

Sorted Z-values of tcf7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_5103349 5.85 ENSDART00000083474
atcaya
ataxia, cerebellar, Cayman type a
chr21_+_20901505 5.31 ENSDART00000132741
c7b
complement component 7b
chr6_-_35487413 4.76 ENSDART00000102461
rgs8
regulator of G protein signaling 8
chr18_+_17611627 4.05 ENSDART00000046891
cetp
cholesteryl ester transfer protein, plasma
chr6_-_35488180 3.56 ENSDART00000183258
rgs8
regulator of G protein signaling 8
chr4_+_10366532 3.55 ENSDART00000189901
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr7_+_38750871 3.41 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
f2
coagulation factor II (thrombin)
chr10_-_26744131 3.14 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fgf13b
fibroblast growth factor 13b
chr9_-_9228941 3.05 ENSDART00000121665
cbsb
cystathionine-beta-synthase b
chr9_+_46745348 2.82 ENSDART00000025256
igfbp2b
insulin-like growth factor binding protein 2b
chr8_-_30979494 2.72 ENSDART00000138959
si:ch211-251j10.3
si:ch211-251j10.3
chr10_+_21677058 2.59 ENSDART00000171499
ENSDART00000157516
pcdh1gb2
protocadherin 1 gamma b 2
chr20_+_22666548 2.57 ENSDART00000147520
lnx1
ligand of numb-protein X 1
chr10_+_21801030 2.54 ENSDART00000160881
ENSDART00000187969
pcdh1g30
protocadherin 1 gamma 30
chr2_+_47623202 2.45 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr20_+_30445971 2.43 ENSDART00000153150
myt1la
myelin transcription factor 1-like, a
chr1_-_38709551 2.41 ENSDART00000128794
gpm6ab
glycoprotein M6Ab
chr15_-_12545683 2.40 ENSDART00000162807
scn2b
sodium channel, voltage-gated, type II, beta
chr3_-_26190804 2.39 ENSDART00000136001
ypel3
yippee-like 3
chr15_+_5901970 2.34 ENSDART00000114134
wrb
tryptophan rich basic protein
chr12_+_24561832 2.34 ENSDART00000088159
nrxn1a
neurexin 1a
chr16_+_23913943 2.32 ENSDART00000175404
ENSDART00000129525
apoa4b.1
apolipoprotein A-IV b, tandem duplicate 1
chr8_+_26859639 2.25 ENSDART00000133440
prdm2a
PR domain containing 2, with ZNF domain a
chr14_-_2196267 2.18 ENSDART00000161674
ENSDART00000125674
pcdh2ab8
pcdh2ab9
protocadherin 2 alpha b 8
protocadherin 2 alpha b 9
chr13_-_9895564 2.14 ENSDART00000169831
ENSDART00000142629
si:ch211-117n7.6
si:ch211-117n7.6
chr2_-_44038698 2.07 ENSDART00000079582
ENSDART00000146804
kirrel1b
kirre like nephrin family adhesion molecule 1b
chr7_-_26308098 2.06 ENSDART00000146440
ENSDART00000146935
ENSDART00000164627
zgc:77439
zgc:77439
chr17_+_3128273 2.03 ENSDART00000122453
zgc:136872
zgc:136872
chr21_+_13387965 2.02 ENSDART00000134347
zgc:113162
zgc:113162
chr19_-_13774502 1.96 ENSDART00000159711
epb41a
erythrocyte membrane protein band 4.1a
chr8_-_1266181 1.90 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr5_-_28149767 1.90 ENSDART00000051515
zgc:110329
zgc:110329
chr21_+_15709061 1.85 ENSDART00000065772
ddt
D-dopachrome tautomerase
chr11_-_23687158 1.83 ENSDART00000189599
pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr2_-_37043540 1.83 ENSDART00000131834
gng7
guanine nucleotide binding protein (G protein), gamma 7
chr16_+_25137483 1.77 ENSDART00000155666
znf576.1
zinc finger protein 576, tandem duplicate 1
chr13_+_27073901 1.76 ENSDART00000146227
slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr5_-_24231139 1.75 ENSDART00000143492
senp3a
SUMO1/sentrin/SMT3 specific peptidase 3a
chr15_+_6109861 1.73 ENSDART00000185154
PCP4 (1 of many)
Purkinje cell protein 4
chr5_-_23696926 1.72 ENSDART00000021462
rnf128a
ring finger protein 128a
chr18_-_13360106 1.71 ENSDART00000091512
cmip
c-Maf inducing protein
chr24_-_5932982 1.70 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acbd5a
acyl-CoA binding domain containing 5a
chr7_+_14632157 1.70 ENSDART00000161264
ntrk3b
neurotrophic tyrosine kinase, receptor, type 3b
chr1_-_26023678 1.69 ENSDART00000054202
si:ch211-145b13.5
si:ch211-145b13.5
chr9_+_38292947 1.69 ENSDART00000146663
tfcp2l1
transcription factor CP2-like 1
chr21_-_4032650 1.68 ENSDART00000151648
ntng2b
netrin g2b
chr4_-_23839789 1.67 ENSDART00000143571
usp6nl
USP6 N-terminal like
chr21_+_36774542 1.66 ENSDART00000130790
prr7
proline rich 7 (synaptic)
chr14_-_2358774 1.62 ENSDART00000164809
si:ch73-233f7.5
si:ch73-233f7.5
chr14_-_2004291 1.61 ENSDART00000114039
pcdh2g5
protocadherin 2 gamma 5
chr22_-_20126230 1.61 ENSDART00000138688
creb3l3a
cAMP responsive element binding protein 3-like 3a
chr12_+_27068525 1.60 ENSDART00000188634
srcap
Snf2-related CREBBP activator protein
chr24_+_5840258 1.55 ENSDART00000087034
trpc1
transient receptor potential cation channel, subfamily C, member 1
chr25_-_12788370 1.50 ENSDART00000158551
slc7a5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr9_+_33009284 1.49 ENSDART00000036926
vangl1
VANGL planar cell polarity protein 1
chr16_-_12097394 1.44 ENSDART00000103944
pex5
peroxisomal biogenesis factor 5
chr17_+_24597001 1.42 ENSDART00000191834
rlf
rearranged L-myc fusion
chr19_-_7033636 1.40 ENSDART00000122815
ENSDART00000123443
ENSDART00000124094
daxx
death-domain associated protein
chr17_+_3993772 1.40 ENSDART00000170822
ENSDART00000168613
ENSDART00000186174
tmx4
thioredoxin-related transmembrane protein 4
chr4_-_2525916 1.39 ENSDART00000134123
ENSDART00000132581
ENSDART00000019508
csrp2
cysteine and glycine-rich protein 2
chr10_+_19569052 1.39 ENSDART00000058425
CABZ01059627.1

chr5_+_60590796 1.38 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr8_+_17869225 1.38 ENSDART00000080079
slc44a5b
solute carrier family 44, member 5b
chr15_-_19677511 1.37 ENSDART00000043743
si:dkey-4p15.3
si:dkey-4p15.3
chr1_-_41374117 1.36 ENSDART00000074777
htt
huntingtin
chr4_+_16827390 1.34 ENSDART00000113344
kiss2
kisspeptin 2
chr4_+_25651720 1.33 ENSDART00000100693
ENSDART00000100717
acot16
acyl-CoA thioesterase 16
chr4_-_14531687 1.27 ENSDART00000182093
ENSDART00000159447
plxnb2a
plexin b2a
chr1_-_50293946 1.27 ENSDART00000053028
ENSDART00000125099
tbck
TBC1 domain containing kinase
chr9_+_13733468 1.26 ENSDART00000165954
ENSDART00000160355
ENSDART00000081040
ENSDART00000138254
ENSDART00000081015
ENSDART00000141314
abi2a
abl-interactor 2a
chr7_-_34329527 1.25 ENSDART00000173454
madd
MAP-kinase activating death domain
chr10_+_45128375 1.24 ENSDART00000164805
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr11_-_42099645 1.23 ENSDART00000173312
abhd6a
abhydrolase domain containing 6a
chr17_+_47116500 1.22 ENSDART00000186627
CLIP4
si:dkeyp-47f9.4
chr15_-_23761580 1.21 ENSDART00000137918
bbc3
BCL2 binding component 3
chr17_+_11500628 1.21 ENSDART00000155660
efcab2
EF-hand calcium binding domain 2
chr5_+_42124706 1.18 ENSDART00000020044
ENSDART00000156372
shpk
sedoheptulokinase
chr5_+_20453874 1.18 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr24_-_6546479 1.17 ENSDART00000160538
arhgap21a
Rho GTPase activating protein 21a
chr23_-_27061072 1.14 ENSDART00000124482
zgc:66440
zgc:66440
chr17_-_20897250 1.13 ENSDART00000088106
ank3b
ankyrin 3b
chr24_-_41267184 1.12 ENSDART00000063504
xylb
xylulokinase homolog (H. influenzae)
chr11_+_44226200 1.11 ENSDART00000191417
gnb4b
guanine nucleotide binding protein (G protein), beta polypeptide 4b
chr5_+_43470544 1.11 ENSDART00000111587
rhobtb2a
Rho-related BTB domain containing 2a
chr6_+_47843760 1.10 ENSDART00000140943
padi2
peptidyl arginine deiminase, type II
chr6_-_57938043 1.10 ENSDART00000171073
tox2
TOX high mobility group box family member 2
chr24_-_6345647 1.10 ENSDART00000108994
zgc:174877
zgc:174877
chr3_+_19914332 1.07 ENSDART00000078982
vat1
vesicle amine transport 1
chr25_+_18964782 1.06 ENSDART00000017299
tdg.1
thymine DNA glycosylase, tandem duplicate 1
chr5_-_16996482 1.06 ENSDART00000144501
galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chr14_-_2036604 1.05 ENSDART00000192446
BX005294.2

chr15_-_17190540 1.03 ENSDART00000154801
itgae.2
integrin, alpha E, tandem duplicate 2
chr5_-_56964547 1.03 ENSDART00000074400
tia1
TIA1 cytotoxic granule-associated RNA binding protein
chr3_+_15773991 1.03 ENSDART00000089923
znf652
zinc finger protein 652
chr20_-_11178022 1.01 ENSDART00000152246
flrt2
fibronectin leucine rich transmembrane protein 2
chr17_+_32500387 0.99 ENSDART00000018423
ywhaqb
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
chr20_+_23315242 0.96 ENSDART00000132248
fryl
furry homolog, like
chr16_-_41131578 0.95 ENSDART00000102649
ENSDART00000145956
ptpn23a
protein tyrosine phosphatase, non-receptor type 23, a
chr14_-_36863432 0.95 ENSDART00000158052
rnf130
ring finger protein 130
chr21_-_40782393 0.94 ENSDART00000075808
apbb3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr24_+_26017094 0.93 ENSDART00000137851
tfr1b
transferrin receptor 1b
chr4_-_2036620 0.92 ENSDART00000150490
si:dkey-97m3.1
si:dkey-97m3.1
chr4_-_1908179 0.90 ENSDART00000139586
ano6
anoctamin 6
chr10_+_4046448 0.90 ENSDART00000123086
ENSDART00000052268
pitpnb
phosphatidylinositol transfer protein, beta
chr13_+_28732101 0.90 ENSDART00000015773
ldb1a
LIM domain binding 1a
chr2_-_59376735 0.88 ENSDART00000193624
ftr38
finTRIM family, member 38
chr12_+_48204891 0.86 ENSDART00000190534
ENSDART00000164427
ndr2
nodal-related 2
chr24_-_11908115 0.86 ENSDART00000184329
tm9sf1
transmembrane 9 superfamily member 1
chr2_-_55903520 0.85 ENSDART00000128828
cplx4c
complexin 4c
chr23_+_1702624 0.85 ENSDART00000149357
rabggta
Rab geranylgeranyltransferase, alpha subunit
chr21_-_18275226 0.82 ENSDART00000126672
ENSDART00000135239
brd3a
bromodomain containing 3a
chr18_+_18861359 0.82 ENSDART00000144605
pllp
plasmolipin
chr4_+_47174366 0.80 ENSDART00000170732
si:dkey-26m3.1
si:dkey-26m3.1
chr21_-_37889727 0.78 ENSDART00000163612
ENSDART00000180958
gabrb4
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr7_+_39688208 0.78 ENSDART00000189682
tbc1d14
TBC1 domain family, member 14
chr14_+_24277556 0.76 ENSDART00000122660
hnrnpa0a
heterogeneous nuclear ribonucleoprotein A0a
chr2_+_37975026 0.76 ENSDART00000034802
si:rp71-1g18.13
si:rp71-1g18.13
chr8_-_2153147 0.74 ENSDART00000124093
si:dkeyp-117b11.1
si:dkeyp-117b11.1
chr18_+_38775277 0.73 ENSDART00000186129
fam214a
family with sequence similarity 214, member A
chr22_+_8753092 0.72 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr16_+_1353894 0.72 ENSDART00000148426
celf3b
cugbp, Elav-like family member 3b
chr1_-_54706039 0.72 ENSDART00000083633
exosc1
exosome component 1
chr18_-_6534516 0.71 ENSDART00000009217
ddx11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr4_-_30422325 0.70 ENSDART00000158444
znf1114
zinc finger protein 1114
chr3_-_1146497 0.68 ENSDART00000149061
si:ch73-211l13.2
si:ch73-211l13.2
chr13_+_33268657 0.67 ENSDART00000002095
tmem39b
transmembrane protein 39B
chr14_+_22293787 0.65 ENSDART00000157967
atp10b
ATPase phospholipid transporting 10B
chr5_+_44064764 0.65 ENSDART00000143843
si:dkey-84j12.1
si:dkey-84j12.1
chr15_+_23784842 0.63 ENSDART00000192889
ENSDART00000138375
ift20
intraflagellar transport 20 homolog (Chlamydomonas)
chr10_-_11261565 0.63 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr10_-_21542702 0.61 ENSDART00000146761
ENSDART00000134502
zgc:165539
zgc:165539
chr6_-_29105727 0.61 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr21_+_22423286 0.60 ENSDART00000133190
capslb
calcyphosine-like b
chr14_-_2193248 0.59 ENSDART00000128659
pcdh2ab10
protocadherin 2 alpha b 10
chr7_-_29223614 0.57 ENSDART00000173598
herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr22_+_12161738 0.57 ENSDART00000168857
ccnt2b
cyclin T2b
chr17_+_13664442 0.57 ENSDART00000171689
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr11_-_17755444 0.54 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr12_+_46512881 0.54 ENSDART00000105454
CU855711.1

chr17_+_43595692 0.54 ENSDART00000156271
cfap99
cilia and flagella associated protein 99
chr2_-_22152797 0.51 ENSDART00000145188
cyp7a1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr6_-_51101834 0.49 ENSDART00000092493
ptprt
protein tyrosine phosphatase, receptor type, t
chr23_+_27051919 0.48 ENSDART00000054237
ptges3a
prostaglandin E synthase 3a (cytosolic)
chr16_-_12097558 0.47 ENSDART00000123142
pex5
peroxisomal biogenesis factor 5
chr9_-_1604601 0.45 ENSDART00000143130
agps
alkylglycerone phosphate synthase
chr1_-_16665044 0.44 ENSDART00000040434
asah1b
N-acylsphingosine amidohydrolase (acid ceramidase) 1b
chr25_-_20574859 0.43 ENSDART00000067288
adal
adenosine deaminase-like
chr1_+_32341484 0.43 ENSDART00000137156
pudp
pseudouridine 5'-phosphatase
chr4_+_69375564 0.42 ENSDART00000150334
si:dkey-246j6.1
si:dkey-246j6.1
chr14_-_36862745 0.42 ENSDART00000109293
rnf130
ring finger protein 130
chr17_-_6076084 0.39 ENSDART00000058890
ephx2
epoxide hydrolase 2, cytoplasmic
chr14_-_6943934 0.39 ENSDART00000126279
clk4a
CDC-like kinase 4a
chr25_+_3294150 0.37 ENSDART00000030683
tmpob
thymopoietin b
chr14_-_38827442 0.37 ENSDART00000160000
spdl1
spindle apparatus coiled-coil protein 1
chr12_+_46462090 0.36 ENSDART00000130748
BX005305.2

chr5_+_67371650 0.36 ENSDART00000142156
sebox
SEBOX homeobox
chr3_+_5297493 0.35 ENSDART00000138596
si:ch211-150d5.3
si:ch211-150d5.3
chr24_+_11105786 0.34 ENSDART00000175182
prlh2
prolactin releasing hormone 2
chr2_-_16254782 0.34 ENSDART00000133708
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr17_-_20897407 0.34 ENSDART00000149481
ank3b
ankyrin 3b
chr10_+_23099365 0.31 ENSDART00000022170
LTN1
si:dkey-175g6.5
chr19_-_18135724 0.30 ENSDART00000186609
cbx3a
chromobox homolog 3a (HP1 gamma homolog, Drosophila)
chr22_+_21549419 0.30 ENSDART00000139411
plpp2b
phospholipid phosphatase 2b
chr7_-_54677143 0.29 ENSDART00000163748
ccnd1
cyclin D1
chr21_-_22474362 0.29 ENSDART00000169659
myo5b
myosin VB
chr15_-_47822597 0.29 ENSDART00000193236
ENSDART00000161391
CZQB01095947.1

chr7_+_35075847 0.28 ENSDART00000193469
ENSDART00000037346
ctrb1
chymotrypsinogen B1
chr10_-_11261386 0.26 ENSDART00000189946
ptbp3
polypyrimidine tract binding protein 3
chr19_+_42469058 0.24 ENSDART00000076915
si:dkey-166k12.1
si:dkey-166k12.1
chr7_+_36898622 0.22 ENSDART00000190773
tox3
TOX high mobility group box family member 3
chr17_+_14711765 0.22 ENSDART00000012889
cx28.6
connexin 28.6
chr7_-_57509447 0.21 ENSDART00000051973
ENSDART00000147036
sirt3
sirtuin 3
chr11_-_3381343 0.20 ENSDART00000002545
mcrs1
microspherule protein 1
chr3_+_41558682 0.20 ENSDART00000157023
card11
caspase recruitment domain family, member 11
chr9_-_28616436 0.18 ENSDART00000136985
si:ch73-7i4.2
si:ch73-7i4.2
chr4_-_32192868 0.18 ENSDART00000164675
CR450785.2

chr11_-_3380959 0.18 ENSDART00000187157
mcrs1
microspherule protein 1
chr5_+_32791245 0.17 ENSDART00000077189
ier5l
immediate early response 5-like
chr17_-_20695998 0.17 ENSDART00000063613
ccdc6a
coiled-coil domain containing 6a
chr1_-_50438247 0.17 ENSDART00000114098
dkk2
dickkopf WNT signaling pathway inhibitor 2
chr2_-_43739740 0.15 ENSDART00000113849
kif5ba
kinesin family member 5B, a
chr1_+_24376394 0.14 ENSDART00000102542
zgc:171517
zgc:171517
chr1_-_17675037 0.13 ENSDART00000142689
si:dkey-256e7.5
si:dkey-256e7.5
chr16_+_7703693 0.12 ENSDART00000125111
ENSDART00000149769
ENSDART00000149752
ENSDART00000081407
cnot10
CCR4-NOT transcription complex, subunit 10
chr19_+_43037657 0.11 ENSDART00000168263
ENSDART00000184771
ENSDART00000164453
ENSDART00000165202
pum1
pumilio RNA-binding family member 1
chr20_-_4031475 0.11 ENSDART00000112053
fam89a
family with sequence similarity 89, member A
chr4_-_3064101 0.10 ENSDART00000135701
plekha5
pleckstrin homology domain containing, family A member 5
chr17_-_6076266 0.10 ENSDART00000171084
ephx2
epoxide hydrolase 2, cytoplasmic
chr14_+_989733 0.10 ENSDART00000161487
ENSDART00000127317
si:ch73-308l14.2
si:ch73-308l14.2
chr23_-_7826849 0.09 ENSDART00000157612
myt1b
myelin transcription factor 1b
chr15_-_1484795 0.08 ENSDART00000129356
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr9_-_37613792 0.07 ENSDART00000138345
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr23_-_19977214 0.07 ENSDART00000054659
ccnq
cyclin Q
chr4_-_77114795 0.04 ENSDART00000144849
CU467646.2

chr14_+_1240604 0.04 ENSDART00000188258
adad1
adenosine deaminase domain containing 1 (testis-specific)
chr9_-_12401871 0.02 ENSDART00000191901
nup35
nucleoporin 35
chr14_+_1240419 0.00 ENSDART00000181248
adad1
adenosine deaminase domain containing 1 (testis-specific)

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.4 4.1 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
1.0 3.0 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.5 5.9 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.5 3.4 GO:0006953 acute-phase response(GO:0006953)
0.4 2.1 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.4 1.2 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.4 1.1 GO:0005997 xylulose metabolic process(GO:0005997)
0.3 0.9 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.3 1.7 GO:0030242 pexophagy(GO:0030242)
0.3 2.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 1.2 GO:0090199 regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 0.9 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.2 3.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 1.1 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.2 1.4 GO:0001839 neural plate morphogenesis(GO:0001839)
0.2 1.9 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.2 1.9 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.2 5.3 GO:0019835 cytolysis(GO:0019835)
0.2 0.5 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.2 0.6 GO:0035790 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.2 0.5 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 0.4 GO:0097264 self proteolysis(GO:0097264)
0.1 1.4 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 1.7 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.9 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 1.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 2.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 1.6 GO:0046847 filopodium assembly(GO:0046847)
0.1 1.7 GO:1990090 response to nerve growth factor(GO:1990089) cellular response to nerve growth factor stimulus(GO:1990090)
0.1 1.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 2.1 GO:0039022 pronephric duct development(GO:0039022)
0.1 0.5 GO:0008206 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.1 0.4 GO:0046102 adenosine catabolic process(GO:0006154) inosine metabolic process(GO:0046102) inosine biosynthetic process(GO:0046103)
0.1 1.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.3 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 1.6 GO:0043486 histone exchange(GO:0043486)
0.1 1.7 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.8 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 11.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.4 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.8 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 1.7 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 1.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.2 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.5 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 1.1 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.9 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 2.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 2.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.9 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0 0.8 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 1.4 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.6 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.3 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0060841 venous blood vessel development(GO:0060841)
0.0 2.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 3.1 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 2.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.8 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 1.9 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 1.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0008298 intracellular mRNA localization(GO:0008298)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.9 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.3 5.3 GO:0005579 membrane attack complex(GO:0005579)
0.3 4.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 2.4 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.6 GO:0000812 Swr1 complex(GO:0000812)
0.1 2.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 2.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 3.5 GO:0043204 perikaryon(GO:0043204)
0.1 4.4 GO:0030175 filopodium(GO:0030175)
0.1 1.2 GO:0015030 Cajal body(GO:0015030)
0.1 1.7 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 2.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.6 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 1.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.0 GO:0008305 integrin complex(GO:0008305)
0.0 0.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.8 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0030427 site of polarized growth(GO:0030427)
0.0 1.8 GO:0000922 spindle pole(GO:0000922)
0.0 1.4 GO:0030018 Z disc(GO:0030018)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.1 GO:0005938 cell cortex(GO:0005938)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.6 3.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 5.9 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.3 1.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 2.8 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.2 1.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 0.9 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 2.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.8 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.2 5.0 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 1.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 2.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 0.5 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.9 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.9 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.9 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 1.1 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.4 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.1 1.7 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 1.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 1.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 1.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 1.1 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 1.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.4 GO:0042805 actinin binding(GO:0042805)
0.0 1.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0070404 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.0 12.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.5 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 1.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 3.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.4 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 2.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.7 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 4.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 2.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 3.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 9.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 0.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 1.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 0.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.0 1.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)