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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tfap2b

Z-value: 0.67

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Transcription factors associated with tfap2b

Gene Symbol Gene ID Gene Info
tfap2b
ENSDARG00000012667 transcription factor AP-2 beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2bdr11_v1_chr20_-_47704973_477049730.075.0e-01Click!

Activity profile of tfap2b motif

Sorted Z-values of tfap2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77551860 9.10 ENSDART00000188176
AL935186.6

chr4_-_77563411 9.05 ENSDART00000186841
AL935186.8

chr4_-_20115570 2.79 ENSDART00000134528
si:dkey-159a18.1
si:dkey-159a18.1
chr8_+_24281512 2.51 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr25_+_31264155 2.45 ENSDART00000012256
tnni2a.3
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr6_-_59942335 2.34 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr7_+_34794829 2.25 ENSDART00000009698
ENSDART00000075089
ENSDART00000173456
esrp2
epithelial splicing regulatory protein 2
chr16_+_26612401 2.11 ENSDART00000145571
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr13_+_32148338 2.10 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr24_+_42074143 2.07 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr14_+_10450216 2.04 ENSDART00000134814
cysltr1
cysteinyl leukotriene receptor 1
chr12_+_5708400 2.00 ENSDART00000017191
dlx3b
distal-less homeobox 3b
chr18_+_24919614 1.69 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr5_+_45921234 1.64 ENSDART00000134355
ankdd1b
ankyrin repeat and death domain containing 1B
chr12_-_27242498 1.60 ENSDART00000152609
ENSDART00000152170
si:dkey-11c5.11
si:dkey-11c5.11
chr7_+_21887787 1.57 ENSDART00000162252
pop7
POP7 homolog, ribonuclease P/MRP subunit
chr8_+_29962635 1.37 ENSDART00000007640
ptch1
patched 1
chr6_+_7322587 1.37 ENSDART00000065500
abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr7_-_61842593 1.33 ENSDART00000023770
HTRA3
HtrA serine peptidase 3
chr2_-_42415902 1.31 ENSDART00000142489
slco5a1b
solute carrier organic anion transporter family member 5A1b
chr4_-_68563862 1.29 ENSDART00000182970
BX548011.2

chr18_+_40364732 1.29 ENSDART00000123661
ENSDART00000130847
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr7_+_1442059 1.22 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr12_-_8958353 1.20 ENSDART00000041728
cyp26a1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr9_+_44721808 1.08 ENSDART00000190578
nckap1
NCK-associated protein 1
chr12_+_35119762 1.07 ENSDART00000085774
si:ch73-127m5.1
si:ch73-127m5.1
chr23_-_1017428 1.06 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr9_-_15424639 1.04 ENSDART00000124346
fn1a
fibronectin 1a
chr23_-_1017605 1.03 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr21_+_28724099 1.02 ENSDART00000138017
puraa
purine-rich element binding protein Aa
chr6_+_102506 1.00 ENSDART00000172678
ldlrb
low density lipoprotein receptor b
chr2_-_30324297 0.96 ENSDART00000099078
jph1b
junctophilin 1b
chr12_+_30360184 0.96 ENSDART00000190718
si:ch211-225b10.3
si:ch211-225b10.3
chr7_-_48667056 0.93 ENSDART00000006378
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr3_+_15271943 0.88 ENSDART00000141752
asphd1
aspartate beta-hydroxylase domain containing 1
chr12_+_30360579 0.81 ENSDART00000152900
si:ch211-225b10.3
si:ch211-225b10.3
chr1_+_58990121 0.80 ENSDART00000171654
CABZ01083166.1

chr1_+_5275811 0.77 ENSDART00000189676
spry2
sprouty RTK signaling antagonist 2
chr17_-_26868169 0.75 ENSDART00000157204
si:dkey-221l4.10
si:dkey-221l4.10
chr10_-_27197044 0.74 ENSDART00000137928
auts2a
autism susceptibility candidate 2a
chr8_+_29963024 0.73 ENSDART00000149372
ptch1
patched 1
chr25_+_17871089 0.70 ENSDART00000133725
btbd10a
BTB (POZ) domain containing 10a
chr21_+_21279159 0.67 ENSDART00000148346
itpkca
inositol-trisphosphate 3-kinase Ca
chr25_+_16945348 0.66 ENSDART00000016591
fgf6a
fibroblast growth factor 6a
chr24_-_38374744 0.63 ENSDART00000007208
lrrc4bb
leucine rich repeat containing 4Bb
chr21_-_27362938 0.62 ENSDART00000131297
rin1a
Ras and Rab interactor 1a
chr3_-_43646733 0.60 ENSDART00000180959
axin1
axin 1
chr7_-_20453661 0.57 ENSDART00000174001
ntn5
netrin 5
chr25_+_8063455 0.57 ENSDART00000073919
kcnc1b
potassium voltage-gated channel, Shaw-related subfamily, member 1b
chr3_+_16455749 0.56 ENSDART00000090767
kcnj12b
potassium inwardly-rectifying channel, subfamily J, member 12b
chr17_-_26867725 0.55 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr14_-_51039702 0.55 ENSDART00000178932
cltb
clathrin, light chain B
chr21_+_26748141 0.52 ENSDART00000169025
pcxa
pyruvate carboxylase a
chr22_+_10781894 0.51 ENSDART00000081183
enc3
ectodermal-neural cortex 3
chr12_-_7807298 0.48 ENSDART00000191355
ank3b
ankyrin 3b
chr11_-_33857911 0.46 ENSDART00000165370
nxph2b
neurexophilin 2b
chr12_-_21834611 0.44 ENSDART00000179553
thrab
thyroid hormone receptor alpha b
chr16_-_21620947 0.43 ENSDART00000115011
ENSDART00000183125
ENSDART00000188856
ENSDART00000189460
ddr1
discoidin domain receptor tyrosine kinase 1
chr15_-_45246911 0.42 ENSDART00000189557
ENSDART00000185291
CABZ01072607.1

chr4_-_60790123 0.41 ENSDART00000137702
si:dkey-254e13.6
si:dkey-254e13.6
chr13_+_16521898 0.39 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr1_+_32528097 0.39 ENSDART00000128317
nlgn4a
neuroligin 4a
chr16_-_20435475 0.38 ENSDART00000139776
chn2
chimerin 2
chr3_-_29925482 0.36 ENSDART00000151525
grna
granulin a
chr24_+_37723362 0.34 ENSDART00000136836
rab11fip3
RAB11 family interacting protein 3 (class II)
chr7_-_38570878 0.33 ENSDART00000139187
ENSDART00000134570
ENSDART00000041055
celf1
cugbp, Elav-like family member 1
chr22_+_508290 0.33 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr4_+_58667348 0.30 ENSDART00000186596
ENSDART00000180673
CR388148.2

chr7_+_529522 0.29 ENSDART00000190811
nrxn2b
neurexin 2b
chr20_-_3160687 0.29 ENSDART00000131697
si:ch73-212j7.3
si:ch73-212j7.3
chr17_-_19019635 0.28 ENSDART00000126666
flrt2
fibronectin leucine rich transmembrane protein 2
chr7_+_48667081 0.28 ENSDART00000083473
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr10_-_5135788 0.25 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr11_-_35975026 0.24 ENSDART00000186219
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr16_+_20496691 0.24 ENSDART00000182737
ENSDART00000078984
cpvl
carboxypeptidase, vitellogenic-like
chr21_+_21205667 0.23 ENSDART00000058311
rictorb
RPTOR independent companion of MTOR, complex 2b
chr15_-_18213515 0.21 ENSDART00000101635
btr21
bloodthirsty-related gene family, member 21
chr25_+_22017182 0.20 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr22_-_17953529 0.16 ENSDART00000135716
ncanb
neurocan b
chr7_+_1521834 0.15 ENSDART00000174007
si:cabz01102082.1
si:cabz01102082.1
chr19_+_41080240 0.14 ENSDART00000087295
ppp1r9a
protein phosphatase 1, regulatory subunit 9A
chr10_-_43964028 0.12 ENSDART00000009134
ENSDART00000133450
sept5b
septin 5b
chr25_+_21180695 0.12 ENSDART00000012923
erc1a
ELKS/RAB6-interacting/CAST family member 1a
chr25_-_26753196 0.11 ENSDART00000155698
usp3
ubiquitin specific peptidase 3
chr7_+_19482084 0.10 ENSDART00000173873
si:ch211-212k18.7
si:ch211-212k18.7
chr22_-_9677264 0.07 ENSDART00000181737
si:dkey-286j17.4
si:dkey-286j17.4
chr20_+_51199666 0.06 ENSDART00000169321
hsp90ab1
heat shock protein 90, alpha (cytosolic), class B member 1
chr9_+_33783061 0.05 ENSDART00000190193
BX572627.1

chr12_+_24562667 0.04 ENSDART00000056256
nrxn1a
neurexin 1a
chr16_+_54209504 0.04 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr2_+_39108339 0.04 ENSDART00000085675
clstn2
calsyntenin 2
chr18_+_18104235 0.04 ENSDART00000145342
cbln1
cerebellin 1 precursor
chr14_+_11103718 0.03 ENSDART00000161311
nexmifb
neurite extension and migration factor b
chr8_+_23861461 0.02 ENSDART00000037109
srpk1a
SRSF protein kinase 1a
chr10_+_6383270 0.01 ENSDART00000170548
zgc:114200
zgc:114200

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.7 2.1 GO:0048389 intermediate mesoderm development(GO:0048389)
0.7 2.0 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.5 1.4 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.3 1.7 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 1.2 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.2 2.1 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.2 0.6 GO:0030910 olfactory placode formation(GO:0030910)
0.1 1.0 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319) acute-phase response(GO:0006953) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.9 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.5 GO:0046959 nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1 2.1 GO:0006265 DNA topological change(GO:0006265)
0.1 2.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 1.3 GO:0031641 regulation of myelination(GO:0031641)
0.1 0.8 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 1.4 GO:0098754 detoxification(GO:0098754)
0.1 1.6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 2.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.4 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.4 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 1.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0071634 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.0 2.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.1 GO:0031638 zymogen activation(GO:0031638)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.5 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 1.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.8 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.0 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 1.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.1 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 2.1 GO:0031032 actomyosin structure organization(GO:0031032)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0043218 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.2 1.0 GO:0030314 junctional membrane complex(GO:0030314)
0.2 1.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 2.5 GO:0005861 troponin complex(GO:0005861)
0.0 1.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130) clathrin coat of coated pit(GO:0030132)
0.0 2.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 3.6 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.5 2.1 GO:0033149 FFAT motif binding(GO:0033149)
0.5 1.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.4 1.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.3 2.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 0.5 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.1 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.0 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.7 GO:0015026 coreceptor activity(GO:0015026)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.4 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.4 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.7 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.3 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 2.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 1.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.0 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 0.6 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 0.8 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 1.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome