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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tfap2d

Z-value: 0.42

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Transcription factors associated with tfap2d

Gene Symbol Gene ID Gene Info
ENSDARG00000023272 transcription factor AP-2 delta (activating enhancer binding protein 2 delta)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2ddr11_v1_chr20_-_47731768_47731768-0.741.2e-17Click!

Activity profile of tfap2d motif

Sorted Z-values of tfap2d motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_188102 7.36 ENSDART00000125391
ENSDART00000170463

chr10_-_322769 5.09 ENSDART00000165244
v-akt murine thymoma viral oncogene homolog 2, like
chr14_-_21064199 4.56 ENSDART00000172099
si:dkey-74k8.3
chr21_+_45685757 4.55 ENSDART00000160530
SEC24 homolog A, COPII coat complex component
chr14_+_52369262 3.83 ENSDART00000169352
ENSDART00000157833
insulin-like growth factor binding protein 7
chr4_-_77557279 3.44 ENSDART00000180113

chr17_-_868004 3.20 ENSDART00000112803
WD repeat domain 20a
chr16_+_54588930 2.94 ENSDART00000159174
DENN/MADD domain containing 4B
chr10_-_373575 2.81 ENSDART00000114487
DM1 protein kinase
chr5_-_26936861 1.36 ENSDART00000191032
HtrA serine peptidase 4
chr25_+_2415131 1.35 ENSDART00000162210
zmp:0000000932
chr6_+_27868146 1.19 ENSDART00000186620
RAB6B, member RAS oncogene family a
chr3_+_31680592 1.02 ENSDART00000172456
myosin, light chain kinase 5
chr23_-_41762797 0.97 ENSDART00000186564
serine/threonine kinase 35
chr5_+_6796291 0.77 ENSDART00000166868
ENSDART00000165308
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr17_+_52823015 0.73 ENSDART00000160507
ENSDART00000186979
Meis homeobox 2a
chr20_-_14925281 0.59 ENSDART00000152641
dynamin 3a
chr5_+_58520266 0.58 ENSDART00000108889
OAF homolog b (Drosophila)
chr13_-_36579086 0.50 ENSDART00000146671
lectin, galactoside binding soluble 3a
chr12_-_19007834 0.39 ENSDART00000153248
chondroadherin-like b
chr1_-_23294753 0.38 ENSDART00000013263
UDP-glucose 6-dehydrogenase

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2d

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.3 4.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 2.9 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 3.8 GO:0001569 patterning of blood vessels(GO:0001569)
0.1 0.5 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1 0.8 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.4 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.0 1.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 5.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 5.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.5 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.1 0.4 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.1 1.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 4.5 GO:0000149 SNARE binding(GO:0000149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation