ISMARA results: tfap4

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tfap4

Z-value: 1.24

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Transcription factors associated with tfap4

Gene Symbol	Gene ID	Gene Info
tfap4 NCBI UniProt	ENSDARG00000103923	transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tfap4	dr11_v1_chr3_-_12227359_12227359	0.37	3.0e-04	Click!

Activity profile of tfap4 motif

Sorted Z-values of tfap4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_35382482 Show fit	9.02	ENSDART00000135284	vsnl1a NCBI UniProt Show fit	visinin-like 1a
chr13_+_36764715 Show fit	8.93	ENSDART00000111832 ENSDART00000085230	atl1 NCBI UniProt Show fit	atlastin GTPase 1
chr1_-_26782573 Show fit	8.59	ENSDART00000090611	sh3gl2a NCBI UniProt Show fit	SH3 domain containing GRB2 like 2a, endophilin A1
chr15_+_40188076 Show fit	8.07	ENSDART00000063779	efhd1 NCBI UniProt Show fit	EF-hand domain family, member D1
chr14_-_32016615 Show fit	7.75	ENSDART00000105761	zic3 NCBI UniProt Show fit	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr1_-_14233815 Show fit	7.09	ENSDART00000044896	camk2d2 NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr6_+_18520859 Show fit	7.04	ENSDART00000158263	si:dkey-10p5.10 NCBI UniProt Show fit	si:dkey-10p5.10
chr3_-_40836081 Show fit	6.83	ENSDART00000143135	wipi2 NCBI UniProt Show fit	WD repeat domain, phosphoinositide interacting 2
chr6_-_43092175 Show fit	6.66	ENSDART00000084389	lrrn1 NCBI UniProt Show fit	leucine rich repeat neuronal 1
chr22_-_16443199 Show fit	6.65	ENSDART00000006290 ENSDART00000193335	plekhb2 NCBI UniProt Show fit	pleckstrin homology domain containing, family B (evectins) member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	11.2	GO:0048263	determination of dorsal identity(GO:0048263)
2.7	10.9	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2	10.5	GO:0009948	anterior/posterior axis specification(GO:0009948)
1.1	9.9	GO:0060036	notochord cell vacuolation(GO:0060036)
0.2	9.3	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.8	9.1	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
2.8	8.3	GO:0032060	bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.1	7.3	GO:0050919	negative chemotaxis(GO:0050919)
0.1	7.2	GO:0007052	mitotic spindle organization(GO:0007052)
0.1	7.1	GO:0099515	vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)

Showing 1 to 10 of 210 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.8	GO:0005770	late endosome(GO:0005770)
0.1	19.5	GO:0005912	adherens junction(GO:0005912)
0.0	13.0	GO:0043005	neuron projection(GO:0043005)
1.4	9.5	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
1.1	9.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	8.6	GO:0005874	microtubule(GO:0005874)
0.0	8.0	GO:0000139	Golgi membrane(GO:0000139)
0.3	7.4	GO:0043195	terminal bouton(GO:0043195)
0.1	7.1	GO:0030426	growth cone(GO:0030426)
0.1	7.1	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)

Showing 1 to 10 of 92 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	22.7	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	20.7	GO:0003924	GTPase activity(GO:0003924)
0.4	20.1	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	11.8	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	11.0	GO:0005096	GTPase activator activity(GO:0005096)
2.7	10.9	GO:0032896	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.4	10.7	GO:0001540	beta-amyloid binding(GO:0001540)
0.1	10.0	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.6	9.7	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.2	9.5	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)

Showing 1 to 10 of 152 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.7	PID INSULIN PATHWAY	Insulin Pathway
0.3	6.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	4.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	4.6	PID AURORA A PATHWAY	Aurora A signaling
0.1	4.5	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	4.4	PID SHP2 PATHWAY	SHP2 signaling
0.3	3.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	3.5	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	3.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	3.3	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	7.5	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.6	7.0	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.4	6.4	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.3	6.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
2.1	6.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.5	4.7	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6	4.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.4	4.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	3.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.2	3.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity

Showing 1 to 10 of 35 entries

Results for tfap4

Z-value: 1.24

Motif logo

Transcription factors associated with tfap4

Activity-expression correlation:

Activity profile of tfap4 motif

Sorted Z-values of tfap4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: