ISMARA results: tfcp2+tfcp2l1+ubp1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tfcp2+tfcp2l1+ubp1

Z-value: 2.16

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Transcription factors associated with tfcp2+tfcp2l1+ubp1

Gene Symbol	Gene ID	Gene Info
ubp1 NCBI UniProt	ENSDARG00000018000	upstream binding protein 1
tfcp2l1 NCBI UniProt	ENSDARG00000029497	transcription factor CP2-like 1
tfcp2 NCBI UniProt	ENSDARG00000060306	transcription factor CP2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tfcp2	dr11_v1_chr23_-_33680265_33680265	0.38	1.9e-04	Click!
tfcp2l1	dr11_v1_chr9_+_38292947_38292947	-0.36	3.3e-04	Click!
ubp1	dr11_v1_chr19_+_42806812_42806814	0.30	3.3e-03	Click!

Activity profile of tfcp2+tfcp2l1+ubp1 motif

Sorted Z-values of tfcp2+tfcp2l1+ubp1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_27647845 Show fit	36.85	ENSDART00000151625	si:ch211-157c3.4 NCBI UniProt Show fit	si:ch211-157c3.4
chr10_-_15048781 Show fit	36.37	ENSDART00000038401 ENSDART00000155674	si:ch211-95j8.2 NCBI UniProt Show fit	si:ch211-95j8.2
chr5_+_39667272 Show fit	23.22	ENSDART00000085388	bmp3 NCBI UniProt Show fit	bone morphogenetic protein 3
chr21_+_25688388 Show fit	22.67	ENSDART00000125709	bicdl2 NCBI UniProt Show fit	bicaudal-D-related protein 2
chr12_-_28794957 Show fit	21.72	ENSDART00000020667	osbpl7 NCBI UniProt Show fit	oxysterol binding protein-like 7
chr5_+_15203421 Show fit	21.53	ENSDART00000040826	tbx1 NCBI UniProt Show fit	T-box 1
chr16_+_23961276 Show fit	19.43	ENSDART00000192754	apoeb NCBI UniProt Show fit	apolipoprotein Eb
chr10_-_36793412 Show fit	18.96	ENSDART00000185966	dhrs13a.2 NCBI UniProt Show fit	dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2
chr24_+_20960216 Show fit	18.95	ENSDART00000133008	si:ch211-161h7.8 NCBI UniProt Show fit	si:ch211-161h7.8
chr8_+_36142734 Show fit	17.87	ENSDART00000159361 ENSDART00000161194	mhc2b NCBI UniProt Show fit	major histocompatibility complex class II integral membrane beta chain gene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tfcp2+tfcp2l1+ubp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	31.6	GO:1990266	neutrophil migration(GO:1990266)
0.7	23.2	GO:0001649	osteoblast differentiation(GO:0001649)
5.7	22.7	GO:0055107	Golgi to secretory granule transport(GO:0055107)
7.2	21.5	GO:0003156	regulation of organ formation(GO:0003156)
6.5	19.4	GO:0034382	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
1.0	19.0	GO:0042574	retinal metabolic process(GO:0042574)
0.5	18.9	GO:0019882	antigen processing and presentation(GO:0019882)
0.1	18.4	GO:0007160	cell-matrix adhesion(GO:0007160)
0.2	17.6	GO:0031101	fin regeneration(GO:0031101)
0.1	17.1	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Showing 1 to 10 of 145 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	41.0	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0	37.5	GO:0005615	extracellular space(GO:0005615)
0.1	29.2	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	28.4	GO:0016324	apical plasma membrane(GO:0016324)
1.4	21.7	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.1	20.1	GO:0031012	extracellular matrix(GO:0031012)
4.9	19.4	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
2.2	17.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	17.7	GO:0000785	chromatin(GO:0000785)
0.1	17.3	GO:0009897	external side of plasma membrane(GO:0009897)

Showing 1 to 10 of 71 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	47.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	41.9	GO:0008270	zinc ion binding(GO:0008270)
0.3	41.6	GO:0042803	protein homodimerization activity(GO:0042803)
0.3	25.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.8	21.7	GO:0015248	sterol transporter activity(GO:0015248)
0.9	20.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
6.5	19.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	19.4	GO:0005125	cytokine activity(GO:0005125)
1.9	19.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
3.9	15.8	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)

Showing 1 to 10 of 120 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	15.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.8	14.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.2	10.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	7.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	7.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.3	4.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	4.2	PID ATM PATHWAY	ATM pathway
0.1	3.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	3.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.8	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.9	14.7	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2	10.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.7	10.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
2.0	10.2	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.5	4.7	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2	4.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	4.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	4.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	3.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)

Showing 1 to 10 of 39 entries

Results for tfcp2+tfcp2l1+ubp1

Z-value: 2.16

Motif logo

Transcription factors associated with tfcp2+tfcp2l1+ubp1

Activity-expression correlation:

Activity profile of tfcp2+tfcp2l1+ubp1 motif

Sorted Z-values of tfcp2+tfcp2l1+ubp1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tfcp2+tfcp2l1+ubp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: