ISMARA results: tgif1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tgif1

Z-value: 2.14

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Transcription factors associated with tgif1

Gene Symbol	Gene ID	Gene Info
tgif1 NCBI UniProt	ENSDARG00000059337	TGFB-induced factor homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tgif1	dr11_v1_chr24_-_9294134_9294134	0.38	1.7e-04	Click!

Activity profile of tgif1 motif

Sorted Z-values of tgif1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_36378494 Show fit	26.67	ENSDART00000058503	gpm6aa NCBI UniProt Show fit	glycoprotein M6Aa
chr20_+_34933183 Show fit	21.98	ENSDART00000062738	snap25a NCBI UniProt Show fit	synaptosomal-associated protein, 25a
chr1_-_12278056 Show fit	18.41	ENSDART00000139336 ENSDART00000137463	cplx2l NCBI UniProt Show fit	complexin 2, like
chr17_-_26926577 Show fit	18.28	ENSDART00000050202	rcan3 NCBI UniProt Show fit	regulator of calcineurin 3
chr15_-_4415917 Show fit	15.97	ENSDART00000062874	atp1b3b NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 3b
chr2_-_12502495 Show fit	15.67	ENSDART00000186781	dpp6b NCBI UniProt Show fit	dipeptidyl-peptidase 6b
chr14_+_22172047 Show fit	15.63	ENSDART00000114750 ENSDART00000148259	gabrb2 NCBI UniProt Show fit	gamma-aminobutyric acid (GABA) A receptor, beta 2
chr4_-_815871 Show fit	15.47	ENSDART00000067455	dpysl5b NCBI UniProt Show fit	dihydropyrimidinase-like 5b
chr14_+_35691889 Show fit	15.03	ENSDART00000074685	glrbb NCBI UniProt Show fit	glycine receptor, beta b
chr10_-_39011514 Show fit	14.83	ENSDART00000075123	pcp4a NCBI UniProt Show fit	Purkinje cell protein 4a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tgif1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	42.4	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.5	35.2	GO:1902476	chloride transmembrane transport(GO:1902476)
0.7	27.1	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.3	26.5	GO:0019722	calcium-mediated signaling(GO:0019722)
0.2	25.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7	23.6	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1	22.7	GO:0006470	protein dephosphorylation(GO:0006470)
0.1	21.0	GO:0071805	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	20.9	GO:0031175	neuron projection development(GO:0031175)
0.6	20.1	GO:0060319	primitive erythrocyte differentiation(GO:0060319)

Showing 1 to 10 of 396 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	95.4	GO:0043005	neuron projection(GO:0043005)
0.3	39.7	GO:0099572	postsynaptic specialization(GO:0099572)
1.6	39.4	GO:0043195	terminal bouton(GO:0043195)
0.2	37.6	GO:0045211	postsynaptic membrane(GO:0045211)
1.1	36.5	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
2.9	29.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
2.2	26.7	GO:0044295	axonal growth cone(GO:0044295)
0.3	23.3	GO:0043025	neuronal cell body(GO:0043025)
3.7	22.0	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.3	21.1	GO:0008076	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Showing 1 to 10 of 156 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	59.2	GO:0017075	syntaxin-1 binding(GO:0017075)
1.1	36.5	GO:0004890	GABA-A receptor activity(GO:0004890)
0.1	35.6	GO:0008017	microtubule binding(GO:0008017)
0.2	32.2	GO:0005516	calmodulin binding(GO:0005516)
0.2	31.0	GO:0019900	kinase binding(GO:0019900)
1.4	29.0	GO:0001671	ATPase activator activity(GO:0001671)
0.1	26.9	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
4.3	26.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	24.6	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.3	21.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)

Showing 1 to 10 of 287 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	18.5	PID ARF 3PATHWAY	Arf1 pathway
0.6	12.0	PID RHOA PATHWAY	RhoA signaling pathway
0.3	10.5	ST GA13 PATHWAY	G alpha 13 Pathway
0.2	10.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.4	9.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	8.7	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.3	8.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.5	8.3	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.3	7.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.6	7.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	33.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	31.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	19.4	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.5	18.9	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.2	18.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	17.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	16.3	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.3	13.0	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.4	10.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
3.2	9.6	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle

Showing 1 to 10 of 73 entries

Results for tgif1

Z-value: 2.14

Motif logo

Transcription factors associated with tgif1

Activity-expression correlation:

Activity profile of tgif1 motif

Sorted Z-values of tgif1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tgif1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: