ISMARA results: tp53

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tp53

Z-value: 2.11

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Transcription factors associated with tp53

Gene Symbol	Gene ID	Gene Info
tp53 NCBI UniProt	ENSDARG00000035559	tumor protein p53
tp53 NCBI UniProt	ENSDARG00000115148	tumor protein p53

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tp53	dr11_v1_chr5_+_24087035_24087035	0.51	1.2e-07	Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_-_31428763 Show fit	39.63	ENSDART00000053545	zgc:153284 NCBI UniProt Show fit	zgc:153284
chr5_+_29831235 Show fit	29.91	ENSDART00000109660	f11r.1 NCBI UniProt Show fit	F11 receptor, tandem duplicate 1
chr6_-_42983843 Show fit	25.72	ENSDART00000130666	tnfrsf18 NCBI UniProt Show fit	tumor necrosis factor receptor superfamily, member 18
chr12_-_5505205 Show fit	24.40	ENSDART00000092319	abi3b NCBI UniProt Show fit	ABI family, member 3b
chr8_+_32406885 Show fit	24.28	ENSDART00000167600	epgn NCBI UniProt Show fit	epithelial mitogen homolog (mouse)
chr22_-_6404807 Show fit	24.03	ENSDART00000149399 ENSDART00000063420	si:rp71-1i20.2 NCBI UniProt Show fit	si:rp71-1i20.2
chr12_+_22576404 Show fit	21.32	ENSDART00000172053	capgb NCBI UniProt Show fit	capping protein (actin filament), gelsolin-like b
chr23_+_23232136 Show fit	19.52	ENSDART00000126479 ENSDART00000187764	plekhn1 NCBI UniProt Show fit	pleckstrin homology domain containing, family N member 1
chr7_-_2430286 Show fit	18.83	ENSDART00000129312	zgc:66473 NCBI UniProt Show fit	zgc:66473
chr16_+_38201840 Show fit	18.65	ENSDART00000044971	myo1eb NCBI UniProt Show fit	myosin IE, b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	33.2	GO:0007596	blood coagulation(GO:0007596)
0.0	31.4	GO:0016567	protein ubiquitination(GO:0016567)
2.1	29.9	GO:0050892	intestinal absorption(GO:0050892)
0.5	25.7	GO:0045785	positive regulation of cell adhesion(GO:0045785)
2.7	24.3	GO:2000273	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.7	23.6	GO:0003094	glomerular filtration(GO:0003094)
0.7	21.3	GO:0051014	actin filament severing(GO:0051014)
0.7	19.6	GO:0033627	cell adhesion mediated by integrin(GO:0033627)
4.9	19.5	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.3	19.2	GO:0006414	translational elongation(GO:0006414)

Showing 1 to 10 of 101 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	76.6	GO:0005615	extracellular space(GO:0005615)
0.4	48.9	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2	46.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	41.9	GO:0030027	lamellipodium(GO:0030027)
0.4	26.1	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	23.7	GO:0000785	chromatin(GO:0000785)
6.5	19.6	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.1	19.2	GO:0009986	cell surface(GO:0009986)
0.4	18.7	GO:0005902	microvillus(GO:0005902)
0.2	16.5	GO:0016459	myosin complex(GO:0016459)

Showing 1 to 10 of 37 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	36.3	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.6	35.1	GO:0000146	microfilament motor activity(GO:0000146)
0.2	32.1	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	30.8	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.5	26.4	GO:0016790	thiolester hydrolase activity(GO:0016790)
5.1	25.7	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.2	25.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	25.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.4	24.4	GO:0017124	SH3 domain binding(GO:0017124)
0.2	23.9	GO:0004896	cytokine receptor activity(GO:0004896)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	30.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.8	25.7	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.8	20.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
1.8	19.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	16.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	15.7	PID P53 REGULATION PATHWAY	p53 pathway
0.6	14.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	14.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	13.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	6.3	PID FGF PATHWAY	FGF signaling pathway

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	19.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	18.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.9	15.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
1.1	11.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.3	9.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
1.7	8.5	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	6.3	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.2	5.8	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.7	5.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis

Showing 1 to 10 of 25 entries

Results for tp53

Z-value: 2.11

Motif logo

Transcription factors associated with tp53

Activity-expression correlation:

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: