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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for vsx2

Z-value: 1.37

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Transcription factors associated with vsx2

Gene Symbol Gene ID Gene Info
vsx2
ENSDARG00000005574 visual system homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
vsx2dr11_v1_chr17_-_31659670_316596700.841.8e-26Click!

Activity profile of vsx2 motif

Sorted Z-values of vsx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_21129752 31.42 ENSDART00000169764
syt1a
synaptotagmin Ia
chr23_+_28731379 30.69 ENSDART00000047378
cort
cortistatin
chr16_+_46111849 27.21 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr15_-_16098531 26.60 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr20_+_35382482 25.85 ENSDART00000135284
vsnl1a
visinin-like 1a
chr18_-_1185772 23.90 ENSDART00000143245
nptnb
neuroplastin b
chr21_+_28958471 18.74 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_43356082 18.07 ENSDART00000171213
uncx
UNC homeobox
chr9_+_11532025 17.70 ENSDART00000109037
cdk5r2b
cyclin-dependent kinase 5, regulatory subunit 2b (p39)
chr24_-_21923930 15.93 ENSDART00000131944
tagln3b
transgelin 3b
chr17_+_31185276 15.39 ENSDART00000062887
disp2
dispatched homolog 2 (Drosophila)
chr1_+_9290103 14.74 ENSDART00000055009
uncx4.1
Unc4.1 homeobox (C. elegans)
chr5_-_16996482 13.69 ENSDART00000144501
galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chr21_-_27185915 13.47 ENSDART00000135052
slc8a4a
solute carrier family 8 (sodium/calcium exchanger), member 4a
chr15_-_9272328 13.04 ENSDART00000172114
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr3_-_46817499 12.68 ENSDART00000013717
elavl3
ELAV like neuron-specific RNA binding protein 3
chr20_-_9436521 12.26 ENSDART00000133000
zgc:101840
zgc:101840
chr23_-_24195519 12.20 ENSDART00000112370
ENSDART00000180377
ano11
anoctamin 11
chr4_-_17629444 12.09 ENSDART00000108814
nrip2
nuclear receptor interacting protein 2
chr16_+_39159752 12.00 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr21_+_25231160 11.56 ENSDART00000063089
ENSDART00000139127
gng8
guanine nucleotide binding protein (G protein), gamma 8
chr13_+_19322686 11.24 ENSDART00000058036
emx2
empty spiracles homeobox 2
chr23_+_28582865 11.20 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr23_-_24195723 10.39 ENSDART00000145489
ano11
anoctamin 11
chr21_+_6751760 9.03 ENSDART00000135914
olfm1b
olfactomedin 1b
chr18_-_2433011 8.74 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr18_+_7639401 7.93 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr23_+_23658474 7.54 ENSDART00000162838
agrn
agrin
chr21_+_6751405 7.42 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr6_-_40713183 7.30 ENSDART00000157113
ENSDART00000154810
ENSDART00000153702
si:ch211-157b11.12
si:ch211-157b11.12
chr24_-_23320223 7.26 ENSDART00000135846
zfhx4
zinc finger homeobox 4
chr18_+_28106139 7.06 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr21_+_32820175 6.97 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr14_+_25817628 6.90 ENSDART00000047680
glra1
glycine receptor, alpha 1
chr23_-_24483311 6.81 ENSDART00000185793
ENSDART00000109248
spen
spen family transcriptional repressor
chr20_-_46362606 6.56 ENSDART00000153087
bmf2
BCL2 modifying factor 2
chr7_+_36898850 6.54 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr22_-_20011476 6.53 ENSDART00000093312
ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr5_-_64831207 6.53 ENSDART00000144816
lix1
limb and CNS expressed 1
chr19_+_22062202 6.48 ENSDART00000100181
sall3b
spalt-like transcription factor 3b
chr15_-_22074315 6.39 ENSDART00000149830
drd2a
dopamine receptor D2a
chr11_+_18873619 6.10 ENSDART00000176141
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr18_+_14529005 5.96 ENSDART00000186379
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr12_-_35095414 5.53 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr14_+_21820034 5.50 ENSDART00000122739
ctbp1
C-terminal binding protein 1
chr6_-_12275836 4.92 ENSDART00000189980
pkp4
plakophilin 4
chr12_-_35386910 4.85 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr21_-_37790727 4.80 ENSDART00000162907
gabrb4
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr11_-_37425407 4.78 ENSDART00000160911
erc2
ELKS/RAB6-interacting/CAST family member 2
chr11_-_42554290 4.76 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr11_+_38280454 4.30 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr12_+_30367079 4.27 ENSDART00000190112
ccdc186
si:ch211-225b10.4
chr20_+_29209615 4.16 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr5_-_28109416 3.99 ENSDART00000042002
si:ch211-48m9.1
si:ch211-48m9.1
chr12_+_30367371 3.89 ENSDART00000153364
ccdc186
si:ch211-225b10.4
chr17_+_3379673 3.85 ENSDART00000176354
sntg2
syntrophin, gamma 2
chr1_+_10318089 3.80 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr11_+_18873113 3.73 ENSDART00000103969
ENSDART00000103968
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr14_+_23717165 3.62 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr14_+_23874062 3.57 ENSDART00000172149
sh3rf2
SH3 domain containing ring finger 2
chr12_-_19862912 3.03 ENSDART00000145788
shisa9a
shisa family member 9a
chr20_+_29209767 2.95 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr3_-_46811611 2.94 ENSDART00000134092
elavl3
ELAV like neuron-specific RNA binding protein 3
chr7_+_22313533 2.73 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr18_-_24989580 2.61 ENSDART00000163449
chd2
chromodomain helicase DNA binding protein 2
chr24_-_25004553 2.48 ENSDART00000080997
ENSDART00000136860
zdhhc20b
zinc finger, DHHC-type containing 20b
chr24_+_39518774 2.34 ENSDART00000132939
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr21_+_27370671 2.30 ENSDART00000009234
ENSDART00000142071
rbm14a
RNA binding motif protein 14a
chr22_-_21897203 2.21 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr4_+_3980247 2.02 ENSDART00000049194
gpr37b
G protein-coupled receptor 37b
chr8_+_18588551 2.01 ENSDART00000177476
ENSDART00000063539
prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr20_+_29209926 2.01 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr21_+_33172526 1.98 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr21_-_32781612 1.91 ENSDART00000031028
cnot6a
CCR4-NOT transcription complex, subunit 6a
chr24_+_35881124 1.81 ENSDART00000143015
klhl14
kelch-like family member 14
chr6_-_32726848 1.64 ENSDART00000155294
zc3h3
zinc finger CCCH-type containing 3
chr11_-_29768054 1.54 ENSDART00000079117
plekha3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr13_-_44630111 1.52 ENSDART00000110092
mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr14_-_7207961 1.38 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr6_+_28208973 1.35 ENSDART00000171216
ENSDART00000171377
ENSDART00000167389
ENSDART00000166988
LSM2 (1 of many)
si:ch73-14h10.2
chr19_-_47323267 1.25 ENSDART00000190077
CU138512.1

chr22_+_9003090 1.22 ENSDART00000106414
rnh1
ribonuclease/angiogenin inhibitor 1
chr13_+_22295905 0.99 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr19_-_19379084 0.92 ENSDART00000165206
smarcc1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b
chr20_-_20270191 0.84 ENSDART00000009356
ppp2r5ea
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr21_-_13661631 0.77 ENSDART00000184408
pnpla7a
patatin-like phospholipase domain containing 7a
chr2_-_26720854 0.29 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr23_-_33709964 0.20 ENSDART00000143333
ENSDART00000130338
pou6f1
POU class 6 homeobox 1
chr15_+_5360407 0.00 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of vsx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.0 GO:0060074 synapse maturation(GO:0060074)
2.5 7.5 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
2.3 6.9 GO:0071361 cellular response to ethanol(GO:0071361)
2.3 22.6 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
1.4 31.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.4 7.0 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
1.2 18.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
1.2 11.2 GO:0060114 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
1.1 13.5 GO:0042044 fluid transport(GO:0042044)
1.1 26.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.8 23.9 GO:0070593 dendrite self-avoidance(GO:0070593)
0.5 11.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.5 6.4 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.4 4.8 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.3 3.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 15.4 GO:0035195 gene silencing by miRNA(GO:0035195)
0.3 2.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.3 4.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 1.5 GO:0035627 ceramide transport(GO:0035627)
0.3 6.6 GO:0010507 negative regulation of autophagy(GO:0010507)
0.2 6.5 GO:0097352 autophagosome maturation(GO:0097352)
0.2 2.0 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.2 6.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 6.0 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.2 22.4 GO:0006836 neurotransmitter transport(GO:0006836)
0.2 13.0 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 4.9 GO:0072114 pronephros morphogenesis(GO:0072114)
0.1 5.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 8.2 GO:0099518 vesicle cytoskeletal trafficking(GO:0099518)
0.1 1.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 3.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 4.8 GO:0030641 regulation of cellular pH(GO:0030641)
0.1 0.8 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 4.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 21.0 GO:0030334 regulation of cell migration(GO:0030334)
0.1 3.6 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 6.0 GO:0051260 protein homooligomerization(GO:0051260)
0.0 13.7 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 12.5 GO:0050767 regulation of neurogenesis(GO:0050767)
0.0 2.0 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 5.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 6.8 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.9 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 2.3 GO:0071773 BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 31.4 GO:0042584 chromaffin granule membrane(GO:0042584)
3.5 17.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
3.1 18.7 GO:0005955 calcineurin complex(GO:0005955)
0.9 11.2 GO:0044295 axonal growth cone(GO:0044295)
0.8 4.8 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.7 11.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.4 27.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 12.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 2.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 6.4 GO:0098978 glutamatergic synapse(GO:0098978)
0.2 3.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 11.7 GO:0034707 chloride channel complex(GO:0034707)
0.2 4.8 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.1 13.5 GO:0042383 sarcolemma(GO:0042383)
0.1 6.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 23.9 GO:0030424 axon(GO:0030424)
0.1 1.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 9.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 8.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.9 GO:0071564 npBAF complex(GO:0071564)
0.1 6.6 GO:0016459 myosin complex(GO:0016459)
0.1 3.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 9.1 GO:0005730 nucleolus(GO:0005730)
0.0 21.4 GO:0030054 cell junction(GO:0030054)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 12.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 22.1 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 24.5 GO:0005829 cytosol(GO:0005829)
0.0 4.9 GO:0043005 neuron projection(GO:0043005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 26.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.1 18.7 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
2.2 11.2 GO:0008046 axon guidance receptor activity(GO:0008046)
1.4 17.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.2 7.0 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
1.0 13.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.8 6.9 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.7 3.6 GO:0050699 WW domain binding(GO:0050699)
0.7 23.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.7 31.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.6 12.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.6 11.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.5 12.0 GO:0019894 kinesin binding(GO:0019894)
0.5 3.8 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.5 6.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.3 8.2 GO:0031267 small GTPase binding(GO:0031267)
0.3 7.5 GO:0043236 laminin binding(GO:0043236)
0.3 1.5 GO:1902388 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.3 27.4 GO:0005254 chloride channel activity(GO:0005254)
0.3 4.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 2.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 25.9 GO:0005179 hormone activity(GO:0005179)
0.1 6.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.3 GO:0097602 cullin family protein binding(GO:0097602)
0.1 4.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 6.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 5.5 GO:0051287 NAD binding(GO:0051287)
0.1 9.8 GO:0060090 binding, bridging(GO:0060090)
0.1 4.9 GO:0045296 cadherin binding(GO:0045296)
0.1 2.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 13.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.8 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 2.6 GO:0003678 DNA helicase activity(GO:0003678)
0.0 9.1 GO:0008017 microtubule binding(GO:0008017)
0.0 18.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 42.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 23.5 GO:0003723 RNA binding(GO:0003723)
0.0 3.5 GO:0003924 GTPase activity(GO:0003924)
0.0 14.7 GO:0022857 transmembrane transporter activity(GO:0022857)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 17.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 12.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 7.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 18.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.7 11.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.5 7.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 13.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.3 6.9 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport