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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for wt1a+wt1b
Z-value: 1.44
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Transcription factors associated with wt1a+wt1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| wt1b | dr11_v1_chr18_-_45617146_45617146 | -0.25 | 1.5e-02 | Click! |
| wt1a | dr11_v1_chr25_-_15214161_15214161 | -0.15 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of wt1a+wt1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.4 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.2 | 13.8 | GO:0045732 | positive regulation of protein catabolic process(GO:0045732) |
| 0.1 | 13.3 | GO:0006909 | phagocytosis(GO:0006909) |
| 0.8 | 12.7 | GO:0006228 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 0.1 | 11.5 | GO:0042552 | myelination(GO:0042552) |
| 0.5 | 11.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 11.1 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.1 | 10.7 | GO:0007626 | locomotory behavior(GO:0007626) |
| 0.6 | 10.5 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 1.5 | 9.2 | GO:0035332 | positive regulation of hippo signaling(GO:0035332) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.9 | 15.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 13.1 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 12.3 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.4 | 11.4 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.2 | 10.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.8 | 10.5 | GO:1990246 | uniplex complex(GO:1990246) |
| 1.7 | 10.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 8.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.4 | 8.6 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 18.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 15.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.3 | 13.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.3 | 13.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.4 | 12.7 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 2.5 | 12.5 | GO:0070004 | cysteine-type exopeptidase activity(GO:0070004) |
| 0.1 | 11.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 11.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.2 | 11.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 9.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 8.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 2.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.2 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 2.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.1 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.5 | 8.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.3 | 7.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 6.1 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.5 | 6.0 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 5.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 4.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.3 | 4.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 4.1 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 4.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |