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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for xbp1
Z-value: 1.52
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Transcription factors associated with xbp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| xbp1 | dr11_v1_chr5_-_15948833_15948920 | 0.77 | 2.1e-19 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23984755 Show fit | 28.56 |
ENSDART00000145328
|
apolipoprotein C-II |
|
| chr7_+_10610791 Show fit | 18.71 |
ENSDART00000166064
|
fumarylacetoacetate hydrolase (fumarylacetoacetase) |
|
| chr16_+_27224369 Show fit | 15.99 |
ENSDART00000136980
|
Sec61 translocon beta subunit |
|
| chr21_+_10702031 Show fit | 15.67 |
ENSDART00000102304
|
lectin, mannose-binding, 1 |
|
| chr21_+_10701834 Show fit | 15.15 |
ENSDART00000192473
|
lectin, mannose-binding, 1 |
|
| chr8_-_14554785 Show fit | 14.50 |
ENSDART00000057645
|
quiescin Q6 sulfhydryl oxidase 1 |
|
| chr24_+_14214831 Show fit | 14.26 |
ENSDART00000004664
|
translocation associated membrane protein 1 |
|
| chr16_+_23984179 Show fit | 13.32 |
ENSDART00000175879
|
apolipoprotein C-II |
|
| chr24_-_42090635 Show fit | 13.02 |
ENSDART00000166413
|
signal sequence receptor, alpha |
|
| chr12_-_990149 Show fit | 12.35 |
ENSDART00000054367
|
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b |
Network of associatons between targets according to the STRING database.
First level regulatory network of xbp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 59.1 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 4.4 | 44.4 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 2.0 | 38.0 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 3.1 | 18.7 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 2.5 | 17.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 1.0 | 14.7 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 14.5 | GO:0006457 | protein folding(GO:0006457) |
| 0.1 | 13.4 | GO:0006956 | complement activation(GO:0006956) |
| 0.6 | 11.2 | GO:0043687 | protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687) |
| 0.6 | 10.7 | GO:0006825 | copper ion transport(GO:0006825) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 113.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 4.2 | 41.9 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.7 | 35.0 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 33.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 5.0 | 30.1 | GO:0005784 | Sec61 translocon complex(GO:0005784) |
| 1.8 | 26.5 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 1.0 | 26.5 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.2 | 14.6 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.1 | 14.2 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 12.9 | GO:0030425 | dendrite(GO:0030425) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 49.3 | GO:0008047 | enzyme activator activity(GO:0008047) |
| 2.4 | 30.8 | GO:0005537 | mannose binding(GO:0005537) |
| 3.7 | 18.7 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 5.7 | 17.2 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 4.8 | 14.5 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.9 | 14.1 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.1 | 13.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 13.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 2.8 | 11.2 | GO:0004579 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.7 | 10.7 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.0 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.3 | 10.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 8.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 7.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 5.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.0 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.3 | 3.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 3.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 3.0 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 83.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 4.2 | 41.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 39.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.4 | 22.3 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.1 | 18.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.8 | 17.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.3 | 8.2 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.8 | 7.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.3 | 7.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.4 | 6.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |