Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for xbp1

Z-value: 1.52

Motif logo

logo of

Transcription factors associated with xbp1

Gene Symbol Gene ID Gene Info
xbp1
ENSDARG00000035622 X-box binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
xbp1dr11_v1_chr5_-_15948833_159489200.772.1e-19Click!

Activity profile of xbp1 motif

Sorted Z-values of xbp1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_23984755 28.56 ENSDART00000145328
apoc2
apolipoprotein C-II
chr7_+_10610791 18.71 ENSDART00000166064
fah
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr16_+_27224369 15.99 ENSDART00000136980
sec61b
Sec61 translocon beta subunit
chr21_+_10702031 15.67 ENSDART00000102304
lman1
lectin, mannose-binding, 1
chr21_+_10701834 15.15 ENSDART00000192473
lman1
lectin, mannose-binding, 1
chr8_-_14554785 14.50 ENSDART00000057645
qsox1
quiescin Q6 sulfhydryl oxidase 1
chr24_+_14214831 14.26 ENSDART00000004664
tram1
translocation associated membrane protein 1
chr16_+_23984179 13.32 ENSDART00000175879
apoc2
apolipoprotein C-II
chr24_-_42090635 13.02 ENSDART00000166413
ssr1
signal sequence receptor, alpha
chr12_-_990149 12.35 ENSDART00000054367
kdelr2b
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr22_+_38194151 10.69 ENSDART00000121965
cp
ceruloplasmin
chr1_-_23308225 10.64 ENSDART00000137567
ENSDART00000008201
smim14
small integral membrane protein 14
chr16_-_46660680 10.62 ENSDART00000159209
ENSDART00000191929
tmem176l.4
transmembrane protein 176l.4
chr6_+_6779114 10.62 ENSDART00000163493
ENSDART00000143359
sec23b
Sec23 homolog B, COPII coat complex component
chr10_-_22150419 10.43 ENSDART00000006173
cldn7b
claudin 7b
chr11_+_44503774 10.10 ENSDART00000169295
ero1b
endoplasmic reticulum oxidoreductase beta
chr19_-_11238620 9.20 ENSDART00000148697
ENSDART00000149169
ssr2
signal sequence receptor, beta
chr6_+_13506841 8.64 ENSDART00000032331
gmppab
GDP-mannose pyrophosphorylase Ab
chr8_+_5024468 8.61 ENSDART00000030938
adra1aa
adrenoceptor alpha 1Aa
chr15_-_32383340 8.36 ENSDART00000185632
c4
complement component 4
chr4_+_25651720 8.09 ENSDART00000100693
ENSDART00000100717
acot16
acyl-CoA thioesterase 16
chr1_-_45049603 7.78 ENSDART00000023336
rps6
ribosomal protein S6
chr23_-_18572685 7.76 ENSDART00000047175
ssr4
signal sequence receptor, delta
chr23_-_18572521 7.49 ENSDART00000138599
ssr4
signal sequence receptor, delta
chr6_-_40071899 7.40 ENSDART00000034730
sec61a1
Sec61 translocon alpha 1 subunit
chr2_-_42492201 7.32 ENSDART00000180762
ENSDART00000009093
esyt2a
extended synaptotagmin-like protein 2a
chr7_+_44715224 7.25 ENSDART00000184630
si:dkey-56m19.5
si:dkey-56m19.5
chr8_+_11471350 7.09 ENSDART00000092355
ENSDART00000136184
tjp2b
tight junction protein 2b (zona occludens 2)
chr4_-_13613148 7.02 ENSDART00000067164
ENSDART00000111247
irf5
interferon regulatory factor 5
chr6_-_23931442 7.00 ENSDART00000160547
sec16b
SEC16 homolog B, endoplasmic reticulum export factor
chr25_+_5983430 6.87 ENSDART00000074814
ppib
peptidylprolyl isomerase B (cyclophilin B)
chr4_-_17725008 6.81 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr8_+_47219107 6.73 ENSDART00000146018
ENSDART00000075068
mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
chr6_-_42388608 6.72 ENSDART00000049425
sec61a1l
Sec61 translocon alpha 1 subunit, like
chr19_+_18903533 6.66 ENSDART00000157523
ENSDART00000166562
slc39a7
solute carrier family 39 (zinc transporter), member 7
chr10_+_39212898 6.39 ENSDART00000159501
stt3a
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr12_+_31783066 6.33 ENSDART00000105584
lrrc59
leucine rich repeat containing 59
chr4_-_19693978 6.28 ENSDART00000100974
ENSDART00000040405
snd1
staphylococcal nuclease and tudor domain containing 1
chr3_-_25377163 6.15 ENSDART00000055490
kpna2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr4_+_68562464 6.07 ENSDART00000192954
BX548011.4

chr20_-_438646 6.06 ENSDART00000009196
ufl1
UFM1-specific ligase 1
chr5_+_24543862 6.06 ENSDART00000029699
atp6v0a2b
ATPase H+ transporting V0 subunit a2b
chr19_+_43119698 5.84 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eef1a1l1
eukaryotic translation elongation factor 1 alpha 1, like 1
chr5_+_2002804 5.83 ENSDART00000064088
vkorc1l1
vitamin K epoxide reductase complex, subunit 1-like 1
chr20_-_30377221 5.73 ENSDART00000126229
rps7
ribosomal protein S7
chr19_-_30404096 5.69 ENSDART00000103475
agr2
anterior gradient 2
chr17_+_23311377 5.53 ENSDART00000128073
ppp1r3ca
protein phosphatase 1, regulatory subunit 3Ca
chr2_-_55298075 5.48 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr1_-_53277187 5.34 ENSDART00000131520
znf330
zinc finger protein 330
chr24_+_42074143 5.32 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr17_+_15213496 5.12 ENSDART00000058351
ENSDART00000131663
gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr15_-_32383529 5.02 ENSDART00000028349
c4
complement component 4
chr19_+_14113886 4.97 ENSDART00000169343
kdf1b
keratinocyte differentiation factor 1b
chr1_-_53277413 4.91 ENSDART00000150579
znf330
zinc finger protein 330
chr2_-_7757273 4.90 ENSDART00000136074
b3gnt5b
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b
chr1_-_44484 4.89 ENSDART00000171547
ENSDART00000164075
ENSDART00000168091
tmem39a
transmembrane protein 39A
chr22_-_817479 4.81 ENSDART00000123487
zgc:153675
zgc:153675
chr10_+_39212601 4.81 ENSDART00000168778
stt3a
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr17_+_53156530 4.73 ENSDART00000126277
ENSDART00000156774
dph6
diphthamine biosynthesis 6
chr14_-_45464112 4.69 ENSDART00000173209
ehd1a
EH-domain containing 1a
chr18_-_34170918 4.63 ENSDART00000015079
slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr4_+_13568469 4.55 ENSDART00000171235
ENSDART00000136152
calua
calumenin a
chr22_-_17781213 4.32 ENSDART00000137984
si:ch73-63e15.2
si:ch73-63e15.2
chr10_-_3427589 4.32 ENSDART00000133452
ENSDART00000037183
tmed2
transmembrane p24 trafficking protein 2
chr22_-_10152629 4.31 ENSDART00000144209
rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr18_-_34171280 4.31 ENSDART00000122321
slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr5_+_65086856 4.11 ENSDART00000169209
ENSDART00000162409
ptrh1
peptidyl-tRNA hydrolase 1 homolog
chr22_+_31059919 4.11 ENSDART00000077063
sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr16_+_53603945 3.90 ENSDART00000083513
sacm1lb
SAC1 like phosphatidylinositide phosphatase b
chr4_-_779796 3.82 ENSDART00000128743
tmem214
transmembrane protein 214
chr5_+_66220601 3.70 ENSDART00000129903
mfsd10
major facilitator superfamily domain containing 10
chr12_+_1592146 3.69 ENSDART00000184575
ENSDART00000192902
SLC39A11
solute carrier family 39 member 11
chr5_-_63644938 3.69 ENSDART00000050865
surf4l
surfeit gene 4, like
chr9_+_21165017 3.57 ENSDART00000145933
ENSDART00000142985
si:rp71-68n21.9
si:rp71-68n21.9
chr5_+_65087226 3.56 ENSDART00000183187
ptrh1
peptidyl-tRNA hydrolase 1 homolog
chr25_+_3759553 3.54 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
thoc5
THO complex 5
chr6_-_32087108 3.43 ENSDART00000150934
ENSDART00000130627
alg6
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
chr20_-_40758410 3.37 ENSDART00000183031
cx34.5
connexin 34.5
chr18_-_16924221 3.34 ENSDART00000122102
wee1
WEE1 G2 checkpoint kinase
chr5_+_69868911 3.33 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
ugt2a5
UDP glucuronosyltransferase 2 family, polypeptide A5
chr19_-_29832876 3.25 ENSDART00000005119
eif3i
eukaryotic translation initiation factor 3, subunit I
chr9_-_27748868 3.22 ENSDART00000190306
tbccd1
TBCC domain containing 1
chr25_-_3759322 3.22 ENSDART00000088077
zgc:158398
zgc:158398
chr2_-_22363460 3.20 ENSDART00000158486
selenof
selenoprotein F
chr20_+_22799857 3.20 ENSDART00000058527
scfd2
sec1 family domain containing 2
chr6_+_47843760 3.19 ENSDART00000140943
padi2
peptidyl arginine deiminase, type II
chr24_-_26485098 3.16 ENSDART00000135496
ENSDART00000009609
ENSDART00000133782
ENSDART00000141029
ENSDART00000113739
eif5a
eukaryotic translation initiation factor 5A
chr25_-_774350 3.14 ENSDART00000166321
ENSDART00000160386
IRAK4
interleukin 1 receptor associated kinase 4
chr3_-_18384501 3.10 ENSDART00000027630
kdelr2a
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a
chr25_-_3034668 3.08 ENSDART00000053405
scamp2
secretory carrier membrane protein 2
chr2_+_36608387 3.07 ENSDART00000159541
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr2_+_37176814 3.03 ENSDART00000048277
ENSDART00000176827
copa
coatomer protein complex, subunit alpha
chr15_-_29326254 3.02 ENSDART00000114492
si:dkey-52l18.4
si:dkey-52l18.4
chr14_+_20351 2.98 ENSDART00000051893
stx18
syntaxin 18
chr23_+_43638982 2.97 ENSDART00000168646
slc10a7
solute carrier family 10, member 7
chr1_-_9486214 2.92 ENSDART00000137821
micall2b
mical-like 2b
chr25_-_37262220 2.91 ENSDART00000153789
ENSDART00000155182
rfwd3
ring finger and WD repeat domain 3
chr16_-_26676685 2.90 ENSDART00000103431
esrp1
epithelial splicing regulatory protein 1
chr12_-_35582683 2.85 ENSDART00000167933
sec24c
SEC24 homolog C, COPII coat complex component
chr6_-_35052145 2.84 ENSDART00000073970
ENSDART00000185790
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr6_+_3864040 2.82 ENSDART00000013743
gorasp2
golgi reassembly stacking protein 2
chr3_-_34586403 2.81 ENSDART00000151515
sept9a
septin 9a
chr8_-_31701157 2.81 ENSDART00000141799
fbxo4
F-box protein 4
chr5_+_65086668 2.75 ENSDART00000183746
ptrh1
peptidyl-tRNA hydrolase 1 homolog
chr24_-_11069237 2.74 ENSDART00000127398
CR753886.1

chr18_-_21746421 2.69 ENSDART00000188809
pskh1
protein serine kinase H1
chr9_+_54695981 2.68 ENSDART00000183605
rab9a
RAB9A, member RAS oncogene family
chr23_+_42819221 2.67 ENSDART00000180495
myl9a
myosin, light chain 9a, regulatory
chr11_-_270210 2.66 ENSDART00000005217
ENSDART00000172779
alas1
aminolevulinate, delta-, synthase 1
chr3_+_29510818 2.65 ENSDART00000055407
ENSDART00000193743
ENSDART00000123619
rac2
Rac family small GTPase 2
chr12_+_30788912 2.64 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr5_+_22791686 2.63 ENSDART00000014806
npas2
neuronal PAS domain protein 2
chr1_-_53277660 2.61 ENSDART00000014232
znf330
zinc finger protein 330
chr7_-_69352424 2.59 ENSDART00000170714
ap1g1
adaptor-related protein complex 1, gamma 1 subunit
chr16_+_35918463 2.59 ENSDART00000160608
sh3d21
SH3 domain containing 21
chr6_+_58289335 2.56 ENSDART00000177399
ralgapb
Ral GTPase activating protein, beta subunit (non-catalytic)
chr6_+_23026714 2.53 ENSDART00000124948
srp68
signal recognition particle 68
chr3_+_28860283 2.51 ENSDART00000077235
alg1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr5_+_58550291 2.50 ENSDART00000184983
ENSDART00000044803
pou2f3
POU class 2 homeobox 3
chr5_-_28968964 2.46 ENSDART00000184936
ENSDART00000016628
fam129bb
family with sequence similarity 129, member Bb
chr5_+_21211135 2.46 ENSDART00000088492
bmp10
bone morphogenetic protein 10
chr16_-_42750295 2.42 ENSDART00000176570
slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr17_+_23730089 2.42 ENSDART00000034913
zgc:91976
zgc:91976
chr1_-_9485939 2.39 ENSDART00000157814
micall2b
mical-like 2b
chr10_+_16165533 2.32 ENSDART00000065045
prrc1
proline-rich coiled-coil 1
chr2_-_9527129 2.30 ENSDART00000157422
ENSDART00000004398
cope
coatomer protein complex, subunit epsilon
chr9_+_25840720 2.30 ENSDART00000024572
gtdc1
glycosyltransferase-like domain containing 1
chr10_-_44305180 2.28 ENSDART00000187552
CDK2AP1
cyclin dependent kinase 2 associated protein 1
chr10_-_34915886 2.26 ENSDART00000141201
ENSDART00000002166
ccna1
cyclin A1
chr15_+_35933094 2.21 ENSDART00000019976
rhbdd1
rhomboid domain containing 1
chr2_-_1227221 2.20 ENSDART00000130897
ABCF3
ATP binding cassette subfamily F member 3
chr5_+_6672870 2.17 ENSDART00000126598
pxna
paxillin a
chr15_-_18115540 2.14 ENSDART00000131639
ENSDART00000047902
arcn1b
archain 1b
chr19_+_1414604 2.13 ENSDART00000159024
btr29
bloodthirsty-related gene family, member 29
chr6_-_52348562 2.13 ENSDART00000142565
ENSDART00000145369
ENSDART00000016890
eif6
eukaryotic translation initiation factor 6
chr14_+_9581896 2.12 ENSDART00000114563
tmem129
transmembrane protein 129, E3 ubiquitin protein ligase
chr18_+_6706140 2.10 ENSDART00000111343
lmf2a
lipase maturation factor 2a
chr20_+_22799641 2.09 ENSDART00000131132
scfd2
sec1 family domain containing 2
chr11_-_6420917 2.03 ENSDART00000193717
FO681393.2

chr22_-_11078988 2.00 ENSDART00000126664
ENSDART00000006927
use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr25_+_34862225 2.00 ENSDART00000149782
CHST6
zgc:194879
chr9_-_56399699 1.98 ENSDART00000170281
rab3gap1
RAB3 GTPase activating protein subunit 1
chr3_+_53773256 1.93 ENSDART00000170461
col5a3a
collagen, type V, alpha 3a
chr19_+_26640096 1.87 ENSDART00000067793
ints3
integrator complex subunit 3
chr4_-_5912951 1.87 ENSDART00000169439
arl1
ADP-ribosylation factor-like 1
chr11_+_6431133 1.87 ENSDART00000190742
FO904935.1

chr11_+_30647545 1.86 ENSDART00000114792
gb:eh507706
expressed sequence EH507706
chr13_-_9875538 1.84 ENSDART00000041609
tm9sf3
transmembrane 9 superfamily member 3
chr12_-_3773869 1.83 ENSDART00000092983
si:ch211-166g5.4
si:ch211-166g5.4
chr5_-_30516646 1.83 ENSDART00000014666
arcn1a
archain 1a
chr16_-_54978981 1.83 ENSDART00000154023
wdtc1
WD and tetratricopeptide repeats 1
chr7_-_65114067 1.82 ENSDART00000110614
ENSDART00000098277
tmem41b
transmembrane protein 41B
chr3_-_36209936 1.80 ENSDART00000175208
csnk1da
casein kinase 1, delta a
chr6_-_35052388 1.78 ENSDART00000181000
ENSDART00000170116
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr15_-_14193659 1.78 ENSDART00000171197
pnkp
polynucleotide kinase 3'-phosphatase
chr3_-_180860 1.77 ENSDART00000059956
ENSDART00000192506
kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr12_-_16452200 1.77 ENSDART00000037601
rpp30
ribonuclease P/MRP 30 subunit
chr18_-_7481036 1.71 ENSDART00000101292
si:dkey-238c7.16
si:dkey-238c7.16
chr20_+_42537768 1.66 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
si:dkeyp-93d12.1
chr13_-_47403154 1.65 ENSDART00000114318
bcl2l11
BCL2 like 11
chr22_-_20386982 1.64 ENSDART00000089015
zbtb7a
zinc finger and BTB domain containing 7a
chr12_+_30789611 1.63 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr1_-_156375 1.62 ENSDART00000160221
pcid2
PCI domain containing 2
chr2_+_43920461 1.61 ENSDART00000123673
si:ch211-195h23.3
si:ch211-195h23.3
chr5_-_56964547 1.60 ENSDART00000074400
tia1
TIA1 cytotoxic granule-associated RNA binding protein
chr5_+_20453874 1.58 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr1_+_29798140 1.58 ENSDART00000019743
tm9sf2
transmembrane 9 superfamily member 2
chr3_-_34180364 1.56 ENSDART00000151819
ENSDART00000003133
yipf2
Yip1 domain family, member 2
chr10_+_37173029 1.52 ENSDART00000136510
ksr1a
kinase suppressor of ras 1a
chr9_+_23825440 1.50 ENSDART00000138470
ints6
integrator complex subunit 6
chr18_-_18587745 1.50 ENSDART00000191973
sf3b3
splicing factor 3b, subunit 3
chr6_+_49722970 1.45 ENSDART00000155934
ENSDART00000154738
stx16
syntaxin 16
chr8_-_44463985 1.44 ENSDART00000016845
mhc1lba
major histocompatibility complex class I LBA
chr10_-_26225548 1.44 ENSDART00000132019
ENSDART00000079194
arfip2b
ADP-ribosylation factor interacting protein 2b
chr9_+_54237100 1.44 ENSDART00000148928
rbm27
RNA binding motif protein 27
chr10_-_2682198 1.42 ENSDART00000183727
pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr15_+_41815703 1.39 ENSDART00000059508
pxylp1
2-phosphoxylose phosphatase 1
chr11_+_7276824 1.37 ENSDART00000185992
si:ch73-238c9.1
si:ch73-238c9.1
chr25_-_34512102 1.37 ENSDART00000087450
klf13
Kruppel-like factor 13
chr2_+_20926202 1.36 ENSDART00000178880
pla2g4aa
phospholipase A2, group IVAa (cytosolic, calcium-dependent)
chr12_-_4206869 1.35 ENSDART00000106572
si:dkey-32n7.9
si:dkey-32n7.9
chr20_-_26929685 1.29 ENSDART00000132556
ftr79
finTRIM family, member 79
chr6_-_40885496 1.27 ENSDART00000189857
sirt4
sirtuin 4
chr14_+_1014109 1.24 ENSDART00000157945
f8
coagulation factor VIII, procoagulant component
chr12_-_35582521 1.20 ENSDART00000162175
ENSDART00000168958
sec24c
SEC24 homolog C, COPII coat complex component
chr16_+_38159758 1.14 ENSDART00000058666
ENSDART00000112165
pi4kb
phosphatidylinositol 4-kinase, catalytic, beta
chr24_-_33291784 1.13 ENSDART00000124938
si:ch1073-406l10.2
si:ch1073-406l10.2
chr21_-_22693730 1.08 ENSDART00000158342
gig2d
grass carp reovirus (GCRV)-induced gene 2d
chr25_-_1687481 1.06 ENSDART00000163553
ENSDART00000179460
mon2
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr7_+_18100996 1.06 ENSDART00000055810
rab1ba
zRAB1B, member RAS oncogene family a
chr15_-_29387446 1.01 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr5_-_41841675 1.00 ENSDART00000141683
si:dkey-65b12.6
si:dkey-65b12.6
chr17_-_24866727 0.97 ENSDART00000027957
hmgcl
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr16_+_6727195 0.95 ENSDART00000148625
znf407
zinc finger protein 407
chr4_-_77979432 0.93 ENSDART00000049170
zgc:85975
zgc:85975
chr13_-_38088627 0.93 ENSDART00000175268
CT027676.1

chr4_+_77957611 0.92 ENSDART00000156692
arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr19_-_30403922 0.92 ENSDART00000181841
agr2
anterior gradient 2
chr9_+_20526472 0.92 ENSDART00000166457
ENSDART00000141775
trim45
tripartite motif containing 45
chr17_-_24866964 0.91 ENSDART00000190601
ENSDART00000192547
hmgcl
3-hydroxymethyl-3-methylglutaryl-CoA lyase

Network of associatons between targets according to the STRING database.

First level regulatory network of xbp1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 44.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
3.1 18.7 GO:0006572 tyrosine catabolic process(GO:0006572)
2.5 17.2 GO:0006621 protein retention in ER lumen(GO:0006621)
2.0 38.0 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
1.9 5.8 GO:0042373 vitamin K metabolic process(GO:0042373)
1.8 7.2 GO:0051645 Golgi localization(GO:0051645)
1.7 10.4 GO:0060876 semicircular canal formation(GO:0060876)
1.7 9.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.4 8.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
1.4 7.0 GO:0070973 positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
1.4 5.5 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
1.4 4.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
1.2 8.6 GO:0010460 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
1.2 6.1 GO:1903573 IRE1-mediated unfolded protein response(GO:0036498) negative regulation of response to endoplasmic reticulum stress(GO:1903573) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
1.2 59.1 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
1.0 14.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.0 5.0 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.9 4.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.8 4.7 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.7 9.7 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.7 2.1 GO:1902626 mature ribosome assembly(GO:0042256) assembly of large subunit precursor of preribosome(GO:1902626)
0.7 6.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.6 2.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.6 3.2 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.6 11.2 GO:0043687 protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687)
0.6 10.7 GO:0006825 copper ion transport(GO:0006825)
0.5 1.6 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.5 2.7 GO:2000389 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.5 1.6 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.5 6.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.5 1.9 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.5 1.8 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.5 3.2 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.4 6.7 GO:0035999 methionine biosynthetic process(GO:0009086) tetrahydrofolate interconversion(GO:0035999)
0.4 3.1 GO:1902902 negative regulation of autophagosome maturation(GO:1901097) negative regulation of autophagosome assembly(GO:1902902)
0.4 3.9 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.4 6.1 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.4 2.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.4 1.4 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.3 3.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 5.3 GO:0070972 protein localization to endoplasmic reticulum(GO:0070972)
0.3 2.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.3 8.9 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.3 1.4 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.3 0.8 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 5.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.3 10.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.3 5.5 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.2 0.7 GO:1901994 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.2 0.5 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.2 6.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 2.2 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.2 0.8 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 0.9 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.2 1.4 GO:0090594 inflammatory response to wounding(GO:0090594)
0.2 2.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 3.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 2.2 GO:0061055 myotome development(GO:0061055)
0.1 13.4 GO:0006956 complement activation(GO:0006956)
0.1 2.6 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 5.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 3.5 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1 14.5 GO:0006457 protein folding(GO:0006457)
0.1 3.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 4.7 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 5.5 GO:0051057 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.1 8.1 GO:0007030 Golgi organization(GO:0007030)
0.1 2.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 5.3 GO:0036269 swimming behavior(GO:0036269)
0.1 0.4 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.1 5.8 GO:0006414 translational elongation(GO:0006414)
0.1 2.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 7.0 GO:0051607 defense response to virus(GO:0051607)
0.1 1.9 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 4.3 GO:0050727 regulation of inflammatory response(GO:0050727)
0.1 2.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 2.1 GO:0030168 platelet activation(GO:0030168)
0.1 3.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.3 GO:0001757 somite specification(GO:0001757)
0.1 5.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 0.7 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 7.8 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 1.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 1.1 GO:0050994 regulation of lipid catabolic process(GO:0050994)
0.1 6.3 GO:0031047 gene silencing by RNA(GO:0031047)
0.1 0.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 3.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 1.7 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 2.6 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 2.1 GO:0006986 response to unfolded protein(GO:0006986)
0.1 6.8 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 0.7 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 0.4 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.1 2.5 GO:0060840 artery development(GO:0060840)
0.0 2.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.9 GO:0030282 bone mineralization(GO:0030282)
0.0 1.1 GO:0060872 semicircular canal development(GO:0060872)
0.0 1.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 7.3 GO:0006869 lipid transport(GO:0006869)
0.0 2.8 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.9 GO:0043491 protein kinase B signaling(GO:0043491)
0.0 0.8 GO:0051923 sulfation(GO:0051923)
0.0 3.1 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.5 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.4 GO:1903286 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 1.9 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 1.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 1.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 2.5 GO:0051604 protein maturation(GO:0051604)
0.0 1.0 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 2.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.3 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 30.1 GO:0005784 Sec61 translocon complex(GO:0005784)
4.2 41.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
1.8 26.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
1.0 26.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.8 3.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.8 6.3 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.8 2.3 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.7 35.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.6 4.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.6 6.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.5 2.6 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.5 3.5 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.5 4.3 GO:0071797 LUBAC complex(GO:0071797)
0.5 1.8 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.4 1.8 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.4 3.7 GO:0031526 brush border membrane(GO:0031526)
0.4 3.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 3.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.4 2.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.4 2.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.3 5.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 1.6 GO:0070390 transcription export complex 2(GO:0070390)
0.3 1.9 GO:0070876 SOSS complex(GO:0070876)
0.3 5.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 9.0 GO:0035861 site of double-strand break(GO:0035861)
0.3 5.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 5.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 14.6 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2 4.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.5 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.2 113.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 5.7 GO:0032040 small-subunit processome(GO:0032040)
0.1 14.2 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.6 GO:0015030 Cajal body(GO:0015030)
0.1 2.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.7 GO:0032039 integrator complex(GO:0032039)
0.1 33.6 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 2.8 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 5.3 GO:0030141 secretory granule(GO:0030141)
0.1 1.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 11.0 GO:0005730 nucleolus(GO:0005730)
0.0 12.9 GO:0030425 dendrite(GO:0030425)
0.0 0.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 4.1 GO:0005840 ribosome(GO:0005840)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 3.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 2.2 GO:0005925 focal adhesion(GO:0005925)
0.0 1.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.8 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0046923 ER retention sequence binding(GO:0046923)
4.8 14.5 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
3.7 18.7 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
2.8 11.2 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
2.4 30.8 GO:0005537 mannose binding(GO:0005537)
2.2 8.6 GO:0008905 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
2.0 6.1 GO:0071568 UFM1 transferase activity(GO:0071568)
1.6 4.9 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
1.5 8.9 GO:0051185 coenzyme transporter activity(GO:0051185)
1.5 10.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.4 6.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
1.3 5.3 GO:0033149 FFAT motif binding(GO:0033149)
1.3 3.9 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.1 8.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.9 14.1 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.9 4.6 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.9 9.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.9 2.7 GO:0016748 succinyltransferase activity(GO:0016748)
0.9 4.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.7 10.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.7 7.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.6 3.2 GO:0008430 selenium binding(GO:0008430)
0.6 1.8 GO:0046403 polynucleotide 3'-phosphatase activity(GO:0046403)
0.5 2.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.5 1.9 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.4 6.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 2.4 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.4 6.1 GO:0051117 ATPase binding(GO:0051117)
0.4 5.5 GO:2001069 glycogen binding(GO:2001069)
0.4 6.1 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.4 3.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 2.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 8.1 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.3 1.5 GO:0030620 U2 snRNA binding(GO:0030620)
0.3 5.8 GO:0048038 quinone binding(GO:0048038)
0.2 6.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.2 1.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 5.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 9.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 3.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.2 2.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2 4.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 1.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 2.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 6.3 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 2.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 5.1 GO:0048029 monosaccharide binding(GO:0048029)
0.1 6.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 49.3 GO:0008047 enzyme activator activity(GO:0008047)
0.1 2.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 10.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 1.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 8.9 GO:0000149 SNARE binding(GO:0000149)
0.1 4.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 13.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0019809 spermidine binding(GO:0019809)
0.1 0.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 3.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 2.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 3.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0004067 asparaginase activity(GO:0004067)
0.0 0.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.0 13.3 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 7.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.8 GO:0060090 binding, bridging(GO:0060090)
0.0 0.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 3.0 GO:0015293 symporter activity(GO:0015293)
0.0 2.5 GO:0008083 growth factor activity(GO:0008083)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.4 GO:0019904 protein domain specific binding(GO:0019904)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 37.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.4 8.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.3 3.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 1.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3 10.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 2.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 3.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 3.0 PID ARF 3PATHWAY Arf1 pathway
0.2 2.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 2.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.1 PID CMYB PATHWAY C-MYB transcription factor network
0.1 1.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 7.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 2.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.1 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 41.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.8 39.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.8 17.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.8 7.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.6 83.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 5.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.4 4.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 6.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.4 22.3 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.3 5.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 8.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 2.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 5.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 3.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 3.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3 2.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 7.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 2.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 2.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 6.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 18.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 5.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 6.1 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.1 1.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 2.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides