ISMARA results: zbtb14

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zbtb14

Z-value: 3.24

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Transcription factors associated with zbtb14

Gene Symbol	Gene ID	Gene Info
zbtb14 NCBI UniProt	ENSDARG00000098273	zinc finger and BTB domain containing 14

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
zbtb14	dr11_v1_chr24_+_41989108_41989108	0.43	1.4e-05	Click!

Activity profile of zbtb14 motif

Sorted Z-values of zbtb14 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_25649626 Show fit	83.69	ENSDART00000146947	tac1 NCBI UniProt Show fit	tachykinin 1
chr16_-_43026273 Show fit	55.56	ENSDART00000156820 ENSDART00000189080	si:dkey-7j14.5 NCBI UniProt Show fit	si:dkey-7j14.5
chr23_+_44732863 Show fit	51.37	ENSDART00000160044 ENSDART00000172268	atp1b2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr16_-_43025885 Show fit	45.98	ENSDART00000193146 ENSDART00000157302	si:dkey-7j14.5 NCBI UniProt Show fit	si:dkey-7j14.5
chr1_-_56223913 Show fit	44.95	ENSDART00000019573	zgc:65894 NCBI UniProt Show fit	zgc:65894
chr21_+_11468934 Show fit	43.39	ENSDART00000126045 ENSDART00000129744 ENSDART00000102368	grin1a NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr4_+_5741733 Show fit	42.50	ENSDART00000110243	pou3f2a NCBI UniProt Show fit	POU class 3 homeobox 2a
chr3_-_21280373 Show fit	42.00	ENSDART00000003939	syngr1a NCBI UniProt Show fit	synaptogyrin 1a
chr22_-_21150845 Show fit	41.08	ENSDART00000027345	tmem59l NCBI UniProt Show fit	transmembrane protein 59-like
chr25_+_21324588 Show fit	40.65	ENSDART00000151842	lrrn3a NCBI UniProt Show fit	leucine rich repeat neuronal 3a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	98.8	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
2.3	93.8	GO:0046847	filopodium assembly(GO:0046847)
1.9	92.9	GO:0036269	swimming behavior(GO:0036269)
16.7	83.7	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
4.1	73.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3	51.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.7	51.4	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
3.2	50.6	GO:0008053	mitochondrial fusion(GO:0008053)
0.3	49.3	GO:0048675	axon extension(GO:0048675)
0.6	45.7	GO:0046839	phospholipid dephosphorylation(GO:0046839)

Showing 1 to 10 of 165 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	146.9	GO:0016020	membrane(GO:0016020)
0.1	81.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.4	78.4	GO:0034703	cation channel complex(GO:0034703)
0.2	70.3	GO:0000139	Golgi membrane(GO:0000139)
1.6	69.7	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
1.4	64.9	GO:0042734	presynaptic membrane(GO:0042734)
2.6	64.1	GO:0031594	neuromuscular junction(GO:0031594)
4.1	61.8	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.5	61.4	GO:0099572	postsynaptic specialization(GO:0099572)
2.4	58.9	GO:0043195	terminal bouton(GO:0043195)

Showing 1 to 10 of 74 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
27.9	83.7	GO:0031835	neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.2	81.8	GO:0005096	GTPase activator activity(GO:0005096)
4.6	69.7	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
3.1	61.8	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.1	61.1	GO:0005509	calcium ion binding(GO:0005509)
0.0	60.2	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.4	54.7	GO:0015279	store-operated calcium channel activity(GO:0015279)
2.6	51.4	GO:0001671	ATPase activator activity(GO:0001671)
0.4	50.5	GO:0005516	calmodulin binding(GO:0005516)
0.1	50.5	GO:0003924	GTPase activity(GO:0003924)

Showing 1 to 10 of 126 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	63.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.0	36.6	PID AURORA B PATHWAY	Aurora B signaling
0.7	30.6	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.6	23.2	PID ILK PATHWAY	Integrin-linked kinase signaling
1.1	15.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	15.0	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.3	15.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.8	13.7	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	9.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.3	8.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	101.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
2.3	39.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
4.1	36.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.6	30.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.3	25.2	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
1.3	19.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	18.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	13.8	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
1.5	13.7	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.9	11.7	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors

Showing 1 to 10 of 29 entries

Results for zbtb14

Z-value: 3.24

Motif logo

Transcription factors associated with zbtb14

Activity-expression correlation:

Activity profile of zbtb14 motif

Sorted Z-values of zbtb14 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: