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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for zbtb18+zbtb42
Z-value: 1.20
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Transcription factors associated with zbtb18+zbtb42
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb18 | dr11_v1_chr13_+_11436130_11436130 | 0.15 | 1.4e-01 | Click! |
| zbtb42 | dr11_v1_chr17_-_1407593_1407725 | 0.01 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_27857051 Show fit | 11.58 |
ENSDART00000043462
ENSDART00000137861 |
activin A receptor like type 1 |
|
| chr15_-_33834577 Show fit | 10.54 |
ENSDART00000163354
|
matrix metallopeptidase 13b |
|
| chr15_-_34567370 Show fit | 10.19 |
ENSDART00000099793
|
sclerostin domain containing 1a |
|
| chr10_-_15128771 Show fit | 9.98 |
ENSDART00000101261
|
secreted phosphoprotein 1 |
|
| chr17_+_42274825 Show fit | 9.91 |
ENSDART00000020156
|
paired box 1a |
|
| chr18_-_6982499 Show fit | 9.54 |
ENSDART00000101525
|
si:dkey-266m15.6 |
|
| chr1_+_40724140 Show fit | 9.44 |
ENSDART00000074839
|
|
|
| chr25_+_35502552 Show fit | 8.68 |
ENSDART00000189612
ENSDART00000058443 |
fin bud initiation factor a |
|
| chr17_+_42274240 Show fit | 8.58 |
ENSDART00000134377
|
paired box 1a |
|
| chr10_+_8968203 Show fit | 7.75 |
ENSDART00000110443
ENSDART00000080772 |
follistatin b |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb18+zbtb42
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.1 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 2.9 | 11.6 | GO:0034405 | response to fluid shear stress(GO:0034405) |
| 0.3 | 10.5 | GO:0044243 | collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243) |
| 0.2 | 10.2 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.1 | 10.0 | GO:0060348 | bone development(GO:0060348) |
| 0.0 | 8.2 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.7 | 7.8 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 6.6 | GO:0070507 | regulation of microtubule cytoskeleton organization(GO:0070507) |
| 0.9 | 6.3 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.8 | 5.6 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 65.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 25.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 2.3 | 11.6 | GO:0070724 | BMP receptor complex(GO:0070724) |
| 0.3 | 6.8 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 6.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.3 | 6.3 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.1 | 6.1 | GO:0048475 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
| 0.3 | 4.4 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.0 | 4.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 4.2 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 11.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 11.8 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.0 | 11.6 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 1.3 | 10.2 | GO:0036122 | BMP binding(GO:0036122) |
| 0.4 | 7.8 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 7.5 | GO:0008201 | heparin binding(GO:0008201) |
| 0.3 | 6.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.8 | 5.6 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.7 | 5.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 11.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.6 | 10.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 7.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.5 | 5.2 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 4.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.4 | 3.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 3.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 2.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 2.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 7.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.6 | 6.6 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 6.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.6 | 4.5 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.3 | 4.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 4.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 4.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.4 | 3.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 3.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |