ISMARA results: zeb1a+zeb1b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zeb1a+zeb1b

Z-value: 5.13

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Transcription factors associated with zeb1a+zeb1b

Gene Symbol	Gene ID	Gene Info
zeb1b NCBI UniProt	ENSDARG00000013207	zinc finger E-box binding homeobox 1b
zeb1a NCBI UniProt	ENSDARG00000016788	zinc finger E-box binding homeobox 1a
zeb1b NCBI UniProt	ENSDARG00000113922	zinc finger E-box binding homeobox 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
zeb1b	dr11_v1_chr12_-_26851726_26851726	-0.61	6.6e-11	Click!
zeb1a	dr11_v1_chr2_-_43851915_43851915	-0.53	3.7e-08	Click!

Activity profile of zeb1a+zeb1b motif

Sorted Z-values of zeb1a+zeb1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_20239141 Show fit	144.31	ENSDART00000101152 ENSDART00000152473	spint2 NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type, 2
chr19_-_48312109 Show fit	89.61	ENSDART00000161103	si:ch73-359m17.9 NCBI UniProt Show fit	si:ch73-359m17.9
chr10_-_2942900 Show fit	79.51	ENSDART00000002622	oclna NCBI UniProt Show fit	occludin a
chr22_+_661711 Show fit	79.39	ENSDART00000113795	elf3 NCBI UniProt Show fit	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr21_-_25741411 Show fit	77.48	ENSDART00000101211	cldnh NCBI UniProt Show fit	claudin h
chr21_-_38153824 Show fit	72.18	ENSDART00000151226	klf5l NCBI UniProt Show fit	Kruppel-like factor 5 like
chr19_-_30404096 Show fit	71.92	ENSDART00000103475	agr2 NCBI UniProt Show fit	anterior gradient 2
chr2_+_68789 Show fit	70.21	ENSDART00000058569	cldn1 NCBI UniProt Show fit	claudin 1
chr1_-_50247 Show fit	69.89	ENSDART00000168428	ildr1a NCBI UniProt Show fit	immunoglobulin-like domain containing receptor 1a
chr16_+_17715243 Show fit	68.39	ENSDART00000149437 ENSDART00000149596	si:dkey-87o1.2 NCBI UniProt Show fit	si:dkey-87o1.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of zeb1a+zeb1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	268.0	GO:0006508	proteolysis(GO:0006508)
1.9	220.8	GO:1990266	neutrophil migration(GO:1990266)
4.5	212.2	GO:0043297	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.9	135.3	GO:0006954	inflammatory response(GO:0006954)
0.6	117.7	GO:0045087	innate immune response(GO:0045087)
11.3	113.2	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
1.1	109.9	GO:0009410	response to xenobiotic stimulus(GO:0009410)
0.8	95.9	GO:0010466	negative regulation of peptidase activity(GO:0010466)
0.5	93.0	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
23.2	92.6	GO:0009957	epidermal cell fate specification(GO:0009957)

Showing 1 to 10 of 535 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	796.5	GO:0005615	extracellular space(GO:0005615)
3.3	409.6	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
7.8	148.1	GO:0030057	desmosome(GO:0030057)
1.7	142.0	GO:0005581	collagen trimer(GO:0005581)
2.1	131.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
1.0	128.7	GO:0016459	myosin complex(GO:0016459)
0.6	118.3	GO:0009897	external side of plasma membrane(GO:0009897)
1.1	103.8	GO:0005795	Golgi stack(GO:0005795)
1.0	93.9	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.8	93.7	GO:0016324	apical plasma membrane(GO:0016324)

Showing 1 to 10 of 182 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	389.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	334.6	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.7	314.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.3	280.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.8	153.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.4	112.6	GO:0051015	actin filament binding(GO:0051015)
0.9	99.6	GO:0004896	cytokine receptor activity(GO:0004896)
0.1	97.0	GO:0043565	sequence-specific DNA binding(GO:0043565)
0.5	92.0	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.7	91.8	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)

Showing 1 to 10 of 398 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	147.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
5.4	139.9	PID NECTIN PATHWAY	Nectin adhesion pathway
1.1	67.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
2.2	58.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
1.7	57.7	PID CERAMIDE PATHWAY	Ceramide signaling pathway
1.3	53.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.2	46.6	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	42.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	40.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.9	37.2	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 83 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	188.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
2.9	142.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.9	100.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
7.7	68.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
20.1	60.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
2.9	54.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
1.8	52.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
1.1	45.2	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.6	43.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.5	43.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Showing 1 to 10 of 124 entries

Results for zeb1a+zeb1b

Z-value: 5.13

Motif logo

Transcription factors associated with zeb1a+zeb1b

Activity-expression correlation:

Activity profile of zeb1a+zeb1b motif

Sorted Z-values of zeb1a+zeb1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of zeb1a+zeb1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: