ISMARA results: zfhx3+zfhx3a+zfhx4

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zfhx3+zfhx3a+zfhx4

Z-value: 1.29

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Transcription factors associated with zfhx3+zfhx3a+zfhx4

Gene Symbol	Gene ID	Gene Info
zfhx3a NCBI UniProt	ENSDARG00000073944	si_ch73-386h18.1
zfhx4 NCBI UniProt	ENSDARG00000075542	zinc finger homeobox 4
zfhx3 NCBI UniProt	ENSDARG00000103057	zinc finger homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
zfhx3	dr11_v1_chr7_-_68373495_68373495	-0.34	7.4e-04	Click!
zfhx4	dr11_v1_chr24_-_23323526_23323526	-0.11	3.1e-01	Click!
si:ch73-386h18.1	dr11_v1_chr18_+_6054816_6054816	-0.06	6.0e-01	Click!

Activity profile of zfhx3+zfhx3a+zfhx4 motif

Sorted Z-values of zfhx3+zfhx3a+zfhx4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_32345187 Show fit	37.87	ENSDART00000147132	c9 NCBI UniProt Show fit	complement component 9
chr5_+_28830643 Show fit	30.10	ENSDART00000051448	serpina7 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_28830388 Show fit	29.34	ENSDART00000149150	serpina7 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr20_-_40754794 Show fit	28.14	ENSDART00000187251	cx32.3 NCBI UniProt Show fit	connexin 32.3
chr5_+_28848870 Show fit	27.23	ENSDART00000149563	zgc:174259 NCBI UniProt Show fit	zgc:174259
chr5_+_28797771 Show fit	26.75	ENSDART00000188845 ENSDART00000149066	si:ch211-186e20.7 NCBI UniProt Show fit	si:ch211-186e20.7
chr5_+_28849155 Show fit	26.39	ENSDART00000079090	zgc:174259 NCBI UniProt Show fit	zgc:174259
chr22_-_24791505 Show fit	25.18	ENSDART00000136837	vtg4 NCBI UniProt Show fit	vitellogenin 4
chr6_-_40058686 Show fit	22.95	ENSDART00000103240	uroc1 NCBI UniProt Show fit	urocanate hydratase 1
chr20_-_40755614 Show fit	22.08	ENSDART00000061247	cx32.3 NCBI UniProt Show fit	connexin 32.3

Showing 1 to 10 of 114 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of zfhx3+zfhx3a+zfhx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	160.5	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
1.1	41.4	GO:0032355	response to estradiol(GO:0032355)
12.6	37.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
7.6	22.9	GO:0043606	formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0	19.9	GO:0006508	proteolysis(GO:0006508)
4.4	17.4	GO:0055091	phospholipid homeostasis(GO:0055091)
2.4	16.6	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.8	13.4	GO:0050728	negative regulation of inflammatory response(GO:0050728)
0.5	10.5	GO:0015701	bicarbonate transport(GO:0015701)
1.1	10.3	GO:0034434	steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)

Showing 1 to 10 of 48 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	200.9	GO:0005615	extracellular space(GO:0005615)
12.6	37.9	GO:0044217	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0	26.8	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	6.7	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	4.8	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	4.6	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
1.1	4.3	GO:0070195	growth hormone receptor complex(GO:0070195)
0.2	3.3	GO:0005801	cis-Golgi network(GO:0005801)
0.0	2.7	GO:0016324	apical plasma membrane(GO:0016324)
0.0	2.4	GO:0005905	clathrin-coated pit(GO:0005905)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	160.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
5.9	41.4	GO:0045735	nutrient reservoir activity(GO:0045735)
0.1	29.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	23.2	GO:0016491	oxidoreductase activity(GO:0016491)
0.3	22.9	GO:0016836	hydro-lyase activity(GO:0016836)
2.1	18.9	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
2.2	13.4	GO:0032052	bile acid binding(GO:0032052)
0.6	10.5	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
2.6	10.3	GO:0034736	sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
1.6	9.9	GO:0005412	glucose:sodium symporter activity(GO:0005412)

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	58.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	17.4	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.6	13.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	2.3	PID BMP PATHWAY	BMP receptor signaling
0.0	1.9	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	1.7	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	1.6	PID ARF 3PATHWAY	Arf1 pathway
0.1	1.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	37.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	22.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.5	16.6	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.2	4.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	2.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	2.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.2	2.0	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	1.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	1.8	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	1.5	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination

Showing 1 to 10 of 12 entries

Results for zfhx3+zfhx3a+zfhx4

Z-value: 1.29

Motif logo

Transcription factors associated with zfhx3+zfhx3a+zfhx4

Activity-expression correlation:

Activity profile of zfhx3+zfhx3a+zfhx4 motif

Sorted Z-values of zfhx3+zfhx3a+zfhx4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of zfhx3+zfhx3a+zfhx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: