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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zic4+zic6

Z-value: 0.50

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Transcription factors associated with zic4+zic6

Gene Symbol Gene ID Gene Info
zic4
ENSDARG00000031307 zic family member 4
zic6
ENSDARG00000071496 zic family member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic6dr11_v1_chr14_+_32022272_320222720.666.0e-13Click!
zic4dr11_v1_chr24_+_4978055_49780550.631.0e-11Click!

Activity profile of zic4+zic6 motif

Sorted Z-values of zic4+zic6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_17067364 5.73 ENSDART00000132687
rab3c
RAB3C, member RAS oncogene family
chr8_-_4618653 5.49 ENSDART00000025535
sept5a
septin 5a
chr16_-_37964325 3.92 ENSDART00000148801
mrap2a
melanocortin 2 receptor accessory protein 2a
chr5_-_10768258 3.80 ENSDART00000157043
rtn4r
reticulon 4 receptor
chr19_-_20113696 3.64 ENSDART00000188813
npy
neuropeptide Y
chr3_+_46724528 3.62 ENSDART00000181358
pde4a
phosphodiesterase 4A, cAMP-specific
chr13_+_16521898 3.45 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr5_+_36611128 3.32 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr7_+_30787903 3.12 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr16_-_55028740 3.12 ENSDART00000156368
ENSDART00000161704
zgc:114181
zgc:114181
chr22_+_4707663 3.00 ENSDART00000042194
cers4a
ceramide synthase 4a
chr24_-_21172122 2.90 ENSDART00000154259
atp6v1ab
ATPase H+ transporting V1 subunit Ab
chr8_+_26859639 2.81 ENSDART00000133440
prdm2a
PR domain containing 2, with ZNF domain a
chr23_+_44741500 2.79 ENSDART00000166421
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr12_-_41619257 2.77 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr8_-_33114202 2.67 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr14_-_32503363 2.38 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr21_+_3093419 2.31 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr10_+_21786656 2.28 ENSDART00000185851
ENSDART00000167219
pcdh1g26
protocadherin 1 gamma 26
chr13_+_12739283 2.26 ENSDART00000102279
lingo2b
leucine rich repeat and Ig domain containing 2b
chr3_-_19091024 2.24 ENSDART00000188485
ENSDART00000110554
grin2ca
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr20_-_28768109 2.24 ENSDART00000114611
ENSDART00000182443
sipa1l1
signal-induced proliferation-associated 1 like 1
chr3_-_25814097 2.05 ENSDART00000169706
ntn1b
netrin 1b
chr11_-_21586157 1.98 ENSDART00000190095
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr17_-_4245311 1.75 ENSDART00000055379
gdf3
growth differentiation factor 3
chr5_+_20693724 1.75 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr7_-_67842997 1.65 ENSDART00000169763
pmfbp1
polyamine modulated factor 1 binding protein 1
chr15_-_26844591 1.61 ENSDART00000077582
pitpnm3
PITPNM family member 3
chr13_-_36534380 1.46 ENSDART00000177857
ENSDART00000181046
ENSDART00000187243
srsf5a
serine/arginine-rich splicing factor 5a
chr6_+_10450000 1.42 ENSDART00000151288
ENSDART00000187431
ENSDART00000192474
ENSDART00000188214
ENSDART00000184766
ENSDART00000190082
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr21_-_21465111 1.38 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr25_-_1079417 1.37 ENSDART00000163134
FO907089.1

chr1_-_58601636 1.34 ENSDART00000141143
si:ch73-236c18.8
si:ch73-236c18.8
chr19_-_17996336 1.30 ENSDART00000186143
ENSDART00000080751
ints8
integrator complex subunit 8
chr3_-_19899914 1.30 ENSDART00000134969
rnd2
Rho family GTPase 2
chr5_+_31944270 1.29 ENSDART00000147850
ungb
uracil DNA glycosylase b
chr8_+_40210398 1.26 ENSDART00000167612
rnf34a
ring finger protein 34a
chr21_-_14664445 1.24 ENSDART00000124223
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr15_+_36941490 1.20 ENSDART00000172664
kirrel3l
kirre like nephrin family adhesion molecule 3, like
chr5_+_13521081 1.20 ENSDART00000171975
si:ch211-230g14.6
si:ch211-230g14.6
chr24_-_20599781 1.19 ENSDART00000179664
ENSDART00000141823
zbtb47b
zinc finger and BTB domain containing 47b
chr11_+_21586335 1.17 ENSDART00000091182
FAM72B
zgc:101564
chr17_+_1499238 1.17 ENSDART00000187561
LO018430.1

chr20_-_14781904 1.09 ENSDART00000187200
ENSDART00000179912
ENSDART00000160481
ENSDART00000026969
suco
SUN domain containing ossification factor
chr2_+_25019387 1.07 ENSDART00000142601
stag1a
stromal antigen 1a
chr20_+_40769265 1.06 ENSDART00000061168
tbc1d32
TBC1 domain family, member 32
chr1_-_46401385 1.03 ENSDART00000150029
atp11a
ATPase phospholipid transporting 11A
chr19_-_17996162 1.01 ENSDART00000150928
ENSDART00000104491
ints8
integrator complex subunit 8
chr19_+_40122160 1.01 ENSDART00000143966
si:ch211-173p18.3
si:ch211-173p18.3
chr6_+_103361 0.98 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr21_-_33995213 0.97 ENSDART00000140184
EBF1 (1 of many)
si:ch211-51e8.2
chr15_+_47746176 0.91 ENSDART00000154481
ENSDART00000160914
stard10
StAR-related lipid transfer (START) domain containing 10
chr19_-_82504 0.88 ENSDART00000027864
ENSDART00000160560
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr14_-_21097574 0.88 ENSDART00000186803
rnf20
ring finger protein 20, E3 ubiquitin protein ligase
chr25_-_27729046 0.84 ENSDART00000131437
zgc:153935
zgc:153935
chr11_-_44999858 0.83 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr3_-_19561058 0.83 ENSDART00000079323
zgc:163079
zgc:163079
chr8_+_15269423 0.81 ENSDART00000020386
gclm
glutamate-cysteine ligase, modifier subunit
chr25_-_1124851 0.78 ENSDART00000067558
spg11
spastic paraplegia 11
chr2_-_58919975 0.78 ENSDART00000114286
sugp1
SURP and G patch domain containing 1
chr8_+_39570615 0.72 ENSDART00000142557
lzts1
leucine zipper, putative tumor suppressor 1
chr23_-_18982499 0.71 ENSDART00000012507
bcl2l1
bcl2-like 1
chr23_+_9057999 0.70 ENSDART00000091899
ccm2l
cerebral cavernous malformation 2-like
chr23_+_7471072 0.69 ENSDART00000135551
si:ch211-200e2.1
si:ch211-200e2.1
chr13_-_39947335 0.66 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr14_+_40852497 0.65 ENSDART00000128588
ENSDART00000166065
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr18_+_49225552 0.65 ENSDART00000135026
si:ch211-136a13.1
si:ch211-136a13.1
chr13_+_32740509 0.63 ENSDART00000076423
ENSDART00000160138
sobpa
sine oculis binding protein homolog (Drosophila) a
chr5_+_69697800 0.62 ENSDART00000178736
ENSDART00000162519
znf1005
zinc finger protein 1005
chr24_-_10897511 0.62 ENSDART00000145593
ENSDART00000102484
ENSDART00000066784
fam49bb
family with sequence similarity 49, member Bb
chr17_-_23895026 0.58 ENSDART00000122108
pdzd8
PDZ domain containing 8
chr10_-_4961923 0.57 ENSDART00000050177
ENSDART00000146066
snx30
sorting nexin family member 30
chr5_-_61588998 0.56 ENSDART00000050912
pex12
peroxisomal biogenesis factor 12
chr24_-_13566015 0.54 ENSDART00000123450
KCNB2
si:dkey-192j17.1
chr5_-_68927728 0.52 ENSDART00000132838
ank1a
ankyrin 1, erythrocytic a
chr5_+_31811662 0.51 ENSDART00000023463
uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1, like 1
chr1_+_40613297 0.49 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
naa15b
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr3_-_37588855 0.49 ENSDART00000149258
arf2a
ADP-ribosylation factor 2a
chr7_+_27220655 0.48 ENSDART00000173987
ENSDART00000173583
plekha7b
pleckstrin homology domain containing, family A member 7b
chr8_-_7851590 0.44 ENSDART00000160692
zgc:113363
zgc:113363
chr11_+_34921492 0.43 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr20_-_28642061 0.43 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr4_+_76349919 0.42 ENSDART00000174194
si:ch73-158p21.2
si:ch73-158p21.2
chr13_+_13821054 0.41 ENSDART00000127417
slc4a11
solute carrier family 4, sodium borate transporter, member 11
chr22_-_18116635 0.37 ENSDART00000005724
ncanb
neurocan b
chr8_+_12925385 0.37 ENSDART00000085377
KIF2A
zgc:103670
chr19_-_81851 0.35 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr11_-_22605981 0.27 ENSDART00000186923
myog
myogenin
chr6_-_59942335 0.26 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr24_-_21587335 0.26 ENSDART00000091528
gpr12
G protein-coupled receptor 12
chr5_+_30596822 0.26 ENSDART00000188375
hinfp
histone H4 transcription factor
chr6_-_7438584 0.25 ENSDART00000053776
fkbp11
FK506 binding protein 11
chr10_+_26973063 0.25 ENSDART00000143162
ENSDART00000186210
tm7sf2
transmembrane 7 superfamily member 2
chr19_+_35799384 0.22 ENSDART00000076023
angpt2b
angiopoietin 2b
chr21_-_32289356 0.21 ENSDART00000183050
clk4b
CDC-like kinase 4b
chr10_+_10677697 0.21 ENSDART00000188705
fam163b
family with sequence similarity 163, member B
chr14_+_790166 0.19 ENSDART00000123912
adra2da
adrenergic, alpha-2D-, receptor a
chr5_-_67750907 0.18 ENSDART00000172097
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr6_+_23026714 0.18 ENSDART00000124948
srp68
signal recognition particle 68
chr1_-_17711361 0.16 ENSDART00000078848
ufsp2
ufm1-specific peptidase 2
chr9_-_37748513 0.14 ENSDART00000188967
ENSDART00000187886
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr1_-_17711636 0.14 ENSDART00000148322
ENSDART00000122670
ufsp2
ufm1-specific peptidase 2
chr11_-_6070192 0.12 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr17_-_4245902 0.10 ENSDART00000151851
gdf3
growth differentiation factor 3
chr17_-_14523722 0.10 ENSDART00000024726
daam1a
dishevelled associated activator of morphogenesis 1a
chr21_-_37973819 0.08 ENSDART00000133405
ripply1
ripply transcriptional repressor 1
chr22_-_26558166 0.05 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr8_-_1266181 0.04 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr25_+_2776511 0.03 ENSDART00000115280
neo1b
neogenin 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of zic4+zic6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.7 2.0 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.4 2.0 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.4 1.9 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.4 3.9 GO:0034394 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.3 3.5 GO:0010996 response to auditory stimulus(GO:0010996)
0.3 1.3 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.2 0.7 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.2 0.8 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 3.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 1.3 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 2.8 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.2 1.3 GO:0009146 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.2 3.8 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 2.8 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 5.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.2 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 0.6 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 1.1 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 1.6 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 3.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 0.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 2.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 0.5 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 1.5 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 4.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 3.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.4 GO:0007286 spermatid development(GO:0007286)
0.0 2.9 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 1.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.5 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.4 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 3.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.8 GO:0001966 thigmotaxis(GO:0001966)
0.0 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.6 GO:1903039 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.0 1.1 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.1 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.1 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0 1.2 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.8 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0097224 sperm connecting piece(GO:0097224)
0.3 2.8 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 0.6 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.2 2.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 5.5 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 2.3 GO:0032039 integrator complex(GO:0032039)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 2.0 GO:0044327 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)
0.0 1.1 GO:0008278 cohesin complex(GO:0008278)
0.0 3.8 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 1.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 2.0 GO:0005604 basement membrane(GO:0005604)
0.0 3.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 1.0 GO:0055037 recycling endosome(GO:0055037)
0.0 7.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.7 3.6 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.3 3.1 GO:0016805 dipeptidase activity(GO:0016805)
0.3 2.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 3.8 GO:0048495 Roundabout binding(GO:0048495)
0.2 2.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 1.3 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.2 3.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 3.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 3.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.8 GO:0001671 ATPase activator activity(GO:0001671)
0.1 3.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 2.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 1.3 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 0.5 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 2.0 GO:0031267 small GTPase binding(GO:0031267)
0.1 1.2 GO:0002039 p53 binding(GO:0002039)
0.1 0.7 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 1.6 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.7 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 5.5 GO:0060090 binding, bridging(GO:0060090)
0.0 0.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 6.9 GO:0003924 GTPase activity(GO:0003924)
0.0 6.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 5.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 2.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 0.7 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 3.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis