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PRJEB1986: zebrafish developmental stages transcriptome

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Results for CABZ01087224.1+hlfb

Z-value: 0.65

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Transcription factors associated with CABZ01087224.1+hlfb

Gene Symbol Gene ID Gene Info
ENSDARG00000061011 HLF transcription factor, PAR bZIP family member b
ENSDARG00000111269 ENSDARG00000111269

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CABZ01087224.1dr11_v1_chr3_+_11568523_11568523-0.662.2e-03Click!
hlfbdr11_v1_chr12_+_32159272_32159272-0.606.7e-03Click!

Activity profile of CABZ01087224.1+hlfb motif

Sorted Z-values of CABZ01087224.1+hlfb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_20195350 2.85 ENSDART00000139675
D-amino-acid oxidase, tandem duplicate 1
chr16_-_45910050 2.29 ENSDART00000133213
antifreeze protein type IV
chr18_-_16922905 2.27 ENSDART00000187165
WEE1 G2 checkpoint kinase
chr22_+_10606573 1.99 ENSDART00000192638
RAD54 like 2
chr4_+_5196469 1.91 ENSDART00000067386
RAD51 associated protein 1
chr10_-_20523405 1.62 ENSDART00000114824
DDHD domain containing 2
chr5_+_22974019 1.51 ENSDART00000147157
ENSDART00000020434
bromodomain and WD repeat domain containing 3
chr3_-_40275096 1.48 ENSDART00000141578
serine hydroxymethyltransferase 1 (soluble)
chr9_-_32300783 1.40 ENSDART00000078596
heat shock 60 protein 1
chr14_-_30905288 1.39 ENSDART00000173449
ENSDART00000173451
si:ch211-126c2.4
chr7_+_15736230 1.36 ENSDART00000109942
multiple C2 domains, transmembrane 2b
chr10_+_22771176 1.30 ENSDART00000192046
transmembrane protein 88 a
chr19_+_16016038 1.27 ENSDART00000131319
CTP synthase 1a
chr16_-_45917322 1.24 ENSDART00000060822
antifreeze protein type IV
chr16_-_45917683 1.24 ENSDART00000184289
antifreeze protein type IV
chr20_+_1272526 1.24 ENSDART00000008115
ENSDART00000133825
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr3_-_26184018 1.23 ENSDART00000191604
si:ch211-11k18.4
chr22_+_10606863 1.22 ENSDART00000147975
RAD54 like 2
chr3_-_26183699 1.17 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
chr9_+_32301456 1.16 ENSDART00000078608
ENSDART00000185153
ENSDART00000144947
heat shock 10 protein 1
chr19_+_15441022 1.13 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr12_+_47917971 1.11 ENSDART00000185933
thymus, brain and testes associated
chr10_-_23099809 1.09 ENSDART00000148333
ENSDART00000079703
ENSDART00000162444
notchless homolog 1 (Drosophila)
chr19_-_24757231 1.07 ENSDART00000128177
si:dkey-154b15.1
chr13_-_25196758 1.06 ENSDART00000184722
adenosine kinase a
chr19_+_15440841 1.02 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr17_+_51744450 0.99 ENSDART00000190955
ENSDART00000149807
ornithine decarboxylase 1
chr6_+_16468776 0.96 ENSDART00000109151
ENSDART00000114667
zgc:161969
chr17_+_25833947 0.94 ENSDART00000044328
ENSDART00000154604
acyl-CoA synthetase short chain family member 1
chr2_+_35595454 0.89 ENSDART00000098734
calcyclin binding protein
chr4_+_17353714 0.89 ENSDART00000136299
nucleoporin 37
chr17_-_43031763 0.87 ENSDART00000132754
ENSDART00000050399
Niemann-Pick disease, type C2
chr9_+_32301017 0.87 ENSDART00000127916
ENSDART00000183298
ENSDART00000143103
heat shock 10 protein 1
chr22_+_786556 0.87 ENSDART00000125347
cryptochrome circadian clock 1bb
chr9_-_32300611 0.86 ENSDART00000127938
heat shock 60 protein 1
chr15_+_19838458 0.85 ENSDART00000101204
activated leukocyte cell adhesion molecule b
chr3_+_30921246 0.84 ENSDART00000076850
claudin i
chr19_-_17210760 0.84 ENSDART00000007906
stathmin 1a
chr3_-_50066499 0.83 ENSDART00000056618
ENSDART00000154561
mitochondrial ribosomal protein L12
chr16_-_29387215 0.81 ENSDART00000148787
S100 calcium binding protein A1
chr8_-_11229523 0.80 ENSDART00000002164
unc-45 myosin chaperone B
chr17_+_17764979 0.80 ENSDART00000105013
alkB homolog 1, histone H2A dioxygenase
chr21_+_38855551 0.80 ENSDART00000171977
DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
chr10_+_18877362 0.79 ENSDART00000138334
protein phosphatase 2, regulatory subunit B, alpha b
chr19_+_12649691 0.79 ENSDART00000192956
ENSDART00000088917
RNA (guanine-7-) methyltransferase
chr1_-_35929143 0.78 ENSDART00000185002
SMAD family member 1
chr13_+_26703922 0.78 ENSDART00000020946
Fanconi anemia, complementation group L
chr7_+_22792895 0.77 ENSDART00000184407
RNA binding motif protein 4.3
chr2_-_37837472 0.77 ENSDART00000165347
methyltransferase like 17
chr4_-_12914163 0.77 ENSDART00000140002
ENSDART00000145917
ENSDART00000141355
ENSDART00000067135
methionine sulfoxide reductase B3
chr20_-_35246150 0.76 ENSDART00000090549
frizzled class receptor 3a
chr6_+_23810529 0.75 ENSDART00000166921
glutamate-ammonia ligase (glutamine synthase) b
chr16_-_21785261 0.75 ENSDART00000078858
si:ch73-86n18.1
chr10_-_2875735 0.74 ENSDART00000034555
DEAD (Asp-Glu-Ala-Asp) box helicase 56
chr12_-_13205572 0.74 ENSDART00000152670
pelota mRNA surveillance and ribosome rescue factor
chr5_+_26121393 0.74 ENSDART00000002221
beta-carotene 15, 15-dioxygenase 2, like
chr1_-_35928942 0.73 ENSDART00000033566
SMAD family member 1
chr13_+_35637875 0.73 ENSDART00000180657
thrombospondin 2a
chr20_-_9760424 0.72 ENSDART00000104936
si:dkey-63j12.4
chr19_+_16015881 0.72 ENSDART00000187135
CTP synthase 1a
chr19_-_17210928 0.72 ENSDART00000164683
stathmin 1a
chr2_-_19234329 0.71 ENSDART00000161106
ENSDART00000160060
ENSDART00000174552
cell division cycle 20 homolog
chr25_+_36292465 0.71 ENSDART00000152649
brambleberry
chr24_+_11908480 0.71 ENSDART00000024224
flap structure-specific endonuclease 1
chr12_+_19199735 0.71 ENSDART00000066393
pdgfa associated protein 1a
chr4_-_25796848 0.69 ENSDART00000122881
transmembrane and coiled-coil domain family 3
chr20_-_36617313 0.69 ENSDART00000172395
ENSDART00000152856
enabled homolog (Drosophila)
chr9_-_9225980 0.69 ENSDART00000180301
cystathionine-beta-synthase b
chr6_-_10752937 0.69 ENSDART00000135093
Obg-like ATPase 1
chr21_+_25625026 0.68 ENSDART00000134678
ovo-like zinc finger 1b
chr4_+_77973876 0.68 ENSDART00000057423
telomeric repeat binding factor a
chr16_+_16529748 0.68 ENSDART00000029579
coiled-coil domain containing 12
chr12_-_13205854 0.67 ENSDART00000077829
pelota mRNA surveillance and ribosome rescue factor
chr5_-_51998708 0.67 ENSDART00000097194
serine incorporator 5
chr19_+_7549854 0.67 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr25_-_26833100 0.65 ENSDART00000014052
nei-like DNA glycosylase 1
chr8_-_21110233 0.65 ENSDART00000127371
ENSDART00000100276
transmembrane and coiled-coil domains 1
chr5_-_36948586 0.65 ENSDART00000193606
H3 histone, family 3C
chr24_+_11908833 0.64 ENSDART00000178622
flap structure-specific endonuclease 1
chr3_-_45281350 0.64 ENSDART00000020168
potassium channel tetramerization domain containing 5a
chr8_+_247163 0.64 ENSDART00000122378
centrosomal protein 120
chr13_-_25774183 0.63 ENSDART00000046981
PDZ and LIM domain 1 (elfin)
chr11_-_22372072 0.63 ENSDART00000065996
transmembrane protein 183A
chr14_-_30901602 0.63 ENSDART00000172925
si:ch211-126c2.4
chr2_+_3044992 0.63 ENSDART00000020463
zgc:63882
chr6_-_48347724 0.62 ENSDART00000046973
capping protein (actin filament) muscle Z-line, alpha 1a
chr21_+_17051478 0.62 ENSDART00000047201
ENSDART00000161650
ENSDART00000167298
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
chr25_+_34845115 0.62 ENSDART00000061996
transmembrane protein 231
chr11_+_39107131 0.61 ENSDART00000105140
zgc:112255
chr3_-_21348478 0.61 ENSDART00000114906
family with sequence similarity 171, member A2a
chr24_+_37799818 0.60 ENSDART00000131975
TEL2, telomere maintenance 2, homolog (S. cerevisiae)
chr15_+_31327455 0.60 ENSDART00000060127
zgc:152857
chr14_-_30905963 0.60 ENSDART00000183543
ENSDART00000186441
si:ch211-126c2.4
chr4_-_27099224 0.59 ENSDART00000048383
cysteine-rich with EGF-like domains 2
chr2_+_37837249 0.59 ENSDART00000113337
poly (ADP-ribose) polymerase 2
chr12_-_20584413 0.59 ENSDART00000170923

chr7_-_21887104 0.59 ENSDART00000019699
methyltransferase like 3
chr13_+_18533005 0.58 ENSDART00000136024
finTRIM family, member 14-like
chr2_-_37277626 0.58 ENSDART00000135340
NAD kinase b
chr25_-_18330503 0.58 ENSDART00000104496
dual specificity phosphatase 6
chr23_-_36441693 0.58 ENSDART00000024354
cysteine sulfinic acid decarboxylase
chr19_-_30811161 0.58 ENSDART00000103524
MYCL proto-oncogene, bHLH transcription factor b
chr4_+_9177997 0.58 ENSDART00000057254
ENSDART00000154614
nuclear transcription factor Y, beta a
chr18_-_15551360 0.57 ENSDART00000159915
ENSDART00000172690
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr3_-_15144067 0.56 ENSDART00000127738
ENSDART00000060426
ENSDART00000180799
family with sequence similarity 173, member A
chr6_+_3716666 0.56 ENSDART00000041627
Sjogren syndrome antigen B (autoantigen La)
chr19_-_3056235 0.56 ENSDART00000137020
block of proliferation 1
chr9_+_21306902 0.56 ENSDART00000138554
ENSDART00000004108
exportin 4
chr22_-_10641873 0.55 ENSDART00000064772
cytochrome b561 family, member D2
chr7_+_46020508 0.55 ENSDART00000170294
cyclin E1
chr25_-_19585010 0.55 ENSDART00000021340
synaptonemal complex protein 3
chr20_-_39391833 0.55 ENSDART00000135149
si:dkey-217m5.8
chr5_-_36949476 0.54 ENSDART00000047269
H3 histone, family 3C
chr15_-_17960228 0.54 ENSDART00000155898
pleckstrin homology-like domain, family B, member 1b
chr15_+_31332552 0.54 ENSDART00000134933
ENSDART00000173915
odorant receptor, family F, subfamily 119, member 2
chr24_+_28561038 0.54 ENSDART00000147063
ATP-binding cassette, sub-family A (ABC1), member 4a
chr18_+_24562188 0.54 ENSDART00000099463
LysM, putative peptidoglycan-binding, domain containing 4
chr5_-_11809404 0.54 ENSDART00000132564
neurofibromin 2a (merlin)
chr9_-_21268576 0.53 ENSDART00000080604
Sin3A-associated protein
chr9_+_30478768 0.52 ENSDART00000101097
acid phosphatase 6, lysophosphatidic
chr13_-_44836727 0.52 ENSDART00000144385
si:dkeyp-2e4.3
chr22_-_10605045 0.52 ENSDART00000184812
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr13_-_25408387 0.52 ENSDART00000002741
inositol 1,4,5-trisphosphate receptor interacting protein
chr2_+_30182431 0.52 ENSDART00000004903
retinol dehydrogenase 10b
chr4_-_17353972 0.51 ENSDART00000041529
PARP1 binding protein
chr7_+_56577522 0.51 ENSDART00000149130
ENSDART00000149624
haptoglobin
chr3_+_40284598 0.51 ENSDART00000009411
BUD31 homolog (S. cerevisiae)
chr16_+_35728992 0.51 ENSDART00000158442
MAP7 domain containing 1a
chr1_-_11104805 0.51 ENSDART00000147648
kinetochore scaffold 1
chr21_-_32467799 0.51 ENSDART00000007675
ENSDART00000133099
zgc:123105
chr5_-_14521500 0.49 ENSDART00000176565
si:ch211-244o22.2
chr13_+_30035253 0.49 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr9_+_27720428 0.49 ENSDART00000112415
leucine carboxyl methyltransferase 2
chr8_-_37249813 0.49 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
RNA binding motif protein 39b
chr12_-_24928497 0.49 ENSDART00000002465
mutS homolog 2 (E. coli)
chr8_-_11324143 0.48 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr14_-_38929885 0.48 ENSDART00000148737
Bruton agammaglobulinemia tyrosine kinase
chr24_-_37338739 0.48 ENSDART00000146844
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
chr1_+_33697170 0.48 ENSDART00000131664
NOP2/Sun RNA methyltransferase family member 3
chr7_+_46019780 0.48 ENSDART00000163991
cyclin E1
chr14_-_38828057 0.48 ENSDART00000186088
spindle apparatus coiled-coil protein 1
chr4_+_9478500 0.48 ENSDART00000030738
lipase maturation factor 2b
chr23_+_11285662 0.48 ENSDART00000111028
cell adhesion molecule L1-like a
chr21_+_18907102 0.47 ENSDART00000160185
ENSDART00000190175
ENSDART00000017937
ENSDART00000191546
ENSDART00000130519
ENSDART00000137143
sphingomyelin phosphodiesterase 4
chr17_-_20236228 0.47 ENSDART00000136490
ENSDART00000029380
BCL2 interacting protein 4
chr24_+_38671054 0.47 ENSDART00000154214
si:ch73-70c5.1
chr10_+_39283985 0.47 ENSDART00000016464
decapping enzyme, scavenger
chr5_+_13870340 0.47 ENSDART00000160690
hexokinase 2
chr7_-_59564011 0.47 ENSDART00000186053
zgc:112271
chr20_-_30900947 0.47 ENSDART00000153419
ENSDART00000062536
heme binding protein 2
chr5_-_69716501 0.46 ENSDART00000158956
MOB kinase activator 1A
chr17_+_35243753 0.46 ENSDART00000016702
isoamyl acetate hydrolyzing esterase 1 (putative)
chr22_+_15973122 0.46 ENSDART00000144545
ring finger and CCCH-type domains 1a
chr25_-_29415369 0.46 ENSDART00000110774
ENSDART00000019183
UDP glucuronosyltransferase 5 family, polypeptide A2
UDP glucuronosyltransferase 5 family, polypeptide A1
chr16_+_40954481 0.46 ENSDART00000058587
glycogen synthase kinase binding protein
chr5_+_6955900 0.46 ENSDART00000099417

chr15_-_47865063 0.46 ENSDART00000151600
H3 histone, family 3B.1
chr5_-_69437422 0.46 ENSDART00000073676
iron-sulfur cluster assembly 1
chr1_-_12394048 0.46 ENSDART00000146067
ENSDART00000134708
sodium channel and clathrin linker 1
chr25_+_34845469 0.46 ENSDART00000145416
transmembrane protein 231
chr17_-_22573311 0.46 ENSDART00000141523
ENSDART00000140022
ENSDART00000079390
ENSDART00000188644
exonuclease 1
chr24_+_11083146 0.46 ENSDART00000009473
zinc finger, AN1-type domain 1
chr21_+_42930558 0.46 ENSDART00000135234
serine/threonine kinase 32A
chr5_-_20185665 0.46 ENSDART00000051612
D-amino-acid oxidase, tandem duplicate 2
chr14_+_6962271 0.46 ENSDART00000148447
ENSDART00000149114
ENSDART00000149492
ENSDART00000148394
heterogeneous nuclear ribonucleoprotein A/Ba
chr15_+_24676905 0.46 ENSDART00000078014
ENSDART00000143137
polymerase (DNA-directed), delta interacting protein 2
chr25_-_19584735 0.46 ENSDART00000137930
synaptonemal complex protein 3
chr19_-_15281996 0.45 ENSDART00000103784
endothelin 2
chr5_+_25585869 0.45 ENSDART00000138060
si:dkey-229d2.7
chr13_+_23157053 0.45 ENSDART00000162359
sorbin and SH3 domain containing 1
chr4_+_26036682 0.45 ENSDART00000126474
si:ch211-265o23.1
chr1_-_45616242 0.45 ENSDART00000150066
activating transcription factor 7 interacting protein
chr6_+_9130989 0.45 ENSDART00000162588
regucalcin
chr13_-_18195942 0.44 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr5_+_26138313 0.43 ENSDART00000010041
dihydrofolate reductase
chr5_-_63509581 0.43 ENSDART00000097325
complement component 5
chr7_+_26058772 0.43 ENSDART00000101123
ENSDART00000173893
si:dkey-6n21.13
chr5_-_26199505 0.43 ENSDART00000132950
RAD17 checkpoint clamp loader component
chr20_-_39391492 0.43 ENSDART00000184886
si:dkey-217m5.8
chr7_+_38380135 0.43 ENSDART00000174005
rhophilin, Rho GTPase binding protein 2
chr16_+_23397785 0.43 ENSDART00000148961
S100 calcium binding protein A10b
chr14_+_1170968 0.43 ENSDART00000125203
ENSDART00000193575
HOP homeobox
chr6_+_18423402 0.42 ENSDART00000159747
RAB11 family interacting protein 4 (class II) b
chr22_-_10570749 0.42 ENSDART00000140736
si:dkey-42i9.6
chr17_+_26965351 0.42 ENSDART00000114215
ENSDART00000147192
grainyhead-like transcription factor 3
chr18_-_14879135 0.42 ENSDART00000099701
selenoprotein O1
chr21_-_13668358 0.42 ENSDART00000180323
patatin-like phospholipase domain containing 7a
chr12_-_23128746 0.42 ENSDART00000170018
armadillo repeat containing 4
chr24_+_37800102 0.42 ENSDART00000187591
TEL2, telomere maintenance 2, homolog (S. cerevisiae)
chr13_+_35472803 0.41 ENSDART00000011583
McKusick-Kaufman syndrome
chr2_+_49860722 0.41 ENSDART00000144060
ribosomal protein L37
chr20_-_48877458 0.41 ENSDART00000163271
5'-3' exoribonuclease 2
chr2_-_49860723 0.41 ENSDART00000083690
biliverdin reductase A
chr5_+_29831235 0.41 ENSDART00000109660
F11 receptor, tandem duplicate 1
chr11_+_12744575 0.41 ENSDART00000131059
ENSDART00000081335
ENSDART00000142481
retinoblastoma binding protein 4, like
chr20_-_30035326 0.40 ENSDART00000141068
SRY (sex determining region Y)-box 11b
chr12_+_37401331 0.40 ENSDART00000125040
si:ch211-152f22.4
chr20_-_23876291 0.40 ENSDART00000043316
katanin p60 (ATPase containing) subunit A 1
chr16_-_6849754 0.40 ENSDART00000149206
ENSDART00000149778
myelin basic protein b
chr5_+_64856666 0.40 ENSDART00000050863
zgc:101858

Network of associatons between targets according to the STRING database.

First level regulatory network of CABZ01087224.1+hlfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.6 2.3 GO:0032755 positive regulation of interleukin-6 production(GO:0032755) protein import into mitochondrial intermembrane space(GO:0045041)
0.5 1.5 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.5 1.8 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.4 1.3 GO:1901295 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.4 1.4 GO:0032790 ribosome disassembly(GO:0032790)
0.2 0.7 GO:1902176 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.2 0.7 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 0.7 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.2 1.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 0.4 GO:0046655 folic acid metabolic process(GO:0046655)
0.2 0.6 GO:0060844 arterial endothelial cell fate commitment(GO:0060844)
0.2 0.9 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.2 1.1 GO:0044209 AMP salvage(GO:0044209)
0.2 0.7 GO:0032208 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.2 0.5 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 0.8 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.2 0.6 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.2 0.9 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 0.4 GO:0042364 L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364)
0.1 4.8 GO:0060030 dorsal convergence(GO:0060030)
0.1 0.9 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.1 0.7 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.1 0.5 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.6 GO:2000301 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.4 GO:0001120 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.1 0.8 GO:0021885 forebrain cell migration(GO:0021885)
0.1 0.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.4 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.1 0.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.2 GO:1904869 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1 0.7 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 1.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.7 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.2 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.8 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.0 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.1 0.5 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.1 2.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.7 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.6 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 0.3 GO:0010893 positive regulation of steroid biosynthetic process(GO:0010893)
0.1 0.5 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.3 GO:0005991 trehalose metabolic process(GO:0005991)
0.1 0.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.2 GO:0007585 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.1 0.6 GO:0060420 regulation of heart growth(GO:0060420)
0.1 2.6 GO:0051085 'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 0.3 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.1 0.4 GO:1902369 negative regulation of RNA catabolic process(GO:1902369)
0.1 0.3 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.1 0.2 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
0.1 0.4 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.4 GO:0035909 aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.1 0.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.8 GO:0071679 commissural neuron axon guidance(GO:0071679)
0.1 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1 0.2 GO:0044821 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.2 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.3 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 0.4 GO:0030104 water homeostasis(GO:0030104)
0.1 0.2 GO:0030091 protein repair(GO:0030091)
0.1 0.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 0.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.2 GO:0043388 cytidine to uridine editing(GO:0016554) positive regulation of DNA binding(GO:0043388) positive regulation of binding(GO:0051099)
0.1 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.3 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.1 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.3 GO:0031106 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.0 0.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.8 GO:0061154 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.0 0.3 GO:0006004 fucose metabolic process(GO:0006004)
0.0 1.3 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.7 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:0015859 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.0 0.2 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.3 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.3 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 1.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.4 GO:0032049 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin biosynthetic process(GO:0032049)
0.0 0.3 GO:1903426 regulation of reactive oxygen species biosynthetic process(GO:1903426)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.3 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.0 0.4 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.5 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.3 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.5 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 2.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.0 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.4 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.5 GO:0002138 retinoic acid biosynthetic process(GO:0002138)
0.0 0.4 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.4 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.0 1.0 GO:0048515 spermatid development(GO:0007286) spermatid differentiation(GO:0048515)
0.0 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.6 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.5 GO:0009749 response to glucose(GO:0009749)
0.0 0.5 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.3 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.0 0.2 GO:0036372 opsin transport(GO:0036372)
0.0 0.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.3 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 1.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 1.6 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.4 GO:0090481 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.1 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.0 0.3 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 1.0 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.1 GO:0006953 acute-phase response(GO:0006953)
0.0 0.4 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.6 GO:0006284 base-excision repair(GO:0006284)
0.0 1.1 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 0.4 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.3 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.1 GO:0030728 ovulation(GO:0030728)
0.0 0.2 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.8 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 1.1 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.3 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.1 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 1.4 GO:0008016 regulation of heart contraction(GO:0008016)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.1 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.4 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.2 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.6 GO:0006282 regulation of DNA repair(GO:0006282)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0097268 cytoophidium(GO:0097268)
0.3 1.0 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.3 1.0 GO:0070209 ASTRA complex(GO:0070209)
0.2 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.5 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 0.8 GO:0005845 mRNA cap binding complex(GO:0005845)
0.1 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.2 GO:0070187 telosome(GO:0070187)
0.1 0.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.5 GO:0035517 PR-DUB complex(GO:0035517)
0.1 0.4 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 0.3 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.1 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.2 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 0.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 1.0 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.2 GO:0055087 Ski complex(GO:0055087)
0.0 5.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.8 GO:0031672 A band(GO:0031672)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 1.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 4.7 GO:0005730 nucleolus(GO:0005730)
0.0 1.9 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0005844 polysome(GO:0005844)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.5 1.5 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905)
0.5 1.8 GO:0003883 CTP synthase activity(GO:0003883)
0.3 1.2 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.4 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.2 1.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.2 0.8 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.2 0.6 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity(GO:0001734)
0.2 1.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 0.9 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.2 0.5 GO:0032356 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.2 0.9 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 0.5 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.1 0.7 GO:0010997 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.1 0.7 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.1 1.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 4.1 GO:0051087 chaperone binding(GO:0051087)
0.1 1.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.3 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.1 1.0 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.1 0.7 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.3 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.5 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.3 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.7 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.1 0.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.5 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1 0.3 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.7 GO:0005522 profilin binding(GO:0005522)
0.1 0.3 GO:0042979 ornithine decarboxylase inhibitor activity(GO:0008073) ornithine decarboxylase regulator activity(GO:0042979)
0.1 0.2 GO:0003913 DNA photolyase activity(GO:0003913)
0.1 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.3 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 1.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.3 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.1 0.3 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.1 0.5 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.6 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.0 0.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.3 GO:0034057 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.0 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 1.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:1902388 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 2.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.6 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.2 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.1 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.4 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.3 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.7 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.1 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.0 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.2 GO:0008198 ferrous iron binding(GO:0008198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.5 PID ALK2 PATHWAY ALK2 signaling events
0.1 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.5 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.4 PID INSULIN PATHWAY Insulin Pathway
0.0 0.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 0.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 1.4 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 1.4 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 1.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.2 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 0.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 2.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.8 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress