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PRJEB1986: zebrafish developmental stages transcriptome

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Results for atf4a+atf4b

Z-value: 0.44

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Transcription factors associated with atf4a+atf4b

Gene Symbol Gene ID Gene Info
atf4b
ENSDARG00000038141 activating transcription factor 4b
atf4a
ENSDARG00000111939 activating transcription factor 4a
atf4b
ENSDARG00000114163 activating transcription factor 4b
atf4b
ENSDARG00000114542 activating transcription factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf4adr11_v1_chr6_+_269204_269204-0.381.1e-01Click!
atf4bdr11_v1_chr3_+_24197934_241979340.194.3e-01Click!

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_41494831 1.27 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr20_+_28266892 1.18 ENSDART00000103330
chac1
ChaC, cation transport regulator homolog 1 (E. coli)
chr9_+_2574122 1.05 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr20_-_29418620 0.88 ENSDART00000172634
ryr3
ryanodine receptor 3
chr18_-_16179129 0.83 ENSDART00000125353
slc6a15
solute carrier family 6 (neutral amino acid transporter), member 15
chr4_+_17279966 0.82 ENSDART00000067005
ENSDART00000137487
bcat1
branched chain amino-acid transaminase 1, cytosolic
chr16_-_12688957 0.81 ENSDART00000147854
ENSDART00000184587
mfap5
microfibril associated protein 5
chr4_+_8797197 0.81 ENSDART00000158671
sult4a1
sulfotransferase family 4A, member 1
chr6_+_41255485 0.78 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr12_+_46960579 0.76 ENSDART00000149032
oat
ornithine aminotransferase
chr17_-_45552602 0.70 ENSDART00000154844
ENSDART00000034432
susd4
sushi domain containing 4
chr15_-_24869826 0.69 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr16_-_13818061 0.68 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr3_+_31933893 0.68 ENSDART00000146509
ENSDART00000139644
lin7b
lin-7 homolog B (C. elegans)
chr4_+_12113105 0.62 ENSDART00000182399
tmem178b
transmembrane protein 178B
chr7_+_49862837 0.59 ENSDART00000174315
slc1a2a
solute carrier family 1 (glial high affinity glutamate transporter), member 2a
chr16_+_34523515 0.58 ENSDART00000041007
stmn1b
stathmin 1b
chr19_+_43341424 0.54 ENSDART00000134815
sesn2
sestrin 2
chr6_-_11780070 0.52 ENSDART00000151195
march7
membrane-associated ring finger (C3HC4) 7
chr14_-_1454045 0.51 ENSDART00000161460
pmt
phosphoethanolamine methyltransferase
chr11_+_45287541 0.51 ENSDART00000165321
ENSDART00000173116
pycr1b
pyrroline-5-carboxylate reductase 1b
chr5_+_3501859 0.51 ENSDART00000080486
ywhag1
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr20_+_16743056 0.50 ENSDART00000050308
calm1b
calmodulin 1b
chr5_-_32323136 0.49 ENSDART00000110804
hspb15
heat shock protein, alpha-crystallin-related, b15
chr2_-_36932253 0.49 ENSDART00000124217
map1sb
microtubule-associated protein 1Sb
chr8_+_31119548 0.46 ENSDART00000136578
syn1
synapsin I
chr13_-_20540790 0.42 ENSDART00000131467
si:ch1073-126c3.2
si:ch1073-126c3.2
chr23_-_27345425 0.42 ENSDART00000022042
ENSDART00000191870
scn8aa
sodium channel, voltage gated, type VIII, alpha subunit a
chr7_+_48761875 0.41 ENSDART00000003690
acana
aggrecan a
chr16_+_41826584 0.39 ENSDART00000147523
si:dkey-199f5.6
si:dkey-199f5.6
chr6_-_48094342 0.39 ENSDART00000137458
slc2a1b
solute carrier family 2 (facilitated glucose transporter), member 1b
chr4_+_1600034 0.39 ENSDART00000146779
slc38a2
solute carrier family 38, member 2
chr20_-_20610812 0.38 ENSDART00000181870
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr20_-_14680897 0.38 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr8_+_40628926 0.37 ENSDART00000163598
dusp2
dual specificity phosphatase 2
chr2_-_28671139 0.37 ENSDART00000165272
ENSDART00000164657
dhcr7
7-dehydrocholesterol reductase
chr3_+_22242269 0.36 ENSDART00000168970
scn4ab
sodium channel, voltage-gated, type IV, alpha, b
chr7_-_52842605 0.36 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr12_+_30788912 0.36 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr25_-_21894317 0.36 ENSDART00000089642
fbxo31
F-box protein 31
chr14_-_7306983 0.36 ENSDART00000158914
si:ch211-51f19.1
si:ch211-51f19.1
chr24_-_38644937 0.36 ENSDART00000170194
slc6a16b
solute carrier family 6, member 16b
chr8_+_46386601 0.35 ENSDART00000129661
ENSDART00000084081
ogg1
8-oxoguanine DNA glycosylase
chr3_+_15505275 0.35 ENSDART00000141714
nupr1
nuclear protein 1
chr23_-_12014931 0.35 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr21_+_21374277 0.34 ENSDART00000079431
rtn2b
reticulon 2b
chr20_-_20611063 0.34 ENSDART00000063492
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr7_-_35036770 0.34 ENSDART00000123174
galr1b
galanin receptor 1b
chr22_+_18469004 0.33 ENSDART00000061430
cilp2
cartilage intermediate layer protein 2
chr5_-_55395964 0.33 ENSDART00000145791
prune2
prune homolog 2 (Drosophila)
chr15_-_29573267 0.33 ENSDART00000099947
samsn1a
SAM domain, SH3 domain and nuclear localisation signals 1a
chr12_+_30789611 0.32 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr22_+_28446365 0.31 ENSDART00000189359
abi3bpb
ABI family, member 3 (NESH) binding protein b
chr8_-_31384607 0.30 ENSDART00000164134
ENSDART00000024872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr17_+_8175998 0.30 ENSDART00000131200
myct1b
myc target 1b
chr17_+_12700617 0.30 ENSDART00000191931
stmn4l
stathmin-like 4, like
chr5_-_57528943 0.30 ENSDART00000130320
pisd
phosphatidylserine decarboxylase
chr1_-_19237576 0.29 ENSDART00000143663
ENSDART00000131579
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr5_-_55395384 0.29 ENSDART00000147298
ENSDART00000082577
prune2
prune homolog 2 (Drosophila)
chr7_+_48761646 0.29 ENSDART00000017467
acana
aggrecan a
chr19_-_8812891 0.29 ENSDART00000151134
ENSDART00000025385
ENSDART00000180291
cers2a
ceramide synthase 2a
chr10_-_31104983 0.28 ENSDART00000186941
pknox2
pbx/knotted 1 homeobox 2
chr12_-_46959990 0.27 ENSDART00000084557
lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr3_+_40856095 0.26 ENSDART00000143207
mmd2a
monocyte to macrophage differentiation-associated 2a
chr22_+_28446557 0.25 ENSDART00000089546
abi3bpb
ABI family, member 3 (NESH) binding protein b
chr24_-_39771667 0.25 ENSDART00000181867
GFOD1
si:ch211-276f18.2
chr8_-_11170114 0.24 ENSDART00000133532
si:ch211-204d2.4
si:ch211-204d2.4
chr15_+_45994123 0.24 ENSDART00000124704
lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr13_-_9300299 0.23 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr5_+_57658898 0.23 ENSDART00000074268
ENSDART00000124568
zgc:153929
zgc:153929
chr2_+_35240764 0.23 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr15_+_20543770 0.23 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr7_+_16033923 0.23 ENSDART00000161669
ENSDART00000114062
immp1l
inner mitochondrial membrane peptidase subunit 1
chr12_-_32066469 0.22 ENSDART00000140685
ENSDART00000062185
rab40b
RAB40B, member RAS oncogene family
chr25_+_26923193 0.22 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr2_-_37059966 0.22 ENSDART00000137967
diras1b
DIRAS family, GTP-binding RAS-like 1b
chr15_-_23908779 0.22 ENSDART00000088808
usp32
ubiquitin specific peptidase 32
chr13_+_4225173 0.22 ENSDART00000058242
ENSDART00000143456
mea1
male-enhanced antigen 1
chr25_-_21894706 0.21 ENSDART00000189158
fbxo31
F-box protein 31
chr20_-_18915376 0.21 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr25_+_28893615 0.21 ENSDART00000156994
ENSDART00000075151
amn1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr2_+_21634128 0.20 ENSDART00000089822
fbxl7
F-box and leucine-rich repeat protein 7
chr9_+_13985567 0.20 ENSDART00000102296
cd28
CD28 molecule
chr25_+_32473277 0.20 ENSDART00000146451
sqor
sulfide quinone oxidoreductase
chr7_+_38090515 0.19 ENSDART00000131387
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr19_+_43341115 0.19 ENSDART00000145846
ENSDART00000102384
sesn2
sestrin 2
chr14_+_30557361 0.19 ENSDART00000019898
mrpl11
mitochondrial ribosomal protein L11
chr17_-_50220228 0.18 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr4_+_20545448 0.18 ENSDART00000189006
BX248410.3

chr20_+_37794633 0.17 ENSDART00000022060
atf3
activating transcription factor 3
chr21_+_944715 0.16 ENSDART00000144766
nars
asparaginyl-tRNA synthetase
chr20_+_18992679 0.16 ENSDART00000147105
ENSDART00000152811
tdh
L-threonine dehydrogenase
chr9_+_747612 0.16 ENSDART00000181004
insig2
insulin induced gene 2
chr3_-_40284744 0.16 ENSDART00000018626
pdap1b
pdgfa associated protein 1b
chr16_+_33143503 0.16 ENSDART00000058471
ENSDART00000179385
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr8_+_54202554 0.15 ENSDART00000020569
creld1b
cysteine-rich with EGF-like domains 1b
chr21_-_43949208 0.15 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr14_-_1454413 0.14 ENSDART00000185403
ENSDART00000191357
pmt
phosphoethanolamine methyltransferase
chr15_-_23908605 0.14 ENSDART00000185578
usp32
ubiquitin specific peptidase 32
chr25_+_32473433 0.13 ENSDART00000152326
sqor
sulfide quinone oxidoreductase
chr14_-_16379843 0.12 ENSDART00000090711
ltc4s
leukotriene C4 synthase
chr2_-_32486080 0.12 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr6_+_27339962 0.12 ENSDART00000193726
klhl30
kelch-like family member 30
chr13_+_21601149 0.12 ENSDART00000179369
sh2d4ba
SH2 domain containing 4Ba
chr7_-_31830936 0.12 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr7_+_25053331 0.11 ENSDART00000173998
si:dkey-23i12.7
si:dkey-23i12.7
chr4_-_13548806 0.11 ENSDART00000067155
il22
interleukin 22
chr10_-_8672820 0.11 ENSDART00000080763
si:dkey-27b3.2
si:dkey-27b3.2
chr12_-_48374728 0.11 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr15_-_5780593 0.11 ENSDART00000163555
ENSDART00000082388
chchd2
coiled-coil-helix-coiled-coil-helix domain containing 2
chr20_-_19532531 0.11 ENSDART00000125830
ENSDART00000179566
ENSDART00000184193
eif2b4
BX276101.2
eukaryotic translation initiation factor 2B, subunit 4 delta

chr1_-_11519934 0.11 ENSDART00000162060
sdk1b
sidekick cell adhesion molecule 1b
chr25_+_34641536 0.10 ENSDART00000167033
CABZ01079011.1

chr12_+_41697664 0.09 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr15_-_25392589 0.09 ENSDART00000124205
si:dkey-54n8.4
si:dkey-54n8.4
chr21_+_30502002 0.08 ENSDART00000043727
slc7a3a
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr6_+_39279831 0.08 ENSDART00000155088
ankrd33ab
ankyrin repeat domain 33Ab
chr14_-_38809561 0.08 ENSDART00000159159
sil1
SIL1 nucleotide exchange factor
chr5_+_13243446 0.08 ENSDART00000186140
CR933528.1

chr2_+_1001560 0.08 ENSDART00000134656
cacna1eb
calcium channel, voltage-dependent, R type, alpha 1E subunit b
chr16_-_20006270 0.07 ENSDART00000079155
hdac9b
histone deacetylase 9b
chr15_-_39948635 0.07 ENSDART00000114836
msh5
mutS homolog 5
chr4_+_5842433 0.06 ENSDART00000124085
ENSDART00000179848
usp18
ubiquitin specific peptidase 18
chr2_-_20890429 0.06 ENSDART00000149989
pdca
phosducin a
chr3_+_32868092 0.05 ENSDART00000137668
zgc:162613
zgc:162613
chr16_-_36093776 0.05 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr12_+_34953038 0.05 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr4_-_17642168 0.05 ENSDART00000007030
klhl42
kelch-like family, member 42
chr25_+_7784582 0.05 ENSDART00000155016
dgkzb
diacylglycerol kinase, zeta b
chr16_-_31351419 0.05 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr23_+_25305431 0.05 ENSDART00000143291
RPL41
si:dkey-151g10.6
chr22_+_30631072 0.04 ENSDART00000059970
zmp:0000000606
zmp:0000000606
chr5_-_69499486 0.04 ENSDART00000023983
ENSDART00000180293
psat1
phosphoserine aminotransferase 1
chr22_+_38276024 0.04 ENSDART00000143792
rcor3
REST corepressor 3
chr8_+_7778770 0.04 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr14_-_30945515 0.04 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr14_-_47882706 0.03 ENSDART00000188772
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr4_+_16784553 0.03 ENSDART00000134054
si:dkey-13i19.8
si:dkey-13i19.8
chr13_+_21600946 0.03 ENSDART00000144045
sh2d4ba
SH2 domain containing 4Ba
chr12_+_27129659 0.02 ENSDART00000076161
hoxb5b
homeobox B5b
chr3_+_1107102 0.02 ENSDART00000092690
srebf2
sterol regulatory element binding transcription factor 2
chr23_+_16760845 0.02 ENSDART00000185952
ENSDART00000147724
si:rp71-1k13.6
si:rp71-1k13.6
chr8_-_25729542 0.02 ENSDART00000078149
ENSDART00000085779
foxp3a
forkhead box P3a
chr2_-_58257624 0.02 ENSDART00000098940
foxl2b
forkhead box L2b
chr23_-_18030399 0.02 ENSDART00000136967
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr16_+_25245857 0.02 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr25_-_25550938 0.01 ENSDART00000150412
ENSDART00000103622
irf7
interferon regulatory factor 7
chr20_+_21583639 0.01 ENSDART00000131069
esr2a
estrogen receptor 2a
chr16_-_42770064 0.01 ENSDART00000112879
slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr3_+_25191467 0.01 ENSDART00000156956
ENSDART00000154799
il2rb
interleukin 2 receptor, beta
chr10_+_506538 0.01 ENSDART00000141713
si:ch211-242f23.3
si:ch211-242f23.3
chr3_-_3297913 0.00 ENSDART00000186350
AL953907.2

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957) regulation of protein activation cascade(GO:2000257)
0.2 2.0 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 0.8 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.2 0.8 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.7 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.7 GO:0003151 outflow tract morphogenesis(GO:0003151)
0.1 0.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.3 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.8 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 1.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.8 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 0.6 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.2 GO:2000639 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.2 GO:0061551 trigeminal ganglion development(GO:0061551)
0.0 0.4 GO:0006868 glutamine transport(GO:0006868)
0.0 1.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.0 0.7 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.4 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.8 GO:0051923 sulfation(GO:0051923)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.9 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.2 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.4 GO:0042446 hormone biosynthetic process(GO:0042446)
0.0 1.0 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:1903826 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0044316 cone cell pedicle(GO:0044316)
0.2 0.7 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.8 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.8 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.9 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 0.7 GO:0097016 L27 domain binding(GO:0097016)
0.2 0.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.3 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.1 0.8 GO:0070728 leucine binding(GO:0070728)
0.1 0.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.4 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.3 GO:0101006 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.1 0.6 GO:0030332 cyclin binding(GO:0030332)
0.1 0.6 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.2 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.0 0.8 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 1.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 0.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis