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PRJEB1986: zebrafish developmental stages transcriptome

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Results for dmbx1a+dmbx1b

Z-value: 0.54

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Transcription factors associated with dmbx1a+dmbx1b

Gene Symbol Gene ID Gene Info
dmbx1b
ENSDARG00000002510 diencephalon/mesencephalon homeobox 1b
dmbx1a
ENSDARG00000009922 diencephalon/mesencephalon homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dmbx1bdr11_v1_chr6_-_3573716_35737160.861.8e-06Click!
dmbx1adr11_v1_chr2_-_10188598_10188598-0.493.3e-02Click!

Activity profile of dmbx1a+dmbx1b motif

Sorted Z-values of dmbx1a+dmbx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_1805421 3.82 ENSDART00000173143
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr14_-_46238186 1.15 ENSDART00000173245
si:ch211-113d11.6
si:ch211-113d11.6
chr17_+_17955063 1.04 ENSDART00000104999
ccdc85ca
coiled-coil domain containing 85C, a
chr20_-_33515890 0.87 ENSDART00000159987
si:dkey-65b13.13
si:dkey-65b13.13
chr1_-_45920632 0.78 ENSDART00000140890
pnpla6
patatin-like phospholipase domain containing 6
chr1_-_45177373 0.73 ENSDART00000143142
ENSDART00000034549
zgc:111983
zgc:111983
chr14_+_2487672 0.64 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr2_+_51783120 0.63 ENSDART00000177559
crygn1
crystallin, gamma N1
chr21_-_3770636 0.59 ENSDART00000053596
scamp1
secretory carrier membrane protein 1
chr1_-_12126535 0.57 ENSDART00000164817
ENSDART00000015251
mttp
microsomal triglyceride transfer protein
chr15_-_8191841 0.57 ENSDART00000156663
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr12_+_3848109 0.55 ENSDART00000144067
ENSDART00000192042
cabp5a
calcium binding protein 5a
chr5_-_5243079 0.53 ENSDART00000130576
ENSDART00000164377
mvb12ba
multivesicular body subunit 12Ba
chr2_+_243778 0.51 ENSDART00000182262
CABZ01085887.1

chr6_-_10320676 0.51 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr7_+_19903924 0.50 ENSDART00000159112
si:ch211-285j22.3
si:ch211-285j22.3
chr6_-_39653972 0.49 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr5_+_69808763 0.47 ENSDART00000143482
fsd1l
fibronectin type III and SPRY domain containing 1-like
chr14_+_11909966 0.44 ENSDART00000171829
frmpd3
FERM and PDZ domain containing 3
chr3_+_32142382 0.42 ENSDART00000133035
syt5a
synaptotagmin Va
chr3_+_16762483 0.40 ENSDART00000132732
tmem86b
transmembrane protein 86B
chr15_-_8191992 0.40 ENSDART00000155381
ENSDART00000190714
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr5_-_69180587 0.37 ENSDART00000156681
ENSDART00000160753
zgc:171967
zgc:171967
chr20_-_1141722 0.36 ENSDART00000152675
gabrr1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr25_-_19068557 0.36 ENSDART00000184780
cacna2d4b
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr3_+_15296824 0.35 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr4_-_42039794 0.35 ENSDART00000110313
si:dkeyp-85d8.5
si:dkeyp-85d8.5
chr23_-_26652273 0.35 ENSDART00000112124
ENSDART00000111029
hspg2
heparan sulfate proteoglycan 2
chr8_-_30424182 0.34 ENSDART00000099021
dock8
dedicator of cytokinesis 8
chr12_+_31729498 0.33 ENSDART00000188546
ENSDART00000182562
ENSDART00000186147
RNF157
si:dkey-49c17.3
chr11_+_27973055 0.32 ENSDART00000135135
alpl
alkaline phosphatase, liver/bone/kidney
chr12_+_31729075 0.31 ENSDART00000152973
RNF157
si:dkey-49c17.3
chr23_+_45512825 0.31 ENSDART00000064846
prelid1b
PRELI domain containing 1b
chr1_+_52560549 0.31 ENSDART00000167514
abca1a
ATP-binding cassette, sub-family A (ABC1), member 1A
chr13_-_14269626 0.30 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr11_-_3366782 0.30 ENSDART00000127982
suox
sulfite oxidase
chr10_-_18468385 0.29 ENSDART00000183302
si:dkey-28o19.1
si:dkey-28o19.1
chr1_+_47585700 0.29 ENSDART00000153746
ENSDART00000084457
sh3pxd2aa
SH3 and PX domains 2Aa
chr17_+_10593398 0.28 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr8_+_54263946 0.28 ENSDART00000193119
TMCC1 (1 of many)
transmembrane and coiled-coil domain family 1
chr13_+_1015749 0.27 ENSDART00000190982
prokr1b
prokineticin receptor 1b
chr18_-_10713230 0.27 ENSDART00000183646
rbm28
RNA binding motif protein 28
chr18_+_5172848 0.26 ENSDART00000190642
CABZ01080599.1

chr7_+_19904136 0.26 ENSDART00000173452
si:ch211-285j22.3
si:ch211-285j22.3
chr22_+_6740039 0.25 ENSDART00000144122
CT583625.2

chr16_+_48678655 0.24 ENSDART00000150156
tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_56577906 0.23 ENSDART00000184023
hp
haptoglobin
chr21_-_20342096 0.23 ENSDART00000065659
rbp4l
retinol binding protein 4, like
chr13_+_40815012 0.22 ENSDART00000016960
prkg1a
protein kinase, cGMP-dependent, type Ia
chr15_-_7337148 0.22 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr10_-_37075361 0.22 ENSDART00000132023
myo18aa
myosin XVIIIAa
chr5_-_30481263 0.22 ENSDART00000086734
phldb1a
pleckstrin homology-like domain, family B, member 1a
chr4_-_49133107 0.22 ENSDART00000150806
znf1146
zinc finger protein 1146
chr18_+_21951551 0.22 ENSDART00000146261
ranbp10
RAN binding protein 10
chr10_+_24504292 0.20 ENSDART00000090059
mtus2a
microtubule associated tumor suppressor candidate 2a
chr18_-_10713414 0.20 ENSDART00000034817
rbm28
RNA binding motif protein 28
chr5_-_69180227 0.20 ENSDART00000154816
zgc:171967
zgc:171967
chr3_-_41995321 0.19 ENSDART00000192277
ttyh3a
tweety family member 3a
chr13_+_50151407 0.18 ENSDART00000031858
gpr137ba
G protein-coupled receptor 137Ba
chr15_+_45640906 0.17 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr15_-_41734639 0.17 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr18_+_45781115 0.16 ENSDART00000151699
ENSDART00000179887
rpl35a
ribosomal protein L35a
chr19_+_3140313 0.16 ENSDART00000125504
zgc:86598
zgc:86598
chr7_+_18989241 0.15 ENSDART00000053213
zgc:194252
zgc:194252
chr17_-_21617618 0.15 ENSDART00000109031
gpr26
G protein-coupled receptor 26
chr18_+_15644559 0.14 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr9_-_38587275 0.13 ENSDART00000077446
si:dkey-101k6.5
si:dkey-101k6.5
chr7_+_65121743 0.13 ENSDART00000108471
ipo7
importin 7
chr7_-_21905851 0.13 ENSDART00000111066
ENSDART00000020288
epoa
erythropoietin a
chr12_+_33894396 0.13 ENSDART00000130853
ENSDART00000152988
mfsd13a
major facilitator superfamily domain containing 13A
chr20_+_12830448 0.12 ENSDART00000164754
BX547930.4

chr16_-_12236362 0.12 ENSDART00000114759
lpcat3
lysophosphatidylcholine acyltransferase 3
chr3_+_19914332 0.12 ENSDART00000078982
vat1
vesicle amine transport 1
chr7_+_19483277 0.11 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr7_+_38395197 0.11 ENSDART00000138669
cep89
centrosomal protein 89
chr7_-_72423666 0.10 ENSDART00000191214
rph3ab
rabphilin 3A homolog (mouse), b
chr12_+_292452 0.09 ENSDART00000189944
CABZ01058222.1

chr5_-_22602979 0.09 ENSDART00000146287
nono
non-POU domain containing, octamer-binding
chr11_-_29082429 0.09 ENSDART00000041443
igsf21a
immunoglobin superfamily, member 21a
chr23_-_27050083 0.09 ENSDART00000142324
ENSDART00000133249
ENSDART00000138751
ENSDART00000128718
zgc:66440
zgc:66440
chr20_-_31308805 0.08 ENSDART00000147045
hpcal1
hippocalcin-like 1
chr11_-_29082175 0.08 ENSDART00000123245
igsf21a
immunoglobin superfamily, member 21a
chr10_+_24504464 0.08 ENSDART00000141387
mtus2a
microtubule associated tumor suppressor candidate 2a
chr21_-_20341836 0.08 ENSDART00000176689
rbp4l
retinol binding protein 4, like
chr7_-_54320088 0.08 ENSDART00000172396
fadd
Fas (tnfrsf6)-associated via death domain
chr21_-_28340977 0.07 ENSDART00000141629
nrxn2a
neurexin 2a
chr18_+_15182965 0.07 ENSDART00000137018
si:ch73-62b13.1
si:ch73-62b13.1
chr19_+_24324967 0.07 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr25_+_11456696 0.07 ENSDART00000171408
AGBL1
si:ch73-141f14.1
chr22_+_2709467 0.07 ENSDART00000141416
znf1171
zinc finger protein 1171
chr20_-_31067306 0.06 ENSDART00000014163
fndc1
fibronectin type III domain containing 1
chr5_-_25733745 0.06 ENSDART00000051566
zgc:101016
zgc:101016
chr16_+_16265850 0.06 ENSDART00000181265
setd2
SET domain containing 2
chr5_-_8817841 0.06 ENSDART00000170921
fgf10b
fibroblast growth factor 10b
chr17_-_31058900 0.05 ENSDART00000134998
ENSDART00000104307
ENSDART00000172721
eml1
echinoderm microtubule associated protein like 1
chr1_+_35949269 0.05 ENSDART00000180628
BX276105.3

chr11_+_29671661 0.05 ENSDART00000024318
ENSDART00000165024
rnf207a
ring finger protein 207a
chr4_+_76671012 0.05 ENSDART00000005585
ms4a17a.2
membrane-spanning 4-domains, subfamily A, member 17a.2
chr4_+_47385355 0.05 ENSDART00000163413
znf1122
zinc finger protein 1122
chr4_-_59152337 0.04 ENSDART00000156770
znf1149
zinc finger protein 1149
chr5_+_25733774 0.04 ENSDART00000137088
ENSDART00000098467
abhd17b
abhydrolase domain containing 17B
chr3_-_21402279 0.04 ENSDART00000164513
CT573446.1

chr7_-_35409027 0.04 ENSDART00000128334
lpcat2
lysophosphatidylcholine acyltransferase 2
chr13_+_1726953 0.04 ENSDART00000103004
zmp:0000000760
zmp:0000000760
chr17_-_8656155 0.04 ENSDART00000148990
ctbp2a
C-terminal binding protein 2a
chr3_+_34919810 0.02 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr20_-_9963713 0.02 ENSDART00000104234
gjd2b
gap junction protein delta 2b
chr19_+_2631565 0.02 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr25_-_32381642 0.01 ENSDART00000133872
ENSDART00000006124
cops2
COP9 signalosome subunit 2
chr2_+_44972720 0.01 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr4_+_33012407 0.01 ENSDART00000151873
si:dkey-26h11.2
si:dkey-26h11.2

Network of associatons between targets according to the STRING database.

First level regulatory network of dmbx1a+dmbx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.5 GO:0044803 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.1 0.9 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.1 0.4 GO:0070317 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.3 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.6 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.1 0.2 GO:0042590 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.2 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.3 GO:0030431 sleep(GO:0030431)
0.0 0.4 GO:0046549 retinal cone cell development(GO:0046549)
0.0 3.7 GO:1901342 regulation of vasculature development(GO:1901342)
0.0 0.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0 0.1 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.0 0.2 GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 0.3 GO:0006801 superoxide metabolic process(GO:0006801)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.4 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.1 0.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.4 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
0.0 0.3 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.0 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC