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PRJEB1986: zebrafish developmental stages transcriptome

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Results for e2f1_e2f7

Z-value: 3.46

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Transcription factors associated with e2f1_e2f7

Gene Symbol Gene ID Gene Info
e2f1
ENSDARG00000103868 E2F transcription factor 1
e2f7
ENSDARG00000008986 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f7dr11_v1_chr4_-_2545310_25453450.795.5e-05Click!
e2f1dr11_v1_chr23_-_43486714_434867140.707.7e-04Click!

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_29498178 11.50 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr14_+_14841685 11.11 ENSDART00000158291
ENSDART00000162039
slbp
stem-loop binding protein
chr19_-_47570672 10.49 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr7_+_24814866 10.46 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr3_+_27027781 10.38 ENSDART00000065495
emp2
epithelial membrane protein 2
chr20_+_34770197 10.13 ENSDART00000018304
mcm3
minichromosome maintenance complex component 3
chr24_+_41690545 9.97 ENSDART00000160069
lama1
laminin, alpha 1
chr7_+_24881680 9.60 ENSDART00000058843
krcp
kelch repeat-containing protein
chr19_+_627899 9.05 ENSDART00000148508
tert
telomerase reverse transcriptase
chr21_+_30721733 9.00 ENSDART00000040443
zgc:110224
zgc:110224
chr13_+_8255106 8.55 ENSDART00000080465
hells
helicase, lymphoid specific
chr8_+_15254564 8.52 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr6_+_12968101 8.30 ENSDART00000013781
mcm6
minichromosome maintenance complex component 6
chr8_-_18211605 7.95 ENSDART00000114177
CT025742.1

chr18_-_16924221 7.90 ENSDART00000122102
wee1
WEE1 G2 checkpoint kinase
chr6_-_33916756 7.49 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr13_-_86847 7.38 ENSDART00000158062
pole2
polymerase (DNA directed), epsilon 2
chr18_+_17021391 7.38 ENSDART00000100160
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr5_-_67365333 7.35 ENSDART00000133438
unga
uracil DNA glycosylase a
chr1_-_38170997 6.98 ENSDART00000142811
hmgb2a
high mobility group box 2a
chr24_-_35561672 6.96 ENSDART00000058564
mcm4
minichromosome maintenance complex component 4
chr11_+_1551603 6.85 ENSDART00000185383
ENSDART00000121489
ENSDART00000040577
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr20_+_13141408 6.84 ENSDART00000034098
dtl
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr13_+_48358467 6.73 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr3_+_25999477 6.69 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr20_+_33994580 6.58 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr10_+_28428222 6.51 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr10_+_10728870 6.43 ENSDART00000109282
swi5
SWI5 homologous recombination repair protein
chr8_+_29635968 6.40 ENSDART00000139029
ENSDART00000091409
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr21_-_23017478 6.27 ENSDART00000024309
rb1
retinoblastoma 1
chr3_-_35865040 6.19 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr2_+_32016516 6.11 ENSDART00000135040
mycb
MYC proto-oncogene, bHLH transcription factor b
chr13_-_25548733 5.85 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr20_-_32446406 5.82 ENSDART00000026635
nr2e1
nuclear receptor subfamily 2, group E, member 1
chr13_+_26703922 5.76 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr8_+_29636431 5.76 ENSDART00000133047
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr9_-_10068004 5.57 ENSDART00000011922
ENSDART00000162818
spopla
speckle-type POZ protein-like a
chr13_-_35908275 5.52 ENSDART00000013961
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr2_-_122154 5.46 ENSDART00000156248
ENSDART00000004071
znfl2a
zinc finger-like gene 2a
chr7_-_26518086 5.39 ENSDART00000058913
eif4a1a
eukaryotic translation initiation factor 4A1A
chr11_-_6970107 5.29 ENSDART00000171255
COMP
si:ch211-43f4.1
chr3_+_43086548 5.28 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr17_-_11368662 5.22 ENSDART00000159061
ENSDART00000188694
ENSDART00000190932
si:ch211-185a18.2
si:ch211-185a18.2
chr5_-_67365750 5.12 ENSDART00000062359
unga
uracil DNA glycosylase a
chr8_+_54013199 5.06 ENSDART00000158497
CABZ01079663.1

chr20_-_36416922 4.95 ENSDART00000019145
lbr
lamin B receptor
chr14_-_22015232 4.92 ENSDART00000137795
ssrp1a
structure specific recognition protein 1a
chr22_-_21676364 4.89 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr22_-_20419660 4.80 ENSDART00000105520
pias4a
protein inhibitor of activated STAT, 4a
chr21_-_25213616 4.73 ENSDART00000122513
rfc2
replication factor C (activator 1) 2
chr7_-_16582187 4.69 ENSDART00000131726
e2f8
E2F transcription factor 8
chr13_-_39160018 4.67 ENSDART00000168795
col9a1b
collagen, type IX, alpha 1b
chr3_+_13603272 4.61 ENSDART00000185084
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr18_+_17020967 4.56 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr9_+_56232548 4.51 ENSDART00000099276
cnot11
CCR4-NOT transcription complex, subunit 11
chr4_+_13586455 4.51 ENSDART00000187230
tnpo3
transportin 3
chr6_-_51573975 4.50 ENSDART00000073865
rbl1
retinoblastoma-like 1 (p107)
chr13_-_39159810 4.47 ENSDART00000131508
col9a1b
collagen, type IX, alpha 1b
chr20_-_38827623 4.45 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr15_+_17406920 4.42 ENSDART00000081059
rps6kb1b
ribosomal protein S6 kinase b, polypeptide 1b
chr22_-_22301672 4.28 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr5_+_39099380 4.24 ENSDART00000166657
bmp2k
BMP2 inducible kinase
chr7_+_27834130 4.20 ENSDART00000052656
rras2
RAS related 2
chr3_-_49514874 4.17 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr7_+_71586485 4.14 ENSDART00000165582
smchd1
structural maintenance of chromosomes flexible hinge domain containing 1
chr23_+_17839187 4.11 ENSDART00000104647
prim1
DNA primase subunit 1
chr3_-_61377127 4.10 ENSDART00000155932
si:dkey-111k8.2
si:dkey-111k8.2
chr13_+_48359573 4.09 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr24_+_9693951 4.09 ENSDART00000082411
topbp1
DNA topoisomerase II binding protein 1
chr24_-_13349464 4.08 ENSDART00000134482
ENSDART00000139212
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr19_-_2582858 4.00 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr6_-_39893501 3.97 ENSDART00000141611
ENSDART00000135631
ENSDART00000077662
ENSDART00000130613
myl6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr20_-_28698172 3.96 ENSDART00000190635
sipa1l1
signal-induced proliferation-associated 1 like 1
chr23_-_29357764 3.92 ENSDART00000156512
si:ch211-129o18.4
si:ch211-129o18.4
chr18_+_20226843 3.86 ENSDART00000100632
tle3a
transducin-like enhancer of split 3a
chr19_+_25465025 3.80 ENSDART00000018553
rpa3
replication protein A3
chr24_+_27548474 3.79 ENSDART00000105774
ENSDART00000123368
ek1
eph-like kinase 1
chr17_-_23412705 3.77 ENSDART00000126995
si:ch211-149k12.3
si:ch211-149k12.3
chr15_-_1484795 3.69 ENSDART00000129356
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr13_-_35907768 3.66 ENSDART00000147522
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr19_-_1947403 3.64 ENSDART00000113951
ENSDART00000151293
ENSDART00000134074
znrf2a
zinc and ring finger 2a
chr1_+_45740183 3.64 ENSDART00000149116
si:ch211-214c7.4
si:ch211-214c7.4
chr2_-_59285085 3.62 ENSDART00000131880
ftr34
finTRIM family, member 34
chr18_-_30499489 3.62 ENSDART00000033746
gins2
GINS complex subunit 2
chr8_+_52415603 3.59 ENSDART00000021604
ENSDART00000191424
gins4
GINS complex subunit 4 (Sld5 homolog)
chr5_+_51248784 3.59 ENSDART00000159571
ENSDART00000189513
ENSDART00000092285
msh3
mutS homolog 3 (E. coli)
chr19_+_1873059 3.57 ENSDART00000145246
snrpd1
small nuclear ribonucleoprotein D1 polypeptide
chr6_-_53334259 3.53 ENSDART00000172465
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr16_+_37891735 3.51 ENSDART00000178753
ENSDART00000142104
cep162
centrosomal protein 162
chr7_+_55518519 3.51 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr20_-_37933237 3.50 ENSDART00000142567
ENSDART00000036371
ENSDART00000061445
angel2
angel homolog 2 (Drosophila)
chr23_+_29358188 3.48 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr18_-_8380090 3.47 ENSDART00000141581
ENSDART00000081143
sephs1
selenophosphate synthetase 1
chr16_-_4770233 3.46 ENSDART00000193228
rpa2
replication protein A2
chr15_-_1485086 3.46 ENSDART00000191651
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr1_+_14020445 3.40 ENSDART00000079716
hpf1
histone PARylation factor 1
chr4_-_2380173 3.38 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1
chr16_-_4769877 3.36 ENSDART00000149421
ENSDART00000054078
rpa2
replication protein A2
chr23_+_25428513 3.35 ENSDART00000144554
fmnl3
formin-like 3
chr5_+_69697800 3.35 ENSDART00000178736
ENSDART00000162519
znf1005
zinc finger protein 1005
chr8_+_28593707 3.31 ENSDART00000097213
tcf15
transcription factor 15
chr24_-_13349802 3.29 ENSDART00000164729
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr5_+_41477526 3.28 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr12_+_17603528 3.26 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr21_-_27413294 3.25 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr16_-_41990421 3.23 ENSDART00000055921
pycard
PYD and CARD domain containing
chr4_+_13586689 3.22 ENSDART00000067161
ENSDART00000138201
tnpo3
transportin 3
chr22_+_1911269 3.20 ENSDART00000164158
ENSDART00000168205
znf1156
zinc finger protein 1156
chr8_+_28547687 3.18 ENSDART00000110291
srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr5_-_7712160 3.15 ENSDART00000168820
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr6_+_33931740 3.14 ENSDART00000130492
ENSDART00000151213
orc1
origin recognition complex, subunit 1
chr7_+_1550966 3.12 ENSDART00000177863
ENSDART00000126840
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit
chr19_+_1872794 3.07 ENSDART00000013217
snrpd1
small nuclear ribonucleoprotein D1 polypeptide
chr25_-_19585010 3.07 ENSDART00000021340
sycp3
synaptonemal complex protein 3
chr8_+_18615938 3.06 ENSDART00000089161
si:ch211-232d19.4
si:ch211-232d19.4
chr24_+_26329018 3.05 ENSDART00000145752
mynn
myoneurin
chr3_+_34988670 3.04 ENSDART00000011319
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr22_-_5655680 3.03 ENSDART00000159629
mcm2
minichromosome maintenance complex component 2
chr9_-_33081978 3.02 ENSDART00000100918
zgc:172053
zgc:172053
chr4_-_64123545 2.94 ENSDART00000170040
BX914205.2

chr5_-_67365006 2.92 ENSDART00000136116
unga
uracil DNA glycosylase a
chr19_+_48024457 2.88 ENSDART00000163823
kpnb1
karyopherin (importin) beta 1
chr23_-_3758637 2.84 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
hmga1a
high mobility group AT-hook 1a
chr4_+_38344 2.84 ENSDART00000170197
ENSDART00000175348
phtf2
putative homeodomain transcription factor 2
chr16_+_4770266 2.83 ENSDART00000038036
ube3d
ubiquitin protein ligase E3D
chr17_+_25833947 2.82 ENSDART00000044328
ENSDART00000154604
acss1
acyl-CoA synthetase short chain family member 1
chr2_+_32016256 2.82 ENSDART00000005143
mycb
MYC proto-oncogene, bHLH transcription factor b
chr19_-_5358443 2.81 ENSDART00000105036
cyt1l
type I cytokeratin, enveloping layer, like
chr9_-_746317 2.79 ENSDART00000129632
ENSDART00000130720
usp37
ubiquitin specific peptidase 37
chr19_-_20199167 2.79 ENSDART00000155527
si:ch211-155k24.9
si:ch211-155k24.9
chr7_+_41812636 2.77 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr15_-_26538989 2.75 ENSDART00000032880
rpa1
replication protein A1
chr22_-_15704704 2.75 ENSDART00000017838
ENSDART00000130238
safb
scaffold attachment factor B
chr1_+_58613972 2.74 ENSDART00000162460
si:ch73-221f6.3
si:ch73-221f6.3
chr1_+_11822 2.73 ENSDART00000166393
cep97
centrosomal protein 97
chr3_-_16719244 2.72 ENSDART00000055859
pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr8_+_10304981 2.72 ENSDART00000160766
pim1
Pim-1 proto-oncogene, serine/threonine kinase
chr1_-_44000940 2.70 ENSDART00000134932
ENSDART00000138447
zgc:66472
zgc:66472
chr17_-_15189397 2.68 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr14_-_16775158 2.67 ENSDART00000113711
ENSDART00000144781
ENSDART00000160411
mrnip
MRN complex interacting protein
chr25_+_8447565 2.67 ENSDART00000142090
fanci
Fanconi anemia, complementation group I
chr13_+_42602406 2.66 ENSDART00000133388
ENSDART00000147996
mlh1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr13_+_28785814 2.66 ENSDART00000039028
nsmce4a
NSE4 homolog A, SMC5-SMC6 complex component
chr5_-_19400166 2.64 ENSDART00000008994
foxn4
forkhead box N4
chr18_-_7456378 2.63 ENSDART00000081459
pdp2
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr5_+_34549365 2.61 ENSDART00000009500
aif1l
allograft inflammatory factor 1-like
chr9_-_54361357 2.61 ENSDART00000149813
rad50
RAD50 homolog, double strand break repair protein
chr10_+_21434649 2.60 ENSDART00000193938
ENSDART00000064558
etf1b
eukaryotic translation termination factor 1b
chr7_+_41812817 2.59 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr1_+_24557414 2.53 ENSDART00000076519
dctpp1
dCTP pyrophosphatase 1
chr2_+_25378457 2.51 ENSDART00000089108
fndc3ba
fibronectin type III domain containing 3Ba
chr1_+_11992 2.51 ENSDART00000161842
cep97
centrosomal protein 97
chr23_+_4483083 2.50 ENSDART00000092389
nup210
nucleoporin 210
chr18_+_30421528 2.50 ENSDART00000140908
gse1
Gse1 coiled-coil protein
chr2_-_59303338 2.47 ENSDART00000100987
ENSDART00000140840
ftr35
finTRIM family, member 35
chr9_-_30555725 2.46 ENSDART00000079222
chaf1b
chromatin assembly factor 1, subunit B
chr12_+_46883785 2.45 ENSDART00000008312
fam53b
family with sequence similarity 53, member B
chr21_+_5862476 2.44 ENSDART00000065848
wdr38
WD repeat domain 38
chr23_-_6722101 2.44 ENSDART00000157828
baz2a
bromodomain adjacent to zinc finger domain, 2A
chr25_-_12824656 2.44 ENSDART00000171801
uba2
ubiquitin-like modifier activating enzyme 2
chr13_+_6188759 2.43 ENSDART00000161062
ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr3_-_5964557 2.41 ENSDART00000184738
BX284638.1

chr13_+_111212 2.39 ENSDART00000167840
dnaaf2
dynein, axonemal, assembly factor 2
chr10_+_2799285 2.39 ENSDART00000030709
pnx
posterior neuron-specific homeobox
chr6_+_22326624 2.34 ENSDART00000020333
rae1
ribonucleic acid export 1
chr11_-_3308569 2.33 ENSDART00000036581
cdk2
cyclin-dependent kinase 2
chr11_+_45153104 2.31 ENSDART00000159204
ENSDART00000177585
tk1
thymidine kinase 1, soluble
chr22_-_4439311 2.28 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr25_+_35020529 2.28 ENSDART00000158016
flnca
filamin C, gamma a (actin binding protein 280)
chr11_+_13176568 2.26 ENSDART00000125371
ENSDART00000123257
mknk1
MAP kinase interacting serine/threonine kinase 1
chr5_+_24047292 2.25 ENSDART00000029889
ctdnep1a
CTD nuclear envelope phosphatase 1a
chr8_-_48847772 2.25 ENSDART00000122458
wrap73
WD repeat containing, antisense to TP73
chr1_+_49415281 2.24 ENSDART00000015007
taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr9_-_2892250 2.24 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr5_+_34549845 2.21 ENSDART00000139317
aif1l
allograft inflammatory factor 1-like
chr5_-_23179319 2.21 ENSDART00000161883
ENSDART00000136260
si:dkey-114c15.5
si:dkey-114c15.5
chr24_+_26328787 2.21 ENSDART00000003884
mynn
myoneurin
chr16_+_55078477 2.21 ENSDART00000170074
azi2
5-azacytidine induced 2
chr3_-_7897305 2.18 ENSDART00000169757
ubn2b
ubinuclein 2b
chr20_-_54245256 2.17 ENSDART00000170482
prpf39
PRP39 pre-mRNA processing factor 39 homolog (yeast)
chr22_-_22301929 2.15 ENSDART00000142027
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr20_-_33487729 2.15 ENSDART00000061843
smek1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr16_+_43139504 2.14 ENSDART00000065643
dbf4
DBF4 zinc finger
chr7_-_37919475 2.14 ENSDART00000052368
heatr3
HEAT repeat containing 3
chr6_+_18544791 2.14 ENSDART00000167463
ENSDART00000169599
atad5b
ATPase family, AAA domain containing 5b
chr8_+_49766338 2.09 ENSDART00000060657
rmi1
RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr6_-_6976096 2.09 ENSDART00000151822
ENSDART00000039443
ENSDART00000177960
tuba8l4
tubulin, alpha 8 like 4
chr16_-_4836218 2.08 ENSDART00000054077
tpbgb
trophoblast glycoprotein b
chr7_+_41812190 2.07 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr20_+_46427984 2.06 ENSDART00000060706
ENSDART00000143858
rad51
RAD51 recombinase
chr4_-_2545310 2.05 ENSDART00000150619
ENSDART00000140760
e2f7
E2F transcription factor 7
chr11_-_27702778 2.01 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr17_+_41992054 2.00 ENSDART00000182878
ENSDART00000111537
kiz
kizuna centrosomal protein
chr16_-_29557338 2.00 ENSDART00000058888
hormad1
HORMA domain containing 1
chr6_-_9282080 1.99 ENSDART00000159506
ccdc14
coiled-coil domain containing 14
chr25_+_35062353 1.98 ENSDART00000089844
zgc:113983
zgc:113983
chr6_-_33931696 1.97 ENSDART00000057290
prpf38a
pre-mRNA processing factor 38A
chr22_+_2511045 1.95 ENSDART00000106425
zgc:173726
zgc:173726
chr3_-_18737126 1.93 ENSDART00000055767
e4f1
E4F transcription factor 1
chr3_+_60589157 1.93 ENSDART00000165367
mettl23
methyltransferase like 23

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.8 GO:0006290 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
3.5 10.4 GO:0003093 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
3.2 35.1 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
3.1 15.4 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
3.0 9.1 GO:0007571 age-dependent general metabolic decline(GO:0007571)
2.9 11.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.5 2.5 GO:0009219 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
2.0 22.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.8 5.4 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
1.8 9.0 GO:0000012 single strand break repair(GO:0000012)
1.6 11.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.5 10.8 GO:0044030 regulation of DNA methylation(GO:0044030)
1.5 4.5 GO:0021563 glossopharyngeal nerve development(GO:0021563)
1.4 10.0 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
1.4 13.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.3 6.7 GO:0032877 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
1.2 1.2 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
1.1 2.1 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
1.0 7.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
1.0 4.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.0 12.2 GO:0000729 DNA double-strand break processing(GO:0000729)
1.0 4.0 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
1.0 4.8 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.9 2.7 GO:0051026 chiasma assembly(GO:0051026)
0.8 17.0 GO:0006270 DNA replication initiation(GO:0006270)
0.8 7.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.8 2.3 GO:0046104 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.7 3.4 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.7 2.0 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.7 2.6 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.6 13.6 GO:0007004 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.6 3.5 GO:0001887 selenium compound metabolic process(GO:0001887)
0.6 1.7 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.6 1.7 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.5 3.2 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.5 3.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.5 2.6 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.5 2.1 GO:0042148 strand invasion(GO:0042148)
0.5 10.8 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.5 2.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.5 2.0 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.5 1.4 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.5 2.8 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.5 2.3 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.5 2.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.4 2.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.4 1.3 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.4 3.5 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.4 3.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 1.2 GO:0045141 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.4 1.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.4 10.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.4 1.6 GO:0031053 primary miRNA processing(GO:0031053)
0.4 3.9 GO:0061056 sclerotome development(GO:0061056)
0.4 1.5 GO:0000338 protein deneddylation(GO:0000338)
0.4 1.1 GO:1904869 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.4 2.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 3.5 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.3 1.7 GO:0051591 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 1.3 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.3 1.6 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.3 3.8 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.3 2.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.3 3.0 GO:0003160 endocardium morphogenesis(GO:0003160)
0.3 39.5 GO:0006260 DNA replication(GO:0006260)
0.3 1.5 GO:1901207 regulation of heart looping(GO:1901207)
0.3 5.6 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.3 1.1 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.3 1.4 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.3 16.1 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.3 1.6 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.3 8.6 GO:0006513 protein monoubiquitination(GO:0006513)
0.3 1.8 GO:0009146 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.3 0.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.3 1.5 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.3 2.3 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.3 8.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.2 4.2 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.2 4.8 GO:0097178 ruffle assembly(GO:0097178)
0.2 1.4 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 2.7 GO:0050684 regulation of mRNA processing(GO:0050684)
0.2 6.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 5.7 GO:0016925 protein sumoylation(GO:0016925)
0.2 1.3 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.2 8.6 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.2 12.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 5.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 1.3 GO:0046546 development of primary male sexual characteristics(GO:0046546)
0.2 4.4 GO:0007286 spermatid development(GO:0007286)
0.1 5.0 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.1 2.3 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1 1.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 2.4 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 4.1 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 1.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 2.7 GO:0007634 optokinetic behavior(GO:0007634)
0.1 3.4 GO:0001878 response to yeast(GO:0001878)
0.1 1.4 GO:0009791 post-embryonic development(GO:0009791)
0.1 2.3 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 0.7 GO:0016574 histone ubiquitination(GO:0016574)
0.1 1.6 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 5.5 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.1 2.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 3.4 GO:0046847 filopodium assembly(GO:0046847)
0.1 1.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 0.2 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.4 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 4.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 0.4 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 2.4 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 1.3 GO:0006298 mismatch repair(GO:0006298)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 5.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 4.4 GO:0006310 DNA recombination(GO:0006310)
0.1 2.2 GO:0048538 thymus development(GO:0048538)
0.1 1.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.2 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 0.8 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902253)
0.1 0.6 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 4.5 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 3.2 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.1 0.2 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 0.9 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 0.2 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 3.3 GO:0048484 enteric nervous system development(GO:0048484)
0.1 0.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 4.4 GO:0031929 TOR signaling(GO:0031929)
0.0 0.5 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.9 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.6 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.9 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 5.7 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 5.5 GO:0001947 heart looping(GO:0001947)
0.0 1.5 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 1.1 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 3.1 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:0009749 response to glucose(GO:0009749)
0.0 1.7 GO:0006414 translational elongation(GO:0006414)
0.0 3.5 GO:0016458 gene silencing(GO:0016458)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 1.8 GO:0048916 posterior lateral line development(GO:0048916)
0.0 2.0 GO:0007051 spindle organization(GO:0007051)
0.0 2.7 GO:0006281 DNA repair(GO:0006281)
0.0 6.3 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 1.6 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 1.1 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.0 3.2 GO:0006814 sodium ion transport(GO:0006814)
0.0 3.9 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 5.3 GO:0008380 RNA splicing(GO:0008380)
0.0 0.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 2.9 GO:0032259 methylation(GO:0032259)
0.0 1.9 GO:1903507 negative regulation of transcription, DNA-templated(GO:0045892) negative regulation of RNA biosynthetic process(GO:1902679) negative regulation of nucleic acid-templated transcription(GO:1903507)
0.0 0.3 GO:0031638 zymogen activation(GO:0031638)
0.0 3.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 1.9 GO:0040008 regulation of growth(GO:0040008)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0032301 MutSalpha complex(GO:0032301)
4.0 11.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
3.0 9.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
2.7 13.4 GO:0005662 DNA replication factor A complex(GO:0005662)
2.3 6.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.3 41.0 GO:0042555 MCM complex(GO:0042555)
2.2 8.9 GO:0033186 CAF-1 complex(GO:0033186)
2.1 8.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.4 7.2 GO:0000811 GINS complex(GO:0000811)
1.4 4.1 GO:1990077 primosome complex(GO:1990077)
1.4 9.5 GO:0032300 mismatch repair complex(GO:0032300)
1.1 8.0 GO:0035101 FACT complex(GO:0035101)
1.0 7.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
1.0 11.9 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.9 6.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.9 5.3 GO:0030870 Mre11 complex(GO:0030870)
0.8 3.2 GO:0061702 inflammasome complex(GO:0061702)
0.8 4.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.8 6.4 GO:0033061 DNA recombinase mediator complex(GO:0033061)
0.7 3.5 GO:0005879 axonemal microtubule(GO:0005879)
0.7 4.7 GO:0005663 DNA replication factor C complex(GO:0005663)
0.6 6.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.6 2.4 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.5 2.6 GO:0018444 translation release factor complex(GO:0018444)
0.5 2.4 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 12.2 GO:0035861 site of double-strand break(GO:0035861)
0.5 6.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 3.2 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.5 2.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.4 1.3 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.4 9.4 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.3 2.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.3 3.0 GO:0000792 heterochromatin(GO:0000792)
0.3 1.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.3 1.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 1.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 2.2 GO:0000243 commitment complex(GO:0000243)
0.2 2.0 GO:0000812 Swr1 complex(GO:0000812)
0.2 4.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.2 2.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 2.7 GO:0043596 nuclear replication fork(GO:0043596)
0.2 3.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 5.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 1.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 5.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 3.1 GO:0000795 synaptonemal complex(GO:0000795)
0.1 1.7 GO:0097346 INO80-type complex(GO:0097346)
0.1 1.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 15.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 8.0 GO:0005581 collagen trimer(GO:0005581)
0.1 10.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.7 GO:0015030 Cajal body(GO:0015030)
0.1 4.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 10.0 GO:0005604 basement membrane(GO:0005604)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 3.9 GO:0005694 chromosome(GO:0005694)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.1 3.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.0 GO:1990391 DNA repair complex(GO:1990391)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 1.0 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.2 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.6 GO:0030686 90S preribosome(GO:0030686)
0.1 1.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 2.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 8.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0032039 integrator complex(GO:0032039)
0.0 6.1 GO:0016604 nuclear body(GO:0016604)
0.0 24.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.3 GO:0005769 early endosome(GO:0005769)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0030663 COPI vesicle coat(GO:0030126) COPI-coated vesicle membrane(GO:0030663)
0.0 123.6 GO:0005634 nucleus(GO:0005634)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 2.8 GO:0005813 centrosome(GO:0005813)
0.0 17.3 GO:0005829 cytosol(GO:0005829)
0.0 5.2 GO:0019866 organelle inner membrane(GO:0019866)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.4 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
4.2 12.7 GO:0032143 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
3.6 3.6 GO:0032135 DNA insertion or deletion binding(GO:0032135)
3.1 22.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.0 9.1 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
2.5 7.4 GO:0071532 ankyrin repeat binding(GO:0071532)
1.7 6.8 GO:0070182 DNA polymerase binding(GO:0070182)
1.7 8.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
1.7 8.3 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
1.6 9.7 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
1.5 4.5 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
1.2 21.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.9 2.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.8 5.9 GO:0030983 mismatched DNA binding(GO:0030983)
0.8 6.7 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.8 10.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 2.1 GO:0000150 recombinase activity(GO:0000150)
0.7 2.6 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.6 8.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.6 2.4 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.6 5.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.6 12.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 5.2 GO:0030332 cyclin binding(GO:0030332)
0.5 2.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.5 4.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.5 4.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 3.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.4 18.3 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.4 1.3 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.4 7.4 GO:0008301 DNA binding, bending(GO:0008301)
0.4 1.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.4 2.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 12.8 GO:0003684 damaged DNA binding(GO:0003684)
0.4 4.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.4 4.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.3 9.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 3.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 3.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.3 2.3 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.3 1.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.3 1.8 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.3 2.6 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 1.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.3 3.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.3 4.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.3 2.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 2.7 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 1.9 GO:0048019 receptor antagonist activity(GO:0048019)
0.2 3.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.2 3.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 3.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 1.5 GO:0035173 histone kinase activity(GO:0035173)
0.2 8.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 1.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 5.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 9.0 GO:0031491 nucleosome binding(GO:0031491)
0.2 1.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 7.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.7 GO:0005522 profilin binding(GO:0005522)
0.2 0.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 4.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 7.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 13.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 5.9 GO:0019003 GDP binding(GO:0019003)
0.1 1.7 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 1.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 3.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 8.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 3.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.6 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 1.3 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.1 17.7 GO:0042393 histone binding(GO:0042393)
0.1 1.6 GO:0030515 snoRNA binding(GO:0030515)
0.1 10.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 2.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.0 GO:0005243 gap junction channel activity(GO:0005243)
0.1 11.2 GO:0003682 chromatin binding(GO:0003682)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.1 GO:0017069 snRNA binding(GO:0017069)
0.1 4.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 5.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.1 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 4.6 GO:0016209 antioxidant activity(GO:0016209)
0.0 23.9 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 4.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.9 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 2.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 2.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 1.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 2.8 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.3 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 6.8 GO:0051015 actin filament binding(GO:0051015)
0.0 10.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.3 GO:0042802 identical protein binding(GO:0042802)
0.0 1.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.9 GO:0008168 methyltransferase activity(GO:0008168)
0.0 3.4 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 10.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.7 59.3 PID E2F PATHWAY E2F transcription factor network
0.7 7.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 25.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 3.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 17.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 4.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 5.1 PID ATR PATHWAY ATR signaling pathway
0.2 3.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 1.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 2.7 PID IL5 PATHWAY IL5-mediated signaling events
0.2 6.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 2.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.2 ST STAT3 PATHWAY STAT3 Pathway
0.1 11.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 7.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 4.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.2 PID REELIN PATHWAY Reelin signaling pathway
0.1 2.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.9 PID P53 REGULATION PATHWAY p53 pathway
0.1 0.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.1 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 6.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 42.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.7 20.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.3 12.1 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.2 28.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 4.1 REACTOME POL SWITCHING Genes involved in Polymerase switching
1.0 13.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
1.0 11.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.0 9.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.9 6.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.7 7.9 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.6 3.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 2.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.6 2.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 5.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.4 6.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.4 6.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.4 4.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3 3.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 5.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.3 4.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 2.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 1.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 11.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.2 1.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 8.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 5.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation