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PRJEB1986: zebrafish developmental stages transcriptome

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Results for e2f2_e2f5

Z-value: 4.47

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Transcription factors associated with e2f2_e2f5

Gene Symbol Gene ID Gene Info
e2f2
ENSDARG00000079233 si_ch211-160f23.5
e2f5
ENSDARG00000038812 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F2dr11_v1_chr17_-_27266053_272660530.939.7e-09Click!
e2f5dr11_v1_chr2_-_31686353_316864030.145.7e-01Click!

Activity profile of e2f2_e2f5 motif

Sorted Z-values of e2f2_e2f5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_39344889 20.76 ENSDART00000009164
esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr20_+_34770197 20.18 ENSDART00000018304
mcm3
minichromosome maintenance complex component 3
chr19_-_47571797 19.18 ENSDART00000166180
ENSDART00000168134
rrm2
ribonucleotide reductase M2 polypeptide
chr13_+_8255106 16.79 ENSDART00000080465
hells
helicase, lymphoid specific
chr9_-_2892250 15.73 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr3_-_54607166 15.62 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr22_-_4439311 12.94 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr11_-_11792766 12.83 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr24_-_35561672 11.99 ENSDART00000058564
mcm4
minichromosome maintenance complex component 4
chr4_-_2545310 11.87 ENSDART00000150619
ENSDART00000140760
e2f7
E2F transcription factor 7
chr2_-_29923403 11.77 ENSDART00000144672
paxip1
PAX interacting (with transcription-activation domain) protein 1
chr3_+_25999477 11.57 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr12_+_9499993 11.39 ENSDART00000135871
dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr2_-_37837056 11.27 ENSDART00000158179
ENSDART00000160317
ENSDART00000171409
mettl17
methyltransferase like 17
chr7_+_55518519 10.85 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr24_+_11908480 10.80 ENSDART00000024224
fen1
flap structure-specific endonuclease 1
chr13_-_13030851 10.79 ENSDART00000009499
nsd2
nuclear receptor binding SET domain protein 2
chr25_-_35095129 10.76 ENSDART00000099866
ENSDART00000099868
kif15
kinesin family member 15
chr23_+_31815423 10.43 ENSDART00000075730
ENSDART00000075726
myb
v-myb avian myeloblastosis viral oncogene homolog
chr2_-_29923630 10.43 ENSDART00000158844
ENSDART00000031130
paxip1
PAX interacting (with transcription-activation domain) protein 1
chr19_-_29294457 10.39 ENSDART00000130815
ENSDART00000103437
e2f3
E2F transcription factor 3
chr3_+_26244353 10.17 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr24_+_11908833 10.02 ENSDART00000178622
fen1
flap structure-specific endonuclease 1
chr20_-_29499363 9.87 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
rrm2
ribonucleotide reductase M2 polypeptide
chr24_+_23840821 9.49 ENSDART00000128595
ENSDART00000127188
pola1
polymerase (DNA directed), alpha 1
chr8_-_4760723 9.48 ENSDART00000064201
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr2_+_37836821 9.43 ENSDART00000143203
parp2
poly (ADP-ribose) polymerase 2
chr1_+_19538299 9.37 ENSDART00000109416
smc2
structural maintenance of chromosomes 2
chr12_+_9499742 9.27 ENSDART00000044150
ENSDART00000136354
dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr7_+_34236238 9.12 ENSDART00000052474
tipin
timeless interacting protein
chr21_+_22558187 9.09 ENSDART00000167599
chek1
checkpoint kinase 1
chr7_-_6464225 9.04 ENSDART00000130760
hist1h2a4
histone cluster 1 H2A family member 4
chr22_-_3152357 9.02 ENSDART00000170983
lmnb2
lamin B2
chr17_+_8799451 8.86 ENSDART00000189814
ENSDART00000191577
tonsl
tonsoku-like, DNA repair protein
chr18_-_16924221 8.71 ENSDART00000122102
wee1
WEE1 G2 checkpoint kinase
chr6_+_33931740 8.61 ENSDART00000130492
ENSDART00000151213
orc1
origin recognition complex, subunit 1
chr9_+_22780901 8.60 ENSDART00000110992
ENSDART00000143972
rif1
replication timing regulatory factor 1
chr2_+_38055529 8.50 ENSDART00000145642
si:rp71-1g18.1
si:rp71-1g18.1
chr6_+_12968101 8.46 ENSDART00000013781
mcm6
minichromosome maintenance complex component 6
chr19_-_10214264 8.39 ENSDART00000053300
ENSDART00000148225
znf865
zinc finger protein 865
chr6_+_7533601 8.34 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr3_-_50046004 8.33 ENSDART00000109544
si:ch1073-100f3.2
si:ch1073-100f3.2
chr19_-_47571456 8.20 ENSDART00000158071
ENSDART00000165841
rrm2
ribonucleotide reductase M2 polypeptide
chr19_+_48060464 8.06 ENSDART00000123163
zgc:85936
zgc:85936
chr17_+_8799661 8.06 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr5_+_12743640 7.99 ENSDART00000081411
pole
polymerase (DNA directed), epsilon
chr9_-_2892045 7.93 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr7_+_24023653 7.78 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr7_+_41812636 7.71 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr6_-_34838397 7.60 ENSDART00000060169
ENSDART00000169605
mier1a
mesoderm induction early response 1a, transcriptional regulator
chr21_-_26490186 7.48 ENSDART00000009889
zgc:110540
zgc:110540
chr1_+_29858032 7.35 ENSDART00000054066
zic2b
zic family member 2 (odd-paired homolog, Drosophila) b
chr2_-_38363017 7.28 ENSDART00000088026
prmt5
protein arginine methyltransferase 5
chr1_-_8553165 7.11 ENSDART00000135197
ENSDART00000054981
zgc:112980
zgc:112980
chr3_+_22335030 7.07 ENSDART00000055676
zgc:103564
zgc:103564
chr7_+_41812817 7.05 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr3_-_26244256 7.01 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr12_-_33817114 7.01 ENSDART00000161265
twnk
twinkle mtDNA helicase
chr11_-_309420 6.95 ENSDART00000173185
poc1a
POC1 centriolar protein A
chr4_+_18441988 6.92 ENSDART00000040827
ncaph2
non-SMC condensin II complex, subunit H2
chr5_+_34549365 6.88 ENSDART00000009500
aif1l
allograft inflammatory factor 1-like
chr6_-_51573975 6.77 ENSDART00000073865
rbl1
retinoblastoma-like 1 (p107)
chr20_-_29498178 6.70 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr8_-_40327397 6.70 ENSDART00000074125
aplnra
apelin receptor a
chr20_-_38827623 6.68 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr25_+_36327034 6.64 ENSDART00000073452
zgc:110216
zgc:110216
chr16_+_41015163 6.61 ENSDART00000058586
dek
DEK proto-oncogene
chr8_+_52415603 6.56 ENSDART00000021604
ENSDART00000191424
gins4
GINS complex subunit 4 (Sld5 homolog)
chr1_-_59313465 6.52 ENSDART00000158067
ENSDART00000159419
txndc11
thioredoxin domain containing 11
chr19_+_9455218 6.30 ENSDART00000139385
si:ch211-288g17.3
si:ch211-288g17.3
chr15_-_26538989 6.28 ENSDART00000032880
rpa1
replication protein A1
chr17_+_4325693 6.22 ENSDART00000154264
mcm8
minichromosome maintenance 8 homologous recombination repair factor
chr2_+_21000334 6.19 ENSDART00000062563
ENSDART00000147809
rreb1b
ras responsive element binding protein 1b
chr3_-_35865040 6.16 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr19_-_2822372 6.16 ENSDART00000109130
ENSDART00000122385
recql4
RecQ helicase-like 4
chr22_+_1930589 5.97 ENSDART00000159807
znf1153
zinc finger protein 1153
chr4_+_69888328 5.97 ENSDART00000170163
si:ch211-145h19.5
si:ch211-145h19.5
chr2_+_44512324 5.92 ENSDART00000155017
ENSDART00000156310
ENSDART00000156686
pask
PAS domain containing serine/threonine kinase
chr5_+_34549845 5.92 ENSDART00000139317
aif1l
allograft inflammatory factor 1-like
chr6_-_33931696 5.84 ENSDART00000057290
prpf38a
pre-mRNA processing factor 38A
chr23_-_18913032 5.73 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr7_+_41812190 5.68 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr20_-_23440955 5.60 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr25_-_13403726 5.59 ENSDART00000056723
gins3
GINS complex subunit 3
chr16_-_43335914 5.57 ENSDART00000111963
atad2
ATPase family, AAA domain containing 2
chr17_-_27266053 5.55 ENSDART00000110903
E2F2
si:ch211-160f23.5
chr7_+_71586485 5.54 ENSDART00000165582
smchd1
structural maintenance of chromosomes flexible hinge domain containing 1
chr6_+_32046202 5.54 ENSDART00000156552
si:dkey-148h10.5
si:dkey-148h10.5
chr20_-_9199721 5.52 ENSDART00000064140
ylpm1
YLP motif containing 1
chr14_-_15956657 5.45 ENSDART00000169197
flt4
fms-related tyrosine kinase 4
chr16_+_40575742 5.42 ENSDART00000161503
ccne2
cyclin E2
chr5_+_23136544 5.39 ENSDART00000003428
ENSDART00000109340
ENSDART00000171039
ENSDART00000178821
prps1a
phosphoribosyl pyrophosphate synthetase 1A
chr20_+_43648369 5.31 ENSDART00000187930
ENSDART00000017269
parp1
poly (ADP-ribose) polymerase 1
chr24_-_21258945 5.19 ENSDART00000111025
boc
BOC cell adhesion associated, oncogene regulated
chr4_+_70556298 5.13 ENSDART00000170985
si:dkey-11d20.1
si:dkey-11d20.1
chr21_-_27413294 5.12 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr2_+_37837249 5.10 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr12_+_9183626 5.04 ENSDART00000020192
tubgcp2
tubulin, gamma complex associated protein 2
chr5_-_72324371 4.99 ENSDART00000006380
tbx3a
T-box 3a
chr23_+_43950674 4.97 ENSDART00000167813
corin
corin, serine peptidase
chr16_-_21140097 4.96 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
si:dkey-271j15.3
chr19_-_20199167 4.88 ENSDART00000155527
si:ch211-155k24.9
si:ch211-155k24.9
chr19_-_14191592 4.86 ENSDART00000164594
tbxta
T-box transcription factor Ta
chr12_+_35650321 4.86 ENSDART00000190446
BX255898.1

chr10_+_21434649 4.86 ENSDART00000193938
ENSDART00000064558
etf1b
eukaryotic translation termination factor 1b
chr3_+_37112693 4.84 ENSDART00000055228
ENSDART00000144278
ENSDART00000138079
psmc3ip
PSMC3 interacting protein
chr7_-_40657831 4.78 ENSDART00000084153
nom1
nucleolar protein with MIF4G domain 1
chr8_+_10304981 4.77 ENSDART00000160766
pim1
Pim-1 proto-oncogene, serine/threonine kinase
chr2_-_44344321 4.68 ENSDART00000084174
lig1
ligase I, DNA, ATP-dependent
chr7_+_1550966 4.65 ENSDART00000177863
ENSDART00000126840
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit
chr17_-_22573311 4.62 ENSDART00000141523
ENSDART00000140022
ENSDART00000079390
ENSDART00000188644
exo1
exonuclease 1
chr20_+_41801913 4.61 ENSDART00000139805
mcm9
minichromosome maintenance 9 homologous recombination repair factor
chr19_-_20777351 4.60 ENSDART00000019206
ngly1
N-glycanase 1
chr23_-_17003533 4.58 ENSDART00000080545
dnmt3bb.2
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr19_-_31007417 4.49 ENSDART00000048144
rbbp4
retinoblastoma binding protein 4
chr23_-_45339439 4.47 ENSDART00000148726
ccdc171
coiled-coil domain containing 171
chr24_-_37338739 4.45 ENSDART00000146844
tsr3
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
chr2_-_44777592 4.45 ENSDART00000113351
ENSDART00000169310
ncapd2
non-SMC condensin I complex, subunit D2
chr4_-_9909371 4.43 ENSDART00000102656
si:dkey-22l11.6
si:dkey-22l11.6
chr5_-_19014589 4.36 ENSDART00000002624
ranbp1
RAN binding protein 1
chr20_-_29633507 4.35 ENSDART00000040292
cpsf3
cleavage and polyadenylation specific factor 3
chr22_-_7006974 4.29 ENSDART00000133143
gpd1b
glycerol-3-phosphate dehydrogenase 1b
chr15_-_14884332 4.28 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr10_+_33588715 4.16 ENSDART00000051198
mis18a
MIS18 kinetochore protein A
chr1_-_42289704 4.13 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr8_-_25761544 4.05 ENSDART00000078152
suv39h1b
suppressor of variegation 3-9 homolog 1b
chr13_+_9612395 4.04 ENSDART00000136689
ENSDART00000138362
slf2
SMC5-SMC6 complex localization factor 2
chr13_-_35908275 4.04 ENSDART00000013961
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr25_-_32363341 4.03 ENSDART00000153892
ENSDART00000114385
cep152
centrosomal protein 152
chr9_+_29671553 3.99 ENSDART00000015377
rnaseh2b
ribonuclease H2, subunit B
chr4_-_5831522 3.88 ENSDART00000008898
foxm1
forkhead box M1
chr5_+_29159777 3.88 ENSDART00000174702
ENSDART00000037891
dpp7
dipeptidyl-peptidase 7
chr7_+_26534131 3.88 ENSDART00000173980
si:dkey-62k3.5
si:dkey-62k3.5
chr5_-_54395488 3.83 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr6_-_1762191 3.82 ENSDART00000167928
orc4
origin recognition complex, subunit 4
chr5_+_22969651 3.75 ENSDART00000089992
ENSDART00000145477
hmgn7
high mobility group nucleosomal binding domain 7
chr22_-_5822147 3.72 ENSDART00000011076
cers5
ceramide synthase 5
chr19_-_2582858 3.68 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr2_-_37837472 3.67 ENSDART00000165347
mettl17
methyltransferase like 17
chr18_-_20532339 3.66 ENSDART00000060291
ighmbp2
immunoglobulin mu binding protein 2
chr7_+_40884012 3.58 ENSDART00000149395
shha
sonic hedgehog a
chr11_+_18216404 3.58 ENSDART00000086437
tmcc1b
transmembrane and coiled-coil domain family 1b
chr14_-_30918662 3.58 ENSDART00000176631
si:ch211-126c2.4
si:ch211-126c2.4
chr12_-_3962372 3.53 ENSDART00000016791
eif3c
eukaryotic translation initiation factor 3, subunit C
chr15_-_23784600 3.51 ENSDART00000059354
rad1
RAD1 homolog (S. pombe)
chr10_-_21362071 3.51 ENSDART00000125167
avd
avidin
chr7_+_24814866 3.47 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr24_+_17345521 3.41 ENSDART00000024722
ENSDART00000154250
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr1_-_20068155 3.38 ENSDART00000102993
mettl14
methyltransferase like 14
chr21_+_30721733 3.35 ENSDART00000040443
zgc:110224
zgc:110224
chr9_+_28232522 3.34 ENSDART00000031761
fzd5
frizzled class receptor 5
chr12_+_17927871 3.32 ENSDART00000172062
trrap
transformation/transcription domain-associated protein
chr7_+_71535045 3.30 ENSDART00000047069
tyms
thymidylate synthetase
chr1_+_26677406 3.30 ENSDART00000183427
ENSDART00000180366
ENSDART00000181997
si:dkey-25o16.4
si:dkey-25o16.4
chr2_-_47957673 3.28 ENSDART00000056305
fzd8b
frizzled class receptor 8b
chr13_+_48358467 3.27 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr5_+_61475451 3.18 ENSDART00000163444
lrwd1
leucine-rich repeats and WD repeat domain containing 1
chr25_-_12824656 3.17 ENSDART00000171801
uba2
ubiquitin-like modifier activating enzyme 2
chr19_+_25465025 3.17 ENSDART00000018553
rpa3
replication protein A3
chr1_-_54622227 3.10 ENSDART00000049010
tekt4
tektin 4
chr7_-_7797654 3.07 ENSDART00000084503
ENSDART00000192779
ENSDART00000173079
trmt10b
tRNA methyltransferase 10B
chr1_+_9199031 3.05 ENSDART00000092058
ENSDART00000182771
chtf18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr18_+_41561285 3.04 ENSDART00000169621
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr13_+_12606821 2.99 ENSDART00000140096
ENSDART00000145136
metap1
methionyl aminopeptidase 1
chr14_+_22129096 2.97 ENSDART00000132514
ccng1
cyclin G1
chr25_-_35140746 2.94 ENSDART00000129969
si:ch211-113a14.19
si:ch211-113a14.19
chr22_+_2819613 2.93 ENSDART00000131234
si:dkey-20i20.3
si:dkey-20i20.3
chr17_-_29224908 2.92 ENSDART00000156288
si:dkey-28g23.6
si:dkey-28g23.6
chr25_-_34740627 2.91 ENSDART00000137665
frs2b
fibroblast growth factor receptor substrate 2b
chr16_+_28728347 2.91 ENSDART00000149240
si:dkey-24i24.3
si:dkey-24i24.3
chr3_+_53116172 2.89 ENSDART00000115117
brd4
bromodomain containing 4
chr18_-_30499489 2.85 ENSDART00000033746
gins2
GINS complex subunit 2
chr13_-_36844945 2.80 ENSDART00000129562
ENSDART00000150899
nin
ninein (GSK3B interacting protein)
chr24_-_38657683 2.80 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr22_-_20419660 2.79 ENSDART00000105520
pias4a
protein inhibitor of activated STAT, 4a
chr1_+_26676758 2.79 ENSDART00000152299
si:dkey-25o16.4
si:dkey-25o16.4
chr21_-_23017478 2.79 ENSDART00000024309
rb1
retinoblastoma 1
chr1_-_59216197 2.78 ENSDART00000062426
lpar2b
lysophosphatidic acid receptor 2b
chr15_+_23784842 2.76 ENSDART00000192889
ENSDART00000138375
ift20
intraflagellar transport 20 homolog (Chlamydomonas)
chr9_-_30576522 2.76 ENSDART00000101085
morc3a
MORC family CW-type zinc finger 3a
chr24_-_41478917 2.76 ENSDART00000192192
CABZ01084131.1

chr17_-_49407091 2.76 ENSDART00000021950
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr16_+_7154266 2.73 ENSDART00000168830
bmper
BMP binding endothelial regulator
chr8_+_30112655 2.72 ENSDART00000099027
fancc
Fanconi anemia, complementation group C
chr4_+_77933084 2.70 ENSDART00000148728
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr22_+_1940595 2.69 ENSDART00000163506
znf1167
zinc finger protein 1167
chr6_+_52242139 2.69 ENSDART00000041549
zc3h10
zinc finger CCCH-type containing 10
chr13_-_35907768 2.68 ENSDART00000147522
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr5_-_58832332 2.65 ENSDART00000161230
arhgef12b
Rho guanine nucleotide exchange factor (GEF) 12b
chr15_-_1584137 2.64 ENSDART00000056772
trim59
tripartite motif containing 59
chr21_-_19915757 2.62 ENSDART00000164317
eri1
exoribonuclease 1
chr13_+_5013572 2.59 ENSDART00000162425
psap
prosaposin
chr14_+_24241241 2.57 ENSDART00000022377
nkx2.5
NK2 homeobox 5
chr9_+_35014728 2.56 ENSDART00000100700
gabpa
GA binding protein transcription factor, alpha subunit
chr20_-_54245256 2.55 ENSDART00000170482
prpf39
PRP39 pre-mRNA processing factor 39 homolog (yeast)
chr25_+_36339867 2.54 ENSDART00000152195
si:ch211-113a14.18
si:ch211-113a14.18
chr25_+_35062353 2.53 ENSDART00000089844
zgc:113983
zgc:113983
chr16_+_41015781 2.51 ENSDART00000124543
dek
DEK proto-oncogene
chr5_+_24179307 2.51 ENSDART00000051552
mpdu1a
mannose-P-dolichol utilization defect 1a
chr22_+_1947494 2.49 ENSDART00000159121
si:dkey-15h8.15
si:dkey-15h8.15

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f2_e2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0034421 post-translational protein acetylation(GO:0034421)
6.8 47.3 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
4.5 45.3 GO:0044030 regulation of DNA methylation(GO:0044030)
4.3 47.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
3.6 25.5 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
3.6 10.8 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
3.4 43.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
3.0 41.4 GO:0000076 DNA replication checkpoint(GO:0000076)
2.8 11.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
2.7 8.0 GO:0006272 leading strand elongation(GO:0006272)
2.4 7.3 GO:0034969 histone arginine methylation(GO:0034969)
2.4 11.9 GO:0032877 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
2.2 6.7 GO:0021563 glossopharyngeal nerve development(GO:0021563)
1.9 24.3 GO:0006270 DNA replication initiation(GO:0006270)
1.7 10.4 GO:0030852 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
1.7 6.7 GO:1903589 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
1.7 8.3 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
1.7 19.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.6 9.7 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.5 1.5 GO:0043111 replication fork arrest(GO:0043111)
1.4 12.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.3 5.4 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.3 10.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.2 6.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.2 4.9 GO:0072045 convergent extension involved in nephron morphogenesis(GO:0072045)
1.1 4.6 GO:0032776 DNA methylation on cytosine(GO:0032776)
1.1 3.4 GO:0070734 histone H3-K27 methylation(GO:0070734)
1.1 3.3 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
1.1 5.5 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
1.1 4.3 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
1.1 7.4 GO:0033278 cell proliferation in midbrain(GO:0033278)
1.0 20.5 GO:0031297 replication fork processing(GO:0031297)
1.0 4.0 GO:0098535 de novo centriole assembly(GO:0098535)
1.0 7.0 GO:0006264 mitochondrial DNA replication(GO:0006264)
1.0 5.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.0 4.9 GO:0002184 cytoplasmic translational termination(GO:0002184)
1.0 2.9 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.9 6.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.9 3.6 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.9 4.4 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.9 2.6 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.9 5.1 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.8 2.5 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.8 3.2 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.8 13.3 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.7 3.0 GO:0070084 protein initiator methionine removal(GO:0070084)
0.7 4.4 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.7 5.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.7 2.8 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.7 2.8 GO:2000583 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.7 3.4 GO:0060019 radial glial cell differentiation(GO:0060019)
0.7 3.4 GO:0000012 single strand break repair(GO:0000012)
0.7 25.4 GO:0048538 thymus development(GO:0048538)
0.6 12.8 GO:0097178 ruffle assembly(GO:0097178)
0.6 10.8 GO:0032508 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.6 1.9 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.6 2.5 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.6 3.1 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.6 2.3 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.6 2.8 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.5 7.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 2.2 GO:0040016 embryonic cleavage(GO:0040016)
0.5 2.1 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.5 4.7 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.5 10.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.5 3.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.5 4.6 GO:0006517 protein deglycosylation(GO:0006517)
0.5 9.6 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.4 9.4 GO:0030261 chromosome condensation(GO:0030261)
0.4 2.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 7.3 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.4 1.9 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.4 2.9 GO:0051673 membrane disruption in other organism(GO:0051673)
0.4 1.4 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.4 1.4 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.4 3.9 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.3 0.7 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.3 1.6 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.3 1.9 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 1.8 GO:0021634 optic nerve formation(GO:0021634)
0.3 1.2 GO:0002568 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) immunoglobulin V(D)J recombination(GO:0033152) T cell receptor V(D)J recombination(GO:0033153)
0.3 5.6 GO:0006298 mismatch repair(GO:0006298)
0.3 2.7 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.3 7.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 9.1 GO:2000779 regulation of double-strand break repair(GO:2000779)
0.3 8.6 GO:0000723 telomere maintenance(GO:0000723) telomere organization(GO:0032200)
0.3 2.3 GO:0006167 AMP biosynthetic process(GO:0006167)
0.3 1.5 GO:0060969 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967) negative regulation of gene silencing(GO:0060969) 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 5.4 GO:0016925 protein sumoylation(GO:0016925)
0.2 1.4 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.2 3.1 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.2 0.2 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.2 5.0 GO:0007020 microtubule nucleation(GO:0007020)
0.2 7.9 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.2 1.5 GO:0014004 microglia differentiation(GO:0014004)
0.2 0.6 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.2 8.7 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.2 1.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 1.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 2.0 GO:0019985 translesion synthesis(GO:0019985)
0.2 2.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 4.8 GO:0007634 optokinetic behavior(GO:0007634)
0.2 1.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 3.5 GO:0000077 DNA damage checkpoint(GO:0000077)
0.2 8.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 2.2 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2 1.2 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 3.5 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.2 4.3 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.2 2.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 2.4 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.2 29.3 GO:0006281 DNA repair(GO:0006281)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 8.3 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.1 1.2 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.1 0.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) negative regulation of metaphase/anaphase transition of cell cycle(GO:1902100) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.1 2.0 GO:0048641 regulation of skeletal muscle tissue development(GO:0048641)
0.1 10.4 GO:0031497 chromatin assembly(GO:0031497)
0.1 3.3 GO:0007286 spermatid development(GO:0007286)
0.1 7.6 GO:0016575 histone deacetylation(GO:0016575)
0.1 3.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.9 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 1.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.3 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 3.0 GO:0043049 otic placode formation(GO:0043049)
0.1 2.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 5.9 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 0.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 4.1 GO:0034968 histone lysine methylation(GO:0034968)
0.1 0.9 GO:0021592 fourth ventricle development(GO:0021592)
0.1 12.3 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 3.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 1.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 2.0 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.1 1.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 13.4 GO:0032259 methylation(GO:0032259)
0.1 2.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.6 GO:0046847 filopodium assembly(GO:0046847)
0.1 1.7 GO:0032543 mitochondrial translation(GO:0032543)
0.1 4.8 GO:0006413 translational initiation(GO:0006413)
0.1 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.5 GO:0051601 exocyst localization(GO:0051601)
0.1 15.8 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 1.8 GO:0060972 left/right pattern formation(GO:0060972)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 1.2 GO:0060997 dendritic spine morphogenesis(GO:0060997) dendritic spine organization(GO:0097061)
0.0 4.0 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.8 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 2.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 4.6 GO:0006401 RNA catabolic process(GO:0006401)
0.0 2.3 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 2.0 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 2.5 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 2.6 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.2 GO:1901571 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571) arachidonate transport(GO:1903963)
0.0 2.1 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.7 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.2 GO:0016441 posttranscriptional gene silencing(GO:0016441) posttranscriptional gene silencing by RNA(GO:0035194)
0.0 0.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:1905207 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.0 1.9 GO:0006417 regulation of translation(GO:0006417)
0.0 1.6 GO:0031929 TOR signaling(GO:0031929)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.3 GO:0045786 negative regulation of cell cycle(GO:0045786)
0.0 2.9 GO:0050770 regulation of axonogenesis(GO:0050770)
0.0 2.1 GO:0001947 heart looping(GO:0001947)
0.0 1.1 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 1.3 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 2.1 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.7 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 84.5 GO:0042555 MCM complex(GO:0042555)
3.5 24.5 GO:0031261 DNA replication preinitiation complex(GO:0031261)
3.3 36.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
2.4 12.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
2.1 6.2 GO:0098536 deuterosome(GO:0098536)
2.0 8.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.9 9.4 GO:0005662 DNA replication factor A complex(GO:0005662)
1.8 9.1 GO:0031298 replication fork protection complex(GO:0031298)
1.7 6.8 GO:0033186 CAF-1 complex(GO:0033186)
1.7 5.0 GO:0008275 gamma-tubulin small complex(GO:0008275)
1.4 5.4 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
1.3 5.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
1.2 3.5 GO:0030896 checkpoint clamp complex(GO:0030896)
1.1 3.3 GO:0032301 MutSalpha complex(GO:0032301)
1.0 4.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.0 4.9 GO:0018444 translation release factor complex(GO:0018444)
0.9 12.9 GO:0000792 heterochromatin(GO:0000792)
0.9 6.9 GO:0000796 condensin complex(GO:0000796)
0.8 3.4 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.8 3.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.7 4.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 4.7 GO:0035101 FACT complex(GO:0035101)
0.6 5.8 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.6 1.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.6 2.5 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.6 7.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 2.1 GO:0016600 flotillin complex(GO:0016600)
0.5 7.8 GO:0070187 telosome(GO:0070187)
0.5 2.4 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.4 8.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.4 2.1 GO:0005879 axonemal microtubule(GO:0005879)
0.4 2.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.4 16.2 GO:0032587 ruffle membrane(GO:0032587)
0.4 3.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 2.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.3 2.3 GO:1990130 Iml1 complex(GO:1990130)
0.3 2.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.3 1.5 GO:0030870 Mre11 complex(GO:0030870)
0.3 1.1 GO:0032040 small-subunit processome(GO:0032040)
0.3 4.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3 9.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 81.1 GO:0000785 chromatin(GO:0000785)
0.2 3.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 4.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 1.5 GO:0032300 mismatch repair complex(GO:0032300)
0.2 1.1 GO:0000801 central element(GO:0000801)
0.2 2.6 GO:0000243 commitment complex(GO:0000243)
0.2 2.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 54.1 GO:0005730 nucleolus(GO:0005730)
0.2 3.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 3.5 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.2 20.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.7 GO:0015030 Cajal body(GO:0015030)
0.1 0.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 29.7 GO:0005694 chromosome(GO:0005694)
0.1 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 1.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.0 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.8 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 3.4 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.5 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 2.4 GO:0016605 PML body(GO:0016605)
0.1 13.8 GO:0005635 nuclear envelope(GO:0005635)
0.1 0.5 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.8 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 6.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.3 GO:0036126 sperm flagellum(GO:0036126)
0.1 7.4 GO:0005819 spindle(GO:0005819)
0.1 2.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 68.6 GO:0005829 cytosol(GO:0005829)
0.0 1.3 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.6 GO:0005840 ribosome(GO:0005840)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 189.4 GO:0005634 nucleus(GO:0005634)
0.0 7.0 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 24.2 GO:0005739 mitochondrion(GO:0005739)
0.0 4.2 GO:0099568 cell cortex(GO:0005938) cytoplasmic region(GO:0099568)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 43.9 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
4.4 109.8 GO:0003688 DNA replication origin binding(GO:0003688)
3.0 20.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.7 10.8 GO:0070182 DNA polymerase binding(GO:0070182)
2.4 7.3 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
2.2 6.7 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
2.0 8.0 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.7 8.3 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
1.7 19.8 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
1.6 4.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.6 4.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
1.6 20.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
1.5 4.6 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
1.5 11.9 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
1.3 5.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.3 6.7 GO:0060182 apelin receptor activity(GO:0060182)
1.3 7.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.2 4.8 GO:0032135 DNA insertion or deletion binding(GO:0032135)
1.1 3.4 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity(GO:0001734)
1.1 4.3 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
1.1 7.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.8 2.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.8 3.2 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.8 3.1 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.8 3.0 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.7 3.7 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.7 3.5 GO:0009374 biotin binding(GO:0009374)
0.7 6.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.7 4.6 GO:0035173 histone kinase activity(GO:0035173)
0.6 1.9 GO:0000150 recombinase activity(GO:0000150)
0.6 1.9 GO:0047690 aspartyltransferase activity(GO:0047690)
0.6 1.3 GO:0000217 DNA secondary structure binding(GO:0000217)
0.6 8.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 6.3 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.6 9.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.5 25.2 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.5 1.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
0.5 2.4 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.5 5.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.5 4.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.4 4.4 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.4 2.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 6.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 2.8 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.4 7.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.4 8.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 2.2 GO:0048256 flap endonuclease activity(GO:0048256)
0.4 22.1 GO:0031072 heat shock protein binding(GO:0031072)
0.4 1.4 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.3 5.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 4.3 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.3 7.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 1.2 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.3 7.1 GO:0003684 damaged DNA binding(GO:0003684)
0.3 5.0 GO:0031491 nucleosome binding(GO:0031491)
0.3 9.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 3.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 9.6 GO:0042054 histone methyltransferase activity(GO:0042054)
0.2 40.5 GO:0042393 histone binding(GO:0042393)
0.2 3.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 2.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 17.4 GO:0016407 acetyltransferase activity(GO:0016407)
0.2 2.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 4.8 GO:0000339 RNA cap binding(GO:0000339)
0.2 2.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 1.4 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 3.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.2 1.5 GO:0008494 translation activator activity(GO:0008494)
0.2 1.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 8.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.2 7.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 3.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 2.2 GO:0031386 protein tag(GO:0031386)
0.1 8.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 19.8 GO:0008168 methyltransferase activity(GO:0008168)
0.1 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 3.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.3 GO:0017069 snRNA binding(GO:0017069)
0.1 2.5 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 2.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 6.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 8.2 GO:0004519 endonuclease activity(GO:0004519)
0.1 0.3 GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.1 1.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 7.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 5.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 5.2 GO:0042802 identical protein binding(GO:0042802)
0.1 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 4.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 8.9 GO:0003682 chromatin binding(GO:0003682)
0.0 1.3 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 18.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.2 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.5 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.1 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 2.1 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.8 GO:0000049 tRNA binding(GO:0000049)
0.0 17.2 GO:0046983 protein dimerization activity(GO:0046983)
0.0 2.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 8.7 GO:0016887 ATPase activity(GO:0016887)
0.0 19.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 53.5 GO:0003677 DNA binding(GO:0003677)
0.0 7.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 3.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.0 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.7 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.0 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 17.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.9 161.3 PID E2F PATHWAY E2F transcription factor network
0.9 5.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.7 26.1 PID ATR PATHWAY ATR signaling pathway
0.6 16.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.5 17.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.4 13.8 PID AURORA B PATHWAY Aurora B signaling
0.4 15.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.4 19.8 PID CMYB PATHWAY C-MYB transcription factor network
0.3 12.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 9.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.3 3.9 PID BARD1 PATHWAY BARD1 signaling events
0.3 12.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 3.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.2 7.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 1.9 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 3.0 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.9 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 2.3 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 2.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 2.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 79.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
4.1 61.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
3.4 67.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
2.8 25.5 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
1.6 17.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.3 19.9 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.8 16.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.8 5.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.7 5.0 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.6 7.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.5 10.8 REACTOME KINESINS Genes involved in Kinesins
0.5 5.9 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.4 2.8 REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION Genes involved in E2F mediated regulation of DNA replication
0.4 6.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.3 2.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 5.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 4.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.5 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.2 6.6 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.2 1.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 2.5 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.2 5.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 12.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 3.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 4.7 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.2 5.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 6.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 2.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 4.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 4.4 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 1.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 2.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.7 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription
0.1 1.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.7 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 2.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import