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PRJEB1986: zebrafish developmental stages transcriptome

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Results for e2f3

Z-value: 0.57

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Transcription factors associated with e2f3

Gene Symbol Gene ID Gene Info
e2f3
ENSDARG00000070463 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f3dr11_v1_chr19_-_29294457_292944570.871.5e-06Click!

Activity profile of e2f3 motif

Sorted Z-values of e2f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_18913032 1.28 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr7_+_26534131 1.24 ENSDART00000173980
si:dkey-62k3.5
si:dkey-62k3.5
chr24_-_38657683 1.22 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr16_+_40575742 1.22 ENSDART00000161503
ccne2
cyclin E2
chr16_+_28728347 1.16 ENSDART00000149240
si:dkey-24i24.3
si:dkey-24i24.3
chr17_-_29224908 1.13 ENSDART00000156288
si:dkey-28g23.6
si:dkey-28g23.6
chr24_+_39108243 1.09 ENSDART00000156353
mss51
MSS51 mitochondrial translational activator
chr4_-_9909371 1.08 ENSDART00000102656
si:dkey-22l11.6
si:dkey-22l11.6
chr15_-_14884332 1.06 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr16_-_21140097 1.05 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
si:dkey-271j15.3
chr6_+_7533601 1.01 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr14_-_30918662 1.01 ENSDART00000176631
si:ch211-126c2.4
si:ch211-126c2.4
chr9_-_2892045 1.00 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr7_+_34236238 0.99 ENSDART00000052474
tipin
timeless interacting protein
chr15_-_34056733 0.98 ENSDART00000170130
ENSDART00000188272
VWDE
si:dkey-30e9.7
chr1_-_42289704 0.92 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr25_+_186583 0.91 ENSDART00000161504
pclaf
PCNA clamp associated factor
chr9_-_2892250 0.88 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr3_+_38540411 0.87 ENSDART00000154943
si:dkey-7f16.3
si:dkey-7f16.3
chr2_-_44344321 0.86 ENSDART00000084174
lig1
ligase I, DNA, ATP-dependent
chr8_+_23355484 0.85 ENSDART00000085361
ENSDART00000125729
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr20_+_26394324 0.78 ENSDART00000078093
zbtb2b
zinc finger and BTB domain containing 2b
chr17_-_32779556 0.78 ENSDART00000077459
smyd2a
SET and MYND domain containing 2a
chr14_+_22076596 0.78 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr7_+_67434677 0.73 ENSDART00000165971
ENSDART00000166702
kars
lysyl-tRNA synthetase
chr14_+_14841685 0.69 ENSDART00000158291
ENSDART00000162039
slbp
stem-loop binding protein
chr5_+_66433287 0.69 ENSDART00000170757
kntc1
kinetochore associated 1
chr19_-_10214264 0.68 ENSDART00000053300
ENSDART00000148225
znf865
zinc finger protein 865
chr21_-_26490186 0.67 ENSDART00000009889
zgc:110540
zgc:110540
chr11_-_11792766 0.65 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr21_-_21514176 0.65 ENSDART00000031205
nectin3b
nectin cell adhesion molecule 3b
chr5_+_13394543 0.62 ENSDART00000051669
ENSDART00000135921
tctn2
tectonic family member 2
chr19_+_636886 0.60 ENSDART00000149192
tert
telomerase reverse transcriptase
chr25_+_36339867 0.59 ENSDART00000152195
si:ch211-113a14.18
si:ch211-113a14.18
chr17_-_6535941 0.58 ENSDART00000109249
cenpo
centromere protein O
chr3_-_54607166 0.55 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr23_+_43950674 0.55 ENSDART00000167813
corin
corin, serine peptidase
chr10_+_17681074 0.52 ENSDART00000057500
drg1
developmentally regulated GTP binding protein 1
chr20_+_26905158 0.47 ENSDART00000138249
rwdd2b
RWD domain containing 2B
chr1_-_9980765 0.41 ENSDART00000142906
si:dkeyp-75b4.7
si:dkeyp-75b4.7
chr8_-_11988065 0.33 ENSDART00000005140
med27
mediator complex subunit 27
chr3_-_32275975 0.31 ENSDART00000178448
cpt1cb
carnitine palmitoyltransferase 1Cb
chr22_-_5822147 0.30 ENSDART00000011076
cers5
ceramide synthase 5
chr11_-_44945636 0.26 ENSDART00000157658
orc2
origin recognition complex, subunit 2
chr19_-_43757568 0.23 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr24_+_21684189 0.19 ENSDART00000014696
pdx1
pancreatic and duodenal homeobox 1
chr1_+_36722122 0.16 ENSDART00000111566
tmem184c
transmembrane protein 184C
chr18_+_54354 0.16 ENSDART00000097163
zgc:158482
zgc:158482
chr18_+_34861568 0.15 ENSDART00000192825
LO018333.1

chr15_-_37425468 0.15 ENSDART00000059630
si:ch211-113j13.2
si:ch211-113j13.2
chr4_-_72100774 0.13 ENSDART00000170099
slco1f1
solute carrier organic anion transporter family, member 1F1
chr7_-_1101071 0.11 ENSDART00000176053
dctn1a
dynactin 1a
chr25_+_6451038 0.10 ENSDART00000009971
snx33
sorting nexin 33
chr5_-_67204202 0.06 ENSDART00000145122
clip1a
CAP-GLY domain containing linker protein 1a
chr21_+_40280027 0.03 ENSDART00000065115
or115-6
odorant receptor, family F, subfamily 115, member 6
chr17_+_6536152 0.03 ENSDART00000062952
ENSDART00000121789
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr19_+_2546775 0.01 ENSDART00000148527
ENSDART00000097528
sp4
sp4 transcription factor

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.2 1.0 GO:0043111 replication fork arrest(GO:0043111)
0.2 0.9 GO:0051103 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
0.1 0.6 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.7 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.8 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.9 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.9 GO:0048538 thymus development(GO:0048538)
0.0 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.9 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 1.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.7 GO:0007286 spermatid development(GO:0007286)
0.0 0.8 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.2 0.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.2 1.0 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.6 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 0.6 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.1 1.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 0.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells