Project

PRJEB1986: zebrafish developmental stages transcriptome

Navigation
Downloads

Results for e2f4

Z-value: 0.74

Motif logo

logo of

Transcription factors associated with e2f4

Gene Symbol Gene ID Gene Info
e2f4
ENSDARG00000101578 E2F transcription factor 4
e2f4
ENSDARG00000109320 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f4dr11_v1_chr25_+_17405458_174054580.893.7e-07Click!

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_29498178 2.84 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr7_+_24814866 2.71 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr19_-_47570672 2.47 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr7_+_24881680 2.17 ENSDART00000058843
krcp
kelch repeat-containing protein
chr23_-_19831739 1.72 ENSDART00000125066
haus7
HAUS augmin-like complex, subunit 7
chr17_-_15189397 1.67 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr13_+_48359573 1.64 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr24_+_41690545 1.42 ENSDART00000160069
lama1
laminin, alpha 1
chr20_+_33994580 1.39 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr2_+_37836821 1.21 ENSDART00000143203
parp2
poly (ADP-ribose) polymerase 2
chr24_+_7153628 1.20 ENSDART00000147715
si:dkeyp-101e12.1
si:dkeyp-101e12.1
chr13_+_15933168 1.09 ENSDART00000131390
fignl1
fidgetin-like 1
chr21_+_30721733 1.07 ENSDART00000040443
zgc:110224
zgc:110224
chr5_-_44496805 1.02 ENSDART00000110076
gas1a
growth arrest-specific 1a
chr3_-_7897305 0.96 ENSDART00000169757
ubn2b
ubinuclein 2b
chr5_+_20453874 0.96 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr17_-_11368662 0.92 ENSDART00000159061
ENSDART00000188694
ENSDART00000190932
si:ch211-185a18.2
si:ch211-185a18.2
chr7_+_27834130 0.85 ENSDART00000052656
rras2
RAS related 2
chr22_-_26274177 0.81 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr14_+_94603 0.81 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr18_+_17021391 0.80 ENSDART00000100160
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr16_-_32128345 0.79 ENSDART00000102100
ENSDART00000137699
cnot3a
CCR4-NOT transcription complex, subunit 3a
chr25_-_35109536 0.77 ENSDART00000185229
CU302436.5

chr3_-_7897563 0.76 ENSDART00000185232
ubn2b
ubinuclein 2b
chr15_-_23936276 0.73 ENSDART00000137569
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr10_-_37487612 0.70 ENSDART00000167964
ENSDART00000171326
si:dkey-65j4.2
si:dkey-65j4.2
chr2_-_37837056 0.65 ENSDART00000158179
ENSDART00000160317
ENSDART00000171409
mettl17
methyltransferase like 17
chr1_-_20970266 0.64 ENSDART00000088545
klhl2
kelch-like family member 2
chr25_+_35062353 0.64 ENSDART00000089844
zgc:113983
zgc:113983
chr5_+_39099380 0.61 ENSDART00000166657
bmp2k
BMP2 inducible kinase
chr18_+_17020967 0.56 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr7_+_57725708 0.47 ENSDART00000056466
ENSDART00000142259
ENSDART00000166198
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr20_-_28433990 0.47 ENSDART00000182824
ENSDART00000193381
wdr21
WD repeat domain 21
chr22_-_21676364 0.47 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr19_-_18855513 0.46 ENSDART00000162708
ppt2
palmitoyl-protein thioesterase 2
chr19_-_18855717 0.45 ENSDART00000158192
ppt2
palmitoyl-protein thioesterase 2
chr2_-_57378748 0.44 ENSDART00000149235
tcf3a
transcription factor 3a
chr20_-_28433616 0.42 ENSDART00000169289
wdr21
WD repeat domain 21
chr7_-_6345507 0.39 ENSDART00000173032
CU457819.4
Histone H3.2
chr17_-_50020672 0.38 ENSDART00000188942
filip1a
filamin A interacting protein 1a
chr14_+_94946 0.37 ENSDART00000165766
ENSDART00000163778
mcm7
minichromosome maintenance complex component 7
chr11_+_24348425 0.37 ENSDART00000089747
nfs1
NFS1 cysteine desulfurase
chr11_+_31680513 0.34 ENSDART00000139900
ENSDART00000040305
diaph3
diaphanous-related formin 3
chr24_+_17345521 0.34 ENSDART00000024722
ENSDART00000154250
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr10_+_406146 0.30 ENSDART00000145124
dact3a
dishevelled-binding antagonist of beta-catenin 3a
chr16_+_35595312 0.30 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr7_+_5960491 0.29 ENSDART00000145370
zgc:112234
zgc:112234
chr6_-_39653972 0.29 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr25_-_36370292 0.28 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr7_-_6415991 0.28 ENSDART00000173349
CU457819.3
Histone H3.2
chr20_+_35445462 0.25 ENSDART00000124497
tdrd6
tudor domain containing 6
chr6_+_50381347 0.24 ENSDART00000055504
cyc1
cytochrome c-1
chr8_+_8947623 0.23 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr20_-_53949798 0.21 ENSDART00000153435
ppp2r5cb
protein phosphatase 2, regulatory subunit B', gamma b
chr21_-_27413294 0.20 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr7_-_73854476 0.18 ENSDART00000186481
zgc:173552
zgc:173552
chr8_-_32506569 0.16 ENSDART00000061792
RFESD (1 of many)
Rieske Fe-S domain containing
chr7_-_6429031 0.16 ENSDART00000173413
zgc:112234
zgc:112234
chr4_-_17725008 0.15 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr23_+_20518504 0.12 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr7_+_34453185 0.11 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr7_-_6459481 0.09 ENSDART00000173158
zgc:112234
zgc:112234
chr6_-_33978622 0.09 ENSDART00000151725
ENSDART00000124917
mpl
MPL proto-oncogene, thrombopoietin receptor
chr25_-_35124576 0.09 ENSDART00000128017
zgc:171759
zgc:171759
chr25_+_35155676 0.05 ENSDART00000114598
zgc:112234
zgc:112234
chr9_-_1703761 0.04 ENSDART00000144822
ENSDART00000137210
ENSDART00000135273
hnrnpa3
heterogeneous nuclear ribonucleoprotein A3
chr21_+_30355767 0.02 ENSDART00000189948
CR749164.1

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.5 5.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.2 1.1 GO:0000012 single strand break repair(GO:0000012)
0.2 1.4 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 1.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 1.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.8 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 0.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.1 1.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 2.9 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.9 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 1.7 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.2 GO:0030719 P granule organization(GO:0030719)
0.0 1.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 1.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.2 GO:0031952 regulation of protein autophosphorylation(GO:0031952)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0032301 MutSalpha complex(GO:0032301)
0.5 1.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 1.7 GO:0070652 HAUS complex(GO:0070652)
0.1 0.2 GO:0033391 chromatoid body(GO:0033391)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.7 GO:0043596 nuclear replication fork(GO:0043596)
0.1 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.4 GO:0005604 basement membrane(GO:0005604)
0.0 0.9 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.3 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 1.6 GO:0032404 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.2 1.2 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.1 1.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 2.7 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 1.1 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.3 PID E2F PATHWAY E2F transcription factor network
0.0 1.2 PID ATR PATHWAY ATR signaling pathway
0.0 1.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules