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PRJEB1986: zebrafish developmental stages transcriptome

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Results for e2f8

Z-value: 1.42

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Transcription factors associated with e2f8

Gene Symbol Gene ID Gene Info
e2f8
ENSDARG00000057323 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f8dr11_v1_chr7_-_16598212_165982120.871.7e-06Click!

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_67390645 4.73 ENSDART00000014822
ebf2
early B cell factor 2
chr7_+_24814866 4.19 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr13_+_46941930 3.91 ENSDART00000056962
fbxo5
F-box protein 5
chr1_-_38170997 3.72 ENSDART00000142811
hmgb2a
high mobility group box 2a
chr12_+_27462225 3.64 ENSDART00000105661
meox1
mesenchyme homeobox 1
chr3_+_25999477 3.55 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr6_-_33916756 3.47 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr2_-_20599315 3.37 ENSDART00000114199
si:ch211-267e7.3
si:ch211-267e7.3
chr24_-_35561672 3.36 ENSDART00000058564
mcm4
minichromosome maintenance complex component 4
chr13_+_48359573 3.27 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr21_-_11970199 3.09 ENSDART00000114524
nop56
NOP56 ribonucleoprotein homolog
chr20_+_13141408 3.02 ENSDART00000034098
dtl
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr7_+_41812636 2.97 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr20_+_34770197 2.79 ENSDART00000018304
mcm3
minichromosome maintenance complex component 3
chr16_+_31942527 2.77 ENSDART00000188334
ENSDART00000188643
ENSDART00000058496
phc1
polyhomeotic homolog 1
chr6_+_15762647 2.68 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr15_-_4596623 2.68 ENSDART00000132227
eif4h
eukaryotic translation initiation factor 4h
chr4_-_11577253 2.67 ENSDART00000144452
net1
neuroepithelial cell transforming 1
chr8_-_2543327 2.65 ENSDART00000134115
si:ch211-51h9.6
si:ch211-51h9.6
chr13_+_48358467 2.63 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr3_-_35865040 2.62 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr4_-_7869731 2.62 ENSDART00000067339
mcm10
minichromosome maintenance 10 replication initiation factor
chr7_+_41812817 2.58 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr25_-_26753196 2.58 ENSDART00000155698
usp3
ubiquitin specific peptidase 3
chr22_-_4439311 2.56 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr4_+_13953537 2.54 ENSDART00000133596
pphln1
periphilin 1
chr3_+_43086548 2.53 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr13_+_8255106 2.51 ENSDART00000080465
hells
helicase, lymphoid specific
chr2_+_32016516 2.51 ENSDART00000135040
mycb
MYC proto-oncogene, bHLH transcription factor b
chr20_-_38827623 2.45 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr1_-_24558838 2.45 ENSDART00000102522
gatb
glutamyl-tRNA(Gln) amidotransferase, subunit B
chr7_+_39166460 2.44 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
mdka
midkine a
chr13_+_26703922 2.41 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr22_+_18349794 2.35 ENSDART00000186580
gatad2ab
GATA zinc finger domain containing 2Ab
chr24_-_13349464 2.33 ENSDART00000134482
ENSDART00000139212
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr3_-_26806032 2.28 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr5_+_22459087 2.20 ENSDART00000134781
BX546499.1

chr4_-_8014463 2.17 ENSDART00000036153
ccdc3a
coiled-coil domain containing 3a
chr13_+_2894536 2.16 ENSDART00000183678
CABZ01087629.1

chr25_+_35020529 2.15 ENSDART00000158016
flnca
filamin C, gamma a (actin binding protein 280)
chr19_-_2582858 2.10 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr16_+_7154266 2.05 ENSDART00000168830
bmper
BMP binding endothelial regulator
chr8_+_52415603 2.04 ENSDART00000021604
ENSDART00000191424
gins4
GINS complex subunit 4 (Sld5 homolog)
chr16_-_9453591 2.03 ENSDART00000126154
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr14_-_44773864 2.01 ENSDART00000158386
si:dkey-109l4.3
si:dkey-109l4.3
chr20_+_33294428 2.00 ENSDART00000024104
mycn
MYCN proto-oncogene, bHLH transcription factor
chr12_+_34732262 1.99 ENSDART00000169634
si:dkey-21c1.8
si:dkey-21c1.8
chr11_-_18107447 1.98 ENSDART00000187376
qrich1
glutamine-rich 1
chr11_-_38554394 1.97 ENSDART00000102858
nucks1a
nuclear casein kinase and cyclin-dependent kinase substrate 1a
chr7_+_41812190 1.94 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr3_-_49514874 1.93 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr4_-_73488406 1.84 ENSDART00000115002
si:ch73-266f23.1
si:ch73-266f23.1
chr23_-_16981899 1.82 ENSDART00000125472
ENSDART00000142297
ENSDART00000143180
dnmt3bb.3
DNA (cytosine-5-)-methyltransferase beta, duplicate b.3
chr1_-_28890028 1.80 ENSDART00000075500
poglut1
protein O-glucosyltransferase 1
chr24_-_13349802 1.79 ENSDART00000164729
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr6_+_21005725 1.79 ENSDART00000041370
cx44.2
connexin 44.2
chr1_-_45614318 1.77 ENSDART00000149725
atf7ip
activating transcription factor 7 interacting protein
chr11_-_6206520 1.72 ENSDART00000150199
ENSDART00000148246
ENSDART00000019440
pole4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr8_-_44238526 1.71 ENSDART00000061115
ENSDART00000132473
ENSDART00000138019
ENSDART00000133021
piwil1
piwi-like RNA-mediated gene silencing 1
chr11_-_18017918 1.71 ENSDART00000040171
qrich1
glutamine-rich 1
chr23_+_29358188 1.71 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr7_+_71535045 1.69 ENSDART00000047069
tyms
thymidylate synthetase
chr16_+_33953644 1.69 ENSDART00000164447
ENSDART00000159969
arid1aa
AT rich interactive domain 1Aa (SWI-like)
chr11_-_18017287 1.64 ENSDART00000155443
qrich1
glutamine-rich 1
chr19_-_30359059 1.63 ENSDART00000103471
khdrbs1b
KH domain containing, RNA binding, signal transduction associated 1b
chr7_+_36898850 1.63 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr20_+_18703454 1.61 ENSDART00000152342
eif5
eukaryotic translation initiation factor 5
chr9_+_30294096 1.58 ENSDART00000026551
srpx
sushi-repeat containing protein, X-linked
chr23_+_10805188 1.57 ENSDART00000035693
ppp4r2a
protein phosphatase 4, regulatory subunit 2a
chr24_-_11821505 1.54 ENSDART00000058992
gli3
GLI family zinc finger 3
chr7_+_41421998 1.52 ENSDART00000083967
chpf2
chondroitin polymerizing factor 2
chr1_+_6243906 1.50 ENSDART00000127329
gtf3c3
general transcription factor IIIC, polypeptide 3
chr23_-_44848961 1.49 ENSDART00000136839
wu:fb72h05
wu:fb72h05
chr14_+_49220026 1.49 ENSDART00000063643
ENSDART00000128744
rmnd5b
required for meiotic nuclear division 5 homolog B
chr23_-_29357764 1.44 ENSDART00000156512
si:ch211-129o18.4
si:ch211-129o18.4
chr23_-_33738945 1.42 ENSDART00000136386
si:ch211-210c8.7
si:ch211-210c8.7
chr10_-_37487612 1.42 ENSDART00000167964
ENSDART00000171326
si:dkey-65j4.2
si:dkey-65j4.2
chr9_-_2892045 1.34 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr1_-_45614481 1.34 ENSDART00000148413
atf7ip
activating transcription factor 7 interacting protein
chr11_-_11792766 1.32 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr22_-_26274177 1.32 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr19_-_31802296 1.31 ENSDART00000103640
hey1
hes-related family bHLH transcription factor with YRPW motif 1
chr24_+_26432541 1.31 ENSDART00000105784
ENSDART00000122554
cldn11b
claudin 11b
chr5_-_16139600 1.30 ENSDART00000051644
coq5
coenzyme Q5, methyltransferase
chr7_+_26545911 1.29 ENSDART00000135313
tnk1
tyrosine kinase, non-receptor, 1
chr24_-_30843250 1.26 ENSDART00000162920
ptbp2a
polypyrimidine tract binding protein 2a
chr9_-_2892250 1.26 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr9_+_26103814 1.24 ENSDART00000026011
efnb2a
ephrin-B2a
chr20_+_2732992 1.24 ENSDART00000152697
syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr17_+_11372531 1.23 ENSDART00000130975
ENSDART00000149366
timm9
translocase of inner mitochondrial membrane 9 homolog
chr6_+_18531932 1.21 ENSDART00000165271
suz12b
SUZ12 polycomb repressive complex 2b subunit
chr14_-_28566238 1.21 ENSDART00000172547
insb
preproinsulin b
chr21_-_27413294 1.20 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr4_-_2380173 1.18 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1
chr18_-_34170918 1.17 ENSDART00000015079
slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr6_-_34008827 1.16 ENSDART00000191183
ENSDART00000003701
ENSDART00000192502
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr18_-_34171280 1.16 ENSDART00000122321
slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr5_-_19394440 1.15 ENSDART00000163771
foxn4
forkhead box N4
chr15_+_14202114 1.15 ENSDART00000169369
si:dkey-243k1.3
si:dkey-243k1.3
chr1_+_6646529 1.13 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr2_+_32016256 1.11 ENSDART00000005143
mycb
MYC proto-oncogene, bHLH transcription factor b
chr20_+_27093042 1.08 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr9_+_33220342 1.08 ENSDART00000100893
ENSDART00000113451
si:ch211-125e6.13
si:ch211-125e6.13
chr21_-_41818359 1.06 ENSDART00000046076
CU929230.1

chr20_-_38525467 1.06 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr1_-_34450622 0.99 ENSDART00000083736
lmo7b
LIM domain 7b
chr12_+_31616412 0.98 ENSDART00000124439
cpn1
carboxypeptidase N, polypeptide 1
chr19_+_40069524 0.98 ENSDART00000151365
ENSDART00000140926
zmym4
zinc finger, MYM-type 4
chr8_-_37461835 0.97 ENSDART00000013446
eif2d
eukaryotic translation initiation factor 2D
chr18_-_35842554 0.96 ENSDART00000088488
opa3
optic atrophy 3
chr6_+_38896158 0.95 ENSDART00000029930
ENSDART00000131347
slc48a1b
solute carrier family 48 (heme transporter), member 1b
chr13_-_18069421 0.94 ENSDART00000146772
ENSDART00000134477
zfand4
zinc finger, AN1-type domain 4
chr17_-_36529016 0.94 ENSDART00000025019
colec11
collectin sub-family member 11
chr25_+_7532627 0.94 ENSDART00000187660
ptdss2
phosphatidylserine synthase 2
chr12_+_17933775 0.91 ENSDART00000186047
ENSDART00000160586
trrap
transformation/transcription domain-associated protein
chr24_-_26945390 0.89 ENSDART00000123354
msl2b
male-specific lethal 2 homolog b (Drosophila)
chr7_-_55648336 0.88 ENSDART00000147792
ENSDART00000135304
ENSDART00000131923
pabpn1l
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr24_-_2829049 0.88 ENSDART00000164913
PPP1R3G
si:ch211-152c8.5
chr25_-_35109536 0.86 ENSDART00000185229
CU302436.5

chr17_-_36529449 0.85 ENSDART00000187252
colec11
collectin sub-family member 11
chr16_-_4640539 0.83 ENSDART00000076955
ENSDART00000131949
cyp4t8
cytochrome P450, family 4, subfamily T, polypeptide 8
chr10_+_10386435 0.83 ENSDART00000179214
ENSDART00000189799
ENSDART00000193875
sardh
sarcosine dehydrogenase
chr4_-_64123545 0.83 ENSDART00000170040
BX914205.2

chr19_-_3381422 0.82 ENSDART00000105146
edn1
endothelin 1
chr6_-_18531760 0.81 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr21_+_37090795 0.81 ENSDART00000085786
znf346
zinc finger protein 346
chr16_+_25116827 0.80 ENSDART00000163244
si:ch211-261d7.6
si:ch211-261d7.6
chr22_-_22301672 0.80 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr1_-_46505310 0.79 ENSDART00000178072
si:busm1-105l16.2
si:busm1-105l16.2
chr25_-_17579701 0.78 ENSDART00000073684
mmp15a
matrix metallopeptidase 15a
chr8_+_29856013 0.78 ENSDART00000061981
ENSDART00000149610
hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
chr20_+_53368611 0.77 ENSDART00000060432
cdc40
cell division cycle 40 homolog (S. cerevisiae)
chr14_-_25956804 0.77 ENSDART00000135627
ENSDART00000146022
ENSDART00000039660
sparc
secreted protein, acidic, cysteine-rich (osteonectin)
chr11_+_24804556 0.76 ENSDART00000082761
ENSDART00000186283
adipor1a
adiponectin receptor 1a
chr3_-_14571514 0.75 ENSDART00000137197
swsap1
SWIM-type zinc finger 7 associated protein 1
chr22_+_11535131 0.75 ENSDART00000113930
npb
neuropeptide B
chr22_+_26703026 0.74 ENSDART00000158756
crebbpa
CREB binding protein a
chr15_-_14210382 0.73 ENSDART00000179599
CR925813.1

chr25_-_35140746 0.73 ENSDART00000129969
si:ch211-113a14.19
si:ch211-113a14.19
chr24_+_10413484 0.72 ENSDART00000111014
myca
MYC proto-oncogene, bHLH transcription factor a
chr18_+_35842933 0.71 ENSDART00000151587
ENSDART00000131121
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr14_+_5861435 0.71 ENSDART00000041279
ENSDART00000147341
tubb4b
tubulin, beta 4B class IVb
chr16_+_32184485 0.71 ENSDART00000084009
zufsp
zinc finger with UFM1-specific peptidase domain
chr25_-_17579242 0.70 ENSDART00000184934
mmp15a
matrix metallopeptidase 15a
chr15_-_36055401 0.69 ENSDART00000154476
col4a4
collagen, type IV, alpha 4
chr3_+_52545400 0.68 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr16_+_53278406 0.67 ENSDART00000010792
ptdss1a
phosphatidylserine synthase 1a
chr5_+_66310495 0.67 ENSDART00000114532
malt1
MALT paracaspase 1
chr13_-_1423008 0.62 ENSDART00000110828
znf451
zinc finger protein 451
chr6_-_43817761 0.58 ENSDART00000183945
foxp1b
forkhead box P1b
chr8_-_45430817 0.57 ENSDART00000150067
ENSDART00000112394
ywhabb
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b
chr3_-_53092509 0.55 ENSDART00000062081
lpar2a
lysophosphatidic acid receptor 2a
chr17_+_14784275 0.55 ENSDART00000005355
rtraf
RNA transcription, translation and transport factor
chr7_-_73854476 0.54 ENSDART00000186481
zgc:173552
zgc:173552
chr20_+_41859277 0.54 ENSDART00000061141
cep85l
centrosomal protein 85, like
chr7_-_6345507 0.54 ENSDART00000173032
CU457819.4
Histone H3.2
chr2_-_6104035 0.52 ENSDART00000053867
zte38
zebrafish testis-expressed 38
chr7_-_804515 0.51 ENSDART00000159359
rela
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr23_-_30045661 0.51 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr23_+_21482571 0.50 ENSDART00000187368
si:dkey-1c11.1
si:dkey-1c11.1
chr3_+_52545014 0.50 ENSDART00000018908
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr7_+_27250186 0.49 ENSDART00000150068
sox6
SRY (sex determining region Y)-box 6
chr11_-_4302251 0.49 ENSDART00000182554
CT033790.1

chr18_+_33788340 0.49 ENSDART00000136950
si:dkey-145c18.2
si:dkey-145c18.2
chr22_+_25590391 0.48 ENSDART00000178133
aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr7_+_1550966 0.48 ENSDART00000177863
ENSDART00000126840
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit
chr16_-_32184460 0.47 ENSDART00000102027
kpna5
karyopherin alpha 5 (importin alpha 6)
chr9_+_34380299 0.47 ENSDART00000131705
lamp1
lysosomal-associated membrane protein 1
chr5_-_64454459 0.47 ENSDART00000172321
ENSDART00000168030
brd3b
bromodomain containing 3b
chr7_-_6415991 0.46 ENSDART00000173349
CU457819.3
Histone H3.2
chr8_+_8196087 0.43 ENSDART00000026965
plxnb3
plexin B3
chr15_+_618376 0.43 ENSDART00000156007
si:ch73-144d13.8
si:ch73-144d13.8
chr8_+_41038141 0.43 ENSDART00000075620
gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr18_+_33762090 0.42 ENSDART00000147605
si:dkey-145c18.4
si:dkey-145c18.4
chr4_-_7231480 0.41 ENSDART00000159436
si:ch211-170p16.1
si:ch211-170p16.1
chr15_+_618081 0.39 ENSDART00000181518
si:ch211-210b2.1
si:ch211-210b2.1
chr9_+_34232503 0.38 ENSDART00000132836
nxpe3
neurexophilin and PC-esterase domain family, member 3
chr5_-_37959874 0.37 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr7_+_26545502 0.37 ENSDART00000140528
tnk1
tyrosine kinase, non-receptor, 1
chr21_-_31252131 0.36 ENSDART00000121946
crcp
calcitonin gene-related peptide-receptor component protein
chr6_-_8466717 0.34 ENSDART00000151577
ENSDART00000151800
ENSDART00000151227
si:dkey-217d24.6
si:dkey-217d24.6
chr6_+_50451337 0.33 ENSDART00000155051
mych
myelocytomatosis oncogene homolog
chr11_-_26576754 0.33 ENSDART00000191733
ENSDART00000002846
st3gal8
ST3 beta-galactoside alpha-2,3-sialyltransferase 8
chr7_+_34453185 0.33 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr8_+_45186989 0.32 ENSDART00000143861
si:ch211-220m6.4
si:ch211-220m6.4
chr16_-_39195318 0.31 ENSDART00000058546
ebag9
estrogen receptor binding site associated, antigen, 9
chr7_+_28724919 0.29 ENSDART00000011324
ccdc102a
coiled-coil domain containing 102A
chr15_+_23657051 0.28 ENSDART00000078336
klc3
kinesin light chain 3
chr13_-_45942000 0.27 ENSDART00000158534
ENSDART00000171822
ENSDART00000166442
si:ch211-62a1.4
si:ch211-62a1.4
chr15_-_17619306 0.26 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr17_+_9009098 0.25 ENSDART00000180856
akap6
A kinase (PRKA) anchor protein 6
chr23_+_39413163 0.25 ENSDART00000184254
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr2_+_17055069 0.24 ENSDART00000115078
thpo
thrombopoietin
chr1_-_58505626 0.24 ENSDART00000171304
si:ch73-236c18.8
si:ch73-236c18.8
chr2_-_37874647 0.24 ENSDART00000039386
zgc:66427
zgc:66427
chr7_+_29509255 0.24 ENSDART00000076172
si:dkey-182o15.5
si:dkey-182o15.5
chr3_+_5504990 0.23 ENSDART00000143626
si:ch73-264i18.2
si:ch73-264i18.2
chr5_-_64168415 0.23 ENSDART00000048395
cmlc1
cardiac myosin light chain-1
chr16_+_24681177 0.22 ENSDART00000058956
ENSDART00000189335
ywhabl
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr25_-_35102781 0.17 ENSDART00000180881
ENSDART00000153747
si:dkey-108k21.24
si:dkey-108k21.24

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
1.4 5.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 3.9 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.9 9.7 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.8 2.5 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.6 1.7 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.5 2.5 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.5 5.1 GO:0044030 regulation of DNA methylation(GO:0044030)
0.5 11.4 GO:0006270 DNA replication initiation(GO:0006270)
0.4 2.7 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.4 3.0 GO:0072425 mitotic G2 DNA damage checkpoint(GO:0007095) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.4 3.6 GO:0061056 sclerotome development(GO:0061056)
0.3 2.0 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 1.7 GO:0035093 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 2.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.3 0.8 GO:1901052 sarcosine metabolic process(GO:1901052)
0.2 1.2 GO:0007412 axon target recognition(GO:0007412)
0.2 2.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.2 3.1 GO:0090308 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.2 2.6 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 1.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 1.2 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.2 1.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 4.1 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.2 0.8 GO:0060584 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 0.5 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 0.8 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 2.7 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.1 1.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 4.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 1.8 GO:0019730 antimicrobial humoral response(GO:0019730)
0.1 2.4 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.1 0.6 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 2.5 GO:0043039 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.1 1.8 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.9 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.7 GO:0051673 membrane disruption in other organism(GO:0051673)
0.1 0.9 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 0.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 2.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 2.2 GO:0042181 ketone biosynthetic process(GO:0042181)
0.1 1.1 GO:0045116 protein neddylation(GO:0045116)
0.1 2.3 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.1 0.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 2.8 GO:0030916 otic vesicle formation(GO:0030916)
0.1 2.6 GO:0048538 thymus development(GO:0048538)
0.1 0.4 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.1 1.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.6 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 3.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.5 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.5 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.9 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 2.5 GO:0048484 enteric nervous system development(GO:0048484)
0.0 1.2 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 1.2 GO:0001878 response to yeast(GO:0001878)
0.0 1.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.2 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.8 GO:0007631 feeding behavior(GO:0007631)
0.0 1.6 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 2.6 GO:0016579 protein deubiquitination(GO:0016579)
0.0 3.2 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.0 GO:0050881 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.0 1.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 2.8 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.2 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.2 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 1.3 GO:0001708 cell fate specification(GO:0001708)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0032301 MutSalpha complex(GO:0032301)
1.0 3.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.6 7.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.5 9.7 GO:0042555 MCM complex(GO:0042555)
0.5 1.6 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.5 2.6 GO:0031298 replication fork protection complex(GO:0031298)
0.5 3.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.4 1.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 2.0 GO:0000811 GINS complex(GO:0000811)
0.4 2.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 1.5 GO:0034657 GID complex(GO:0034657)
0.3 0.8 GO:0033186 CAF-1 complex(GO:0033186)
0.3 1.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.2 2.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 3.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 1.7 GO:0035060 brahma complex(GO:0035060)
0.2 4.1 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.2 2.6 GO:0000792 heterochromatin(GO:0000792)
0.2 1.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 2.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.8 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.9 GO:0072487 MSL complex(GO:0072487)
0.1 2.0 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.5 GO:0035101 FACT complex(GO:0035101)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.0 0.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 2.5 GO:0005581 collagen trimer(GO:0005581)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.9 GO:0005819 spindle(GO:0005819)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 4.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.4 GO:0043186 P granule(GO:0043186) germ plasm(GO:0060293)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.2 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0032143 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
1.4 4.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.8 2.5 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.6 1.8 GO:0042806 fucose binding(GO:0042806)
0.5 13.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 2.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.4 2.7 GO:0034057 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.3 2.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 1.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.3 1.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 1.8 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.2 3.7 GO:0008301 DNA binding, bending(GO:0008301)
0.2 1.7 GO:0034584 piRNA binding(GO:0034584)
0.2 0.8 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.2 2.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.2 3.9 GO:0030515 snoRNA binding(GO:0030515)
0.2 1.5 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 1.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.8 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 0.5 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 4.2 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.9 GO:0015232 heme transporter activity(GO:0015232)
0.1 1.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 6.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 1.6 GO:0008143 poly(A) binding(GO:0008143)
0.1 2.2 GO:0031491 nucleosome binding(GO:0031491)
0.1 2.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.4 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 11.1 GO:0042393 histone binding(GO:0042393)
0.0 2.5 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 2.7 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 2.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.8 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 0.5 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 4.8 GO:0003682 chromatin binding(GO:0003682)
0.0 3.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 13.4 GO:0046983 protein dimerization activity(GO:0046983)
0.0 2.4 GO:0008201 heparin binding(GO:0008201)
0.0 2.6 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 1.1 GO:0061650 ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 1.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.4 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 6.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 1.1 GO:0004519 endonuclease activity(GO:0004519)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID BARD1 PATHWAY BARD1 signaling events
0.1 3.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 6.3 PID E2F PATHWAY E2F transcription factor network
0.1 4.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 2.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.4 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.2 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 3.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 11.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 8.8 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 4.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.3 5.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.6 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 2.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 3.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.7 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.5 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 2.7 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 1.8 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 2.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.7 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.5 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 1.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.6 REACTOME TRANSLATION Genes involved in Translation
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+