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PRJEB1986: zebrafish developmental stages transcriptome

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Results for fosb+fosl2+si:ch211-153j24.3

Z-value: 0.79

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Transcription factors associated with fosb+fosl2+si:ch211-153j24.3

Gene Symbol Gene ID Gene Info
ENSDARG00000040623 fos-like antigen 2
ENSDARG00000055751 FBJ murine osteosarcoma viral oncogene homolog B
ENSDARG00000068428 si_ch211-153j24.3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-153j24.3dr11_v1_chr20_+_46560258_46560258-0.771.2e-04Click!
fosl2dr11_v1_chr17_+_41302660_41302660-0.681.5e-03Click!
fosbdr11_v1_chr18_+_36769758_36769785-0.597.3e-03Click!

Activity profile of fosb+fosl2+si:ch211-153j24.3 motif

Sorted Z-values of fosb+fosl2+si:ch211-153j24.3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_48359259 3.80 ENSDART00000167353
shugoshin 1
chr20_-_26532167 2.24 ENSDART00000061914
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr20_-_25626198 1.73 ENSDART00000126716
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr20_-_26531850 1.61 ENSDART00000183317
ENSDART00000131994
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr12_+_25945560 1.34 ENSDART00000109799
multimerin 2b
chr6_+_44197348 1.33 ENSDART00000075486
protein phosphatase 4, regulatory subunit 2b
chr25_-_13408760 1.24 ENSDART00000154445
GINS complex subunit 3
chr7_-_8490886 1.23 ENSDART00000159012
jacalin 6
chr11_-_24681292 1.21 ENSDART00000089601
olfactomedin-like 3b
chr14_-_11456724 1.19 ENSDART00000110424
si:ch211-153b23.4
chr21_-_44512893 1.19 ENSDART00000166853
zgc:136410
chr6_+_44197099 1.19 ENSDART00000124168
protein phosphatase 4, regulatory subunit 2b
chr19_+_15441022 1.16 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr7_-_8417315 1.15 ENSDART00000173046
jacalin 1
chr5_+_44806374 1.06 ENSDART00000184237
cathepsin La
chr16_-_21785261 1.05 ENSDART00000078858
si:ch73-86n18.1
chr7_-_8438657 1.04 ENSDART00000173054
si:dkeyp-32g11.8
chr23_+_35714574 1.04 ENSDART00000164616
tubulin, alpha 1c
chr13_+_24280380 1.01 ENSDART00000184115
actin, alpha 1b, skeletal muscle
chr7_-_8504355 1.01 ENSDART00000173067
hypothetical protein LOC564660
chr10_+_31222656 1.00 ENSDART00000140988
ENSDART00000143387
transmembrane protein 218
chr7_-_20611039 0.93 ENSDART00000170422
si:dkey-19b23.8
chr4_-_13902188 0.91 ENSDART00000032805
glucoside xylosyltransferase 1b
chr11_+_11267829 0.90 ENSDART00000026814
ENSDART00000173346
ENSDART00000151926
protein tyrosine phosphatase type IVA, member 1
chr7_-_8602864 0.89 ENSDART00000173291
jacalin 2
chr7_-_8577190 0.88 ENSDART00000173174
jacalin 3
chr7_+_8543317 0.87 ENSDART00000114998
jacalin 8
chr18_+_46382484 0.87 ENSDART00000024202
ENSDART00000142790
dynein assembly factor with WDR repeat domains 1
chr9_+_41024973 0.83 ENSDART00000014660
ENSDART00000144467
ORMDL sphingolipid biosynthesis regulator 1
chr5_+_44804791 0.83 ENSDART00000122288
cathepsin La
chr22_+_24220937 0.81 ENSDART00000165380
ubiquitin carboxyl-terminal hydrolase L5
chr2_+_48288461 0.81 ENSDART00000141495
hes family bHLH transcription factor 6
chr1_-_40914752 0.80 ENSDART00000113087
H6 family homeobox 1
chr8_+_28695914 0.78 ENSDART00000033386
osteoclast stimulatory transmembrane protein
chr9_+_426392 0.76 ENSDART00000172515
basic leucine zipper and W2 domains 1b
chr22_+_16759010 0.74 ENSDART00000079638
ENSDART00000113099
TM2 domain containing 1
chr8_-_20245892 0.73 ENSDART00000136911
alkaline ceramidase 1
chr5_+_44805269 0.72 ENSDART00000136965
cathepsin La
chr18_+_50526290 0.72 ENSDART00000175194
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr22_+_16497670 0.72 ENSDART00000014330
immediate early response 5
chr14_+_46216703 0.71 ENSDART00000136045
ENSDART00000142317
microsomal glutathione S-transferase 2
chr25_+_13191391 0.70 ENSDART00000109937
si:ch211-147m6.2
chr7_-_8515550 0.69 ENSDART00000111896
jacalin 9
chr4_+_16715267 0.69 ENSDART00000143849
plakophilin 2
chr2_-_17115256 0.69 ENSDART00000190488
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr11_+_24251141 0.68 ENSDART00000182684
purine nucleoside phosphorylase 4a
chr3_+_32118670 0.68 ENSDART00000055287
ENSDART00000111688
zgc:109934
chr20_+_19066858 0.67 ENSDART00000192086
SRY (sex determining region Y)-box 7
chr18_-_45617146 0.67 ENSDART00000146543
wilms tumor 1b
chr20_+_19066596 0.67 ENSDART00000130271
SRY (sex determining region Y)-box 7
chr2_-_17114852 0.66 ENSDART00000006549
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr12_-_48312647 0.65 ENSDART00000114415
activating signal cointegrator 1 complex subunit 1
chr5_+_34549845 0.63 ENSDART00000139317
allograft inflammatory factor 1-like
chr1_+_14253118 0.63 ENSDART00000161996
chemokine (C-X-C motif) ligand 8a
chr18_-_18850302 0.63 ENSDART00000131965
ENSDART00000167624
transglutaminase 2, like
chr7_+_50395856 0.63 ENSDART00000032324
HD domain containing 3
chr5_+_44805028 0.63 ENSDART00000141198
cathepsin La
chr2_+_17524278 0.62 ENSDART00000165633
Pim proto-oncogene, serine/threonine kinase, related 196
chr6_-_19378982 0.61 ENSDART00000182344
growth factor receptor-bound protein 2a
chr7_+_23943597 0.60 ENSDART00000157408
si:dkey-183c6.7
chr5_+_24089334 0.60 ENSDART00000183748
tumor protein p53
chr2_+_30379650 0.60 ENSDART00000129542
cysteine-rich secretory protein LCCL domain containing 1b
chr4_+_5317483 0.60 ENSDART00000150366
si:ch211-214j24.10
chr4_+_42450386 0.60 ENSDART00000168211
si:dkey-11d20.1
chr17_-_28707898 0.59 ENSDART00000135752
ENSDART00000061853
adaptor-related protein complex 4, sigma 1 subunit
chr13_-_9213207 0.59 ENSDART00000139861
ENSDART00000140524
si:dkey-33c12.11
chr22_+_39084829 0.58 ENSDART00000002826
GDP-mannose pyrophosphorylase B
chr6_-_35439406 0.56 ENSDART00000073784
regulator of G protein signaling 5a
chr14_-_26436951 0.56 ENSDART00000140173
si:dkeyp-110e4.6
chr21_+_22828500 0.56 ENSDART00000151109
si:rp71-1p14.7
chr16_+_20915319 0.55 ENSDART00000079383
homeobox A9b
chr16_+_23960744 0.55 ENSDART00000058965
apolipoprotein Eb
chr2_-_39759059 0.54 ENSDART00000007333
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr3_+_24197934 0.54 ENSDART00000055609
activating transcription factor 4b
chr7_+_38680034 0.54 ENSDART00000171691
ENSDART00000007913
proteasome 26S subunit, ATPase 3
chr5_+_38276582 0.54 ENSDART00000158532
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr19_-_32641725 0.53 ENSDART00000165006
ENSDART00000188185
hippocalcin
chr22_-_15593824 0.53 ENSDART00000123125
tropomyosin 4a
chr18_-_34170918 0.51 ENSDART00000015079
solute carrier family 33 (acetyl-CoA transporter), member 1
chr24_+_31361407 0.51 ENSDART00000162668
cAMP responsive element modulator b
chr16_+_42829735 0.51 ENSDART00000014956
polymerase (RNA) III (DNA directed) polypeptide G like b
chr2_-_21847935 0.51 ENSDART00000003940
RAB2A, member RAS oncogene family
chr1_-_22861348 0.50 ENSDART00000139412
si:dkey-92j12.6
chr21_+_22892836 0.50 ENSDART00000065565
ALG8, alpha-1,3-glucosyltransferase
chr16_+_9762261 0.50 ENSDART00000020654
proteasome 26S subunit, non-ATPase 4b
chr8_-_25033681 0.49 ENSDART00000003493
nuclear transcription factor Y, alpha, like
chr3_-_32859335 0.49 ENSDART00000158916
si:dkey-16l2.20
chr1_-_33380340 0.48 ENSDART00000181515
CD99 molecule
chr2_+_26179096 0.48 ENSDART00000024662
phospholipid phosphatase related 3a
chr25_+_3549401 0.48 ENSDART00000166312
coiled-coil domain containing 77
chr4_-_16833518 0.48 ENSDART00000179867
lactate dehydrogenase Ba
chr25_+_13191615 0.47 ENSDART00000168849
si:ch211-147m6.2
chr7_+_56453646 0.47 ENSDART00000112483
solute carrier family 22, member 31
chr11_+_11267493 0.47 ENSDART00000148425
protein tyrosine phosphatase type IVA, member 1
chr8_-_53926228 0.46 ENSDART00000015554
UbiA prenyltransferase domain containing 1
chr24_+_17140938 0.45 ENSDART00000149134
MLLT10, histone lysine methyltransferase DOT1L cofactor
chr16_+_23403602 0.45 ENSDART00000159848
S100 calcium binding protein W
chr2_+_21486529 0.45 ENSDART00000047468
inhibin, beta Ab
chr5_-_25582721 0.45 ENSDART00000123986
annexin A1a
chr25_+_8955530 0.45 ENSDART00000156444
si:ch211-256a21.4
chr1_-_30762264 0.45 ENSDART00000085454
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
chr3_-_34816893 0.45 ENSDART00000084448
ENSDART00000154696
proteasome 26S subunit, non-ATPase 11a
chr1_+_59073436 0.44 ENSDART00000161642
si:zfos-2330d3.3
chr10_+_26747755 0.44 ENSDART00000100329
coagulation factor IXb
chr4_-_19742300 0.44 ENSDART00000066964
ENSDART00000100952
hepatocyte growth factor a
chr12_-_28363111 0.43 ENSDART00000016283
ENSDART00000164156
proteasome 26S subunit, non-ATPase 11b
chr23_+_3731375 0.43 ENSDART00000141782
small integral membrane protein 29
chr22_-_17489040 0.43 ENSDART00000141286
si:ch211-197g15.6
chr7_-_44963154 0.43 ENSDART00000073735
Ras-related associated with diabetes
chr4_-_6809323 0.43 ENSDART00000099467
interferon-related developmental regulator 1
chr25_+_32474031 0.42 ENSDART00000152124
sulfide quinone oxidoreductase
chr8_-_22288004 0.42 ENSDART00000100042
si:ch211-147a11.3
chr25_-_11378623 0.42 ENSDART00000166586
ectodermal-neural cortex 2
chr5_+_42064144 0.42 ENSDART00000035235
si:ch211-202a12.4
chr6_+_29791164 0.42 ENSDART00000017424
prothymosin, alpha a
chr23_-_36446307 0.42 ENSDART00000136623
zgc:174906
chr14_-_16807206 0.42 ENSDART00000157957
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr12_-_49154934 0.41 ENSDART00000153363
H6 family homeobox 3b
chr11_+_13630107 0.41 ENSDART00000172220
si:ch211-1a19.3
chr10_+_35275965 0.41 ENSDART00000077404
P450 (cytochrome) oxidoreductase a
chr2_-_37837472 0.41 ENSDART00000165347
methyltransferase like 17
chr21_-_21020708 0.41 ENSDART00000064032
eukaryotic translation initiation factor 4E binding protein 1
chr12_-_45669050 0.41 ENSDART00000124455
F-box and leucine-rich repeat protein 15
chr6_-_24143923 0.41 ENSDART00000157948
si:ch73-389b16.1
chr10_+_25947946 0.41 ENSDART00000064393
ubiquitin-fold modifier 1
chr2_-_32366287 0.40 ENSDART00000144758
upstream binding transcription factor, like
chr13_-_11035420 0.40 ENSDART00000108709
centrosomal protein 170Aa
chr19_+_15440841 0.40 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr20_+_16721933 0.39 ENSDART00000063950
proteasome 26S subunit, ATPase 1b
chr19_+_41173386 0.39 ENSDART00000142773
ankyrin repeat and SOCS box containing 4
chr5_-_66028714 0.39 ENSDART00000022625
ENSDART00000164228
NOTCH regulated ankyrin repeat protein b
chr22_-_26595027 0.39 ENSDART00000184162

chr25_+_7423770 0.38 ENSDART00000155458
ubiquitin associated protein 1-like a
chr1_-_52498146 0.38 ENSDART00000122217
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr4_-_76488854 0.38 ENSDART00000132323
finTRIM family, member 51
chr2_-_985417 0.38 ENSDART00000140540
si:ch211-241e1.3
chr21_-_30415524 0.38 ENSDART00000101036
GrpE-like 2, mitochondrial
chr5_+_63390315 0.38 ENSDART00000124616
RAB14, member RAS oncogene family
chr1_+_58677434 0.37 ENSDART00000158488

chr4_-_77216726 0.37 ENSDART00000099943
proteasome subunit beta 10
chr22_+_21950838 0.37 ENSDART00000143075
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4
chr6_+_51713076 0.37 ENSDART00000146281
RIPOR family member 3
chr19_+_32947910 0.36 ENSDART00000052091
ATPase H+ transporting V1 subunit C1b
chr19_-_7420867 0.36 ENSDART00000081741
RAB25, member RAS oncogene family a
chr8_-_18010735 0.36 ENSDART00000125014
acyl-CoA thioesterase 11b
chr7_+_15736230 0.36 ENSDART00000109942
multiple C2 domains, transmembrane 2b
chr18_+_30421528 0.35 ENSDART00000140908
Gse1 coiled-coil protein
chr15_-_23442891 0.35 ENSDART00000059376
ubiquitination factor E4A (UFD2 homolog, yeast)
chr5_-_26330313 0.35 ENSDART00000148656
ARVCF, delta catenin family member b
chr7_+_36041509 0.34 ENSDART00000162850
iroquois homeobox 3a
chr9_-_27805644 0.34 ENSDART00000192431
si:rp71-45g20.10
chr7_+_53541173 0.34 ENSDART00000159449
GRAM domain containing 2Aa
chr25_+_30196039 0.34 ENSDART00000005299
hydroxysteroid (17-beta) dehydrogenase 12a
chr2_+_29995590 0.34 ENSDART00000151906
RNA binding motif protein 33b
chr19_-_103289 0.34 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr2_+_15100742 0.34 ENSDART00000027171
coagulation factor IIIb
chr14_+_21820034 0.33 ENSDART00000122739
C-terminal binding protein 1
chr17_+_32623931 0.33 ENSDART00000144217
cathepsin Ba
chr8_-_45729248 0.33 ENSDART00000187736

chr1_+_41588170 0.33 ENSDART00000139175
si:dkey-56e3.2
chr11_+_21050326 0.33 ENSDART00000065984
zgc:113307
chr22_-_5006801 0.33 ENSDART00000106166
retinal homeobox gene 1
chr4_-_4535189 0.33 ENSDART00000057519
zgc:194209
chr5_-_29531948 0.33 ENSDART00000098360
arrestin domain containing 1a
chr18_+_14477740 0.32 ENSDART00000146472
potassium voltage-gated channel, subfamily G, member 4a
chr23_-_33738945 0.32 ENSDART00000136386
si:ch211-210c8.7
chr14_-_26436760 0.32 ENSDART00000088677
si:dkeyp-110e4.6
chr20_-_34767472 0.32 ENSDART00000186710
progestin and adipoQ receptor family member VIII
chr12_+_8074343 0.32 ENSDART00000124084
ciliary associated calcium binding coiled-coil 1
chr18_+_30441740 0.32 ENSDART00000189074
Gse1 coiled-coil protein
chr23_-_39636195 0.32 ENSDART00000144439
von Willebrand factor A domain containing 1
chr19_+_42847306 0.31 ENSDART00000135164
programmed cell death 6 interacting protein
chr10_+_31222433 0.31 ENSDART00000185080
transmembrane protein 218
chr8_-_7603516 0.31 ENSDART00000179826
ENSDART00000190153
interleukin-1 receptor-associated kinase 1
chr9_-_27805801 0.30 ENSDART00000140608
ENSDART00000114542
si:rp71-45g20.10
chr4_-_28958601 0.30 ENSDART00000111294
zgc:174315
chr2_-_34072218 0.30 ENSDART00000184618
eukaryotic translation initiation factor 2B, subunit 3 gamma
chr2_-_17828279 0.30 ENSDART00000083314
protein tyrosine phosphatase, receptor type, f, b
chr3_+_17616201 0.30 ENSDART00000156775
RAB5C, member RAS oncogene family
chr14_+_33882973 0.30 ENSDART00000019396
chloride intracellular channel 2
chr20_-_42972599 0.30 ENSDART00000100751
proopiomelanocortin b
chr23_-_9855627 0.30 ENSDART00000180159
protein kinase C binding protein 1, like
chr21_+_22845317 0.30 ENSDART00000065555
baculoviral IAP repeat containing 2
chr10_+_26118122 0.29 ENSDART00000079207
tripartite motif containing 47
chr3_-_61185746 0.29 ENSDART00000028219
parvalbumin 4
chr9_+_29323163 0.29 ENSDART00000184908
oxoglutarate (alpha-ketoglutarate) receptor 1b
chr23_+_28128453 0.29 ENSDART00000182618
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a
chr3_+_22345497 0.29 ENSDART00000191274
ENSDART00000129697
ENSDART00000193100
interferon phi 3
chr25_+_21324588 0.29 ENSDART00000151842
leucine rich repeat neuronal 3a
chr19_+_348729 0.29 ENSDART00000114284
MCL1, BCL2 family apoptosis regulator a
chr9_+_11293830 0.29 ENSDART00000144440
wingless-type MMTV integration site family, member 6b
chr24_+_38522254 0.29 ENSDART00000156189
si:ch1073-66l23.1
chr3_+_32842825 0.28 ENSDART00000122228
proline rich 14
chr25_+_18583877 0.28 ENSDART00000148741
MET proto-oncogene, receptor tyrosine kinase
chr10_+_31953502 0.28 ENSDART00000185634
LHFPL tetraspan subfamily member 6
chr8_-_22288258 0.28 ENSDART00000140978
ENSDART00000100046
si:ch211-147a11.3
chr13_+_18533005 0.28 ENSDART00000136024
finTRIM family, member 14-like
chr7_-_32981559 0.28 ENSDART00000175614
plakophilin 3b
chr15_-_4568154 0.28 ENSDART00000155254
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr5_-_1047504 0.28 ENSDART00000159346
methyl-CpG binding domain protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of fosb+fosl2+si:ch211-153j24.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.8 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.3 3.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 0.6 GO:0002544 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.2 0.8 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.2 0.6 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 0.6 GO:0032197 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.2 0.5 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.2 0.5 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2 0.7 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.2 1.2 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 1.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 1.2 GO:0016266 O-glycan processing(GO:0016266)
0.2 0.5 GO:0071498 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.1 0.4 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.7 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 1.2 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.4 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.5 GO:2000391 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.1 0.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 0.2 GO:0031280 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.1 0.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 1.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.5 GO:0045899 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.4 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.5 GO:2001279 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.3 GO:0060546 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 0.7 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.7 GO:0021681 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.2 GO:0001774 microglial cell activation(GO:0001774)
0.1 0.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.6 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.5 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.1 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0051099 cytidine to uridine editing(GO:0016554) positive regulation of DNA binding(GO:0043388) positive regulation of binding(GO:0051099)
0.0 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.1 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.0 0.9 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.6 GO:0061055 myotome development(GO:0061055)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.3 GO:2001271 regulation of execution phase of apoptosis(GO:1900117) negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0006699 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.0 0.5 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.2 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.0 0.4 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.3 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.7 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 1.3 GO:0060840 artery development(GO:0060840)
0.0 0.1 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.0 0.5 GO:0060729 maintenance of gastrointestinal epithelium(GO:0030277) intestinal epithelial structure maintenance(GO:0060729)
0.0 0.2 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.1 GO:1902765 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.2 GO:0034205 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.5 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.5 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 0.4 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.2 GO:0019372 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.3 GO:0097178 ruffle assembly(GO:0097178)
0.0 1.0 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.8 GO:0007596 blood coagulation(GO:0007596)
0.0 0.5 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.4 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.2 1.2 GO:0000811 GINS complex(GO:0000811)
0.2 0.8 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 1.0 GO:0005869 dynactin complex(GO:0005869)
0.1 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.7 GO:0014704 intercalated disc(GO:0014704)
0.1 0.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.8 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.5 GO:0000177 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0044609 DBIRD complex(GO:0044609)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.8 GO:0000776 kinetochore(GO:0000776)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0016234 inclusion body(GO:0016234)
0.0 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 1.4 GO:0005657 replication fork(GO:0005657)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0000502 proteasome complex(GO:0000502)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.4 1.7 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.3 1.4 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.2 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.5 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 0.7 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 0.6 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 0.6 GO:0004475 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.1 0.4 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.1 0.9 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.7 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.4 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 0.3 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.1 0.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.3 GO:0048531 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.3 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.8 GO:0070628 proteasome binding(GO:0070628)
0.1 0.6 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 1.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.6 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.3 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.4 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.5 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.3 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.2 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 1.2 GO:0000049 tRNA binding(GO:0000049)
0.0 1.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 3.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0004532 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.2 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.8 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins