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PRJEB1986: zebrafish developmental stages transcriptome
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Results for fosb+fosl2+si:ch211-153j24.3
Z-value: 0.79
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Transcription factors associated with fosb+fosl2+si:ch211-153j24.3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:ch211-153j24.3 | dr11_v1_chr20_+_46560258_46560258 | -0.77 | 1.2e-04 | Click! |
| fosl2 | dr11_v1_chr17_+_41302660_41302660 | -0.68 | 1.5e-03 | Click! |
| fosb | dr11_v1_chr18_+_36769758_36769785 | -0.59 | 7.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_48359259 Show fit | 3.80 |
ENSDART00000167353
|
shugoshin 1 |
|
| chr20_-_26532167 Show fit | 2.24 |
ENSDART00000061914
|
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like |
|
| chr20_-_25626198 Show fit | 1.73 |
ENSDART00000126716
|
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
|
| chr20_-_26531850 Show fit | 1.61 |
ENSDART00000183317
ENSDART00000131994 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like |
|
| chr12_+_25945560 Show fit | 1.34 |
ENSDART00000109799
|
multimerin 2b |
|
| chr6_+_44197348 Show fit | 1.33 |
ENSDART00000075486
|
protein phosphatase 4, regulatory subunit 2b |
|
| chr25_-_13408760 Show fit | 1.24 |
ENSDART00000154445
|
GINS complex subunit 3 |
|
| chr7_-_8490886 Show fit | 1.23 |
ENSDART00000159012
|
jacalin 6 |
|
| chr11_-_24681292 Show fit | 1.21 |
ENSDART00000089601
|
olfactomedin-like 3b |
|
| chr14_-_11456724 Show fit | 1.19 |
ENSDART00000110424
|
si:ch211-153b23.4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosb+fosl2+si:ch211-153j24.3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.8 | GO:0071962 | mitotic sister chromatid cohesion, centromeric(GO:0071962) |
| 0.3 | 3.8 | GO:0035999 | tetrahydrofolate interconversion(GO:0035999) |
| 0.2 | 1.7 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.1 | 1.4 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.1 | 1.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 1.3 | GO:0060840 | artery development(GO:0060840) |
| 0.2 | 1.2 | GO:1902315 | cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975) |
| 0.2 | 1.2 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 1.2 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.0 | 1.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0000776 | kinetochore(GO:0000776) |
| 0.8 | 2.5 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.0 | 1.4 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 1.2 | GO:0000811 | GINS complex(GO:0000811) |
| 0.1 | 1.1 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.1 | 1.0 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 1.0 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 0.9 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 0.9 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.8 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.0 | 3.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 2.5 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.4 | 1.7 | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 0.3 | 1.4 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 1.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 1.2 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.1 | 1.1 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 1.1 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 0.9 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.2 | PID S1P S1P2 PATHWAY | S1P2 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 1.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.8 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.1 | 0.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 0.6 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.5 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |