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PRJEB1986: zebrafish developmental stages transcriptome

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Results for foxo3b+foxo6a+foxo6b

Z-value: 0.77

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Transcription factors associated with foxo3b+foxo6a+foxo6b

Gene Symbol Gene ID Gene Info
foxo6b
ENSDARG00000024619 forkhead box O6 b
foxo3b
ENSDARG00000042904 forkhead box O3b
foxo6a
ENSDARG00000100486 forkhead box O6 a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo6adr11_v1_chr16_-_7362806_73628060.771.3e-04Click!
foxo3bdr11_v1_chr20_-_32332736_323327360.483.9e-02Click!
foxo6bdr11_v1_chr19_+_15571290_155712900.427.1e-02Click!

Activity profile of foxo3b+foxo6a+foxo6b motif

Sorted Z-values of foxo3b+foxo6a+foxo6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_26118855 4.02 ENSDART00000009028
ela3l
elastase 3 like
chr2_+_10134345 3.25 ENSDART00000100725
ahsg2
alpha-2-HS-glycoprotein 2
chr14_-_46238186 3.02 ENSDART00000173245
si:ch211-113d11.6
si:ch211-113d11.6
chr6_+_30091811 2.29 ENSDART00000088403
meltf
melanotransferrin
chr1_+_5576151 2.28 ENSDART00000109756
cpo
carboxypeptidase O
chr3_-_61203203 2.15 ENSDART00000171787
pvalb1
parvalbumin 1
chr1_-_43915423 1.92 ENSDART00000181915
ENSDART00000113673
scpp5
secretory calcium-binding phosphoprotein 5
chr5_+_38726854 1.91 ENSDART00000138484
ENSDART00000142867
si:dkey-58f10.7
si:dkey-58f10.7
chr18_-_44527124 1.79 ENSDART00000189471
aplp2
amyloid beta (A4) precursor-like protein 2
chr5_-_12031174 1.78 ENSDART00000159896
castor1
cytosolic arginine sensor for mTORC1 subunit 1
chr23_-_12158685 1.73 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr3_+_19299309 1.69 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr9_+_5862040 1.61 ENSDART00000129117
pdzk1
PDZ domain containing 1
chr3_-_48716422 1.58 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr22_+_7480465 1.52 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr22_+_7486867 1.48 ENSDART00000034586
CELA1 (1 of many)
zgc:112302
chr18_-_46208581 1.42 ENSDART00000141278
si:ch211-14c7.2
si:ch211-14c7.2
chr9_-_12574473 1.36 ENSDART00000191372
ENSDART00000193667
igf2bp2a
insulin-like growth factor 2 mRNA binding protein 2a
chr21_+_11468934 1.31 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr2_-_38125657 1.29 ENSDART00000143433
cbln12
cerebellin 12
chr15_-_12319065 1.25 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr3_-_62380146 1.23 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr7_-_65492048 1.22 ENSDART00000162381
dkk3a
dickkopf WNT signaling pathway inhibitor 3a
chr16_-_45178430 1.21 ENSDART00000165186
si:dkey-33i11.9
si:dkey-33i11.9
chr5_+_28433215 1.20 ENSDART00000165072
ENSDART00000168005
nsmfb
NMDA receptor synaptonuclear signaling and neuronal migration factor b
chr2_-_37478418 1.16 ENSDART00000146103
dapk3
death-associated protein kinase 3
chr14_-_4682114 1.11 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr10_+_38526496 1.04 ENSDART00000144329
acer3
alkaline ceramidase 3
chr2_+_44571200 1.03 ENSDART00000098132
klhl24a
kelch-like family member 24a
chr2_-_43850637 1.02 ENSDART00000136077
zeb1a
zinc finger E-box binding homeobox 1a
chr20_+_13956106 1.01 ENSDART00000152826
si:dkey-249p7.4
si:dkey-249p7.4
chr14_-_2221877 0.99 ENSDART00000106704
pcdh2ab1
protocadherin 2 alpha b 1
chr19_-_47323267 0.98 ENSDART00000190077
CU138512.1

chr6_+_3516926 0.98 ENSDART00000151607
faah
fatty acid amide hydrolase
chr7_-_36358303 0.93 ENSDART00000130028
fto
fat mass and obesity associated
chr12_+_31713239 0.91 ENSDART00000122379
habp2
hyaluronan binding protein 2
chr2_-_56757069 0.89 ENSDART00000164461
hmha1a
histocompatibility (minor) HA-1 a
chr1_+_19708508 0.89 ENSDART00000054581
ENSDART00000131206
march1
membrane-associated ring finger (C3HC4) 1
chr9_-_3149896 0.88 ENSDART00000020861
pdk1
pyruvate dehydrogenase kinase, isozyme 1
chr10_-_21046917 0.87 ENSDART00000091004
pcdh1a
protocadherin 1a
chr16_-_44878245 0.85 ENSDART00000154391
ENSDART00000154925
ENSDART00000154697
arhgap33
Rho GTPase activating protein 33
chr7_-_36358735 0.85 ENSDART00000188392
fto
fat mass and obesity associated
chr22_+_7462997 0.84 ENSDART00000106082
zgc:112368
zgc:112368
chr5_-_17876709 0.84 ENSDART00000141978
si:dkey-112e17.1
si:dkey-112e17.1
chr21_-_43949208 0.84 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr8_-_16464453 0.83 ENSDART00000098691
rnf11b
ring finger protein 11b
chr6_-_51386656 0.80 ENSDART00000154732
ENSDART00000177990
ENSDART00000184928
ENSDART00000180197
ptprt
protein tyrosine phosphatase, receptor type, t
chr6_+_58549080 0.80 ENSDART00000180117
stmn3
stathmin-like 3
chr6_+_39279831 0.79 ENSDART00000155088
ankrd33ab
ankyrin repeat domain 33Ab
chr10_+_36650222 0.78 ENSDART00000126963
ucp3
uncoupling protein 3
chr9_+_11587629 0.78 ENSDART00000102508
ENSDART00000146585
si:dkey-69o16.5
si:dkey-69o16.5
chr15_-_2973368 0.77 ENSDART00000163131
zgc:153184
zgc:153184
chr18_-_44526940 0.76 ENSDART00000077125
aplp2
amyloid beta (A4) precursor-like protein 2
chr17_-_5610514 0.75 ENSDART00000004043
enpp4
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr14_-_6402769 0.74 ENSDART00000121552
slc44a1b
solute carrier family 44 (choline transporter), member 1b
chr7_-_57949117 0.73 ENSDART00000138803
ank2b
ankyrin 2b, neuronal
chr19_+_19599528 0.72 ENSDART00000163054
hibadha
3-hydroxyisobutyrate dehydrogenase a
chr2_-_43850897 0.72 ENSDART00000005449
zeb1a
zinc finger E-box binding homeobox 1a
chr20_+_46216431 0.69 ENSDART00000185384
stx7l
syntaxin 7-like
chr5_-_62940851 0.68 ENSDART00000137052
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr21_-_293146 0.68 ENSDART00000157781
plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr5_-_30145939 0.67 ENSDART00000086795
zbtb44
zinc finger and BTB domain containing 44
chr15_+_1134870 0.65 ENSDART00000155392
p2ry13
purinergic receptor P2Y13
chr5_+_4575800 0.65 ENSDART00000180952
cst14b.2
cystatin 14b, tandem duplicate 2
chr4_+_20536120 0.65 ENSDART00000125685
zmp:0000000650
zmp:0000000650
chr11_+_41560792 0.64 ENSDART00000127292
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr1_+_10018466 0.63 ENSDART00000113551
trim2b
tripartite motif containing 2b
chr2_+_22409249 0.62 ENSDART00000182915
zgc:56628
zgc:56628
chr15_-_33304133 0.62 ENSDART00000186092
nbeab
neurobeachin b
chr1_+_6357059 0.61 ENSDART00000166620
hecw2b
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b
chr8_+_52642869 0.61 ENSDART00000163617
ENSDART00000189997
si:dkey-90l8.3
si:dkey-90l8.3
chr5_+_30179010 0.61 ENSDART00000134624
adamts15a
ADAM metallopeptidase with thrombospondin type 1 motif, 15a
chr23_+_31405497 0.60 ENSDART00000053546
sh3bgrl2
SH3 domain binding glutamate-rich protein like 2
chr21_-_22828593 0.60 ENSDART00000150993
angptl5
angiopoietin-like 5
chr16_+_48753664 0.60 ENSDART00000155148
si:ch73-31d8.2
si:ch73-31d8.2
chr10_+_40700311 0.59 ENSDART00000157650
ENSDART00000138342
taar19n
trace amine associated receptor 19n
chr4_+_75458537 0.57 ENSDART00000166278
si:ch211-266c8.1
si:ch211-266c8.1
chr22_-_5958066 0.57 ENSDART00000145821
si:rp71-36a1.3
si:rp71-36a1.3
chr12_-_47782623 0.56 ENSDART00000115742
selenou1b
selenoprotein U1b
chr21_-_13123176 0.55 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr4_-_53047883 0.55 ENSDART00000157496
si:dkey-201g16.5
si:dkey-201g16.5
chr6_-_46560207 0.52 ENSDART00000187607
kcnb1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr9_-_16877456 0.52 ENSDART00000161105
ENSDART00000160869
fbxl3a
F-box and leucine-rich repeat protein 3a
chr9_-_52386733 0.49 ENSDART00000171721
dap1b
death associated protein 1b
chr24_+_32411753 0.49 ENSDART00000058530
neurod6a
neuronal differentiation 6a
chr1_-_37383741 0.49 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
scpp1
secretory calcium-binding phosphoprotein 1
chr17_+_8291561 0.49 ENSDART00000152006
si:ch211-236p5.3
si:ch211-236p5.3
chr9_-_3834686 0.48 ENSDART00000141492
myo3b
myosin IIIB
chr11_-_22303678 0.47 ENSDART00000159527
ENSDART00000159681
tfeb
transcription factor EB
chr20_+_22067337 0.46 ENSDART00000152636
clocka
clock circadian regulator a
chr3_-_46115232 0.45 ENSDART00000074537
shisa9b
shisa family member 9b
chr15_+_29276508 0.45 ENSDART00000170537
ENSDART00000126559
rap1gap2a
RAP1 GTPase activating protein 2a
chr17_-_2834764 0.43 ENSDART00000024027
bdkrb1
bradykinin receptor B1
chr13_-_8601184 0.42 ENSDART00000045086
prkceb
protein kinase C, epsilon b
chr8_-_52091696 0.42 ENSDART00000108923
vps13a
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr24_+_32472155 0.40 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr16_-_8663493 0.40 ENSDART00000014944
ENSDART00000181533
ENSDART00000182721
ENSDART00000162988
cobl
cordon-bleu WH2 repeat protein
chr17_-_28198099 0.37 ENSDART00000156143
htr1d
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr1_-_37383539 0.37 ENSDART00000127579
scpp1
secretory calcium-binding phosphoprotein 1
chr19_-_19599372 0.36 ENSDART00000160002
ENSDART00000171664
tax1bp1a
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr1_+_8314826 0.36 ENSDART00000160440
cacna1hb
calcium channel, voltage-dependent, T type, alpha 1H subunit b
chr7_+_40094081 0.36 ENSDART00000186054
si:ch73-174h16.4
si:ch73-174h16.4
chr5_-_323712 0.35 ENSDART00000188793
HOOK3
hook microtubule tethering protein 3
chr15_+_22014029 0.35 ENSDART00000079504
ankk1
ankyrin repeat and kinase domain containing 1
chr7_-_20241346 0.35 ENSDART00000173619
ENSDART00000127699
si:ch73-335l21.4
si:ch73-335l21.4
chr24_+_9612410 0.34 ENSDART00000142460
ENSDART00000110629
nphp3
nephronophthisis 3
chr15_-_44465679 0.34 ENSDART00000054605
aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr25_-_16832705 0.34 ENSDART00000171336
ENSDART00000189396
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr3_+_43460696 0.34 ENSDART00000164581
galr2b
galanin receptor 2b
chr19_-_23470709 0.33 ENSDART00000138884
pimr80
Pim proto-oncogene, serine/threonine kinase, related 80
chr3_+_60828813 0.32 ENSDART00000128260
CABZ01087514.1

chr2_-_7131657 0.30 ENSDART00000175565
ENSDART00000092116
extl2
exostosin-like glycosyltransferase 2
chr9_+_24088062 0.28 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr25_-_8160030 0.28 ENSDART00000067159
tph1a
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
chr10_-_7472323 0.27 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
nrg1
neuregulin 1
chr3_-_26341959 0.27 ENSDART00000169344
ENSDART00000142878
ENSDART00000087196
zgc:153240
zgc:153240
chr21_+_17541634 0.26 ENSDART00000191700
ENSDART00000163238
stom
stomatin
chr19_+_8481802 0.26 ENSDART00000050217
efna1a
ephrin-A1a
chr8_-_36125849 0.26 ENSDART00000159581
CT583723.1

chr19_-_32600138 0.25 ENSDART00000052101
zgc:91944
zgc:91944
chr4_+_70791887 0.24 ENSDART00000164234
si:ch211-127b6.2
si:ch211-127b6.2
chr10_-_25570647 0.24 ENSDART00000134215
grik1a
glutamate receptor, ionotropic, kainate 1a
chr18_-_10995410 0.23 ENSDART00000136751
tspan33b
tetraspanin 33b
chr11_+_23933016 0.23 ENSDART00000000486
cntn2
contactin 2
chr4_-_49133107 0.22 ENSDART00000150806
znf1146
zinc finger protein 1146
chr6_+_28124393 0.22 ENSDART00000089195
gpr17
G protein-coupled receptor 17
chr1_-_10347198 0.22 ENSDART00000109141
ENSDART00000152565
si:ch211-243g6.3
si:ch211-243g6.3
chr2_-_31540922 0.21 ENSDART00000056686
mrc1b
mannose receptor, C type 1b
chr13_-_37608441 0.21 ENSDART00000140230
zgc:123068
zgc:123068
chr16_+_35343493 0.20 ENSDART00000171269
si:dkey-34d22.1
si:dkey-34d22.1
chr12_-_4424424 0.20 ENSDART00000152314
si:ch211-173d10.1
si:ch211-173d10.1
chr7_+_3597413 0.20 ENSDART00000064281
si:dkey-192d15.2
si:dkey-192d15.2
chr2_+_18017000 0.20 ENSDART00000186877
BX511224.1

chr22_-_29586608 0.19 ENSDART00000059869
adra2a
adrenoceptor alpha 2A
chr22_+_2524615 0.17 ENSDART00000134277
znf1003
zinc finger protein 1003
chr24_-_36723116 0.17 ENSDART00000088204
si:ch73-334d15.1
si:ch73-334d15.1
chr15_-_8191841 0.17 ENSDART00000156663
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr13_+_36613359 0.15 ENSDART00000140598
si:ch211-67f24.7
si:ch211-67f24.7
chr8_-_49201258 0.15 ENSDART00000114584
ENSDART00000142172
zgc:171501
zgc:171501
chr22_-_34995333 0.14 ENSDART00000110900
kcnip2
Kv channel interacting protein 2
chr6_+_10077756 0.14 ENSDART00000150982
htr2ab
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b
chr19_-_7690975 0.14 ENSDART00000151384
si:dkey-204a24.10
si:dkey-204a24.10
chr16_-_31351419 0.13 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr21_-_28640316 0.12 ENSDART00000128237
nrg2a
neuregulin 2a
chr7_+_61906903 0.12 ENSDART00000108540
tdrd7b
tudor domain containing 7 b
chr24_+_5829265 0.12 ENSDART00000155242
si:ch211-157j23.5
si:ch211-157j23.5
chr13_-_29420885 0.12 ENSDART00000024225
chata
choline O-acetyltransferase a
chr14_-_17306261 0.12 ENSDART00000191747
jakmip1
janus kinase and microtubule interacting protein 1
chr21_-_32301109 0.11 ENSDART00000139890
clk4b
CDC-like kinase 4b
chr25_-_35127617 0.11 ENSDART00000125128
hist1h2a4
histone cluster 1 H2A family member 4
chr16_+_53519048 0.10 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr14_-_45551572 0.09 ENSDART00000111410
ganab
glucosidase, alpha; neutral AB
chr1_+_31942961 0.09 ENSDART00000007522
anos1a
anosmin 1a
chr15_-_8191992 0.09 ENSDART00000155381
ENSDART00000190714
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr23_-_1017605 0.08 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr12_+_46582168 0.08 ENSDART00000189402
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr17_+_24111392 0.08 ENSDART00000180123
ENSDART00000182787
ENSDART00000189752
ENSDART00000184940
ENSDART00000185363
ENSDART00000064067
ehbp1
EH domain binding protein 1
chr24_-_33284945 0.07 ENSDART00000155429
ENSDART00000112845
zgc:195173
zgc:195173
chr16_+_46000956 0.06 ENSDART00000101753
ENSDART00000162393
mtmr11
myotubularin related protein 11
chr4_-_46946643 0.06 ENSDART00000180392
ENSDART00000184563
si:dkey-16p6.1
si:dkey-16p6.1
chr18_+_48943875 0.05 ENSDART00000076803
FO681288.1

chr23_-_17470146 0.05 ENSDART00000002398
trim101
tripartite motif containing 101
chr9_-_31135901 0.05 ENSDART00000113027
ENSDART00000193210
ENSDART00000128896
si:ch211-184m13.4
si:ch211-184m13.4
chr13_+_4205724 0.05 ENSDART00000134105
dlk2
delta-like 2 homolog (Drosophila)
chr7_-_30932094 0.04 ENSDART00000057677
terb2
telomere repeat binding bouquet formation protein 2
chr14_+_34547554 0.04 ENSDART00000074819
gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr16_-_21181128 0.03 ENSDART00000133403
pde11al
phosphodiesterase 11a, like
chr19_-_7441686 0.03 ENSDART00000168194
gabpb2a
GA binding protein transcription factor, beta subunit 2a
chr8_+_47897734 0.03 ENSDART00000140266
mfn2
mitofusin 2
chr3_+_25195966 0.02 ENSDART00000112338
il2rb
interleukin 2 receptor, beta
chr7_-_52558495 0.02 ENSDART00000138263
ENSDART00000009938
ENSDART00000174292
ENSDART00000174218
ENSDART00000174335
tcf12
transcription factor 12
chr16_-_45230084 0.02 ENSDART00000184652
si:dkey-33i11.4
si:dkey-33i11.4
chr23_+_36308428 0.02 ENSDART00000134607
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr17_-_50436199 0.02 ENSDART00000156494
si:ch211-235i11.6
si:ch211-235i11.6
chr16_-_29480335 0.02 ENSDART00000148930
lingo4b
leucine rich repeat and Ig domain containing 4b
chr7_-_19966406 0.01 ENSDART00000010932
snx15
sorting nexin 15
chr17_-_50454957 0.01 ENSDART00000171616
ENSDART00000075195
si:ch211-235i11.7
si:ch211-235i11.7
chr15_+_791220 0.01 ENSDART00000136137
si:dkey-7i4.1
si:dkey-7i4.1
chr8_-_23573084 0.01 ENSDART00000139084
wasb
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr17_-_50472864 0.01 ENSDART00000161066
ENSDART00000156963
si:ch211-235i11.3
si:ch211-235i11.3
chr1_-_11607062 0.01 ENSDART00000158253
si:dkey-26i13.6
si:dkey-26i13.6
chr5_-_3118346 0.00 ENSDART00000167554
hsf5
heat shock transcription factor family member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo3b+foxo6a+foxo6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0042245 RNA repair(GO:0042245)
0.4 1.6 GO:0099563 modification of synaptic structure(GO:0099563)
0.3 1.7 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.3 1.7 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.2 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 0.7 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 1.0 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.1 0.7 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 1.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.7 GO:0006574 valine catabolic process(GO:0006574)
0.1 1.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.3 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.8 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.3 GO:0036135 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.1 1.0 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.1 0.6 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.2 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 1.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 2.3 GO:0006826 iron ion transport(GO:0006826)
0.1 0.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.6 GO:0098900 regulation of action potential(GO:0098900)
0.1 0.4 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.1 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.3 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.5 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 0.1 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 3.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.1 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222)
0.0 1.2 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 1.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.5 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.9 GO:0010906 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.0 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) regulation of behavior(GO:0050795)
0.0 1.4 GO:0051028 mRNA transport(GO:0051028)
0.0 1.0 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 0.9 GO:0007596 blood coagulation(GO:0007596)
0.0 0.0 GO:0045141 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.4 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.8 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.8 GO:0003146 heart jogging(GO:0003146)
0.0 0.5 GO:0021591 ventricular system development(GO:0021591)
0.0 0.1 GO:0071679 commissural neuron axon guidance(GO:0071679)
0.0 1.8 GO:1990778 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0061700 GATOR2 complex(GO:0061700)
0.2 1.2 GO:0070062 extracellular exosome(GO:0070062)
0.1 2.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.5 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.7 GO:0030315 T-tubule(GO:0030315)
0.0 1.6 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 0.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.3 GO:0055037 recycling endosome(GO:0055037)
0.0 1.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.6 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0034618 arginine binding(GO:0034618)
0.4 1.8 GO:0043734 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.4 1.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.3 1.0 GO:0017040 ceramidase activity(GO:0017040)
0.2 1.0 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.2 1.2 GO:0039706 co-receptor binding(GO:0039706)
0.2 0.8 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 0.7 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.1 1.6 GO:0043495 protein anchor(GO:0043495)
0.1 0.5 GO:0070513 death domain binding(GO:0070513)
0.1 0.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 2.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.1 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.5 GO:0070888 E-box binding(GO:0070888)
0.1 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.3 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.8 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 1.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 1.5 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 2.5 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 5.7 GO:0008236 serine-type peptidase activity(GO:0008236) serine hydrolase activity(GO:0017171)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0010857 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698) calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 1.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.