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PRJEB1986: zebrafish developmental stages transcriptome

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Results for glis3

Z-value: 0.22

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Transcription factors associated with glis3

Gene Symbol Gene ID Gene Info
glis3
ENSDARG00000069726 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glis3dr11_v1_chr10_-_690072_690170-0.846.5e-06Click!

Activity profile of glis3 motif

Sorted Z-values of glis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_30704075 1.22 ENSDART00000134098
efemp2a
EGF containing fibulin extracellular matrix protein 2a
chr8_+_46641314 0.98 ENSDART00000113803
her3
hairy-related 3
chr5_+_67662430 0.41 ENSDART00000137700
ENSDART00000142586
si:dkey-70b23.2
si:dkey-70b23.2
chr20_-_26588736 0.36 ENSDART00000134337
exoc2
exocyst complex component 2
chr8_-_15182232 0.34 ENSDART00000138855
bcar3
BCAR3, NSP family adaptor protein
chr5_+_25760112 0.32 ENSDART00000088011
ENSDART00000182046
tmem2
transmembrane protein 2
chr15_-_41245962 0.31 ENSDART00000155359
smco4
single-pass membrane protein with coiled-coil domains 4
chr3_-_25106878 0.31 ENSDART00000142503
rbx1
ring-box 1, E3 ubiquitin protein ligase
chr4_+_77981553 0.28 ENSDART00000174108
ENSDART00000122459
terfa
telomeric repeat binding factor a
chr17_+_8925232 0.24 ENSDART00000036668
psmc1a
proteasome 26S subunit, ATPase 1a
chr3_+_30190419 0.24 ENSDART00000157320
akt1s1
AKT1 substrate 1 (proline-rich)
chr21_+_20950161 0.18 ENSDART00000079698
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr5_+_45000597 0.13 ENSDART00000051146
dmrt3a
doublesex and mab-3 related transcription factor 3a
chr3_-_53092509 0.10 ENSDART00000062081
lpar2a
lysophosphatidic acid receptor 2a
chr18_+_33100606 0.09 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr21_+_20949976 0.09 ENSDART00000135342
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr14_-_34044369 0.04 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr17_+_49500820 0.02 ENSDART00000170306
AREL1
apoptosis resistant E3 ubiquitin protein ligase 1
chr18_-_41375120 0.02 ENSDART00000098673
ptx3a
pentraxin 3, long a
chr10_+_29260096 0.02 ENSDART00000088973
sytl2a
synaptotagmin-like 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of glis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.1 1.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.3 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.3 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:0046661 male sex differentiation(GO:0046661)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol