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PRJEB1986: zebrafish developmental stages transcriptome

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Results for grhl1

Z-value: 1.33

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Transcription factors associated with grhl1

Gene Symbol Gene ID Gene Info
grhl1
ENSDARG00000061391 grainyhead-like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
grhl1dr11_v1_chr17_-_32426392_32426413-0.223.6e-01Click!

Activity profile of grhl1 motif

Sorted Z-values of grhl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_13541514 4.16 ENSDART00000063834
zgc:86586
zgc:86586
chr4_-_9780931 4.02 ENSDART00000134280
ENSDART00000150664
ENSDART00000150304
ENSDART00000080744
svopl
SVOP-like
chr1_+_49352900 3.67 ENSDART00000008468
msx1b
muscle segment homeobox 1b
chr11_+_6116503 3.29 ENSDART00000176170
nr2f6b
nuclear receptor subfamily 2, group F, member 6b
chr13_+_18533005 3.29 ENSDART00000136024
ftr14l
finTRIM family, member 14-like
chr14_+_46216703 3.20 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr3_-_29977495 3.06 ENSDART00000077111
hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr1_-_52498146 2.66 ENSDART00000122217
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr16_+_7154753 2.62 ENSDART00000163281
ENSDART00000168274
bmper
BMP binding endothelial regulator
chr15_-_5901514 2.60 ENSDART00000155252
si:ch73-281n10.2
si:ch73-281n10.2
chr4_-_14954029 2.57 ENSDART00000038642
slc26a5
solute carrier family 26 (anion exchanger), member 5
chr14_-_33945692 2.52 ENSDART00000168546
ENSDART00000189778
zdhhc24
zinc finger, DHHC-type containing 24
chr21_+_25625026 2.48 ENSDART00000134678
ovol1b
ovo-like zinc finger 1b
chr14_+_4276394 2.41 ENSDART00000038301
gnpda2
glucosamine-6-phosphate deaminase 2
chr15_+_42560354 2.29 ENSDART00000059484
CLDN8 (1 of many)
zgc:110333
chr9_-_30264415 2.09 ENSDART00000060150
mid1ip1a
MID1 interacting protein 1a
chr16_+_35661771 2.07 ENSDART00000161393
map7d1a
MAP7 domain containing 1a
chr24_+_38671054 1.99 ENSDART00000154214
si:ch73-70c5.1
si:ch73-70c5.1
chr4_-_14954327 1.99 ENSDART00000182729
slc26a5
solute carrier family 26 (anion exchanger), member 5
chr15_+_509126 1.95 ENSDART00000102274
ftr86
finTRIM family, member 86
chr25_+_7435291 1.85 ENSDART00000172567
ENSDART00000163017
prc1a
protein regulator of cytokinesis 1a
chr9_-_14108896 1.84 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr2_-_47620806 1.78 ENSDART00000038228
ap1s3b
adaptor-related protein complex 1, sigma 3 subunit, b
chr19_-_41472228 1.78 ENSDART00000113388
dlx5a
distal-less homeobox 5a
chr1_-_52497834 1.76 ENSDART00000136469
ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr22_+_25672155 1.76 ENSDART00000087769
si:ch211-250e5.2
si:ch211-250e5.2
chr16_-_10837245 1.72 ENSDART00000036891
rabac1
Rab acceptor 1 (prenylated)
chr1_-_9858508 1.70 ENSDART00000147904
mad1l1
mitotic arrest deficient 1 like 1
chr7_+_19835569 1.68 ENSDART00000149812
ovol1a
ovo-like zinc finger 1a
chr13_-_30161684 1.61 ENSDART00000040409
ppa1b
pyrophosphatase (inorganic) 1b
chr21_-_13668358 1.59 ENSDART00000180323
pnpla7a
patatin-like phospholipase domain containing 7a
chr19_-_32500373 1.56 ENSDART00000052104
fuca1.1
alpha-L-fucosidase 1, tandem duplicate 1
chr16_+_35661331 1.54 ENSDART00000161725
map7d1a
MAP7 domain containing 1a
chr16_+_17715243 1.51 ENSDART00000149437
ENSDART00000149596
si:dkey-87o1.2
si:dkey-87o1.2
chr10_-_22127942 1.47 ENSDART00000133374
ponzr2
plac8 onzin related protein 2
chr22_+_22021936 1.47 ENSDART00000149586
gna15.1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
chr12_+_30705769 1.45 ENSDART00000186448
ENSDART00000066259
kcnk1a
potassium channel, subfamily K, member 1a
chr6_+_23057311 1.36 ENSDART00000026448
evpla
envoplakin a
chr10_+_4924388 1.32 ENSDART00000108595
slc46a2
solute carrier family 46 member 2
chr1_+_45922699 1.23 ENSDART00000033669
lipt1
lipoyltransferase 1
chr16_-_9675982 1.23 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)
chr3_-_18755651 1.21 ENSDART00000145277
zgc:113333
zgc:113333
chr6_+_30668098 1.20 ENSDART00000112294
ttc22
tetratricopeptide repeat domain 22
chr3_+_34140507 1.19 ENSDART00000131802
si:dkey-204f11.64
si:dkey-204f11.64
chr14_-_763744 1.12 ENSDART00000165856
trim35-27
tripartite motif containing 35-27
chr25_+_15994100 1.12 ENSDART00000144723
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr16_+_35905031 1.05 ENSDART00000162411
sh3d21
SH3 domain containing 21
chr2_-_17827983 1.04 ENSDART00000166518
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr1_-_48933 1.03 ENSDART00000171162
ildr1a
immunoglobulin-like domain containing receptor 1a
chr3_-_16537441 1.02 ENSDART00000080749
ENSDART00000133824
eps8l1
eps8-like1
chr19_+_30885258 0.99 ENSDART00000143394
yars
tyrosyl-tRNA synthetase
chr4_+_4232562 0.99 ENSDART00000177529
smkr1
small lysine rich protein 1
chr8_-_24252933 0.90 ENSDART00000057624
zgc:110353
zgc:110353
chr6_-_18560190 0.90 ENSDART00000168636
tefm
transcription elongation factor, mitochondrial
chr25_-_24202576 0.88 ENSDART00000048507
uevld
UEV and lactate/malate dehyrogenase domains
chr7_-_24193051 0.86 ENSDART00000169737
ENSDART00000171085
si:ch211-216p19.6
si:ch211-216p19.6
chr9_-_40014339 0.84 ENSDART00000166918
IKZF2
si:zfos-1425h8.1
chr16_-_28091597 0.80 ENSDART00000166595
CR626941.1

chr12_+_30706158 0.80 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr23_+_43668756 0.78 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr16_-_20294236 0.77 ENSDART00000059623
plekha8
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
chr24_-_8412526 0.77 ENSDART00000150055
slc35b3
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
chr10_-_36793412 0.77 ENSDART00000185966
dhrs13a.2
dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2
chr15_+_5901970 0.75 ENSDART00000114134
wrb
tryptophan rich basic protein
chr21_+_5801105 0.72 ENSDART00000151225
ENSDART00000184487
ccng2
cyclin G2
chr7_+_54259657 0.66 ENSDART00000170174
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr4_-_12725513 0.66 ENSDART00000132286
mgst1.2
microsomal glutathione S-transferase 1.2
chr3_-_32831429 0.65 ENSDART00000184932
zgc:153733
zgc:153733
chr12_+_30360579 0.64 ENSDART00000152900
si:ch211-225b10.3
si:ch211-225b10.3
chr5_+_4006837 0.64 ENSDART00000138862
pigw
phosphatidylinositol glycan anchor biosynthesis, class W
chr13_+_42544009 0.63 ENSDART00000145409
si:dkey-221j11.3
si:dkey-221j11.3
chr10_+_19525839 0.63 ENSDART00000162912
ENSDART00000158512
vsig8a
V-set and immunoglobulin domain containing 8a
chr16_-_31976269 0.58 ENSDART00000139664
styk1
serine/threonine/tyrosine kinase 1
chr3_+_37196258 0.57 ENSDART00000187944
ENSDART00000185896
fmnl1a
formin-like 1a
chr17_+_28102487 0.53 ENSDART00000131638
ENSDART00000076265
zgc:91908
zgc:91908
chr4_-_26413391 0.46 ENSDART00000145955
b4galnt3a
beta-1,4-N-acetyl-galactosaminyl transferase 3a
chr14_+_45702521 0.44 ENSDART00000112470
ccdc88b
coiled-coil domain containing 88B
chr23_-_19225709 0.43 ENSDART00000080099
oard1
O-acyl-ADP-ribose deacylase 1
chr8_-_13029297 0.42 ENSDART00000144305
dennd2da
DENN/MADD domain containing 2Da
chr11_-_42417194 0.40 ENSDART00000191086
ENSDART00000076650
ENSDART00000165903
ENSDART00000104444
slmapa
sarcolemma associated protein a
chr5_-_29570141 0.39 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr11_+_8152872 0.26 ENSDART00000091638
ENSDART00000138057
ENSDART00000166379
samd13
sterile alpha motif domain containing 13
chr15_+_41919484 0.26 ENSDART00000099821
ENSDART00000146246
nlrp16
NACHT, LRR and PYD domains-containing protein 16
chr23_-_33986762 0.25 ENSDART00000144609
tmed4
transmembrane p24 trafficking protein 4
chr20_+_20731052 0.24 ENSDART00000047662
ppp1r13bb
protein phosphatase 1, regulatory subunit 13Bb
chr11_-_17964525 0.18 ENSDART00000018948
cishb
cytokine inducible SH2-containing protein b
chr2_+_5521671 0.16 ENSDART00000099647
ENSDART00000138443
crfb16
cytokine receptor family member B16
chr4_+_71401321 0.12 ENSDART00000158076
si:ch211-76m11.7
si:ch211-76m11.7
chr3_-_30186296 0.11 ENSDART00000134395
ENSDART00000077057
ENSDART00000017422
tbc1d17
TBC1 domain family, member 17
chr3_-_18756076 0.08 ENSDART00000055766
zgc:113333
zgc:113333
chr24_+_42074143 0.07 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr16_-_12097394 0.04 ENSDART00000103944
pex5
peroxisomal biogenesis factor 5
chr3_+_32832042 0.04 ENSDART00000132679
ENSDART00000035759
cd2bp2
CD2 (cytoplasmic tail) binding protein 2
chr22_-_14361022 0.04 ENSDART00000140224
si:dkeyp-122a9.2
si:dkeyp-122a9.2
chr8_+_3405612 0.03 ENSDART00000163437
zgc:112433
zgc:112433
chr17_+_22102791 0.03 ENSDART00000047772
mal
mal, T cell differentiation protein

Network of associatons between targets according to the STRING database.

First level regulatory network of grhl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0019532 oxalate transport(GO:0019532)
0.8 2.4 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.6 3.2 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.3 1.6 GO:0006004 fucose metabolic process(GO:0006004)
0.2 1.2 GO:0045056 transcytosis(GO:0045056)
0.2 1.7 GO:0070285 pigment cell development(GO:0070285)
0.2 1.8 GO:0021553 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.2 0.8 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.7 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.2 6.3 GO:0043049 otic placode formation(GO:0043049)
0.2 1.2 GO:0009249 protein lipoylation(GO:0009249)
0.2 1.8 GO:0051256 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.1 1.0 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.8 GO:0035627 ceramide transport(GO:0035627)
0.1 2.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 0.4 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 0.7 GO:0014028 notochord formation(GO:0014028)
0.0 1.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.8 GO:0042574 retinal metabolic process(GO:0042574)
0.0 2.1 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 0.4 GO:0001881 receptor recycling(GO:0001881)
0.0 1.4 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 2.5 GO:0009913 epidermal cell differentiation(GO:0009913)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 3.2 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 4.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.8 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.8 3.2 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.5 1.6 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.4 1.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.4 4.4 GO:0004046 aminoacylase activity(GO:0004046)
0.3 0.8 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.2 4.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.4 GO:0019215 intermediate filament binding(GO:0019215)
0.2 1.5 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 0.8 GO:1902387 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.1 2.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 2.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.5 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.8 GO:0016208 AMP binding(GO:0016208)
0.1 1.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 3.3 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.4 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.6 GO:0008374 O-acyltransferase activity(GO:0008374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase